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PUVA에 의한 피부 염증 반응 - C57BL mouse의 귀부종 반응 -
이주흥(Joo Heung Ree),윤재일(Jai Il Youn) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.5
We have observed the dark effect of 8-methoxypsoralen(8-M(P) on the viability and DNA synthesis in human lymphocyte cultures after stimulaticn with phytohemagglutinin (PHA) in the absence of ultraviolet A radiation. The concentratioiis of 8-MOP was 0.5-32 ug/ml. We have also measured the LDH activity in supernatant. of lymphocyte cultures treated with 8-MOP. The results were as follows: 1. There was no 8-MOP dose-dependent decrease in the viability of lymphocytes up to 8- MOP 32pg/ml. 2. There was a 8-MOP dose-dependent decrease in PHA-induced DNA synthesis of lymphocytes from the concentration of 8-MOP 2 ug/ml. 3. There was a time-dependent decrease in PHA-induced DNA synthesis of lymphocytes at the concentration of 8-MOP 32 ug/ml. 4. There was no LDH release in supernatant of lymphocyte ciltu es after incubation with 8-MOP up to 8-MOP 32ug/ml. (Kor J Dermatol 992;30(5):601-607)
이주흥(Joo Heung Ree),조광현(Kwang Hyun Cho),은희철(Hee Chul Eun),이유신(Yoo Shin Lee),박명희(Myoung Hee Park) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.5
A study was made of the differences in clinical features and immunological aspects between herpes zoster patients with malignancies and those without malignant tumors. The results obtained from the retrospective review of medical records are as follows: Herpes zoster occurred more frequently in younger patients(less than twenty) with malignanciee as compared with the control group of the same ages,' Male was dominant among zoster patients with malignancies as is the contrary to contral group; Tihere were no marked differences in primarilly involved dermatomes between the two groups; Generalized varicelliform eruptiona were more common in zoster pa,tients with malignaneies than in control group, It seemed that zoster patients with malignancies complained of milder degree of pain. Zoeter patienta associated with malignancies were more frequently DNCB-negative and had decreased OKT3+ pan T cells, OKT4+ helper/inducer T cells as compared with control group, which suggest impaired cell mediated immunity in the former.
PUVA에 의한 C57BL Mice에서의 멜라닌 세포 변화에 관한 연구
이주홍(Joo Heung Ree),윤재일(Jai Il Youn) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.4
The object of this study is to evaluate the effects of repeat,ed PUVA applications on epidermal melanocytes. The changes in the number of melanocyes is compared to the frequency of PUVA applications. 26 adult male C57BL mice were used. About an hour after appliction of 0.1% solution of 8-methoxypsoralen, UVA was delivered two or four times a weels on both ears of mice with blacklight fluorescent tube l,'Waldmann UV-800). Weekly examinations of melanocytes were made for 4 weeks on split epidermal sheets treated with DOPA solution. The results were as follows. 1. Repeated PUVA applications revealed a significant increase in the number of melanocytes. With PUVA, two times a week, the number of me anocytes was increased from 83.2+7.2/mm (unir radiated ear) to 250.6+34.7/mm after ore week and 525.5+66.7 /mm after 4 weeks. With PUVA, four times a week, the number of melanocytes was increased from 83.2+7.. 2/mm (unirradiated ear) to 437.0+74.0/mm after one week and 686.3+27.8/mm after 4 weeks. 2. PUVA, four times a wcek, elicited higher melanocyte density than PUVA, two times a week, under the same period of treatment. 3. After two weeks, the same amount of irradiation increased the number of melanocytes more in PUVA, four times a week than in PUVA, t,wo times a week. (Kor J Dermatol 1992;30(4):484-491)
이주흥(Joo Heung Ree),박경찬(Kyung Chan Park),이유신(Yoo Shin Lee) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6
We report four cases of hyalinosis cutis et mucosae. They developed hosrseness in their infancy and all had past history of frequent skin infections with accompanying varioliform scars. On physical examination, all the patients had beaded papules along their eyelid margins, hoarseness, varioliform scars and various skin and mucous membrane infiltrations. Pathologic examinations performed on skin infiltrations and eyelid papules revealed diastase resistant periodic acid Schiff positive materials deposited mainly in upper dermis. We have given three of four patients 1g/day of dimethyl sulphoxide from 6 to 12 months with no significant side effects nor remarkable clinical improvement.
