Treatment-failure tularemia in children

Karli, Arzu,Sensoy, Gulnar,Paksu, Sule,Korkmaz, Muhammet Furkan,Ertugrul, Omer,Karli, Rifat The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.2

Purpose: Tularemia is an infection caused by Francisella tularensis. Its diagnosis and treatment may be difficult in many cases. The aim of this study was to evaluate treatment modalities for pediatric tularemia patients who do not respond to medical treatment. Methods: A single-center, retrospective study was performed. A total of 19 children with oropharyngeal tularemia were included. Results: Before diagnosis, the duration of symptoms in patients was $32.15{\pm}17.8days$. The most common lymph node localization was the cervical chain. All patients received medical treatment (e.g., streptomycin, gentamicin, ciprofloxacin, and doxycycline). Patients who had been given streptomycin, gentamicin, or doxycycline as initial therapy for 10-14 days showed no response to treatment, and recovery was only achieved after administration of oral ciprofloxacin. Response to treatment was delayed in 5 patients who had been given ciprofloxacin as initial therapy. Surgical incision and drainage were performed in 9 patients (47.5%) who were unresponsive to medical treatment and were experiencing abcess formation and suppuration. Five patients (26.3%) underwent total mass excision, and 2 patients (10.5%) underwent fine-needle aspiration to reach a conclusive differential diagnosis and inform treatment. Conclusion: The causes of treatment failure in tularemia include delay in effective treatment and the development of suppurating lymph nodes.

Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19

Choudhary Sarita,Sreenivasulu Karli,Mitra Prasenjit,Misra Sanjeev,Sharma Praveen 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.2

Since its first report in December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged as a pandemic affecting nearly all countries worldwide. As the COVID-19 pandemic progresses, the need to identify genetic risk factors for susceptibility to this serious illness has emerged. Host genetic factors, along with other risk factors may help determine susceptibility to respiratory tract infections. It is hypothesized that the ACE2 gene, encoding angiotensin-converting enzyme 2 (ACE2), is a genetic risk factor for SARS-CoV-2 infection and is required by the virus to enter cells. Together with ACE2, transmembrane protease serine 2 (TMPRSS2) and dipeptidyl peptidase-4 (DPP4) also play an important role in disease severity. Evaluating the role of genetic variants in determining the direction of respiratory infections will help identify potential drug target candidates for further study in COVID-19 patients. We have summarized the latest reports demonstrating that ACE2 variants, their expression, and epigenetic factors may influence an individual’s susceptibility to SARS-CoV-2 infection and disease outcome.

Effects of Partial Nephrectomy on Postoperative Blood Pressure

Nathan Lawrentschuk,Greg Trottier,Karli Mayo,Ricardo A Rendon 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.3

Purpose: The effects of partial nephrectomy (PN) on postoperative blood pressure (BP) are not known, and PN has the potential to worsen BP. We therefore sought to determine whether PN alters postoperative BP. Materials and Methods: Patients who underwent PN for suspected malignancy at our institution from 2002 to 2008 were included. Data on BP and medication from before and after PN were retrieved from family physicians. BP and number of antihypertensive medications were compared after surgery with preoperative values by use of paired t tests and Chi-squared analyses, respectively. Results: Of 74 patients undergoing PN and providing consent, 48 met the inclusion and exclusion criteria, with a median follow-up of 24 months. For the early postoperative period (1 month to 1 year after surgery), the mean BPs (132.3/77.0 mmHg) were unchanged compared with preoperative values (132.4/78.0 mmHg; p=0.59 systolic BP and p=0.30 diastolic BP). For the later postoperative period (beyond 1 year after surgery), the mean postoperative systolic BP was unchanged from the mean preoperative systolic BP (131.2 mmHg vs. 132.4 mmHg, respectively; p>0.30). However, the corresponding average diastolic BP was lower in the long term (78.0 mmHg versus 76.4 mmHg respectively; p=0.01). No significant difference in the mean number of BP medications prescribed preoperatively, at one year, and beyond one year was identified (p>0.37). Conclusions: PN does not result in initial or long-term postoperative deterioration in BP. Purpose: The effects of partial nephrectomy (PN) on postoperative blood pressure (BP) are not known, and PN has the potential to worsen BP. We therefore sought to determine whether PN alters postoperative BP. Materials and Methods: Patients who underwent PN for suspected malignancy at our institution from 2002 to 2008 were included. Data on BP and medication from before and after PN were retrieved from family physicians. BP and number of antihypertensive medications were compared after surgery with preoperative values by use of paired t tests and Chi-squared analyses, respectively. Results: Of 74 patients undergoing PN and providing consent, 48 met the inclusion and exclusion criteria, with a median follow-up of 24 months. For the early postoperative period (1 month to 1 year after surgery), the mean BPs (132.3/77.0 mmHg) were unchanged compared with preoperative values (132.4/78.0 mmHg; p=0.59 systolic BP and p=0.30 diastolic BP). For the later postoperative period (beyond 1 year after surgery), the mean postoperative systolic BP was unchanged from the mean preoperative systolic BP (131.2 mmHg vs. 132.4 mmHg, respectively; p>0.30). However, the corresponding average diastolic BP was lower in the long term (78.0 mmHg versus 76.4 mmHg respectively; p=0.01). No significant difference in the mean number of BP medications prescribed preoperatively, at one year, and beyond one year was identified (p>0.37). Conclusions: PN does not result in initial or long-term postoperative deterioration in BP.

