EFFECTS OF ANTITUMOR POLYSACCHARIDES FROM ALBIZZIA JULIBRISSIN ON THE IMMUNE FUNCTION

Kang, Tak-Lim 大田大學校 1985 論文集 Vol.4 No.1

Polysaccharide fractions were prepared from Albizzia julibrissin by different extraction schedules. The fractions obtained were designated as PS-I and PS-II respectively. PS-I was further purified by Sephadex G 200 columnchromatography and obtained two subfractions (Alju A and Alju B). Each fraction showed marked antitumor activity against sarcoma 180 solid form but did not ascite form. PS-I and PS-II increased delayed hypersensitivity in normal and tumor bearing mice and PS-I treatment somewhat restored the suppressed antibody production in bearing mice.

Studies on Bioresponse of Sophorae Radix (Ⅰ)

Kang, Tak Lim,Hwang, Gwi Seo 대전대학교 韓醫學연구소 1992 한의학연구소 논문집 Vol.1 No.1

淸熱燥濕, 祛風殺蟲의 효능이 있는 苦蔘의 체내 면역활성에 미치는 영향에 대해 실험한 결과 아래와 같은 지견을 얻었다. ICR 생쥐에 苦蔘 수침액을 투여한 결과 백혈구수 및 면역장기 변화는 없었다. in vitro실험에서는 IgM PFCs에 유의성 있는 영향을 주지 못했고, BSA를 주사한 생쥐에서는 Arthus 반응에도 영향이 없었다. 그러나 지연형 과민반응을 억제하였으며, 비특이적 면역에 관여하는 macrophage의 탐식능을 약간 저하시켰다. 이상의 결과 苦蔘 水浸液은 세포성 면역을 억제하는 것으로 사료된다.

Studies on Bioresponses of Galangae Rhizoma (Ⅰ)

Kang, Tak Lim,Hwang, Gwi Seo 대전대학교 韓醫學연구소 1992 한의학연구소 논문집 Vol.1 No.1

散寒止病의 效能이 있는 高良薑이 체내 면역활성에 미치는 영향을 검토하기 위하여 인삼과 함께 실험을 행하여 아래와 같은 결과를 얻었다. 高良薑 및 임삼 수침액을 Sarcoma-180 고형 종양 세포를 이식한 생쥐에 투여하여 생존기간을 연장시켰다. 이를 바탕으로 면역에 대한 효과를 검토한 결과, 정상 ICR 생쥐에서 高良薑 수침책은 백혈구수, 체중에 대한 상대적 비장의 무게를 약간 감소시켰으나 통계적으로는 유의성이 없었고, 간에는 영향을 주지 않았다. in vitro 실험에서, splenic IgM PFCs을 유의성있게 증가시켰으며, BSA를 주사한 생쥐에서의 Arthus반응도 증가시켰다. 그러나, 지연형 과민반응에는 영향을 주지 않았으며, 비특이성 면역에 관여하는 Macrophage 등의 탐식 세포의 기능에도 영향을 주지 않았다. 이상의 결과, 고양강은 체액성 면역을 강화할 것으로 보여진다.

DETERMINATION OF CARBOXYL DRUGS BY GAS CHROMATOGRAPHY-FLAME PHOTOMETRIC DETECTOR

KANG, TAK-LIM 大田大學校 1986 論文集 Vol.5 No.1

단일 카르복실기를 지닌 藥物인 mefenamic acid, alclofenac, ketoprofen, cicloxilic acid 및 tolfenamic acid등을 분석할 때, a) 흡광도법¹, b) TLC 혹은 여지크로마토그라프법²³, c) 형과분석법⁴, d) 폴라로그라프법?, e)방사성동위원소추적법??, f) GC-FID, GC-ECD 혹은 GC-Mass법??, 그리고 g) 고속액체크프로마토그라프법??에 의한 방법이 보고되고 있다. 위의 a)~d)에 의한 분석방법은 일반적으로 定量誤差가 크며, e)의 방법은 高感度分析 할 수 있는 장점은 있으나 操作이 불편하다. 최근에 f)와 g)에 의한 방법이 많이 시도되고 있으나 生體試料성분에 의한 방해효과가 있는 경우가 종종 나타나고 있다. 저자들??이 앞서 보고한 바와 같이 硫黃화합물만 선택적으로 검출분석할 수 있는 가스크로마토그라프-炎光光度檢出器 (GC-FPD)를 써서 카로복실기를 지닌 약물에 硫黃原子를 도입한 수 분석함으로써 f)와 g)의 방법에서 나타날 수 있는 短點을 보완하고자 하였다. 硫黃導入試藥으로 카르복실기를 에스텔화시키는 여러가지 방법??이 알려져 있으나, 이중 One등??의 방법이 촉매로 사용된 1.8-diazabicyclo〔5.4.0〕undec-7-ene(DBU)의 再生回收가 쉽고 立體障碍를 받는 酸에 대해서 높은 收率을 보이고 있다. 따라서 이 방법으로 試料를 정량적으로 methylthiomethyl (MTM) 에스텔화시키고 GC-FPD로 분석한 결과 plasma중에서 약 15fmol까지 간편하게 정량할 수 있었다. Such carboxyl drugs as mefenamic acid, alclofenac, ketoprofen, cicloxilic acid and tolfenamic acid in rat plasma were determined by the gas chromatography - flame photometric detector (GC-FPD). After methylthiomethyl (MTM) esterification with MTM-chloride in 1,8-diazabicyclo 5.4.0 undec-7-ene (DBU) catalyst, determination of these drugs by this method was tried and compared with that by the GC-flame ionization detector (FID) method in respect to sensitivity and effect of interferences. The results showed it was possible to analyze with accuracy by this method because of specificity of the FPD, although these drugs were not separated from interferences in plasma on GC column. The GC-FPD method was more sensitive than GC-FID method and the minimum detectable amount of monocarboxylic drugs on 3% QF-1 column was about 15 fmol/injection.

