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( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon ),( Jeong-ju Yoo ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Ji Hye Lee ),( Hong Soo Kim ),( Sae Hwan Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: It remains uncertain whether antiviral treatment improve surivival in hepatitis B virus (HBV)-hepatocellular carcinoma (HCC) patients receiving palliative therapy. The purpose of this study is to evaluate the role of antiviral therapy in HBV-HCC patients after diagnosis of HCC. Methods: This retrospective study analyzed 113 HBV-HCC patients who underwent transarterial chemoembolization (TACE) in two university hospital. Overall survival (OS) was compared in patients treated with/without antiviral treatment after diagnosis of HCC. Subgroup analysis and Cox regression analysis were performed to determine the efficiency of antiviral treatment and prognostic factors for OS. Results: OS was not different between the patients treated with antiviral treatment (n = 67) and the patients who received no antiviral treatment (n = 46) (P=0.103). Barcelona Clinic Liver Cancer (BCLC) was independent prognostic factors for OS of HBV-related HCC patients who were treated with TACE. By subgroup analysis, antiviral therapy achieved better survival improvement in BCLC stage B and C (P<0.001) but had no survival improvement in BCLC stage 0 and A (P=0.605). Antiviral therapy was one of the independent prognostic factors for patients with BCLC stage B and C (HR 0.230, 95% CI 0.094-0.565, P=0.001). Conclusions: Antiviral therapy did not improve survival of HBV-related HCC patients treated with TACE. However, antiviral therapy shows survival benefit only in BCLC stage B and C disease.
Fabrication of SOI p-MOSFET with a 35-nm Gate Length by Using PBF-SPD Process
Won-ju Cho,Chang-geun Ahn,In-bok Baek,Jihoon Oh,Jong-heon Yang,Kiju Im,이성재 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.3
We developed a novel shallow junction formation technique for SOI p-MOSFET application. A poly boron lm (PBF) was used as the diusion source for a solid phase diusion (SPD) process. Rapid thermal annealing (RTA) was utilized to diuse the boron from the PBF source. With the advantages of the SPD technique, an extremely shallow p+-n junction less than 10 nm in depth was formed and the p+-n-n+ diodes showed excellent junction properties. Based on optimized device fabrication processes, SOI p-MOSFETs with a gate length of 35 nm were successfully fabricated and revealed good electrical characteristics and superior device scalability.
( Baek Gyu Jun ),( Sang Gyune Kim ),( Young Don Kim ),( Gab Jin Cheon ),( Jeong-ju Yoo ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Sang-wook Yi ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Body mass index (BMI) is known to be associated with higher risk of hepatocellular carcinoma (HCC) in the general population. However, the association between BMI and risk of HCC in patients with various liver disease is not well understood. Methods: We used data from National Health Insurance Service (NHIS) that provides compulsory health insurance coverage and national health screening for all citizens in the Republic of Korea. Hazard ratios (HRs) were calculated using Cox regression models to examine associations between body mass index (BMI) and risk of HCC. We included 15016551 adults (aged 18-99 years) who underwent health examinations between 2003 and 2006, in the NHIS database. Participants were classified into six groups according to the liver diseases; liver cirrhosis (LC), hepatitis B or C virus infection (HBVHCV), other liver disease (O-LD), unidentified liver disease with alanine aminotransferase (ALT) ≥40 or aspartate aminotransferase (AST) ≥40 (ALT40), no known liver diseases with 20≤ALT<40 or 20≤AST<40 IU/ml (ALT2040), and ALT<20 and AST<20 (ALT20). Results: During mean 13.7 years of follow-up. HCC occurred in 71570 individuals. In total population, BMI had a non-linear association with HCC. In BMI above 25 kg/m², BMI was positively associated with risk of HCC regardless of liver disorder. In the multivariable adjusted analysis, the HR per 5 kg/m² increase in BMI above 25 kg/m² was 1.48 (95% CI 1.44-1.52) in total population, 1.11 (95% CI 1.00-1.23) in LC, 1.12 (95% CI 1.44-1.52) in HBVHCV, 1.32 (95% CI 1.22-1.44) in O-LD, 1.07 (95% CI 1.03-1.12) in ALT40, 1.47 (95% CI 1.38-1.57) in ALT2040, 1.67 (95% CI 1.32-2.09) in ALT20. In the subgroup analysis for the HCC high-risk group, the HR of HCC (95% CI) for a 5 kg/m2 increase in BMI was 1.21 in HBV-LC (1.01-1.46), 1.13 in other LC (1.08-1.19) and 1.15 in HBV without LC (1.04- 1.27), 1.14 in HCV without LC (0.92 -1.40) and 1.05 in HCV-LC (0.64-1.74). Associations between BMI and risk of HCC in HBV (HR; 1.46 vs 1.05), HCV (HR; 1.30 vs 0.92) and LC (HR; 1.28 vs 1.02) patients were stronger in female than in male. Conclusions: Our study showed that BMI was positively associated with risk of HCC regardless of liver disorder in BMI above 25 kg/m². As the severity of liver disease weakened, the association between increased BMI and HCC became stronger. Inpatients with HBV, HCV, and LC, the harmful effects of higher BMI on HCC risk was stronger in women than in men.
