Morgellons Disease

( Jungyoon Ohn ),( Seon Yong Park ),( Jungyoon Moon ),( Yun Seon Choe ),( Kyu Han Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.2

Morgellons disease is a rare disease with unknown etiology. Herein, we report the first case of Morgellons disease in Korea. A 30-year-old woman presented with a 2-month his-tory of pruritic erythematous patches and erosions on the arms, hands, and chin. She insisted that she had fiber-like ma-terials under her skin, which she had observed through a magnifying device. We performed skin biopsy, and observed a fiber extruding from the dermal side of the specimen. Histopathological examination showed only mild lympho-cytic infiltration, and failed to reveal evidence of any microorganism. The polymerase chain reaction for Borrelia burgdorferi was negative in her serum. (Ann Dermatol 29(2) 223∼225, 2017)

FINGERPRINT IMAGE DENOISING AND INPAINTING USING CONVOLUTIONAL NEURAL NETWORK

JUNGYOON BAE,HAN-SOO CHOI,SUJIN KIM,MYUNGJOO KANG 한국산업응용수학회 2020 Journal of the Korean Society for Industrial and A Vol.24 No.4

Fingerprint authentication identifies a user based on the individual’s unique fingerprint features. Fingerprint authentication methods are used in various real-life devices because they are convenient and safe and there is no risk of leakage, loss, or oblivion. However, fingerprint authentication methods are often ineffective when there is contamination of the given image through wet, dirty, dry, or wounded fingers. In this paper, a method is proposed to remove noise from fingerprint images using a convolutional neural network. The proposed model was verified using the dataset from the ChaLearn LAP Inpainting Competition Track 3-Fingerprint Denoising and Inpainting, ECCV 2018. It was demonstrated that the model proposed in this paper obtains better results with respect to the methods that achieved high performances in the competition.

Addition of Albumin-Bilirubin Grade to PAGE-B Score Enhances Risk Assessment for Hepatocellular Carcinoma Development among Patients on Entecavir Therapy

( Jungyoon Kim ),( Dong Hyun Sinn ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: PAGE-B is a validated simple score, made of age, sex and platelet count, that can help predict the risk of developing hepatocellular carcinoma (HCC) among chronic hepatitis B patients on antiviral therapy. Yet, PAGE-B score encompass patients at intermediate risk, and requires cross-validation from Asian countries. We tested usefulness of PAGE-B score among chronic hepatitis B patients on entecavir therapy. We also tested whether performance of PAGE-B score can be improved by adding albumin-bilirubin (ALBI) grade. Methods: A total of 894 treatment-naïve, chronic hepatitis B patients, who started entecavir therapy between January 2007 and June 2012 were analyzed. The virological parameters and biochemical laboratory data including platelet, albumin, bilirubin for calculation of ALBI and PAGE scores were measured at baseline and at 1 year of entecavir therapy. Results: During a median 5.6 years of follow-up (range: 1.0 - 10.2 years), HCC was diagnosed in 100 patients (11.2%). The ALBI and PAGE score both at baseline and at year 1, respectively, were associated with development of HCC. After 1 year of entecavir therapy, the ALBI score improved (median: -2.69 to -2.96, P<0.001), whereas PAGE-B score did not (median: 14 to 14.5, P=0.619). Combination of ALBI and PAGE-B score showed the highest areas under the receiver operating characteristic curves (AUROCs) for the prediction of HCC development at 3 and 5 years, at baseline and at year 1, respectively, compared with ALBI and PAGE-B alone. Especially, the ALBI grade was able to further classify patient with intermediate risk according to PAGE grade at baseline and year 1, respectively. Conclusions: The use of ALBI score and PAGE-B score in combination, compared to their solitary use, was more effective in predicting HCC risk for chronic hepatitis B patients on entecavir therapy. Performance of PAGE-B score can be improved by simply adding ALBI score.