어머니會가 이웃 사이의 家族計劃 코뮤니케이숀 樣相에 미친 影響에 對한 事例硏究

康坼林(Tak Lim Kang) 서울대학교 보건환경연구소 1976 보건학논집 Vol.13 No.1

지유의 수치에 관한 연구 -볶은 지유로부터 불리된 토멘토솔린산-

강탁림(Tak Lim Kang),박만기(Man Ki Park) 대한약학회 1994 약학회지 Vol.38 No.6

Some traditional herbal drugs have been used after processing to modify its activities. For example, roasted "chiyu"(Sanguisorbae radix) has been used as antihemorrhagics while raw one used as anti-emetics. The composition of herbal drug is expected to be changed during this process. We tried to reveal the compositional difference between raw and roasted "chiyu", and isolated a compound which is not present in raw one but in processed one. The structure of the isolated compound was elucidated as tomentosolic acid. The content of tomentosolic acid in roasted "chiyu" was approximately 0.05%.

Reduction in proteinuria after immunosuppress-sive therapy and long-term kidney outcomes in patients with immunoglobulin A nephropathy

( Shin Chan Kang ),( Hyung Woo Kim ),( Tae Ik Chang ),( Ea Wha Kang ),( Beom Jin Lim ),( Jung Tak Park ),( Tae-hyun Yoo ),( Hyeon Joo Jeong ),( Shin-wook Kang ),( Seung Hyeok Han ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.5

Background/Aims: Despite controversy regarding the benefits of immunosuppressive therapy in immunoglobulin A nephropathy (IgAN), clinical outcomes may vary depending on the patient’s responsiveness to this therapy. This study evaluated long-term kidney outcomes according to the extent of proteinuria reduction after immunosuppression in IgAN patients. Methods: Among 927 patients with biopsy-proven IgAN, 127 patients underwent immunosuppression. Time-averaged urine protein-creatinine ratio before and within 1 year after start of immunosuppression were calculated, and responsiveness to immunosuppression was assessed as the reduction of proteinuria between the two periods. Patients were classified into tertiles according to the extent of proteinuria reduction. We compared the slopes of estimated glomerular filtration rate (eGFR) decline using a linear mixed model, and estimated hazard ratios (HRs) for disease progression (defined as development of a ≥ 30% decline in eGFR or end-stage renal disease) using a Cox proportional hazard model. Results: Median extent of proteinuria reduction was -2.1, -0.9, and -0.2 g/gCr in the first, second, and third tertiles, respectively. There were concomitant changes in the slopes of annual eGFR decline: -2.03, -2.44, and -4.62 mL/min/1.73 ㎡ among the first, second, and third tertiles, respectively. In multivariable Cox analysis, the HRs (95% confidence intervals) for disease progression were 0.30 (0.12 to 0.74) in the first tertile and 0.70 (0.34 to 1.45) in the second tertile compared with the thirdtertile. Conclusions: This study showed that greater proteinuria reduction after immunosuppression was associated with a lower risk of disease progression in patients with IgAN, suggesting that responsiveness to immunosuppression may be an important determinant of kidney outcomes.

Mineralization of Oxalic Acid by Ni(II) With Gamma Radiation

Kang Lee,Dongwoo Kim,TaeHun Kim,Tak-hyun kim,Seungjoo Lim 한국방사성폐기물학회 2018 한국방사성폐기물학회 학술논문요약집 Vol.2018 No.10

약국의료보험의 성과와 존폐론

김탁림 대한보건협회 1997 대한보건연구 Vol.23 No.2

Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region in Korea

Kang, Seok-Jeong,Lee, Jae-Min,Hah, Jeong-Ok,Shim, Ye-Jee,Lee, Kun-Soo,Shin, Hyun-Jung,Kim, Heung-Sik,Choi, Eun-Jin,Jeon, So-Eun,Lim, Young-Tak,Park, Ji-Kyeong,Park, Eun-Sil The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.3

Purpose: Natural history and consequences of the novel 2009 influenza A H1N1(2009 H1N1) infection in immunocompromised pediatric patients are not yet fully understood. In this study, we investigated the clinical features and outcomes of the 2009 H1N1 infection in pediatric patients with hematological and oncological diseases. Methods: We retrospectively reviewed the medical records of 528 patients who had hematological and oncological diseases and who were treated at 7 referral centers located in the Yeungnam region. Among the 528 patients, 27 with definite diagnosis of 2009 H1N1 infection were the subjects of this study. All patients were divided into the following 3 groups: patients who were receiving chemotherapy (group 1), patients who were immunosuppressed due to a nonmalignant hematological disease (group 2), and patients who were off chemotherapy and had undergone their last chemotherapy course within 2 years from the influenza A pandemic (group 3). Results: All 28 episodes of 2009 H1N1 infection were treated with the antiviral agent oseltamivir ($Tamiflu^{(R)}$), and 20 episodes were treated after hospitalization. Group 1 patients had higher frequencies of lower respiratory tract infection and longer durations of fever and hospitalization as compared to those in group 2. Ultimately, all episodes resolved completely with no complications. Conclusion: These results suggest that early antiviral therapy did not influence the morbidity or mortality of pediatric patients with hematological and oncological diseases in the Yeungnam region of Korea after the 2009 H1N1 infection. However, no definite conclusions can be drawn because of the small sample size.