http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Recurrent Epidural Fluid Collection after Cranioplasty
Seok Won Kim,Chang Il Ju,Hui Sun Wang 조선대학교 의학연구원 2016 The Medical Journal of Chosun University Vol.41 No.2
Cranioplasty following decompressive craniectomy is regarded as a relatively simple and safe procedure to protect the brain and improve neurological function. However, some serious complications, such as infection, hematoma, bone resorption, seizure, and epidural or subdural fluid collection may develop after cranioplasty. Among these complications, epidural fluid collection after cranioplasty is not well described and with limited reports on the same. Here, we report recurrent epidural fluid collection after cranioplasty, eventually necessitating the removal of the bone flap. This study discusses the possible pathological mechanisms of this undesirable complication with a review of the literature.
Ju, Won Seok,Song, Ilchan,Park, Se-Ra,Seo, Sang Young,Cho, Jin Hyoung,Min, Sung-Hun,Kim, Dae-Heon,Kim, Ji-Su,Kim, Sun-Uk,Park, Soon Ju,Ko, Kisung,Choo, Young-Kug The Korean Society of Plant Biotechnology 2019 식물생명공학회지 Vol.46 No.3
Production of therapeutic monoclonal antibodies (mAbs) using a plant platform has been considered an alternative to the mammalian cell-based production system. A plant-derived mAb CO17-1AK ($mAb^P$ COK) can specifically bind to various types of cancer cell lines. The target protein of $mAb^P$ COK is the epithelial cell adhesion molecule (EpCAM) highly expressed in human epithelial cancer cells, including breast and colorectal cancer cells. It has been hypothesized that its overexpression supports tumor growth and metastasis. A ganglioside is extended well beyond the surfaces of the various cell membranes and has roles in cell growth, inflammation, differentiation, and carcinogenesis. However, the regulation of EpCAM gene expression in breast cancers and the role of gangliosides in oncogenesis are unclear. Here, the purpose of this study was to determine the effects of $mAb^P$ COK on human breast cancer cell proliferation, apoptosis, and ganglioside expression patterns. Our results show that treatment with $mAb^P$ COK suppressed the growth of breast cancer cells and induced apoptotic cell death. It also upregulated the expression of metastasis-related gangliosides in breast cancer cells. Thus, treatment with $mAb^P$ COK may have chemo-preventive therapeutic effects against human breast cancer.
( Seok Min Kim ),( Dong Hyuk Eun ),( Jun Young Kim ),( Yong Hyun Jang ),( Weon Ju Lee ),( Do Won Kim ),( Seok-jong Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Unlike giant congenital melanocytic nevi (CMN), small and medium-sized CMN (smCMN) are not generally considered as a precursor lesion for malignant melanoma (MM), but we often confront MM arising from smCMN in a clinical setting. Objectives: The purpose of this study is to investigate clinicopathological features of MM arising from smCMN and to compare their features with non CMN-MM. Methods: A retrospective study has been conducted based on the medical records of patients with MM arising from smCMN from 2011 to 2017. Their sex, age, Breslow thickness (BT), type of melanoma and metastasis were identified and these findings were compared with those of invasive MM arising from non CMN skin. Results: MM was found in 10 of 380 (2.6%) smCMN and they comprised 10 of 121 (8.3%) total invasive MM of the same period. They developed more in female and showed earlier onset age (49.2 years), thinner mean BT (4.7mm) than those of non CMN-MM (62.8 years, 5.7mm, respectively). Most of them were nodular melanoma (80.0%). The rates of nodal and distant metastasis (20%, 0%) were both lower than those of non CMN-MM (27.0%, 4.5%, respectively). Conclusion: MM occurred at a relatively higher frequency than expected in smCMN which should also be paid more attention to prevent delay in the treatment of potential MM. Limitation: This is a single center study done by small number of patient from a university-setting hospital.
P204 Clinicoepidemiological study on pigmented contact dermatitis
( Seok Min Kim ),( Dong Hyuk Eun ),( Min Ji Kim ),( Yong Hyun Jang ),( Seok-jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Pigmented contact dermatitis (PCD) is a noneczematous variant of contact dermatitis, characterized clinically by hyperpigmentation. It frequently occurs from 2 months to 2 years after exposure, mostly on facial area. Objectives: To investigate clinicopathological characteristics and possible causative agents of recently increasing PCD. Methods: A retrospective study has been conducted based on the medical records of 95 PCD patients who visited Department of Dermatology in Kyungpook National University Hospital from January 2011 to July 2016. We analyzed demographical and clinicopathological characteristics, such as sex, age, distribution, symptoms, duration, histopathological findings, causative agents, and treatment. Results: The number of PCD patients has rapidly increased for 1 year, especially in the age group of 50s. Female showed 5 times higher incidence rate than male with lesions mostly concentrated on facial and neck area. Twenty nine patients (30.5%) suspected a hair dye as a causative agent. Among them, 23 patients (24.2%) had an experience of using a henna hair dye. Out of patients who underwent patch test, 78.7% showed positive results, most commonly nickel. And 7 patients had positive results on a henna hair dye. Histopathological findings showed pigmentary incontinence in the upper dermis. Conclusion: The number of PCD patients has increased in recent years. This study provides us with good information on the clinicoepidemiological characteristics of PCD.
( Seok Jong Lee ),( Hyun Jung Lim ),( Yoon Hyuk Choi ),( Yong Hyun Chang ),( Weon Ju Lee ),( Do Won Kim ),( Ghil Suk Yoon ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.1
Background: There are various histological prognostic parameters of cutaneous malignant melanoma, including tumor thickness and ulceration. Tumor-infiltrating lymphocytes (TIL) are among these parameters and can be further classified into three categories: ``absent``, ``non-brisk`` and ``brisk``. Brisk TIL usually indicates better clinical prognosis. Microscopic satellite (Ms) is defined as a nest of tumor cells that is greater than 0.05 mm in diameter and definitely separated from the main tumor. Even though the incidence of Ms varies according to Breslow thickness, the presence of Ms generally indicates poor prognosis. Objective: Clinical significance of both TIL and Ms has been extensively studied in western populations but much less so in Asian countries, including Korea, where acral melanoma is the most common subtype. Methods: We reviewed 90 patients with acral melanoma diagnosed at Kyungpook National University Hospital in Korea. Tissue specimens were examined using hematoxylin-eosin and HMB45 immunohistochemical staining. They were also evaluated by the presence and categorization of TIL (absent, non-brisk and brisk) and the presence of Ms. We further evaluated their impact on survival events (recurrence, distant metastasis and death). Results: The number of survival events by TIL type was 22 in the absent category (22/64, 34.4%), 3 in the non-brisk category (3/25, 12.0%) and 0 in the brisk category. For Ms, survival events were present in 7 patients in Ms-present group (7/11, 63.6%) and 21 patients in Ms-absent group (21/79, 26.6%). Conclusion: We suggest the possibility of TIL and Ms as prognostic indicators for acral melanoma in Korean population. (Ann Dermatol 25(1) 61∼66, 2013)