Nodal tumor response according to the count of peripheral blood lymphocyte subpopulations during preoperative chemoradiotherapy in locally advanced rectal cancer

Heo, Jaesung,Oh, Young-Taek,Noh, O Kyu,Chun, Mison,Park, Jun-Eun,Cho, Sung-Ran The Korean Society for Radiation Oncology 2016 Radiation Oncology Journal Vol.34 No.4

Purpose: The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. Materials and Methods: From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy. Surgical resection was performed at 4 to 8 weeks after the completion of preoperative CRT. The absolute blood lymphocyte subpopulation was obtained prior to and after 4 weeks of CRT. We analyzed the association between a tumor response and change in the lymphocyte subpopulation during CRT. Results: Among 10 patients, 2 (20%) had evidence of pathologic complete response. In 8 patients with clinically node positive, 4 (50%) had nodal tumor response. All lymphocyte subpopulation counts at 4 weeks after CRT were significantly lower than those observed during pretreatment (p < 0.01). A high decrease in natural killer (NK) cell, count during CRT (baseline cell count - cell count at 4 weeks) was associated with node down staging (p = 0.034). Conclusion: Our results suggest that the change of lymphocyte subset to preoperative CRT may be a predictive factor for tumor response in rectal cancer.

Nodal tumor response according to the count of peripheral blood lymphocyte subpopulations during preoperative chemoradiotherapy in locally advanced rectal cancer

Jaesung Heo,Young Taek Oh,O Kyu Noh,Mison Chun,Jun Eun Park,Sung Ran Cho 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.4

Purpose: The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. Materials and Methods: From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy. Surgical resection was performed at 4 to 8 weeks after the completion of preoperative CRT. The absolute blood lymphocyte subpopulation was obtained prior to and after 4 weeks of CRT. We analyzed the association between a tumor response and change in the lymphocyte subpopulation during CRT. Results: Among 10 patients, 2 (20%) had evidence of pathologic complete response. In 8 patients with clinically node positive, 4 (50%) had nodal tumor response. All lymphocyte subpopulation counts at 4 weeks after CRT were significantly lower than those observed during pretreatment (p < 0.01). A high decrease in natural killer (NK) cell, count during CRT (baseline cell count − cell count at 4 weeks) was associated with node down staging (p = 0.034). Conclusion: Our results suggest that the change of lymphocyte subset to preoperative CRT may be a predictive factor for tumor response in rectal cancer.

CT-based quantitative evaluation of radiation-induced lung fibrosis: a study of interobserver and intraobserver variations

Jaesung Heo,Oyeon Cho,O Kyu Noh,Young-Taek Oh,Mison Chun,Mi-Hwa Kim,Hae-Jin Park 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.1

Purpose: The degree of radiation-induced lung fibrosis (RILF) can be measured quantitatively by fibrosis volume (VF) on chest computed tomography (CT) scan. The purpose of this study was to investigate the interobserver and intraobserver variability in CT-based measurement of VF. Materials and Methods: We selected 10 non-small cell lung cancer patients developed with RILF after postoperative radiation therapy (PORT) and delineated VF on the follow-up chest CT scanned at more than 6 months after radiotherapy. Three radiation oncologists independently delineated VF to investigate the interobserver variability. Three times of delineation of VF was performed by two radiation oncologists for the analysis of intraobserver variability. We analysed the concordance index (CI) and inter/intra-class correlation coefficient (ICC). Results: The median CI was 0.61 (range, 0.44 to 0.68) for interobserver variability and the median CIs for intraobserver variability were 0.69 (range, 0.65 to 0.79) and 0.61(range, 0.55 to 0.65) by two observers. The ICC for interobserver variability was 0.974 (p < 0.001) and ICCs for intraobserver variability were 0.996 (p < 0.001) and 0.991 (p < 0.001), respectively. Conclusion: CT-based measurement of VF with patients who received PORT was a highly consistent and reproducible quantitative method between and within observers.