Influence of infection and antibiotic exposure on the development of atopic dermatitis: a nationwide population-based case-control study

( Jungyoon Ohn ),( Chong Won Choi ),( Bo Ram Yang ),( Dong In Suh ),( So-hyun Choi ),( Jong Soo Hong ),( Joongyub Lee ),( Kyu Han Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Previous studies suggested the association between atopic dermatitis (AD) and exposure to microorganisms and antibiotics. However, the previous studies have limitations and the sole influence of each on the development of AD was elusive. Objectives: To investigate the association between AD and early-life infection or antibiotic exposure and to reveal the sole influence of each on the development of AD. Methods: We performed a nationwide population-based case-control study in Korean population and enrolled 244,805 children with AD from among 2,283,601 children born between January 2010 and December 2014 and equal number of sex and age-matched healthy children as controls. Results: Infections and antibiotic exposure increased the risk for AD (OR, 1.60 for infections and OR, 1.11 for antibiotic exposure, respectively). A dose-dependent relationship was observed between risk for AD and number of infectious episodes and duration of antibiotic exposure. On further analysis using a conditional logistic model, infection with the use of antibiotics, infection without the use of antibiotics, and antibiotic exposure when uninfected increased the risk for AD. Risk for AD was the lowest when infections were treated with antibiotics. Additionally, risk for AD decreased when infections treated with antibiotics lasted for < 7 days. Conclusion: Infections and antibiotic exposure increased the risk for AD. However, the risk varied depending on duration of infection and antibiotic use.

[P134] Linear cutaneous lupus erythematosus along the Blaschko line in a child improved by topical tacrolimus ointment

( Jungyoon Ohn ),( Kyu Han Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

A 35-month-old female patient presented with erythematous a little scaly and slightly elevated plaques arranged linearly on the right infraorbital, perioral, and pre- and post-auricular areas for 7 months. The associated symptom was negative. Her past medical and familial history was nonspecific. After 12 weeks, the skin lesion progressed slowly to the chin, nasolabial fold, and retro-auricular area along the Blaschko line. Histological findings showed mild papillomatosis and superficial perivascular and periadnexal lymphocytic infiltration. The anti-dsDNA level in the laboratory examination was very low. Based on the clinical and histopathologic manifestation, she was diagnosed as having linear cutaneous lupus erythematosus (LCLE). After applying 0.03% topical tacrolimus ointment for 4 months, the lesions much improved. LCLE is a rare variant of lupus erythematosus in children without systemic involvement. It usually presents as an erythematous, atrophic, and dyschromic macule or patch linearly arranged in the head and neck area associated with Blaschko line. Treatment modality includes oral hydroxychloroquine, dapsone, and topical corticosteroids. Our case was very well responded to topical tacrolimus ointment.

[P077] Kaposiform hemangioendothelioma: A cases report

( Jungyoon Ohn ),( Kyu Han Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

A 2-month-old male patient presented with a violaceous to erythematous subcutaneous mass on the right forearm for 1 month. His past medical and familial history was nonspecific. No abnormality was found in a complete blood cell count test. MRI and ultrasonography study revealed 3.8 x 1.6 x 4.2 cm sized mass in the subcutaneous layer without muscular and bone involvement. Histological findings showed infiltrating fascicles of spindle shaped endothelial cells, and crescentic vascular channels. Immunohistochemistry staining revealed that endothelial cells were diffusely positive for ERG. Based on the clinical and histopathologic manifestation, he was diagnosed as having Kaposiform hemangioendothelioma (KHE). He was under observation with topical timolol and oral steroid. KHE, a rare vascular tumor of infancy and child, is locally aggressive with intermediate malignant potential. It could be located in skin, bone, or retroperitoneal soft tissue. It is commonly complicated by Kasabach-Merritt syndrome, causing fatal result. Although complete excision is the most effective treatment, systemic medication could be considered for un-respectable or extensive case: corticosteroids, interferon-alpha, vincristine, ticlopidine, and aspirin. Recently sirolimus was reported to be the most effective and promising agent for severe cases resistant to other systemic therapies. Local embolization or radiation therapy has been reported.

Infantile myofibromatosis: A cases report

( Jungyoon Ohn ),( Yun Seon Choe ),( Kyu Han Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

A 3-month-old female patient presented with three cherry colored indurated subcutaneous mass on birth; each on the anterior chest, Rt. axillary fossa and back, respectively. Her medical history included a neonatal seizure episode caused by traumatic subdural hemorrhage and hypocalcemia with calcium supplement. Histological findings showed spindle cell proliferation in the dermis. Immunohistochemistry staining revealed smooth muscle actin positive. MRI and ultrasonography study showed that it involved multiple organs: thigh muscles, left distal femur, liver, and spleen. Based on the clinical and histopathologic manifestation, she was diagnosed as having infantile myofibromatosis. Infantile myofibromatosis is usually presented as firm nodules in the multiple organs: skin, liver, lung, muscle, bone, and so on. Its histological manifestation is that spindle shaped cell bundles, producing collagen, invade adjacent structures. Its prognosis is relatively good, with a high rate of spontaneous resolution. But visceral involvement may cause a high mortality rate.

