Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients

Ka Shing Cheung,Lok Ka Lam,Rex Wan Hin Hui,Xianhua Mao,Ruiqi R Zhang,Kwok Hung Chan,Ivan FN Hung,Wai Kay Seto,Man-Fung Yuen 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.3

Background/Aims: Studies of hepatic steatosis (HS) effect on COVID-19 vaccine immunogenicity are lacking. We aimed to compare immunogenicity of BNT162b2 and CoronaVac among moderate/severe HS and control subjects. Methods: Two hundred ninety-five subjects who received BNT162b2 or CoronaVac vaccines from five vaccination centers were categorized into moderate/severe HS (controlled attenuation parameter ≥268 dB/m on transient elastography) (n=74) or control (n=221) groups. Primary outcomes were seroconversion rates of neutralising antibody by live virus Microneutralization (vMN) assay (titer ≥10) at day21 (BNT162b2) or day28 (CoronaVac) and day56 (both). Secondary outcome was highest-tier titer response (top 25% of vMN titer; cutoff: 160 [BNT162b2] and 20 [CoronaVac]) at day 56. Results: For BNT162b2 (n=228, 77.3%), there was no statistical differences in seroconversion rates (day21: 71.7% vs. 76.6%; day56: 100% vs. 100%) or vMN geometric mean titer (GMT) (day21: 13.2 vs. 13.3; day56: 91.9 vs. 101.4) among moderate/severe HS and control groups respectively. However, lower proportion of moderate/severe HS patients had highest-tier response (day56: 5.0% vs. 15.5%; P=0.037). For CoronaVac (n=67, 22.7%), there was no statistical differences in seroconversion rates (day21: 7.1% vs. 15.1%; day56: 64.3% vs. 83.0%) or vMN GMT (5.3 vs. 5.8,) at day28. However, moderate/severe HS patients had lower vMN GMT (9.1 vs. 14.8, P=0.021) at day 56 with lower proportion having highesttier response (21.4% vs. 52.8%, P=0.036). Conclusions: While there was no difference in seroconversion rate between moderate/severe HS and control groups after two doses of vaccine, a lower proportion of moderate/severe HS patients achieved highest-tier response for either BNT162b2 or CoronaVac.

Twenty-four months long-term follow-up report on the effect of poly lactic-co-glycolic acid suspension suture in Asian with mild-moderate face laxity

Lam Phoebe Kar Wai,Fung Chi Pun,Lam James Yui,Luk Wang Lung,Lee Alvin Ka Wai,Lee Cheuk Hung,Tam Paul Man Kei,Lau Edwin Kwan Chark 대한미용의학회 2022 대한미용의학회지 Vol.6 No.1

Background: There was evidence of improvement in mid-face laxity using three pairs of suspension sutures in mid-face lifting in our early and mid-term follow-up. Objective: This 24-month prospective follow-up study aimed to determine the efficacy of mid-face lifting and lower jawline contouring using poly lactic-co-glycolic acid (PLGA) sutures in Asian patients. Methods: Ten healthy volunteers received three pairs of 8-cones bidirectional cones sutures at the mid-face. One of the ten volunteers lost to follow-up, and all remaining patients followed up for 24 months. Our primary outcome measure is the change in the facial laxity rating scale (FLRS), an “improvement” defined as at least “one-grade change” in FLRS. Other assessment parameters include the severity of the nasolabial fold (NLF), assessed on the wrinkle severity rating scale (WSRS). The secondary outcome measures were the self-satisfaction rating scale (SSRS) and global aesthetic improvement scale (GAIS), rated by participants at each follow-up interval. Results: A linear improvement in the mid-face was observed almost immediately after treatment, with progressive improvement up to at least 12 months following the intervention and no deterioration by 24 months. This improvement was significant (p<0.05), and the differences between before and after treatment at each follow-up interval were large (Cohen’s d>0.8). Contour improvement for the lower face followed a similar trend, except for a delay in the observable differences at three months (Cohen’s d=0.29, 0.8 at six weeks and three months, respectively). The differences in the level of patient satisfaction were significant (p<0.05) from 6 weeks to 24 months, peaking between 12 and 18 months, based on both the GAIS and SSRS ratings. No observed complications. Conclusion: Mid-facing lifting in Asian patients with mild-to-moderate laxity is safe and effective with PLGA bidirectional cone sutures, with concurrent improvement in the lower face contour and elevated patient satisfaction over the 24-month follow-up period.

