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Hwang, Ji Sun,Kim, Geum Jin,Choi, Hyun Gyu,Kim, Min Cheol,Hahn, Dongyup,Nam, Joo-Won,Nam, Sang-Jip,Kwon, Hak Choel,Chin, Jungwook,Cho, Sung Jin,Hwang, Hayoung,Choi, Hyukjae American Chemical Society and American Society of 2017 Journal of natural products Vol.80 No.8
<P>Angiogenesis is the process of new blood vessel formation. Excessive angiogenesis is a critical factor in the progression of cancer, macular degeneration, and other chronic inflammatory diseases. When investigating the effects of crude extracts of cultured marine microorganisms, an extract of the cultured Streptomyces sp. YP127 strain was found to inhibit human umbilical vein endothelial cell (HUVEC) tube formation. Bioassay-guided fractionation and spectroscopic data analyses led to the identification of napyradiomycin A1 (1) as an antiangiogenic component of the extract. Compound 1 inhibited HUVEC tube formation in a concentration-dependent manner. It inhibited endothelial cell proliferation but did not affect human dermal fibroblast proliferation. Compound 1 also suppressed migration and invasion of vascular endothelial cells. In addition, compound 1 suppressed vascular endothelial cadherin expression and increased the permeability of the endothelial cell membrane. These results suggested that compound 1 modulates cell permeability and inhibits the angiogenesis of endothelial cells.</P>
자동차 기능안전 표준 ISO-26262에 따른 개발방법 및 EPS용 토크센서 개발에 적용사례
황건열(Keonyeol Hwang),유광호(Kwangho Yoo),서정욱(Jungwook Seo),김완일(Wanil Kim) 한국자동차공학회 2012 한국자동차공학회 부문종합 학술대회 Vol.2012 No.5
In this paper, we introduce functional safety standard ISO-26262 based development process. It is required to change not only existing processes but also organization to correspond to ISO-26262 standard requirements effectively. Development method modification can be summarized following 4 steps. First, adding of new process steps and roles. Second, finding relationships with existing process and roles and applying new steps. Third, applying new development method based on ISO-26262 standard. And finally, changing and adding supporting processes. And we also include case study of torque sensor development based on ISO-2626 for EPS. Major analysis such as hazard analysis and risk assessment, functional/technical safety concept, FMEDA and FIT are discussed to recommend approach to the standard requirements.
RNAseq-based Transcriptome Analysis of Burkholderia glumae Quorum Sensing
Kim, Sunyoung,Park, Jungwook,Kim, Ji Hyeon,Lee, Jongyun,Bang, Bongjun,Hwang, Ingyu,Seo, Young-Su The Korean Society of Plant Pathology 2013 Plant Pathology Journal Vol.29 No.3
Burkholderia glumae causes rice grain rot and sheath rot by producing toxoflavin, the expression of which is regulated by quorum sensing (QS). The QS systems of B. glumae rely on N-octanoyl homoserine lactone, synthesized by TofI and its cognate receptor TofR, to activate the genes for toxoflavin biosynthesis and an IclR-type transcriptional regulator gene, qsmR. To understand genome-wide transcriptional profiling of QS signaling, we employed RNAseq of the wild-type B. glumae BGR1 with QS-defective mutant, BGS2 (BGR1 tofI::${\Omega}$) and QS-dependent transcriptional regulator mutant, BGS9 (BGR1 qsmR::${\Omega}$). A comparison of gene expression profiling among the wild-type BGR1 and the two mutants before and after QS onset as well as gene ontology (GO) enrichment analysis from differential expressed genes (DEGs) revealed that genes involved in motility were highly enriched in TofI-dependent DEGs, whereas genes for transport and DNA polymerase were highly enriched in QsmR-dependent DEGs. Further, a combination of pathways with these DEGs and phenotype analysis of mutants pointed to a couple of metabolic processes, which are dependent on QS in B. glumae, that were directly or indirectly related with bacterial motility. The consistency of observed bacterial phenotypes with GOs or metabolic pathways in QS-regulated genes implied that integration RNAseq with GO enrichment or pathways would be useful to study bacterial physiology and phenotypes.
Man Kadayat, Tara,Lee, Geumwoo,Jung, Kyungjin,Hwang, Hee-Jong,Joo, Jeongmin,Hahn, Dongyup,Hwang, Hayoung,Park, Keun-Gyu,Cho, Sung Jin,Kim, Kyung-Hee,Chin, Jungwook Elsevier 2018 Tetrahedron letters: the international organ for t Vol.59 No.50
<P><B>Abstract</B></P> <P>Peroxisome proliferator-activated receptor delta (PPARδ) is considered as a promising biological target for the development of new drugs to treat metabolic syndrome including hyperlipidemia. In this study, a simple and efficient method for the preparation of a unique dimethyl thiazoline containing intermediate (<B>13</B>) of new PPARδ agonists as GW501516 analogue is described. The intermediate <B>13</B> was readily obtained by coupling reaction of 4-(chloromethyl)-5,5-dimethyl-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrothiazole (<B>11</B>) with 4-mercapto-2-methylphenol (<B>12</B>) in the presence of tetrabutylammonium hydrogensulfate (TBAHS) and Cs<SUB>2</SUB>CO<SUB>3</SUB> in DMF at 80 °C for 1 h. This unique intermediate could be useful for the synthesis of various novel PPARδ agonists to understand the structural and biological significance of PPARδ.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Method for unique dimethyl thiazoline containing intermediate of PPARδ agonists. </LI> <LI> <I>TBAHS</I> as catalyst for efficient coupling of <B>11</B> with <B>12</B>. </LI> <LI> Potential use of intermediate <B>13</B> for synthesis of novel PPARδ-selective agonists. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Dongyup Hahn ),( Hiyoung Kim ),( Inho Yang ),( Jungwook Chin ),( Hoosang Hwang ),( Dong Hwan Won ),( Byoungchan Lee ),( Sang Jip Nam ),( Merrick Ekins ),( Hyukjae Choi ),( Heonjoong Kang ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Three new structurally related depsipeptides, halieylindramides F-H (1-3), and two known halieylindra-mides were isolated from a Petrosia sp. marine sponge collected off the shore of Youngdeok-Gun, East Sea, Republic of Korea. Their planar structures were elucidated by extensive spectroscopic data analyses including ID and 2D NMR data as well as MS data. The absolute configurations of halicylin-drarnides F-H (1-3) were determined by Marfey``s method in combination with Edman degradation. The absolute config-urations at C-4 of the dioxyindolyl alanine (Dioia) residues of halieylindramides G (2) and H (3) were determined as 4S and 4R, respectively, based on ECD spectroscopy. The C-2 configurations of Dioia in 2 and 3 were speculated to both be 2R based on the shared biogenesis of the halicylindramides. Halieylindrarnides F (1), A (4), and C (5) showed human farnesoid X receptor (hFXR) antagonistic activities, but did not bind directly to hFXR.