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Park, Jungmin,Ku, Minhee,Kim, Eunjung,Park, Yeonji,Hong, Yoochan,Haam, Seungjoo,Cheong, Jae-Ho,Park, Eun Sung,Suh, Jin-Suck,Huh, Yong-Min,Yang, Jaemoon Oxford University Press 2013 Integrative biology Vol.5 No.4
<P>We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.</P>
Microstructure guided multi-scale liquid patterning on an open surface
Park, Dohyun,Kang, Myeongwoo,Choi, Jin Woo,Paik, Sang-Min,Ko, Jihoon,Lee, Somin,Lee, Younggyun,Son, Kyungmin,Ha, Jungmin,Choi, Munseok,Park, Woohyun,Kim, Ho-Young,Jeon, Noo Li The Royal Society of Chemistry 2018 Lab on a chip Vol.18 No.14
<P>Liquid patterning is a quintessential aspect in cell-based screening. While there are a variety of methods to handle microliquids utilizing surface treatments, complex microfluidic systems, and automated dispensing, most of the stated methods are both expensive and difficult to implement. Here, we present a fast multi-scale microliquid-patterning method on an open surface using embossed microstructures without surface modification. Arrays of micropillars can trap microliquids when a bulk drop is swept by an elastic sweeper on polystyrene (PS) substrates. The patterning mechanism on a basic form of a 2 × 2 rectangular array of circular pillars is analyzed theoretically and verified with experiments. Nanoliter-to-microliter volumes of liquids are patterned into various shapes by arranging the pillars based on the analysis. Furthermore, an array of geometrically modified pillars can capture approximately 8000 droplets on a large substrate (55 mm × 55 mm) in one step. Given the simplistic method of wipe patterning, the proposed platform can be utilized in both manual benchtop and automated settings. We will provide proof of concept experiments of single colony isolation using nanoliter-scale liquid patterning and of human angiogenic vessel formation using sequential patterning of microliter-scale liquids.</P>