Methodological Study on the Evaluation of Face Mask Use Scale among Public Adult: Cross-Language and Psychometric Testing

Lam, Simon Ching,Chong, Andy Chun Yin,Chung, Jessie Yuk Seng,Lam, Ming Yee,Chan, Lai Man,Shum, Cho Yee,Wong, Eliza Yi Ni,Mok, Yat Man,Lam, Ming Tat,Chan, Man Man,Tong, Ka Ying,Chu, Oi Lee,Siu, Fong Ki 한국성인간호학회 2020 성인간호학회지 Vol.32 No.1

Purpose: This study aimed to establish the translation adequacy and examine the psychometric properties of FaceMask Use Scale (FMUS). Methods: This methodological study employed a cross-sectional design with repeatedmeasures. Phase 1 examined the equivalence and relevance of English and Chinese versions of FMUS. Phase2 examined the internal consistency, stability and construct validity. Different sample batches (213 universitystudents and 971 general public) were used appropriately for psychometric testing. The 2-phase data were collectedbetween January and April 2017. Results: In Phase 1, the semantic equivalence and relevance (item- and scale-levelcontent-validity-index=100%) was satisfactory. Furthermore, from 133 paired test-retest responses, the quadraticweighted kappa (.53~.73, p<.001) and Intraclass Correlation Coefficient (ICC=.81) between the English andChinese version of FMUS were satisfactory. In Phase 2, FMUS demonstrated satisfactory internal consistency(Cronbach’s ⍺=.80~.81; corrected item-total correlation coefficients=.46~.67) and two-week test-retest stability(ICC=.84). The known-groups method (t=3.08, p<.001), exploratory (71.10% of total variance in two-factor model)and confirmatory factory analysis (x2/df=4.02, Root Mean Square Residual=.03, Root Mean Square Error ofApproximation=.06, Goodness of Fit Index=.99, Comparative Fit Index=.99) were all satisfactory for establishingthe construct validity. Conclusion: The FMUS has an equivalence Chinese and English versions, satisfactoryreliability and validity for measuring the practice of face mask use. This poses clinical and research implications forthose community health nurses who works on respiratory protection. Further research should be conducted on the‘negligent practice’ of FMU.

1910년대 『매일신보』 소재 하몽 이상협의 창작 소설 연구 -독자,관객과의 소통 양상을 중심으로-

정가람 ( Ka Lam Zeong ) 한국문학연구학회 2007 현대문학의 연구 Vol.0 No.33

근대계몽기 『경향신문』소재 쇼셜의 특성 연구

정가람(Ka Lam Zeong) 한국현대소설학회 2004 현대소설연구 Vol.- No.24

鍛辭成章: 「閱讀促進學習」教學法中筆記摘錄與共同建構在香港非華 語初中課堂的實踐與成效

Loh Ka Yee Elizabeth,Shum Shui Kee Mark,Lai Kwok Chang,Leung Tit Hei Nixon,Lam Ka Chun 단국대학교 한문교육연구소 2019 International Han-character Education Research Vol.1 No.1