CT-based quantitative evaluation of radiation-induced lung fibrosis: a study of interobserver and intraobserver variations

Heo, Jaesung,Cho, Oyeon,Noh, O Kyu,O, Young-Taek,Chun, Mison,Kim, Mi-Hwa,Park, Hae-Jin The Korean Society for Radiation Oncology 2014 Radiation Oncology Journal Vol.32 No.1

Purpose: The degree of radiation-induced lung fibrosis (RILF) can be measured quantitatively by fibrosis volume (VF) on chest computed tomography (CT) scan. The purpose of this study was to investigate the interobserver and intraobserver variability in CT-based measurement of VF. Materials and Methods: We selected 10 non-small cell lung cancer patients developed with RILF after postoperative radiation therapy (PORT) and delineated VF on the follow-up chest CT scanned at more than 6 months after radiotherapy. Three radiation oncologists independently delineated VF to investigate the interobserver variability. Three times of delineation of VF was performed by two radiation oncologists for the analysis of intraobserver variability. We analysed the concordance index (CI) and inter/intra-class correlation coefficient (ICC). Results: The median CI was 0.61 (range, 0.44 to 0.68) for interobserver variability and the median CIs for intraobserver variability were 0.69 (range, 0.65 to 0.79) and 0.61(range, 0.55 to 0.65) by two observers. The ICC for interobserver variability was 0.974 (p < 0.001) and ICCs for intraobserver variability were 0.996 (p < 0.001) and 0.991 (p < 0.001), respectively. Conclusion: CT-based measurement of VF with patients who received PORT was a highly consistent and reproducible quantitative method between and within observers.

Metabolic comorbidities and medical institution utilization among breast cancer survivors: a national population-based study

( Jaesung Heo ),( Mison Chun ),( Young-taek Oh ),( O Kyu Noh ),( Logyoung Kim ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2

Background/Aims: We investigated metabolic comorbidity status and patterns of medical institution utilization among breast cancer survivors using medical claims data from the Health Insurance Review and Assessment Service (HIRA). Methods: Using claims data obtained from the HIRA, we selected breast cancer survivors between 2010 and 2015. Descriptive statistics were calculated to determine the frequency of metabolic comorbidities, as well as to analyze patterns of medical institution utilization in accordance with disease status. Results: A total of 89,953 breast cancer survivors were identified. Among these, 12,364 (13.7%) had hypercholesterolemia, 20,754 (23.1%) had hypertension (HTN), and 11,102 (12.3%) had diabetes mellitus (DM). In particular, more than half of breast cancer survivors older than 60 years had HTN, and other diseases sharply increased beginning at age 50 years. For HTN, a total of 531,292 claims were submitted; more than 80% (n = 473,737) were from primary medical institutions, whereas only 2.4% (n = 12,551) were from tertiary medical institutions. The number of claims submitted for DM was 231,526; those from primary medical institutions accounted for 68.5% (n = 158,566), whereas claims from tertiary medical institutions accounted for 12.0% (n = 27,693). In subgroup analyses, the utilization of secondary and tertiary medical institutions was higher among patients with severe diseases and those diagnosed following their breast cancer diagnosis. Conclusions: More than 10% of breast cancer survivors were diagnosed with a metabolic comorbidity. Through analysis of medical institution utilization patterns, we ascertained that a communication system linking secondary and tertiary medical institutions with primary medical institutions is needed.