Determination of Genetic Diversity Using 15 Simple Sequence Repeats Markers in Long Term Selected Japanese Quail Lines

Karabag, Kemal,Balcioglu, Murat Soner,Karli, Taki,Alkan, Sezai Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.12

Japanese quail is still used as a model for poultry research because of their usefulness as laying, meat, and laboratory animals. Microsatellite markers are the most widely used molecular markers, due to their relative ease of scoring and high levels of polymorphism. The objective of the research was to determine genetic diversity and population genetic structures of selected Japanese quail lines (high body weight 1 [HBW1], HBW2, low body weight [LBW], and layer [L]) throughout 15th generations and an unselected control (C). A total of 69 individuals from five quail lines were genotyped by fifteen microsatellite markers. When analyzed profiles of the markers the observed ($H_o$) and expected ($H_e$) heterozygosity ranged from 0.04 (GUJ0027) to 0.64 (GUJ0087) and 0.21 (GUJ0027) to 0.84 (GUJ0037), respectively. Also, $H_o$ and $H_e$ were separated from 0.30 (L and LBW) to 0.33 (C and HBW2) and from 0.52 (HBW2) to 0.58 (L and LBW), respectively. The mean polymorphic information content (PIC) ranged from 0.46 (HBW2) to 0.52 (L). Approximately half of the markers were informative ($PIC{\geq}0.50$). Genetic distances were calculated from 0.09 (HBW1 and HBW2) to 0.33 (C and L). Phylogenetic dendrogram showed that the quail lines were clearly defined by the microsatellite markers used here. Bayesian model-based clustering supported the results from the phylogenetic tree. These results reflect that the set of studied markers can be used effectively to capture the magnitude of genetic variability in selected Japanese quail lines. Also, to identify markers and alleles which are specific to the divergence lines, further generations of selection are required.

Visualizing the Non-Buddhist Other: A Historical Analysis of the Shambhala Myth in Mongolia at the Turn of the Twentieth Century

Karénina Kollmar-Paulenz 고려대학교 민족문화연구원 2019 Cross-Currents Vol.0 No.31

The huge Shambhala thangka preserved at the National Gallery in Prague, Czech Republic, is allegedly of Tibetan origin and dates to the nineteenth century. The conventional depiction of the realm of Shambhala in this thangka shows some surprisingly unconventional details in the scenes that illustrate the battle between the infidels and the Buddhist warriors led by Raudracakrin, the last ruler (kalki) of Shambhala. These details hint at a possible Mongolian origin. This article examines the visual aspects of the Shambhala myth as depicted in the Prague thangka, paying special attention to the representation of the final battle and the so-called enemies of the dharma. By engaging with textual, visual, and performative sources that inform the Prague thangka, the author argues that the production of knowledge in the visual language of the thangka is tied to the emerging conditions of globality, incorporating local life-worlds in the context of religious encounters, trade relations, and political negotiations.

생활체육참여자의 여가활동 유형이 생활만족에 미치는 영향

김의영,김의영,김영숙,윤대중,이병기 龍仁大學校 體育科學硏究所 2002 體育科學硏究論叢 Vol.12 No.1

This research is designed to make a comparative analysis of the types of leisure activities and the degree of and life satisfaction by demographic background variable and to present basic materials necessary for the development of programs for local policies on leisure in accordance with the local autonomous system with a view to determining the relationship between life satisfaction by type of leisure activity. The following are the findings. First, the survey failed to test a statistically significant difference between family member's mutual satisfaction, or the subordinate variable of age, job and health and general life satisfaction, or the subordinate variable of income. But there was a statistically significant difference in life satisfaction by gender, age, education, job, income and health at a level of 1 percent. Second, the survey on the influences of the types of leisure activities on leisure satisfaction and life satisfaction revealed that there was a statistically significant influences in all the subordinate variables of and life satisfaction.