Baek, Jong-Suep,Hwang, Chan-Ju,Jung, Hyo-Won,Park, Yong-Ki,Kim, Young-Ho,Kang, Jong-Seong,Cho, Cheong-Weon Informa Healthcare USA, Inc. 2014 DRUG DELIVERY Vol.21 No.6
<P>KOB extracts are a polyherbal medicine had been prescribed for the treatment of hyperhydrosis and allergic diseases such as allergic asthma and rhinitis in oriental clinics. Therefore, the pharmacokinetic studies of the KOB extract administered orally to normal rats and rhinitis-induced rats to understand the correlation of the efficacy and plasma concentration of KOB in patients of allergic rhinitis in future were performed. The study was conducted according to administration for pure baicalin in normal rats, baicalin in KOB extract in normal rats and rhinitis-induced rats. Baicalin in rat plasma was analyzed and validated by HPLC analysis. The interday precision based on the standard deviation of replicates of quality control samples ranged from 3.6% to 7.9% with accuracy ranging from 92.9% to 101.2% for baicalin. Based on validated analysis, pharmacokinetic study was carried out. Pure baicalin in normal rats and baicalin in KOB extract in normal rats showed bimodal curves due to direct absorption and glucuronidation. The <I>T</I><SUB>max</SUB>, <I>C</I><SUB>max</SUB> and AUC of pure baicalin in normal rats or baicalin in KOB extract in normal rats were 12 h, 0.68 µg/ml and 9.85 µg h/ml, respectively, or 12 h, 0.46 µg/ml and 6.36 µg h/ml, respectively. The analytical method showed excellent sensitivity, precision and accuracy, being successfully employed in a pharmacokinetic study of polyherbal medicine, KOB extract. Allergic-induced condition did not affect the pharmacokinetics of KOB extracts, suggesting KOB extracts did not require dosage adjustment in subjects with allergic-induced diseases.</P>
( Won Kyu Lee ),( Hye Jung Kim ),( Je Hyun Baek ),( Eun Hee Lee ),( Hyun Ju Jung ),( Yeon Gyu Yu ),( Sung Weon Ryoo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Mycobacterium bovis bacillus Calmette-Guerin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. To establish a Korean tuberculosis vaccine derived from BCG Pasteur 1173P2, genome sequencing of a BCG Korea was completed by Joung and coworkers (2013). Here, we report the proteomics data of BCG Korea, the strain that will be actually used in Korea for vaccine production. Methods: The tryptic peptides were loaded onto a fused silica microcapillary column (12 cm x 75 μm) packed with C18 reversed phase resin (5 μm, 100 A). The column was directly connected to an LTQ linear ion-trap mass spectrometer equipped with a nano-electrospray ion source. All spectra were acquired in data-dependent scan mode. The acquired LC-ESI-MS/MS fragment spectra were searched in the BioWorks- BrowserTM with the SEQUEST search engine against NCBI non-redundant database including reverse database. The putative function of proteins, which were not listed in UniProtKB, was further analyzed using Pfam and gene ontology databases. Scaffold was used to validate MS/MS based peptide and protein identifi cations. Results: A total of 914 proteins were identifi ed from LC-ESI-MS/MS analysis and their abundance was estimated by SWATH methods. Some predominant proteins, including fatty acid synthase, mycocerosic acid synthase, RNA polymerase, heat shock protein and peptide synthase which represent potential prominent antigens in the humoral and cellular immune response. Conclusions: The aim of this study was to construct a reference protein map for these proteins in BCG Korea. Especially, the SWATH is very straightforward and provides a promising approach owing to its strong reliability and reproducibility during the proteomic analysis. These results will be compared with the currently used BCG strains and basic information for the development of a novel vaccine.
( Won Kyu Lee ),( Hye Jung Kim ),( Je Hyun Baek ),( Eun Hee Lee ),( Hyun Ju Jung ),( Yeon Gyu Yu ),( Sung Weon Ryoo ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Mycobacterium bovis bacillus Calmette-Guerin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. To establish a Korean tuberculosis vaccine derived from BCG Pasteur 1173P2, genome sequencing of a BCG Korea was completed by Joung and coworkers (2013). Here, we report the proteomics data of BCG Korea, the strain that will be actually used in Korea for vaccine production. Methods: The tryptic peptides were loaded onto a fused silica microcapillary column (12 cm x 75 μm) packed with C18 reversed phase resin (5 μm, 100 A). The column was directly connected to an LTQ linear ion-trap mass spectrometer equipped with a nano-electrospray ion source. All spectra were acquired in data-dependent scan mode. The acquired LC-ESI-MS/MS fragment spectra were searched in the BioWorksBrowserTM with the SEQUEST search engine against NCBI non-redundant database including reverse database. The putative function of proteins, which were not listed in UniProtKB, was further analyzed using Pfam and gene ontology databases. Scaffold was used to validate MS/MS based peptide and protein identifications. Results: A total of 914 proteins were identified from LC-ESI-MS/MS analysis and their abundance was estimated by SWATH methods. Some predominant proteins, including fatty acid synthase, mycocerosic acid synthase, RNA polymerase, heat shock protein and peptide synthase which represent potential prominent antigens in the humoral and cellular immune response. Conclusions: The aim of this study was to construct a reference protein map for these proteins in BCG Korea. Especially, the SWATH is very straightforward and provides a promising approach owing to its strong reliability and reproducibility during the proteomic analysis. These results will be compared with the currently used BCG strains and basic information for the development of a novel vaccine.
Baek-Ju Lee(이백주),Dong-Won Seo(서동원),Jae-Wook Choi(최재욱) 대한전자공학회 2021 대한전자공학회 학술대회 Vol.2021 No.6
In this study, silicon nitride thin films deposited in space division plasma-enhanced atomic-layer deposition were studied in detail. The defect density and impurity concentration of the silicon nitride thin films have a great influence on reading and writing information; therefore, it was confirmed how these parameters change according to process conditions. Plasma treatment was performed to improve the density and impurities of the silicon nitride thin films, and it was analyzed how plasma treatment affects the defect density and impurity concentration of silicon nitride.