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Reference thermal neutron field at KRISS for calibration of neutron detectors
Kim, Yun Ho,Park, Hyeonseo,Kim, Yong Kyun,Kim, Jungho,Kang, Jeongsoo Elsevier 2017 Radiation measurements Vol.107 No.-
<P><B>Abstract</B></P> <P>A reference thermal neutron field has been established at the Korea Research Institute of Standards and Science (KRISS) by using a <SUP>241</SUP>Am-Be neutron source and a high-purity graphite pile constructed by stacking graphite blocks. The properties of the graphite blocks such as impurities, density, and dimensions were studied thoroughly to understand the characteristics of the generated field. The energy spectrum and thermal neutron fractions were simulated with the Monte Carlo N-Particle eXtended code using measured physical parameters. The neutron effective temperature was 308 K, and the fraction of thermal neutrons was approximately 95% at the reference position of the thermal neutron field. The thermal neutron fluence rate was determined by adopting the Westcott convention method based on neutron activation analysis using a gold foil. The Westcott fluence rate for thermal neutron at the reference position was (2326.7 ± 8.4) cm<SUP>−2</SUP>s<SUP>−1</SUP>. The true thermal neutron fluence rate at the reference position in the KRISS thermal neutron field was (2700 ± 29) cm<SUP>−2</SUP>s<SUP>−1</SUP> (at the reference date of June 30, 2014). The response of a spherical proportional counter with He-3 (SP9 neutron detector) was evaluated in the newly established field as (3.083 ± 0.045) cm<SUP>2</SUP> for the reference calibration condition (a parallel neutron beam with a Maxwellian energy distribution having a most probable energy of 0.025 eV).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thermal neutron field was developed for the calibration of neutron detectors. </LI> <LI> A <SUP>241</SUP>Am-Be neutron source and a pure graphite pile were used for the construction. </LI> <LI> Monte Carlo simulation was performed to understand characteristics of the field. </LI> <LI> Thermal neutron fluence rate was determined based on neutron activation analysis. </LI> <LI> The sensitivity of the SP9 detector was calibrated with an uncertainty of ∼3%. </LI> </UL> </P>
IMA: Identifying disease-related genes using MeSH terms and association rules
Kim, Jeongwoo,Bang, Changbae,Hwang, Hyeonseo,Kim, Doyoung,Park, Chihyun,Park, Sanghyun Elsevier 2017 Journal of biomedical informatics Vol.76 No.-
<P><B>Abstract</B></P> <P>Genes play an important role in several diseases. Hence, in biology, identifying relationships between diseases and genes is important for the analysis of diseases, because mutated or dysregulated genes play an important role in pathogenesis. Here, we propose a method to identify disease-related genes using MeSH terms and association rules. We identified genes by analyzing the MeSH terms and extracted information on gene-gene interactions based on association rules. By integrating the extracted interactions, we constructed gene-gene networks and identified disease-related genes. We applied the proposed method to study five cancers, including prostate, lung, breast, stomach, and colorectal cancer, and demonstrated that the proposed method is more useful for identifying disease-related and candidate disease-related genes than previously published methods. In this study, we identified 20 genes for each disease. Among them, we presented 34 important candidate genes with evidence that supports the relationship of the candidate genes with diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We propose a method to identify disease-related genes using MeSH terms and association rules. </LI> <LI> We construct gene-gene interaction networks for each disease. </LI> <LI> We identify disease-related genes and meaningful disease-related candidate genes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>