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Bing Chun Yan,In Hye Kim,Joon Ha Park,Ji Hyeon Ahn,Jeong-Hwi Cho,Bai Hui Chen,Jae-Chul Lee,Jung Hoon Choi,Ki-Yeon Yoo,Choong Hyun Lee,Jun Hwi Cho,Jong-Dai Kim,Moo-Ho Won 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.3
In the present study, we investigated the effect of Tetaus toxin (TeT) on cell proliferation and neuroblast differentiation using specific markers: 5-bromo-2-deoxyuridine (BrdU) as an exogenous marker for cell proliferation, Ki-67 as an endogenous marker for cell proliferation and doublecortin (DCX) as a marker for neuroblasts in the mouse hippocampal dentate gyrus (DG) after TeT treatment. Mice were intraperitoneally administered 2.5 and 10 ng/kg TeT and sacrificed 15 days after the treatment. In both the TeT-treated groups, no neuronal death occurred in any layers of the DG using neuronal nuclei (NeuN, a neuron nuclei maker) and Fluoro-Jade B (F-J B, a high-affinity fluorescent marker for the localization of neuronal degeneration). In addition, no significant change in glial activation in both the 2.5 and 10 ng/kg TeT-treated-groups was found by GFAP (a marker for astrocytes) and Iba-1 (a marker for microglia) immunohistochemistry. However, in the 2.5 ng/kg TeT-treated-group, the mean number of BrdU, Ki-67 and DCX immunoreactive cells, respectively, were apparently decreased compared to the control group, and the mean number of each in the 10 ng/kg TeT-treated-group was much more decreased. In addition, processes of DCX-immunoreactive cells, which projected into the molecular layer, were short compared to those in the control group. In brief, our present results show that low dosage (10 ng/kg) TeT treatment apparently decreased cell proliferation and neuroblast differentiation in the mouse hippocampal DG without distinct gliosis as well as any loss of adult neurons.
Chen, Jianbo,Wu, Enqi,Zhu, Hongmei,Lee, Kwan-Jun,Chu, Van Men,Cho, Cheong-Weon,Kim, Young-Ho,Park, Yong-Ki,Lee, Won-Jae,Kang, Jong-Seong Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.8
High-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) were used to identify five active components in the modified herbal decoction Bo-Yang-Hwan-O-Tang (mBHT), i.e., amygdalin, decursin, paeoniflorin, salvianolic acid B, and calycosin-7-O-${\beta}$-D-glycoside. These components were identified by comparing their retention times and mass spectra with those of reference compounds. The conditions of both analytical methods were optimized and validated. Sufficient separation of target analytes was achieved using a buffer consisting of 40 mM sodium borate and 60 mM sodium dodecylsulfate (SDS) containing 10% methanol (pH 9.5) at 250 nm for CE analysis and gradient elution with a water-methanol mobile phase and ultraviolet (UV) photodiode array detector (DAD) at 250 nm for HPLC analysis. The mBHT components were determined within 65 min by HPLC and 16 min by CE. All calibration curves showed high linearity (R > 0.999) within the ranges tested. Intra-day and inter-day precision were less than 1.6% and 1.8% for HPLC and 2.5% and 4.8% for CE, respectively. The accuracy of the methods ranged from 98.8% to 102.3% for HPLC and from 95.9% to 108.2% for CE.
Zhao, Chen,Kim, Sae Woong,Yang, Dae Yul,Kim, Je Jong,Park, Nam Cheol,Lee, Sung Won,Paick, Jae Seung,Ahn, Tai Young,Moon, Ki Hak,Chung, Woo Sik,Min, Kweon Sik,Suh, Jun‐,Kyu,Hyun, Jae Seog,Park, K Blackwell Publishing Ltd 2012 BJU INTERNATIONAL Vol.110 No.11
<P>Study Type – Therapy (RCT)</P><P>Level of Evidence 1b</P><P><B>What's known on the subject? and What does the study add?</B></P><P>Avanafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor newly developed for treating erectile dysfunction (ED). Preclinical and clinical phase I studies showed that avanafil had enhanced selectivity, faster onset of action and a favourable side‐effect profile relative to currently available PDE5 inhibitors.</P><P>As the result of phase III clinical trial for the efficacy and safety of avanafil treatment (100 and 200 mg), taken as needed over a period of 12 weeks, in Korean patients with ED, avanafil is an effective and well‐tolerated therapy for ED of broad‐spectrum aetiology and severity.</P><P><B>OBJECTIVE</B></P><P><P>To evaluate the efficacy and safety of avanafil, a new potent selective phosphodiesterase type 5 (PDE5) inhibitor, in patients with erectile dysfunction (ED).</P></P><P><B>PATIENTS AND METHODS</B></P><P><P>The present study was a multicentre, randomized, double‐blind, placebo‐controlled, fix‐dosed phase three clinical trial involving 200 patients with ED.</P><P>The subjects were treated with placebo or avanafil (100 or 200 mg) for 12 weeks and were asked to complete the International Index of Erectile Function (IIEF), the Sexual Encounter Profile (SEP) diary, and the Global Assessment Questionnaire (GAQ).</P><P>The primary outcome variable was the change from baseline for IIEF erectile function domain (EFD) score.</P><P>The secondary outcome variables were SEP Q2 and Q3, the shift to normal rate (EFD ≥ 26), and response to the GAQ.</P></P><P><B>RESULTS</B></P><P><P>Compared with placebo, patients who took 100 or 200 mg of avanafil had significantly improved IIEF‐EFD score.</P><P>There were similar results when comparing Q2 and Q3 in the SEP diary and the GAQ.</P><P>Flushing was the most common treatment‐related adverse event.</P><P>Most adverse events were transient and mild or moderate in severity.</P></P><P><B>CONCLUSION</B></P><P><P>Avanafil is an effective and well‐tolerated therapy for ED of broad‐spectrum aetiology and severity.</P></P>
