Diagnostic Conundrum: Fever and Pyuria Preceding Diagnosis of Kawasaki Disease in Children

( Jiseon Park ),( Young June Choe ),( Seung Ah Choe ),( Jue Seong Lee ),( Hyung Eun Yim ),( Yun-kyung Kim ) 대한소아감염학회 2023 Pediatric Infection and Vaccine Vol.30 No.3

농뇨는 가와사키병 환아의 약 30-60%에 동반되는 소견으로, 임상적 증후가 다 나타나지 않은 초기의 가와사키병 또는 불완전 가와사키병에서 요로감염으로 오인할 수 있으나, 불완전 가와사키병 진단에 중요한 검사실 소견 중 하나일 수 있다. 본 연구에서는 한국의 5세 미만 영유아에서 가와사키병 진단 전 요로감염으로 선행 진단 사례의 유병률과 역학적 위험인자를 평가하고자 한다. 건강보험심사평가원에서 제공하고 있는 보건의료 빅데이터 개방시스템 자료를 바탕으로 2007년 11월부터 2019년 10월까지 가와사키병과 요로감염으로 진료, 청구된 대상자에 대해 후향적 단면연구를 시행하였다. 가와사키병 확정 진단 전 1주일 이내의 요로감염 선행 진단된 환아의 발생률을 계산하였고, 카이제곱 (χ2 test) 검정을 실시하였다. 연령, 성별, 지역, 계절별 발생률에 대한 요로감염 선행 진단 여부에 대해 로지스틱 분석 (logistic regression)을 수행하였다. 연구 결과, 총 53,822명의 가와사키병 환자가 포함되었으며 그 중 304명 (0.56%)이 선행요로감염 진단이 있었다. 12개월 미만에서의 요로감염 선행 진단률이 가장 높았으며 (0.95%), 4세와 비교했을 때 요로감염 선행진단의 오즈비는 3.12 (2.05-4.77) 였다. 발열을 동반한 농뇨가 있는 영아의 일부에서는 불완전 가와사키병의 감별진단이 필요할 수 있다 Purpose: Children with incomplete Kawasaki disease (KD) and pyuria may be misdiagnosed with urinary tract infection (UTI) during the early phase of the prodrome. We investigated the percentage of UTI diagnoses preceding a KD diagnosis. Methods: Using the National Health Insurance data of South Korea, we assessed differences in UTI diagnoses made during the week preceding a KD diagnosis, according to demographic and geographic factors from November 2007-October 2019. Results: A total of 53,822 KD cases were identified, including 304 patients (0.56%) diagnosed with a UTI during the week preceding a KD diagnosis. The younger age group (0-11 months) showed the highest percentage of preceding UTI diagnoses (0.95%), with higher odds than 4-year-old children (3.12; 95% confidence interval, 2.05-4.77). Conclusions: These findings suggest a potentially misleading presentation of incomplete KD, a clinical conundrum requiring further investigation and validation, particularly in infants

대학수학능력시험 수학 영역의 내용 영역에 대한 고찰

조성민 ( Seong Min Cho ),김재홍 ( Jae Hong Kim ),최지선 ( Jiseon Choi ),최인선 ( Imseom Choi ) 한국수학교육학회 2014 수학교육논문집 Vol.28 No.2

대학수학능력시험은 고등학교 교육과정을 바탕으로 대학 교육에 필요한 수학 능력을 측정하는 시험으로, 대학입시제도가 갖고 있는 사회적 영향력으로 인해 모든 국민의 관심을 받고 있는 고부담 시험이다. 대학수학능력시험은 교육과정의 개정에 따른 영향 뿐 아니라 공교육의 정상화, 수험생의 학습 부담 완화 등과 같은 외적 요인에 의해 여러차례 변화되어왔다. 본 고에서는 교육과정의 개정에 따른 수학 영역의 평가 내용의 변화와 해외 대학입학 수학시험의 내용 영역에 대한 분석을 통해 향후 대학수학능력시험의 개선 방향 탐색을 위한 시사점을 도출하고자 한다. The College Scholastic Ability Test(CSAT) is the Korean national university examination based on the nationalcurriculum. The CSAT is a high-stakes test because of powerful social forces which the college admission system hasin Korea. This examination has changed many times through not only the national curriculum revision but also variousexternal factors including the normalization of public education, mitigating the burden of students, etc. This studyanalysis the changes of assessment contents of the Mathematics of the CSAT due to the national curriculum revision. Additionally, this study analysis the mathematics content domains of the college entrance examinations in some foreigncountries. Based on the result of this analysis, this study will derive implications for improvement directions of theMathematics of the CSAT

소외계층 초등 정보영재학생을 위한 머신러닝 온라인 교육 프로그램 개발

김성원(Seong-Won Kim),김지선(Jiseon Kim),류지영(Jiyoung Ryu) 한국컴퓨터정보학회 2020 한국컴퓨터정보학회 학술발표논문집 Vol.28 No.2

