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( Jiwook Lee ),( Sung Hyun Park ),( Young Zoon Kim ) 대한뇌종양학회 대한신경종양학회 2018 Brain Tumor Research and Treatment Vol.6 No.1
Background The aims of this study were to investigate the role of the Neurological Assessment of Neuro-Oncology (NANO) scale in predicting the prognosis of patients with glioblastoma, and compare these results to predicted data of the Karnofsky Performance Scale (KPS), and Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) performance status. Additionally, we examined other prognostic factors in glioblastoma patients. Methods The medical records of 76 patients with a new diagnosis of histologically ascertained glioblastoma in the period from January 2002 to December 2015 at the authors’ institution were retrospectively reviewed. Clinical factors, including epidemiologic, radiologic, and therapeutic values were reviewed as well as the performance status assessed by the KPS, ECOG/WHO performance status, and NANO scale. Results The mean overall survival was 19.8 months (95% confidence interval 15.2-25.4 months). At initial diagnosis, the mean value [±standard deviation (SD)] of KPS score, ECOG/WHO performance status, and NANO scale were 81 (±7.4), 1.3 (±0.6), and 7.3 (±3.8), respectively. Multivariate analysis for predicting survival showed odds ratios of KPS score, ECOG/WHO performance status, and NANO scale were 2.502 (≥80 vs. <80; p=0.024), 1.691 (0-1 vs. 2-5; p=0.047), and 2.763 (0-7 vs. 8-23; p=0.020), respectively. At the time of progression, the mean value (±SD) of KPS score, ECOG/WHO performance status, and NANO scale were 69 (±8.2), 1.6 (±0.7), and 11.4 (±4.2), respectively; multivariate analysis for predicting survival showed that the odd ratios for KPS score, ECOG/ WHO performance status, and NANO scale were 2.007 (≥80 vs. <80; p=0.035), 1.321 (0-1 vs. 2-5; p=0.143), and 3.182 (0-7 vs. 8-23; p=0.002), respectively. Conclusion The NANO scale provided a more detailed and objective measure of neurologic function than that currently used for predicting the prognosis of glioblastoma patients, especially at the time of progression.
( Jiwook Lee ),( Mee-seon Kim ),( Young Zoon Kim ) 대한뇌종양학회 대한신경종양학회 2019 Brain Tumor Research and Treatment Vol.7 No.1
Meningeal dissemination (MDS) of glioblastoma is rare, although its incidence might have been underestimated. MDS of glioblastoma has a fatal course. Thus, rapid and precise diagnosis of MDS is important for further palliative treatment. Unfortunately, MDS of glioblastoma could be diagnosed at a delayed time, causing failure to treat patient optimally. Herein, we present a case of a 56-year-old male with MDS of glioblastoma mimicking chronic subdural hemorrhage (CSDH) after head trauma due to slip down. During treatment for CSDH, MDS of glioblastoma was not controlled appropriately. The patient succumbed to MDS of glioblastoma at 9 weeks after the date of diagnosis of CSDH which could be an MDS.
증례 : 순환기 ; 심실중격결손에 의해 과다 폐색전증의 증상이 발현되지 않은 1예
이경용 ( Kyoung Yong Lee ),정우조 ( Woo Cho Chung ),김경중 ( Kyung Joong Kim ),두영재 ( Young Jae Doo ),최지욱 ( Jiwook Choi ),윤영섭 ( Yeong Seop Yun ),이재범 ( Jae Beom Lee ) 대한내과학회 2015 대한내과학회지 Vol.89 No.1
과다 폐색전증, 심실중격결손과다 폐색전증(massive pulmonary thromboembolism)은 빠른 치료가 사망률을 낮출 수 있기 때문에 폐색전증 중에서도 초기에 진단하는 것이 중요하다. 그러나 환자의 여러 요인으로 인해 폐색전증은 다른 양상의 혈역학적 효과를 보일 수있으므로 초기 진단이 어려울 수 있으며, 이는 사망률을 높이게 될 수 있다. 저자 등은 72세 여자 환자에서 2개월 전부터 서서히 악화된 호흡곤란을 급성 관동맥 증후군으로 생각하여 검사를 진행하였으나, 결과적으로는 흉부 전산화 단층 촬영을 통해 과다 폐색전증을 진단하였다. 폐색전증 환자에서 일반적 병태생리와 다른 경우에는 심실중격결손의 합병유무에 대해서도 염두에 둘 필요가 있을 것으로 보인다. 저자 등은 72세 여자 환자에서 심실중격결손에 의해 숨겨졌던과다 폐색전증의 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Patients with massive pulmonary embolism may present with severe dyspnea at rest, syncope, or cardiac arrest. Early diagnosis and treatment are essential to reduce mortality; however, patient-specific factors can influence the hemodynamic effect of pulmonary embolism. Here, we present a case of massive pulmonary embolism masked by a ventricular septal defect in a 73-year-old female. (Korean J Med 2015;89:85-90)
Jiwook Kim,Tak Kyu Oh,Jaebong Lee,Saeyeon Kim,In-Ae Song 대한중환자의학회 2019 Acute and Critical Care Vol.34 No.1
Background:Postoperative body temperature is closely associated with prognosis although there is limited research regarding this association at postoperative intensive care unit (ICU) admission. Furthermore, no studies have used digital axillary thermometers to measure postoperative body temperature. This study investigated the association between mortality and postoperative temperature measured using a digital axillary thermometer within 10 minutes after ICU admission. Methods:This retrospective observational study evaluated data from adult patients admitted to an ICU after elective or emergency surgery. The primary outcome was 1-year mortality after ICU admission. Multivariable logistic regression analysis with restricted cubic splines was used to evaluate the association between temperature and outcomes. Results:We evaluated data from 5,868 patients admitted between January 1, 2013 and May 31, 2016, including 5,311 patients (90.5%) who underwent noncardiovascular surgery and 557 patients (9.5%) who underwent cardiovascular surgery. Deviation from the median temperature (36.6°C) was associated with increases in 1-year mortality (≤ 36.6°C: linear coefficient, –0.531; P<0.001 and ≥36.6°C: spline coefficient, 0.756; P<0.001). Similar statistically significant results were observed in the noncardiovascular surgery group, but not in the cardiovascular surgery group. Conclusions:An increase or decrease in body temperature (vs. 36.6°C) measured using digital axillary thermometers within 10 minutes of postoperative ICU admission was associated with increased 1-year mortality. However, no significant association was observed after cardiovascular surgery. These results suggest that postoperative temperature is associated with longterm mortality in patients admitted to the surgical ICU in the postoperative period.
Robust Landing Control of a Quadcopter on a Slanted Surface
Jiwook Choi,Donghun Cheon,Jangmyung Lee 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.6
A robust landing control algorithm is proposed for a quadcopter, as well as for a landing platform to land on an inclined or problematic surface. To use the quadcopter for outdoor application, it is necessary to design a landing platform that can withstand environmental obstacles such as wind and weight load during landing. Conventional retractor landing platforms are not suitable for achieving a stable landing on inclined surfaces or obstacles. Therefore, in this paper, 2-link structured landing legs are applied to stably land on an inclined surface or obstacle with a suitable control algorithm. To achieve stable landing on a slanted surface, a cooperative control algorithm of the quadcopter and the landing platform has been proposed. The proposed robust landing system comprises two controllers, i.e., a high-speed proportional derivative control for the landing platform and a neural network-based proportional–integral–derivative control for controlling the quadcopter in real time. A quadcopter with a robust landing platform has been implemented, and the performance of the robust landing control algorithm has been demonstrated with the system.