Magnetically-refreshable receptor platform structures for reusable nano-biosensor chips
Yoo, Haneul,Lee, Dong Jun,Cho, Dong-guk,Park, Juhun,Nam, Ki Wan,Cho, Young Tak,Park, Jae Yeol,Chen, Xing,Hong, Seunghun IOP 2016 Nanotechnology Vol.27 No.4
<P>We developed a magnetically-refreshable receptor platform structure which can be integrated with quite versatile nano-biosensor structures to build <I>reusable</I> nano-biosensor chips. This structure allows one to easily remove used receptor molecules from a biosensor surface and reuse the biosensor for repeated sensing operations. Using this structure, we demonstrated reusable immunofluorescence biosensors. Significantly, since our method allows one to place receptor molecules very close to a nano-biosensor surface, it can be utilized to build reusable carbon nanotube transistor-based biosensors which require receptor molecules within a Debye length from the sensor surface. Furthermore, we also show that a single sensor chip can be utilized to detect two different target molecules simply by replacing receptor molecules using our method. Since this method does not rely on any chemical reaction to refresh sensor chips, it can be utilized for versatile biosensor structures and virtually-general receptor molecular species.</P>
All-fiber 6-mode multiplexers based on fiber mode selective couplers
Chang, Sun Hyok,Moon, Sang-Rok,Chen, Haoshuo,Ryf, Roland,Fontaine, Nicolas K.,Park, Kyung Jun,Kim, Kwangjoon,Lee, Joon Ki The Optical Society 2017 Optics express Vol.25 No.5
<P>All-fiber 6-mode multiplexer composed of two consecutive LP11-mode selective couplers (MSC), two LP21-MSCs and an LP02-MSC is fully characterized by wavelength-swept interferometer technique. The MSCs are fabricated by polished-type fiber couplers coupling LP01 mode of a single mode fiber into a higher-order mode of a few mode fiber. A pair of the mode multiplexers has minimum mode dependent loss of 4 dB and high mode group selectivity of over 15 dB. Mode division multiplexed transmission enabled by the all-fiber mode multiplexers is demonstrated over fiber spans of 117 km employing an in-line multi-mode optical amplifier. 6 modes of 120 Gb/s dual polarization quadrature phase shift keying signals combined with 30 wavelength channels are successfully transmitted. (C) 2017 Optical Society of America</P>
Synthesis and characterization of 9,10-diphenylanthracene-based blue light emitting materials
Kim, Sul Ong,Jung, Hyun Cheol,Lee, Min-Jung,Jun, Chen,Kim, Yun-Hi,Kwon, Soon-Ki Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of polymer science Part A, Polymer chemist Vol.47 No.21
<P>A new series of conjugated polymers having diphenylanthracene vinylene biphenylene and diphenylanthracene vinylene terphenylene in the main chain and fluorene pendant group, were synthesized by nickel catalized Yamamoto coupling and palladium catalized Suzuki coupling. The obtained polymers showed good solubility in the common organic solvent and number average molecular weights of 14,000–9500 with a polydispersity indexes ranging from 1.7 to 2.1. Both polymers possess excellent thermal stability with glass transition temperatures of 123–127 °C and the onset decomposition temperatures of 420–400 °C. The obtained polymers showed blue emission (λ<SUB>max</SUB> = 461 for PFPA and λ<SUB>max</SUB> = 455 nm for PFPAME) in PL spectra, specially, PFPAME containing diphenylanthracene vinylene terphenylenevinylene showed the consistent emission in the solution and film. The double-layered device with an ITO/PEDOT/PFPAME/LiF/Al structure has a turn-on voltage of about 5.8 V, maximum brightness of 152 cd/m<SUP>2</SUP> and an electroluminescent efficiency of 0.143 lm/W, and stable blue EL emission that is not altered by increased voltage. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5908–5916, 2009</P> <B>Graphic Abstract</B> <P>A new series of conjugated polymers having diphenylanthracene vinylene biphenylene and diphenylanthracene vinylene terphenylene in the main chain and fluorene pendant group, were synthesized by nickel catalized Yamamoto coupling and palladium catalized Suzuki coupling. The polymers showed blue emission (λ<SUB>max</SUB> = 461 for PFPA and λ<SUB>max</SUB> = 455 nm for PFPAME) in PL spectra. The double-layered device with an ITO/PEDOT/PFPAME/LiF/Al structure has a turn-on voltage of about 5.8 V, maximum brightness of 152 cd/m<SUP>2</SUP> and an electroluminescent efficiency of 0.143 lm/W. <img src='wiley_img/0887624X-2009-47-21-POLA23636-gra001.gif' alt='wiley_img/0887624X-2009-47-21-POLA23636-gra001'> </P>