http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jinyu Xu (검색결과 16 건)
- 무료
- 기관 내 무료
- 유료
-
Linfen Xu,Ling liu,Xiaoyan Zhao,Jinyu Lin,Shaohan Xu,Jinlian He,Debin Jiang,Yong Xia The Korean Electrochemical Society 2023 Journal of electrochemical science and technology Vol.14 No.1
The effective detection of human chorionic gonadotropin (HCG) is considerably important for the clinical diagnosis of both of early pregnancy and nonpregnancy-related diseases. In this work, a simple and sensitive electrochemical sandwich-type immunosensing platform was designed by synthesizing b-cyclodextrin (CD) functionalized graphene (CD/GN) hybrid as simultaneously sensing platform and signal transducer coupled with rhodamine b (RhB) as probe. In brief, GN offers large surface area and high conductivity, while CD exhibits superior host-guest recognition capability, thus the primary antibody (Ab1) of HCG can be bound into the cavities of CD/GN to form stable Ab1/CD/GN inclusion complex; meanwhile, the secondary antibody (Ab2) and RhB can also enter into the cavities, producing RhB/Ab2/CD/GN complex. Then, by using Ab1/CD/GN as sensing platform and RhB/Ab2/CD/GN as signal transducer (in which RhB was signal probe), a simple sandwich-type immunosensor was constructed. Under the optimum parameters, the designed immunosensor exhibited a considerable low analytical detection of 1.0 pg mL<sup>-1</sup> and a wide linearity of 0.002 to 10.0 ng mL<sup>-1</sup> for HCG, revealing the developed sandwich-type electrochemical immunosensing platform offered potential real applications for the determination of HCG.
-
Jinyue He,Jiezhong Deng,Yusheng Yang,Tingting Zheng,Fei Luo,Jianzhong Xu,Zehua Zhang 대한척추신경외과학회 2023 Neurospine Vol.20 No.4
Objective: To illustrate a simultaneous single-position oblique lateral interbody fusion (SPOLIF) combined with unilateral percutaneous pedicle screw fixation in treating single-level lumbar tuberculosis, compared with posterior-only approach in clinical and radiographic evaluations. Methods: Consecutive patients who had undergone surgeries for single-level lumbar tuberculosis from January 2018 to December 2020 were retrospectively reviewed. The patients included were divided into SP-OLIF and posterior-only groups according to surgical methods applied, with follow-up for at least 36 months. Outcomes included estimated blood loss, operative time, and complications for safety evaluation; visual analogue scale (VAS), Oswestry Disability Index (ODI) for efficacy evaluation; erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for evaluating tuberculosis activity; x-ray and computed tomography scan were used for radiographic evaluation. Results: A total of 136 patients had been enrolled in the study (60 for SP-OLIF and 76 for Posterior-only). The median operative time, blood loss, and hospital stay in SP-OLIF group were significantly less, with a lower complication rate. Meanwhile, the SP-OLIF group showed substantially lower VAS in 1 and 7 days and decreased ODI in the first month postoperatively, without significant difference afterward. Similarly, the median CRP and ESR in SP-OLIF group were significantly lower in 3 and 7 days postoperatively. All indicators had reduced to normal after 3 months. No recurrence had been reported throughout the whole follow-up. Conclusion: SP-OLIF was an efficient minimally invasive protocol for single-level lumbar tuberculosis, facilitating earlier clinical improvement, with decreased blood loss, operative time and hospital stay compared with posterior-only approach.
-
Deyu Xu,Jing Zhao,Guoqiang Cao,Jinyu Wang,Qinggang Li,Ping Zheng,Shuxin Zhao,Jibin Sun 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.1
Phosphoenolpyruvate carboxylase (PEPC) catalyzes the carboxylation of phosphoenolpyruvate (PEP) in the presence of bicarbonate to form oxaloacetate (OAA), and it plays an important role in high-efficient production of OAA-derived metabolites such as lysine, glutamate and succinate. However, PEPCs often suffered from serious feedback inhibition by various metabolic effectors like aspartate. Here, the feedback inhibition of PEPC from Corynebacterium glutamicum was removed by adding a short terminal peptide like His-tag. The effect of His-tag location on the structure and important properties such as activity, thermostability and feedback inhibition of PEPC has been investigated. The purified untagged PEPC, Nterminal His-tagged PEPC (PEPC-N-His) and C-terminal His-tagged PEPC (PEPC-C-His) were characterized. PEPCN- His (439.71/sec/mM) showed a 1.26 and 186-fold higher catalytic efficiency than untagged PEPC (348.59/sec/mM) and PEPC-C-His (2.36/sec/mM), respectively. Both PEPCN- His and untagged PEPC were significantly inhibited by aspartate at the concentrations above 4 mM (residual activities < 10%), while PEPC-C-His was almost desensitized to aspartate within 10 mM (around 90% of residual activity). Structural analysis showed that the extension of C-terminus may cause steric hindrance for aspartate binding with enzymes, leading to the deregulation of feedback inhibition of PEPC-C-His. This study provides a deeper understanding of the effect of terminal fragments on the structure and function of PEPCs, and helps to engineer the feedback inhibition of PEPCs and structurally similar enzymes.