( Taeyun Kim ),( Hyun Joo Song ),( Seung Uk Jeong ),( Eun Kwang Choi ),( Eun Kwang Choi ),( Heung Up Kim ),( Byung Cheol Song ),( Kwang Sig Kim ),( Bong Soo Kim ),( Young Ree Kim ) 대한소화기학회 2013 Gut and Liver Vol.7 No.1
Background/Aims: Anisakiasis is frequent in Jeju Island because of the people`s habit of ingesting raw fish. This study evaluated the clinical characteristics of patients with small bowel anisakiasis and compared them with those of patients with gastric anisakiasis. Methods: We retrospectively reviewed the medical records of 109 patients diagnosed with anisakiasis between May 2003 and November 2011. Results: Of the 109 patients diagnosed with anisakiasis, those with suspicious anisakiasis (n=38) or possible anisakiasis (n=12) were excluded. The age and gender distributions did not differ between patients with small bowel anisakiasis (n=30; age, 45±13 years) and those with gastric anisakiasis (n=29; age, 46±10 years). The mean duration of hospitalization was 5.4±4.3 days for patients with small bowel anisakiasis and 0.5±1.7 days for patients with gastric anisakiasis. Small bowel anisakiasis was accompanied by leukocytosis (76.7% vs 25.5%, p=0.003) and elevated C-reactive protein levels (3.4±3.2 mg/dL vs 0.5±0.3 mg/dL, p=0.009). Contrast-enhanced abdominopelvic computed tomography showed small bowel wall thickening with dilatation in 93.3% (28/30) of patients and a small amount of ascites in 80.0% (24/30) of patients with small bowel anisakiasis. Conclusions: Compared with gastric anisakiasis patients, small bowel anisakiasis patients had a longer hospitalization time, higher inflammatory marker levels, and small bowel wall thickening with ascites. (Gut Liver 2013;7:23-29)
건선의 임상적 연구 - 1 . 침범범위에 따른 경중도의 분류 및 임상적 비교 관찰 -
윤재일(Jai Il Youn),이주홍(Joo Heung Ree),이유신(Yoo Shin Lee) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.6
In study of 360 psoriatic patients between June 1982 and May 1987 in Seoul National University Hospital, psoriasis was classified according to the severity based on the extent of involvement. The guideline of the extent of involvement was as follows, 1) mi1d less than 5% involvement of whole surface area 2) moderate : 5% 30% involvement of whole surface area 3) severe: over 30% involvement of whole surface area This study was done to evaluate the distribution and clinical features of psoriasis according to the extent, of involvement. Among 360 psoriatics, 180(50.0%) patients had mild psoriasis, 140(38.9%) patients had moderate psoriasis and 40(11.1%) patients presented as severe psoriasis. The duration of psoriasis seemed longer in moderate and severe groups than in mild group but the difference was not signifcant. There was also a tendency that patients developing psoriasis before the age of 20 were more prevalent in severe group.
건선의 임상적 연구 - 2 . 활동성에 따른 경중도의 분류 및 임상적 비교 관찰 -
서대헌(Dae Hun Suh),이주흥(Joo Heung Ree),윤재일(Jai Il Youn),김정애(Jeong Aee Kim) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3
In the study of 142 psoriatic patients who visited psoriasis clinic in Seoul Nstional University Hospital during recent five years, psoriasis was classified according to the severity based on the activity. The guideline of activity was as follows : 1. Mild: skin lesions stationary for the last one month. 2. Moderate : peripherally spreading plaque lesions with only occasionally small papules. 3. Severe . rapidly developing new lesions from the periphery of plaques or normal skin, or newly developing pustules. This study was done to evaluate the distribution and clinical features of psoriasis according to the activity. Among 142 patients of psoriasis, 84(59.2%) patients had mild psoriasis, 39(27. 4%) patients had moderate psoriasis, and 19(13.4%) patients were presented as severe psoriasis. (Kor J Dermstol 28(3): 295 301, 1990)
Song, Joon Young,Cheong, Hee Jin,Woo, Heung Jeong,Wie, Seong-Heon,Lee, Jin-Soo,Chung, Moon-Hyun,Kim, Yang Ree,Jung, Sook In,Park, Kyung-Hwa,Kim, Tae Hyong,Uh, Soo-Taek,Kim, Woo Joo The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.2
<P>Influenza vaccines are the primary method for controlling influenza and its complications. This study was conducted as a phase 3, randomized, double-blind, controlled, multi-center trial at seven university hospitals to evaluate the immunogenicity and safety of an inactivated, split, trivalent influenza vaccine (GC501, Green Cross Corporation, Yongin, Korea), which was newly manufactured in Korea in 2008. Between September 21 and 26, a total of 329 healthy subjects were recruited for the immunogenicity analysis, while 976 subjects were enrolled for the safety analysis. The GC501 vaccine met both FDA and EMEA criteria with ≥ 80% of subjects achieving post-vaccination titers ≥ 40 for all three subtypes, even in the elderly. The vaccine was well tolerated with only mild systemic and local adverse events. In summary, GC501 showed excellent immunogenicity and a good safety profile in both young adults and the elderly. The licensure of GC501 might be an important basis in preparation for the future influenza pandemic.</P>
조광현(Kwang Hyun Cho),이주홍(Joo Heung Ree),이유신(Yoo Shin Lee),한성구(Sung Koo Han) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.4
We report a 58 year old man who complained that his nails didn't grow for a year and developed yellowish discoloration. On physical examination his nails showed yellow greenish discoloration, increased corvexity, loss of lunulae and cuticles. C]iest X ray revealed atelectasis on right lower lung field and bronchiectasis on left lower lung field. Mild restrictive pattern was observed in pulmoniry function test. We gave him 800IU of Vitamin E claily for 3 months, but rio remarkable changes have been observed as yet..