[P229] Incontinentia pigmenti in male: two cases report

( Jungyoon Ohn ),( Kyu Han Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

First, an 18-day-old male patient presented with erythema followed by vesicles and crusts on the right leg posterior aspect along the Blaschko’s line from birth. His pastmedical and familial history was nonspecific. Second, a 1-month-old male patient presented with linearly distributed vesicles and scales on the left leg along the Blaschko’s line from birth. Histological findings showed superficial perivascular lymphocyte and eosinophil infiltration with dyskeratotic cells. No mutation in the inhibitor of nuclear factor kappa B kinase subunit gamma (IKBKG) gene was observed in the leukocyte in peripheral blood samples of both cases. The ophthalmologic and neurologic examination failed to reveal any abnormal finding. Based on the clinical and histopathologic manifestation, they were diagnosed as having incontinentia pigmenti (IP). IP is a chromosome X-linked dominant genetic disorder. The mutated gene in IP patients is located in Xq28 and encodes a protein, IKBKG. It is characterized by typical 4 staged cutaneous findings: vesicular, verrucous, hyperpigmented, and atrophic. Abnormalities of ectodermal and mesodermal organ could be associated. Although it is mostly considered to be fatal in utero in male, postzygotic mutation or somatic mosaicism has been suggested as a pathogenesis of IP in males born alive.

Development of therapeutic technology through analysis of growth factor of myoma

( Jungyoon Park ),( Youngsin Han ),( Hyejin Hwang ),( Suhyun Shim ),( Yoon Jee Cheung ),( Hyun Hee Cho ),( Jang Heub Kim ),( Mee Ran Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: The purpose of this study was to compare the level of expression of various growth factors in myoma and to investigate the effect of growth factor inhibitor and to compare the effect of conventional regimens. Methods: The expression levels of growth factors in normal myometrium and myoma were compared by immunohistochemical staining. After primary culture of normal myometrial cells and myoma cells, cell viability was confirmed by treatment with 100 nM Ulipristal acetate (UPA) and Mifepristone (RU486) for 48 hours. Western blot analysis was performed to determine the protein expression of each of these growth factors. Cell viability was determined by treatment with 10uM TGF inhibitor(LY364947) and 5uM VEGF inhibitor(Axitinib) for 24 hours in cultured normal myometrial cells and myoma cells. Results: Immunohistochemical staining revealed that TGF expression was 20% in normal myometrium and 60% in myoma. VEGF expression was 1% in normal myometrium and 16% in myoma respectively. Cell viability was the most significant decrease with 58.59% mifepristone treatment in myoma tissue, and 57.20% in normal myometrium with UPA treatment. In the protein expression, EGF was significantly increased by 80% and IGF was significantly increased by 250% when UPA treated to normal myometrial cells. The expression of VEGF was decreased by 70% when Mifepristone treated to myoma cells. In normal myometrial cell, cell viability was significantly decreased by 60% of the TGF inhibitor treated cells and by 70% of the VEGF inhibitor treated cells. Cell viability of myoma cells was significantly decreased by 27.69% treated with TGF inhibitor and 27.34% treated with VEGF inhibitor. Conclusion: In myoma, TGF was the most expressed among the various growth factors, and VEGF was next increased to be expressed. The administration of inhibitor significantly inhibited the growth of myoma cells, and the suppressive effect was significantly greater than that of conventional drug therapy.

Juvenile xanthogranuloma: A case of atypical manifestation

( Jungyoon Ohn ),( Yun Seon Choe ),( Kyu Han Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

A 7-month-old male patient presented with a light brown colored bean-sized macule on the lower back from birth. It had multiple satellite lesions. Her medical history was non-specific. Histological findings showed foamy histiocytic collection in dermis with many multinucleated giant cells. Based on the clinical and histopathologic manifestation, she was diagnosed as having a juvenile xanthogranuloma. Juvenile xanthogranuloma, a variant of non-Langerhans’ cell histiocytosis, is characterized by yellow, red or brown colored, firm to rubbery, papules or nodules in infants. Typical manifestations would help make an easy diagnosis. But atypical cases were also reported, mimicking dermatofibroma, keloid, pyogenic granuloma, keratoacanthoma, and so on. In this case, it was presented as a nevus lipomatosus superficialis or connective tissue nevi.