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Park, Jungmin,Ku, Minhee,Kim, Eunjung,Park, Yeonji,Hong, Yoochan,Haam, Seungjoo,Cheong, Jae-Ho,Park, Eun Sung,Suh, Jin-Suck,Huh, Yong-Min,Yang, Jaemoon Oxford University Press 2013 Integrative biology Vol.5 No.4
<P>We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.</P>
Shape Optimization of Flow Channels Using Lattice Boltzmann Method
Jungmin Park(박정민),Kyung Chun Kim(김경천) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12
A new optimality criterion algorithm is presented for producing modified shape designs for fluid flow inside channels. To compute the fluid motion in a channel, the Lattice Boltzmann Method (LBM) was used based on D2Q9 lattice spaces associated with the Bhatnagar-Gross-Krook (BGK) collision term. An experiential optimality method to design channels with the lowest pressure drop along the passage is introduced. The positions of solid cells and fluid cells are exchanged based on the strain rate tensor at the solid-fluid interface. To obtain the optimized shape, the cells are changed until the optimality condition is obtained with the restriction of constant fluid volume. Examples are presented to validate the algorithm, including an elbow tube as well as symmetrical and nonsymmetrical T-junction channels. The validation exercises demonstrate that the algorithm is suitable for optimal channel design.