달리기 시 발의 인체측정학적 변인과 운동역학적 변인의 관계

( Young Seong Lee ),( Jiseon Ryu ) 한국운동역학회 2019 한국운동역학회지 Vol.29 No.3

Objective: The aim of this study was to investigate the correlation coefficients between anthropometric parameters of the foot and kinetic variables during running. Method: This study was conducted on 21 healthy young adults (age: 24.8±2.1 yes, height: 177.2 ±5.8 cm, body mass: 73.3±7.3 kg, foot length: 256.5±12.3 mm) with normal foot type and heel strike running. To measure the anthropometric parameters, radiographs were taken on the frontal and sagittal planes, and determined the length and width of each segment and the navicular height. Barefoot running was performed at a preferred velocity (3.0±0.2 m/s) and a fixed velocity (4.0 m/s) on treadmill (Bertec, USA) in order to measure the kinetic variables. The vertical impact peak force, the vertical active peak force, the braking peak force, the propulsion peak force, the vertical force at mid-stance (vertical ground reaction when the foot is fully landed in mid-stance or at the point where the weight was uniformly distributed on the foot) and the impact loading rate were calculated. Pearson's correlation coefficient was used to investigate the relationship between anthropometric variables and kinetical variables. The significance level was set to α = .05. Results: At the preferred velocity running, the runner with longer forefoot had lower active force (r=-.448, p=.041) than the runner with short forefoot. At the fixed velocity, as the navicular height increases, the vertical force at full landing moment increases (r= .671, p= .001) and as the rearfoot length increases, the impact loading rate decreases (r=- .469, p= .032). Conclusion: There was a statistically significant difference in the length of fore-foot and rearfoot, and navicular height. Therefore it was conclude that anthropometric properties need to be considered in the foot study. It was expected that the relationship between anthropometric parameters and kinetical variables of foot during running can be used as scientific criteria and data in various fields including performance, injury and equipment development.

Serum amyloid A inhibits osteoclast differentiation to maintain macrophage function

Kim, Jiseon,Yang, Jihyun,Park, Ok-Jin,Kang, Seok-Seong,Yun, Cheol-Heui,Han, Seung Hyun Society for Leukocyte Biology 2016 Journal of leukocyte biology Vol.99 No.4

<P>Serum amyloid A is an acute phase protein that is elevated under inflammatory conditions. Additionally, the serum levels of serum amyloid A are associated with the progression of inflammatory arthritis; thus, serum amyloid A might be involved in the regulation of osteoclast differentiation. In the present study, we examined the effects of serum amyloid A on osteoclast differentiation and function. When bone marrow-derived macrophages, as osteoclast precursors, were stimulated with serum amyloid A in the presence of M-CSF and receptor activator of nuclear factor-kappa B ligand, osteoclast differentiation and its bone-resorption activity were substantially inhibited. TLR2 was important in the inhibitory effect of serum amyloid A on osteoclast differentiation, because serum amyloid A stimulated TLR2. The inhibitory effect was absent in bone marrow-derived macrophages obtained from TLR2-deficient mice. Furthermore, serum amyloid A inhibited the expression of c-Fos and nuclear factor of activated T cells c1, which are crucial transcription factors for osteoclast differentiation, but prevented downregulation of IFN regulatory factor-8, a negative regulator of osteoclast differentiation. In contrast, serum amyloid A sustained the endocytic capacity of bone marrow-derived macrophages and their ability to induce the proinflammatory cytokines, IL-6, IL-1 beta, and TNF-alpha. Taken together, these results suggest that serum amyloid A, when increased by inflammatory conditions, inhibits differentiation of macrophages to osteoclasts, likely to maintain macrophage function for host defense.</P>

소외계층 학생을 위한 온라인 교육 프로그램 개발

김성원(Seong-Won Kim),김지선(Jiseon Kim),류지영(Jiyoung Ryu) 한국컴퓨터정보학회 2019 한국컴퓨터정보학회 학술발표논문집 Vol.27 No.2

Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation : BACTERIAL LIPOPROTEINS INDUCE BONE DESTRUCTION

Kim, Jiseon,Yang, Jihyun,Park, Ok-Jin,Kang, Seok-Seong,Kim, Woo-Shin,Kurokawa, Kenji,Yun, Cheol-Heui,Kim, Hong-Hee,Lee, Bok Luel,Han, Seung Hyun Wiley Blackwell (John Wiley Sons) 2013 Journal of bone and mineral research Vol.28 No.11