-
Hongyan Xing,Xu Yang,Jinyu Zhang 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.6
In order to accurately obtain the location of thunderstorm cloud and improve the accuracy and stability of thunderstorm cloud localization, a thunderstorm cloud localization algorithm of a three-dimensional atmospheric electric feld apparatus is proposed. An electric feld measurement model is established, and the localization parameters are defned based on the model. According to the theory of mirror method, the potential distribution of the thunderstorm cloud at the atmospheric electric feld apparatus is obtained. Using the potential distribution formula, the three-dimensional electric feld components are derived and the thunderstorm cloud coordinates are obtained. The relationship between the electric feld component measurement error, the azimuth angle, the elevation angle and the ranging and direction-fnding accuracy is given, and the localization performance is analyzed. The results show that the method has a ranging error rate of about 5% and a directionfnding error rate of about 3%, which has a good localization efect.
-
Spinosin Inhibits Aβ<sub>1-42</sub> Production and Aggregation via Activating Nrf2/HO-1 Pathway
( Xiaoying Zhang ),( Jinyu Wang ),( Guowei Gong ),( Ruixin Ma ),( Fanxing Xu ),( Tingxu Yan ),( Bo Wu ),( Ying Jia ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.3
The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid precursor protein (APP). Wild type mouse Neuro-2a cells (N2a/WT) and N2a stably expressing human APP695 (N2a/APP695) cells were treated with spinosin for 24 h. The levels of APP protein and secreted enzymes closely related to APP procession were examined by western blot analysis. Oxidative stress related proteins, such as nuclear factor-erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) were detected by immunofluorescence assay and western blot analysis, respectively. The intracellular reactive oxygen species (ROS) level was analyzed by flow cytometry, the levels of Aβ<sub>1-42 </sub>were determined by ELISA kit, and Thioflavin T (ThT) assay was used to detect the effect of spinosin on Aβ<sub>1-42 </sub>aggregation. The results showed that ROS induced the expression of ADAM10 and reduced the expression of BACE1, while spinosin inhibited ROS production by activating Nrf2 and up-regulating the expression of HO-1. Additionally, spinosin reduced Aβ<sub>1-42 </sub>production by impacting the procession of APP. In addition, spinosin inhibited the aggregation of Aβ<sub>1-42</sub>. In conclusion, spinosin reduced Aβ<sub>1-42</sub> production by activating the Nrf2/HO-1 pathway in N2a/WT and N2a/ APP695 cells. Therefore, spinosin is expected to be a promising treatment of AD.
-
Application of Biophysical Properties of Meridians in the Visualization of Pericardium Meridian
Xiong Feng,Xu Ruimin,Li Tongju,Wang Jinyu,Hu Qingchuan,Song Xiaojing,Wang Guangjun,Su Huanhuan,Jia Shuyong,Wang Shuyou,Zhu Zongxiang,Zhang Weibo 사단법인약침학회 2023 Journal of Acupuncture & Meridian Studies Vol.16 No.3
Background: The biophysical properties of the meridian system, an important concept of traditional Chinese medicine, include low impedance, resounding voice, and high acoustic conductance, all of which are helpful for elucidating the essence of meridians. Objectives: To visualize the human pericardium meridian (PC) based on the resounding voice property of meridians. Methods: Visualization of the PC was performed by injection of fluorescein sodium at the PC6 acupoint (Neiguan) on the PC. Before injection, percussion active points (PAPs) were identified by the virtue of their resounding voice properties. After injection, the trajectories of fluorescein migration throughout the body surface were recorded and analyzed. The distribution of fluorescein in the tissue was further studied using cross-sections of hind limbs of mini-pigs, in which fluorescein was injected into low impedance points. Results: The identified PAP lines were colocalized with PC. Following intradermal fluorescein injection, 1-3 fluorescent lines, which were unrelated to the arm veins, were observed in 7 of 10 participants; 85.4% of fluorescent signals were coincident with PAPs and their intensity had a negative correlation with the body mass index (r = –0.56, p = 0.045). Cross-sections showed a Y-shaped fluorescence pattern where the two migration lines on the surface were the two vertices of the “Y.” Conclusion: The trajectories of fluorescein in the body are suggestive of the anatomical structure of meridians. The PC is related to the deep horizontal interstitial channels that connect to the body surface through vertical interstitial spaces. These biophysical properties and techniques for meridian visualization are valuable for revealing the anatomical structure of meridians.