최근 홍콩에서 중국어를 모국어로 사용하지 않는 학생들을 합격시킨 주류 중등학교들이 급증하고 있다.(2016, 입법회). 이 학교는 이러한 학생의 학습 차이를 고려하여 다양한 대처를 필요로 하고 있다. 다양한 방식을 채택하여 학생들이 중국어 학습을 잘 마칠 수 있게 지원하여, 그들의 진학이 구직난을 해소하고 사회 상류로의 진출 기회가 될 수 있도록 해야 한다.(Leung et al 2017; Loh & Tam, 2016). (중국은) 중국어를 사용하지 않는 학생들에게 적합한 중국어 교육법을 제공하 는 것이 필요하다고 판단하고 있으며, 이는 해결해야 할 급선무 문제가 되었다.(shum, 2015). 본 연구는 이러한 홍콩의 상황에 집중하였다. 「阅读促进学习」(Rose&Martin, 2012) 교수법은 비 중국어 사용자 학생들의 비율이 비교적 높은 중등학교 한 곳을 선정하고, 제2외국어 교육 과정을 중국어로 하는 대외한어교육현장에서 제 2외국어 학습 기관(홍콩교육국, 2014) 및 국제 일반 중등학교 교육 증서(IGCSE)의 교육과정 개요를 참조하여, 본 교육과정(커리큘럼)을 수정 하였다. 협업과 회의를 통해 공동으로 수업을 준비하고 교육현장을 관찰하는데, 교사와 학생들이 모인 소그룹 인터뷰, 필기 및 수업 원본 분석 등의 방법을 진행하였다. 이를 통해 본 교수법이 학생들에게 설명문 종류의 글을 읽고 쓰는 능력을 향상시키고 학습 동기를 높일 수 있는지의 여부를 검토하였다. 교사는 학생들이 본문을 자세하게 읽도록 한 후, 그룹 협업을 통해 그 문장에 서 핵심 키워드를 발췌하여 노트에 기록하도록 학생들을 지도하는 방법(Note Making)을 시행하고, 이어서 학생들은 상호 간의 교류와 협력에 의해 문장 속에 등장한 핵심 단어들과 구 형식, 문장 형식을 활용하여, 협업을 통해 새로운 글을 창작하고, 마지막으로 학생들이 각자 개별적으로 작문을 수행하게 하였다. 본 연구를 통해, 상술한 단계가 학생들이 문장 형식에 따른 다양한 언어 능력의 차이를 이해하도록 돕는데 효과적이며, 서로 다른 글쓰기 활동에 활용할 수 있음을 발견했다. 원전 분석 및 소그룹 인터뷰 또한 위 교수법이 학생들의 중국어 학습 동기를 향상시키는 데 효과가 있음과 학생들의 학습에 대한 믿음이 증가한 것을 보여주었다. 본 연구는 阅读促进学习 교수법이 학생들의 읽기와 쓰기 능력을 개선하고, 각 교육 절차의 실천적 성과들이 모두 시사성이 있음을 검증하였다는데 그 의의가 있다. In Hong Kong, the number of secondary schools admitting Non-Chinese Speaking (NCS) students has increased tremendously in recent years (LegCo, 2016), in which most of them are mainstream schools. To cater the learning differences of NCS students, various supportin g programs have been employed to help NCS students to improve their Chinese so as to ease their difficulties in applying for universities and finding jobs (Loh & Tam, 2016), and hence enhancing upward social mobility (Leung et al, 2017). Thus developing suitable Chinese as a Second Language (CSL) pedagogies has caught much scholarly attention with pressing needs. Under such backdrop, the paper discusses the use of “Reading to Learn (R2L)” Pedagogy (Rose & Martin, 2012) to support the junior secondary CSL teaching and learning in a secondary school with high NCS density. The research team developed school-based teachin g and learning materials based on Chinese Language Curriculum Second Language Adapted Learning Framework (EDB, 2014) and International General Certificate of Secondary Educat ion (IGCSE) syllabus. Based on collaborative lesson preparation, class observation, teachers and students focus groups, close examination of students’work, the study aims at finding the effectiveness of R2L in enhancing students’ reading and writing abilities of explanatory essays, as well as their motivation. Through Detailed Reading, Note-making, Joint Rewriting and Joint Construction, with extensive scaffolding and teacher-student interaction, students are able to understand the register variables and transfer to individual writing of explanatory essays. Discourse analysis and focus group interviews also show that R2L can enhance the motivation of students and their confidence in learning Chinese. The study explores the potential of applying R2L pedagogy to enhance the reading and writing of explanatory essay s, as well as discerning the praxis and effectiveness of various teaching stages.