달리기 시 발의 인체측정학적 변인과 운동역학적 변인의 관계

Lee, Young Seong,Ryu, Jiseon 한국운동역학회 2019 한국운동역학회지 Vol.29 No.3

Objective: The aim of this study was to investigate the correlation coefficients between anthropometric parameters of the foot and kinetic variables during running. Method: This study was conducted on 21 healthy young adults (age: $24.8{\pm}2.1yes$, height: $177.2{\pm}5.8cm$, body mass: $73.3{\pm}7.3kg$, foot length: $256.5{\pm}12.3mm$) with normal foot type and heel strike running. To measure the anthropometric parameters, radiographs were taken on the frontal and sagittal planes, and determined the length and width of each segment and the navicular height. Barefoot running was performed at a preferred velocity ($3.0{\pm}0.2m/s$) and a fixed velocity (4.0 m/s) on treadmill (Bertec, USA) in order to measure the kinetic variables. The vertical impact peak force, the vertical active peak force, the braking peak force, the propulsion peak force, the vertical force at mid-stance (vertical ground reaction when the foot is fully landed in mid-stance or at the point where the weight was uniformly distributed on the foot) and the impact loading rate were calculated. Pearson's correlation coefficient was used to investigate the relationship between anthropometric variables and kinetical variables. The significance level was set to ${\alpha}=.05$. Results: At the preferred velocity running, the runner with longer forefoot had lower active force (r=-.448, p=.041) than the runner with short forefoot. At the fixed velocity, as the navicular height increases, the vertical force at full landing moment increases (r= .671, p= .001) and as the rearfoot length increases, the impact loading rate decreases (r=- .469, p= .032). Conclusion: There was a statistically significant difference in the length of fore-foot and rearfoot, and navicular height. Therefore it was conclude that anthropometric properties need to be considered in the foot study. It was expected that the relationship between anthropometric parameters and kinetical variables of foot during running can be used as scientific criteria and data in various fields including performance, injury and equipment development.

Effect of rGO loading on Fe₃O₄: A visible light assisted catalyst material for carbamazepine degradation

Moztahida, Mokrema,Jang, Jiseon,Nawaz, Mohsin,Lim, Seong-Rin,Lee, Dae Sung Elsevier 2019 Science of the Total Environment Vol.667 No.-

<P><B>Abstract</B></P> <P>Carbamazepine (CBZ), an anticonvulsant drug, is one of the most recalcitrant pharmaceuticals detected in wastewater. For the photocatalytic degradation of CBZ, visible light assisted heterogeneous Fenton-like hybrid composites were synthesized via a co-precipitation method by anchoring magnetite (Fe<SUB>3</SUB>O<SUB>4</SUB>) with reduced graphene oxide (rGO). The rGO loading not only reduced the aggregation of Fe<SUB>3</SUB>O<SUB>4</SUB> nanoparticles, but also increased the adsorption capacity of the hybrid composites. The mass ratio of rGO in the composites substantially affected CBZ photocatalytic degradation and a 10 wt% rGO loading (rGF10) provided nearly complete CBZ degradation within 3 h. Moreover, the addition of rGO reduced the charge recombination of the bare Fe<SUB>3</SUB>O<SUB>4</SUB> nanoparticles and provided more accessible reactive sites, enhancing the degradation capacity. The visible light excited Fe<SUB>3</SUB>O<SUB>4</SUB> nanoparticles yielded reactive species such as hydroxyl radicals (·OH), holes (h<SUP>+</SUP>), and superoxide radicals (O<SUB>2</SUB>·<SUP>−</SUP>) during the photodegradation process that were evaluated by using specific scavengers during the degradation experiment. The hybrid catalyst was effective under wide pH ranges (from 3 to 9) and showed faster degradation rates in the acidic condition. The composites were magnetically separable, easily regenerated, and exhibited considerably high photocatalytic activity up to five cycles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A Fenton-like composite was synthesized by co-precipitation method. </LI> <LI> The composite photochemically degraded CBZ molecule under solar light. </LI> <LI> Certain amount of rGO loading in magnetite increased the photodegradation capacity. </LI> <LI> A 10 wt% rGO loading was optimum to get highest degradation capacity. </LI> <LI> The composite was reusable and the TOC removal was high after the reaction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Characterization of a Potential Probiotic Lactiplantibacillus plantarum LRCC5310 by Comparative Genomic Analysis and its Vitamin B 6 Production Ability

Lee Yunjeong,Jaikwang Nattira,Kim Seong keun,Jeong Jiseon,Sukhoom Ampaitip,Kim Jong-Hwa,Kim Wonyong 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5

Safety assessment and functional analysis of probiotic candidates are important for their industrial applications. Lactiplantibacillus plantarum is one of the most widely recognized probiotic strains. In this study we aimed to determine the functional genes of L. plantarum LRCC5310, isolated from kimchi, using next-generation, whole-genome sequencing analysis. Genes were annotated using the Rapid Annotations using Subsystems Technology (RAST) server and the National Center for Biotechnology Information (NCBI) pipelines to establish the strain’s probiotic potential. Phylogenetic analysis of L. plantarum LRCC5310 and related strains showed that LRCC5310 belonged to L. plantarum. However, comparative analysis revealed genetic differences between L. plantarum strains. Carbon metabolic pathway analysis based on the Kyoto Encyclopedia of Genes and Genomes database showed that L. plantarum LRCC5310 is a homofermentative bacterium. Furthermore, gene annotation results indicated that the L. plantarum LRCC5310 genome encodes an almost complete vitamin B6 biosynthetic pathway. Among five L. plantarum strains, including L. plantarum ATCC 14917T, L. plantarum LRCC5310 detected the highest concentration of pyridoxal 5’-phosphate with 88.08 ± 0.67 nM in MRS broth. These results indicated that L. plantarum LRCC5310 could be used as a functional probiotic for vitamin B6 supplementation.