-
Liangxue Nie,Jinyu Xu,Erlei Bai 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.20 No.2
The Hydraulically driven test system and 100 mm split Hopkinson pressure bar(SHPB) test device were employed to research the quasi-static and dynamic mechanical properties of concrete specimens which has been immersed for 60 days in sodium sulfate (group S1) and sodium chloride (group S2) solution, the evolution of their mass during corrosive period was explored at the same time, and the mechanism of performances lost was analyzed from the microscopic level by using scanning electron microscope. Results of the experimental indicated that: their law of mass both presents the trend of continuous rising during corrosive period, and it increases rapidly on the early days, the mass growth of group S1 and group S2 in first 7 days are 76.78% and 82.82% of their total increment respectively; during the corrosive period, the quasi-static compressive strength of specimens in two groups are significantly decreased, both of which present the trend of increase first and then decrease, the maximum growth rate of group S1 and group S2 are 7.52% and 12.71% respectively, but they are only 76.23% and 82.84% of specimens which under normal environment (group N) on day 60; after immersed for 60 days, there were different decrease to dynamic compressive strength and specific energy absorption, and so as their strain rate sensitivities. So the high salinity environment has a significant effect of weaken the quasi-static and dynamic mechanical performance of concrete.
-
An Integrated Artificial Neural Network-based Precipitation Revision Model
( Tao Li ),( Wenduo Xu ),( Li Na Wang ),( Ningpeng Li ),( Yongjun Ren ),( Jinyue Xia ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.5
Precipitation prediction during flood season has been a key task of climate prediction for a long time. This type of prediction is linked with the national economy and people's livelihood, and is also one of the difficult problems in climatology. At present, there are some precipitation forecast models for the flood season, but there are also some deviations from these models, which makes it difficult to forecast accurately. In this paper, based on the measured precipitation data from the flood season from 1993 to 2019 and the precipitation return data of CWRF, ANN cycle modeling and a weighted integration method is used to correct the CWRF used in today’s operational systems. The MAE and TCC of the precipitation forecast in the flood season are used to check the prediction performance of the proposed algorithm model. The results demonstrate a good correction effect for the proposed algorithm. In particular, the MAE error of the new algorithm is reduced by about 50%, while the time correlation TCC is improved by about 40%. Therefore, both the generalization of the correction results and the prediction performance are improved.
-
Xiongyu Luo,Muxuan Yang,Jinyu Bu,Tiantong Chen,Allen Y. Yi,Weinan Xu 한국고분자학회 2023 Macromolecular Research Vol.31 No.8
The integration of two or more types of metal oxides in the same nanostructures leads to several unique characteristics including tunable optical properties and band gap, enhanced catalytic property and stability. However, current approaches for the generation of those mixed metal oxides are predominantly based on bottom-up synthesis, which have limitations in fabricating precise nanostructures with monodispersed size and shape, and low compatibility with lithography-based micro-/nanofabrication processes. Here, we report a new approach for the precise fabrication of nanostructured mixed metal oxides (NMMOs) by the integration of soft nanoimprinting and sol–gel synthesis. The hybrid ink for nanoimprinting is composed of metal–organic compound and metal oxide colloidal nanoparticles of different metal species, after nanoimprinting, sol–gel reaction, and calcination, NMMOs with well-defined size and geometry are successfully obtained. The morphology, size, composition, and crystalline structure of the NMMOs are systematically tuned and studied, their potential application in photocatalysis is also investigated.
-
Wei Wenying,Wang Zhen,Yin Yanhua,Han Jinyu,Xu Wen 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.3
Composition Group Vector Space (CGVS) method for estimating melting and boiling point Tm, Tb of organic compound has been proposed, and the principle of this method has been elucidated. The models for estimating Tm, Tb have been established and the numerical values of relative parameters have been presented. The average percentage deviations of Tm, Tb estimation are 7.53 and 1.58, respectively, which show that the present method demonstrates significant improvement in applicability to predict the above properties, compared to conventional group methods
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