Review of chemical peeling in photoaging skin

Cheuk Hung Lee(Cheuk Hung Lee),Kar Wai Alvin Lee(Kar Wai Alvin Lee ),Lisa Kwin Wah Chan(Lisa Kwin Wah Chan ),Kar Fai Victor Lee(Kar Fai Victor Lee ) 대한미용의학회 2023 대한미용의학회지 Vol.7 No.1

Photoaging is a process in which ultraviolet radiation damages the normal skin architecture. Topical chemical peeling is used to treat this condition. The authors aimed to understand the mechanism and level of evidence of the different depths of chemical peeling used to treat photoaging. Various topical chemical peelings have been used in cosmetic medicine for many years to treat photodamaged skin. This review compares the efficacy and the level of evidence. This systematic review evaluates the efficacy of different chemical peeling methods. Keywords included “Photoaging,” “Alpha-hydroxy acid,” “Lipo-hydroxy acid,” “Trichloroacetic acid,” “Jessner’s solution,” and “Phenol” were typed on Ovid, PubMed, MEDLINE for relevant studies published on photoaging treatment. There is a wealth of Level I evidence supporting the use of topical retinoic acid, vitamin B, and vitamin C. The evidence behind the use of topical vitamin E exists but is mainly drawn from studies from the Level IV of the evidence hierarchy. Topical vitamins can effectively treat photodamaged skin. Level of Evidence: I

Treatment of acne fulminans with intense pulsed light: a case report

Cheuk Hung Lee(Cheuk Hung Lee),Kar Wai Alvin Lee(Kar Wai Alvin Lee),Kwin Wah Chan(Kwin Wah Chan),Kar Wai Phoebe Lam(Kar Wai Phoebe Lam ) 대한미용의학회 2022 대한미용의학회지 Vol.6 No.2

Acne fulminans is a severe form of acne that has a considerable psychosocial impact. Acne scarring is a potential complication of this condition. The treatment of acne fulminans includes conventional topical antibiotics, systemic antibiotics, hormonal therapy, isotretinoin, and light therapy. Intense pulsed light can have marked effects on acne fulminans. We aimed to describe the treatment of acne fulminans with intense pulsed light. This article is a case report together with a literature review to demonstrate how intense pulsed light can be used to treat acne fulminans. Pre-treatment and post-treatment clinical photographs are provided to show the effects of intense pulsed light therapy on acne fulminans. No comparisons were made with the other treatment modalities; nevertheless, this study provides an alternative treatment option for acne fulminans. Our case report revealed that intense pulse light using multiple filters at certain energy levels can effectively treat acne fulminans. Current evidence suggests that ablative CO2 and Er:YAG lasers provide the best curative effect on acne scars on all skin types. Potential complications with intense pulsed light include pain, burns, and post-inflammatory hyperpigmentation. Intense pulsed light is an effective treatment modality for acne fulminans. However, more cases of acne fulminans treated with intense pulsed light need to be documented in order to affirm intense pulsed light as one of the best options for treating this severe form of acne.

Review of topical vitamins in photoaging skin

Cheuk Hung Lee(Cheuk Hung Lee),Kar Wai Alvin Lee(Kar Wai Alvin Lee),Kwin Wah Chan(Kwin Wah Chan),Kar Fai Victor Lee(Kar Fai Victor Lee),Kar Wai Phoebe Lam(Kar Wai Phoebe Lam ) 대한미용의학회 2022 대한미용의학회지 Vol.6 No.2

Photoaging is a process of normal skin architecture damage caused by ultraviolet radiation. Topical vitamins have been used to treat these conditions. The authors aimed to understand the mechanism and level of evidence of topical vitamins used to treat photodamaged skin. A range of topical vitamins has been used in cosmetic medicine for many years to treat photodamaged skin. This review article compares their efficacy and level of evidence. This study was a systematic review to evaluate the efficacy of different topical vitamins. Keywords including “Photoaging,” “Botanicals,” “Peptides,” “Retinoids,” “Vitamins” were searched on Ovid, PubMed, MEDLINE for relevant studies published on photoaging treatment. There is a wealth of Level I evidence supporting the use of topical retinoic acid, vitamins B and C. There is evidence supporting the use of topical vitamin E although it is mainly drawn from Level IV studies of the evidence hierarchy. Topical vitamins can effectively treat photodamaged skin. Level of Evidence: I

Economic values of the APCN multi-model ensemble categorical seasonal predictions

Kar, Sarat C.,Hovsepyan, Anahit,Park, C. K. Wiley (John WileySons) 2006 Meteorological applications Vol.13 No.3