Effects of Nutritional Status on 6-Month Outcome of Hip Fractures in Elderly Patients

Ka Ying Doris Miu,Pui Shan Lam 대한재활의학회 2017 Annals of Rehabilitation Medicine Vol.41 No.6

Objective To identify the prevalence of malnutrition in elderly hip fracture and to investigate the relationship between hip fracture patients and malnutrition on functional recovery and mortality. Methods All hip fracture patients age >65 years admitted to a rehabilitation unit were recruited from July 2015 to June 2016. Nutritional status was assessed by Mini-Nutritional Assessment Short-Form (MNA-SF) within 72 hours of admission. Patients were reassessed at 6 months for functional status and place of residence. Length of hospital stay, in-patient mortality rate, and 6-month mortality rate were also recorded. Results There were 218 patients recruited. The mean age was 83.5±7.5 years. According the MNA-SF, 46 (21.1%) were well nourished, 115 (52.6%) were at risk of malnutrition, and 57 (26.1%) were malnourished. Malnourished individuals were significantly older, had lower Mini-Mental State Examination score and albumin level, were functionally more dependent and were more likely to reside in elderly care facility. A higher proportion of elderly care residents were at-risk or were malnourished on admission, discharge and at 6 months. Functional recovery was slower in the malnourished group. In-patient mortality was higher in malnourished individuals compared to those at risk of malnourishment and well-nourished individuals.Conclusion The prevalence of malnutrition is high and is associated with poor functional recovery and elderly care placement. Residents of elderly care facilities are especially at risk due a higher prevalence of malnourishment. Health authorities are encouraged to evaluate the dietetic component in elderly care facilities and initiate nutrition supplementation in their planning of healthcare resources.

DOES GEN Z SEEK INDIVIDUALITY? EXAMINING THE SUBCONSCIOUS CONFORMITY IN FASHION CONSUMPTION BEHAVIOUR

Ka Lai Kalis Wan,Ngan Yi Kitty Lam 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07

Numerous studies suggested that Generation Z (Gen Z) is an age group that seeks individuality more than other generations. Their aesthetics, identity, and belief must represent their self-value. The consumption of fashion was selected as a focus of this study. Our consumption of fashion represents our value, and we construct and present our identity with physically what we wear when we face society daily. Looking at the fashion styles of Generation Z, this study aims to examine whether Generation Z in Hong Kong practice individuality or conformity in the course of their fashion consumption behaviour by a preliminary study. Generation Z perceives their fashion consumption behaviour to reflect their individualism and values. However, the findings suggest that there is a high degree of conformity among Generation Z's fashion consumption behaviour. This conformity is observed in the creation of a distinctive fashion style, which is influenced by the cultural aesthetics, values, and preferences of Generation Z, resulting in a unifying effect that goes unnoticed by the individuals. This complex formation of Generation Z fashion consumption behaviour has a complex implication to fashion marketing, where both the sense of exclusivity and conformity must both be exhibited to satisfy the consumption needs of Generation Z.

Chemopreventive Effect of Metformin on Gastric Cancer Development

Cheung Ka Shing,Chung Kit Lam,Leung Wai K. 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.2

Although Helicobacter pylori infection is the most important causative factor for gastric cancer (GC), H. pylori eradication alone does not completely eliminate the GC risk. In addition to H. pylori eradication, other risk factors for GC should be identified and targeted. Diabetes mellitus (DM) confers a 20% increased risk of GC, which could be mediated via several biological mechanisms including the stimulation of cell proliferation via hyperinsulinemia and increased insulingrowth factor production, the promotion of angiogenesis, and DNA damage. With a current global prevalence of 9.3% and a predicted rise to 10.2% by 2030, DM could contribute substantially to the burden of GC cases worldwide. Emerging evidence showed that metformin possesses chemopreventive effects via both direct (e.g., adenosine monophosphate-activated protein kinase activation and subsequent inhibition of the mammalian target of rapamycin pathway) and indirect (e.g., modulation of the interaction between tumor cells and their microenvironment and gut microbiota) pathways. A recent meta-analysis of observational studies showed that metformin use was associated with 24% lower GC risk. However, many available observational studies related to metformin effects suffered from biases including the failure to adjust for the H. pylori infection status and serial glycemic control and time-related biases. Future prospective studies addressing these pitfalls are needed.

Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer

( Yuk Fai Lam ),( Wai Kay Seto ),( Teresa Tong ),( Ka Shing Cheung ),( Oswens Lo ),( Ivan Fn Hung ),( Wai Lun Law ),( Wai K Leung ) 대한장연구학회 2018 Intestinal Research Vol.16 No.4

Background/Aims: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. Methods: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. Results: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37-0.68 vs. 0.22; 95% CI, 0.08-0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. Conclusions: Patients with L-sided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy. (Intest Res 2018;16:619-627)