http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hong, JinWoo,Yun, Chae-Ok Elsevier 2019 Molecular and cellular endocrinology Vol.487 No.-
<P><B>Abstract</B></P> <P>Relaxin (RLX) is an insulin-like polypeptide hormone that was initially introduced for its pregnancy-related function. Subsequent studies revealed that RLX possesses anti-fibrotic functions in tumors and nonreproductive tissues, such as skin, lungs, and others. This aspect of the RLX has been explored for the treatment of various illnesses, such as cardiac fibrosis, liver fibrosis, and solid tumors. With gene therapy coming into age with increasing number of products being approved by regulatory bodies in Europe and United States, we aim to discuss how RLX have been utilized in scope of gene therapy for treatment of various illnesses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Relaxin is a promising antifibrotic, pleiotropic, and cardioregulatory hormone. </LI> <LI> Recent phase III trial of recombinant relaxin has been disappointing. </LI> <LI> Relaxin gene therapy overcomes major hurdles of recombinant protein therapy. </LI> <LI> Relaxin gene therapy can be promising treatment for various illnesses. </LI> </UL> </P>
Chang, Jinwoo,Lee, Jin Bok,Kim, Jin Seog,Lee, Jin-Hong,Hong, Kiryong The Korean Society of Analytical Sciences 2022 분석과학 Vol.35 No.5
Deuterium (D) is an isotope with one more neutron number than hydrogen (H). Heavy elements rarely change their chemical properties with little effect even if the number of neutrons increases, but low-mass elements change their vibration energy, diffusion rate, and reaction rate because the effect cannot be ignored, which is called an isotope effect. Recently, in the semiconductor and display industries, there is a trend to replace hydrogen gas (H<sub>2</sub>) with deuterium gas (D<sub>2</sub>) in order to improve process stability and product quality by using the isotope effect. In addition, as the demand for D<sub>2</sub> in industries increases, domestic gas producers are making efforts to produce and supply D<sub>2</sub> on their own. In the case of high purity D<sub>2</sub>, most of them are produced by electrolysis of heavy water (D<sub>2</sub>O), and among D<sub>2</sub>, hydrogen deuteride (HD) molecules are present as isotope impurities. Therefore, in order to maximize the isotope effect of hydrogen in the electronic industry, HD, which is an isotope impurity of D<sub>2</sub> used in the process, should be small amount. To this end, purity analysis of D<sub>2</sub> for industrial processing is essential. In this study, HD quantitative analysis of D<sub>2</sub> for high purity D<sub>2</sub> purity analysis was established and hydrogen isotope RM (Reference material) was developed. Since hydrogen isotopes are difficult to analyze with general gas analysis instrument, they were analyzed using a high-precision mass spectrometer (Gas/MS, Finnigan MAT271). High purity HD gas was injected into Gas/MS, sensitivity was determined by a signal according to pressure, and HD concentrations in two bottles of D<sub>2</sub> were quantified using the corresponding sensitivity. The amount fraction of HD in each D<sub>2</sub> was (4518 ± 275) μmol/mol, (2282 ± 144) μmol/mol. D<sub>2</sub>, which quantifies HD amount using the developed quantitative analysis method, will be manufactured with hydrogen isotope RM and distributed for quality management and maintenance of electronic industries and gas producers in the future.
Single enzyme nanoparticles armored by a thin silicate network: Single enzyme caged nanoparticles
Hong, Sung-Gil,Kim, Byoung Chan,Na, Hyon Bin,Lee, Jinwoo,Youn, Jongkyu,Chung, Seung-Wook,Lee, Chang-Won,Lee, Byoungsoo,Kim, Han Sol,Hsiao, Erik,Kim, Seong H.,Kim, Byung-Gee,Park, Hyun Gyu,Chang, Ho Na Elsevier 2017 Chemical engineering journal Vol.322 No.-
<P><B>Abstract</B></P> <P>For the encapsulation of biomolecules in inorganic materials, we have developed a unique enzyme-silicate conjugate material that consists of a self-assembled molecularly thin silicate layer on the surface of each individual enzyme molecule. The enzyme-silicate conjugate materials, called single enzyme caged nanoparticles (SECNs), were synthesized via the silica polymerization on the surface of enzyme molecule after solubilizing each enzyme molecule in hexane by using a tiny amount of surfactant, called “ion-pairing”. SECNs possess near native enzyme activity in aqueous media with minimal substrate diffusional limitations, and are highly stable under the protection of silicate network cage. Due to their nearly molecular size, SECNs can also be adsorbed into mesoporous silica materials to yield robust and easily-recyclable enzymatic systems that can be used in a number of potential biocatalytic applications such as diagnostics, biosensors, biotransformations, biofuel production, bioremediation and CO<SUB>2</SUB> capture.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Protocol of single enzyme caged nanoparticles (SECNs) has been developed. </LI> <LI> SECNs have ultra-thin silicate network on the surface of individual enzyme molecule. </LI> <LI> SECNs minimize substrate diffusional limitation, and inhibit the enzyme denaturation. </LI> <LI> SECNs can be immobilized into mesoporous silica for recyclable enzymatic systems. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>