진화정신의학 관점에서 본 <에쿠우스>

허재성 ( Heo Jaesung ) 한국드라마학회 2021 드라마연구 Vol.- No.64

어느 시대든 과학기술은 세계관의 한계를 규정지어 왔다. 예술 작품의 제작과 해석은 이러한 세계관에 기반하여 이루어지기에, 과학의 발전은 예술 작품의 재해석을 자극한다. 프로이트가 발견한 무의식이 삶과 예술에 관한 정신분석적 해석이라는 새로운 시각을 제시했듯, 다윈의 진화론은 인간 심리의 제반 면모를 진화적 관점으로 이해하는 진화심리학의 발전을 이끌었다. 본 논문은 진화심리학에 기반하여 발전한 진화정신의학의 관점으로 <에쿠우스>를 분석하여 새로운 해석을 더 한다. 구체적으로는 알런이 보인 모습에서 불안, 중독, 망상이라는 정신병리적 특성이 드러나는 지점을 진화정신의학의 관점으로 해석한다. 진화심리학과 진화정신의 학은 유전자와 환경의 상호작용을 진화적 시간에 걸쳐 파악하여 정상과 비정상의 판단에 영향을 미치는 다양한 요소를 발견하였으며, 이들 중 상당수가 사회, 문화적 맥락에 따라 변동됨을 확인하였다. 이러한 특징은 알런의 불안, 중독, 망상 증상에 잘 드러나고 이는 다이사트와 관객으로 하여금 정상과 비정상의 경계에 대해 계속된 혼란을 갖게 만든다. 결국 이러한 혼란은 인간 심리가 환경과 상호작용하며 진화하는 과정에서 발달한 본능에 기인한 것이다. 본 논문은 지난 세기의 정신분석학적 관점에서 쓰인 예술 작품을 지금의 진화심리학적 관점에서 이해함으로써, 과학의 발달에 따른 인식의 변화에 발맞춘 예술 해석의 한 시도가 될 것이다. Science and technology have defined the limits of the worldview in any era. Since the production and interpretation of works of art are based on this worldview, the development of science stimulates the reinterpretation of art works. Just as Freud's discovery of the unconsciousness presented a new perspective on life and art as a psychoanalytic interpretation, Darwin's theory of the evolution has led to the development of evolutionary psychology that understands all aspects of human psychology from the evolutionary perspective. This paper adds a new interpretation by analyzing Equus from the perspective of evolutionary psychiatry, a branch of psychiatry based on evolutionary psychology. Specifically, we interpret from the evolutionary psychiatry point of view where the psychopathic characteristics of Alan's behavior reveal anxiety, addiction, and delusion. Evolutionary psychology and evolutionary psychiatry have identified the interactions between genes and their environment over evolutionary time to discover a variety of factors affecting normal and abnormal judgments, many of which vary across social and cultural contexts. These features are well-illustrated in Alan's anxiety, addiction, and delusional symptoms, which continue to confuse Dysart and the audience about the boundaries between normal and abnormal. After all, this confusion is due to instincts developed in the evolving process of human psychology interacting with the environment. This paper will be an attempt at art interpretation in line with changes in perception with the development of science, by understanding an artwork written from the psychoanalysis perspective of the past century with a state-of-the-art point of view of evolutionary psychiatry.

Graphene–nanowire hybrid structures for high-performance photoconductive devices

Lee, Hyungwoo,Heo, Kwang,Park, Jaesung,Park, Yongju,Noh, Seunguk,Kim, Kwang S.,Lee, Changhee,Hong, Byung Hee,Jian, Jikang,Hong, Seunghun The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.17

<P>Graphene–CdS nanowire (NW) hybrid structures with high-speed photoconductivity were developed. The hybrid structure was comprised of CdS NWs which were selectively grown in specific regions on a single-layer graphene sheet. The photoconductive channels based on graphene–CdS NW hybrid structures exhibited much larger photocurrents than graphene-based channels and much faster recovery speed than CdS NW network-based ones. Our graphene–CdS NW structures can be useful because they were much faster than commercial CdS film-based photodetectors and had photocurrents large enough for practical applications.</P> <P>Graphic Abstract</P><P>We have developed a photoconductive channel based on graphene–CdS nanowire hybrid structures which exhibited large photocurrent and fast recovery speed. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm16565a'> </P>

베트남 TOU요금제 기반 비선형 최적화 기법을 활용한 ESS 차익거래 알고리즘 개발

허강준(Kangjoon Heo),정재성(Jaesung Jung) 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.7

CMOS binary image sensor with high-sensitivity metal-oxide semiconductor field-effect transistor-type photodetector for high-speed imaging

( Juneyoung Jang ),( Wonbin Heo ),( Jaesung Kong ),( Young-mo Kim ),( Jang-kyoo Shin ) 한국센서학회 2021 센서학회지 Vol.30 No.5

In this study, we present a complementary metal-oxide-semiconductor (CMOS) binary image sensor. It can shoot an object rotating at a high-speed by using a gate/body-tied (GBT) p-channel metal-oxide-semiconductor field-effect transistor (PMOSFET)-type photodetector. The GBT PMOSFET-type photodetector amplifies the photocurrent generated by light. Therefore, it is more sensitive than a standard N+/P-substrate photodetector. A binary operation is installed in a GBT PMOSFET-type photodetector with high-sensitivity characteristics, and the high-speed operation is verified by the output image. The binary operations circuit comprise a comparator and memory of 1- bit. Thus, the binary CMOS image sensor does not require an additional analog-to-digital converter. The binary CMOS image sensor is manufactured using a standard CMOS process, and its high- speed operation is verified experimentally.

국내 적합성 제고를 위한 분산자원관리시스템(DERMS) 분석

허강준(Kang-Joon Heo),정재성(Jaesung Jung) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.7