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- 저자 : Jae-Woong Yu (검색결과 297 건)
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Yu, Hak Ki,Kim, Woong-Kwon,Park, Eung Chul,Kim, Jae Sung,Koo, Bon-Woong,Kim, Young-Woon,Ryu, Jae Hwa,Lee, Jong-Lam American Chemical Society 2011 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.115 No.36
<P>A number of oxygen vacancies were found in the MgO film when a nanoscale-metal embedded MgO film (MgO/nanoscale metal film/MgO) was exposed to a pulsed KrF excimer laser. This was due to the interfacial reaction between embedding nanoscale metal and MgO film. In a case of Nb embedding metal, the Nb<SUB>2</SUB>O<SUB>5</SUB> crystallites were evidenced to proceed the reaction at the MgO/Nb interface; 5MgO + 2Nb → Nb<SUB>2</SUB>O<SUB>5</SUB> + 5Mg + 5V<SUB>O</SUB><SUP>··</SUP>. The oxygen vacancies formed the F centers in the MgO bandgap, resulting in high cathodoluminescence intensity at the 431 and 526 nm region, corresponding to F<SUP>+</SUP> and F centers. The F centers in MgO played a role in increasing secondary electron emission coefficient (γ). As several kinds of nanoscale metals for creating F centers (Cr, Ti, V, In, Ta, and Nb) were embedded into MgO film, the γ values were found to be inversely linear with the Δ<I>G</I><SUB>f</SUB> for the formation of metal oxides. The Nb embedded MgO film showed the highest γ value of ∼0.232 compared with normal MgO film (0.034).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2011/jpccck.2011.115.issue-36/jp205759s/production/images/medium/jp-2011-05759s_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp205759s'>ACS Electronic Supporting Info</A></P>
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Yu, Jae-Woong,Kim, Jai Kyeong,Kim, Dong Young,Kim, Chulhee,Song, Nam Woong,Kim, Dongho Elsevier 2006 Current Applied Physics Vol.6 No.1
<P><B>Abstract</B></P><P>The energy transfer process upon photoexcitation in binary polymer blends with different donor/acceptor pairs were investigated with the aid of the steady-state and time-resolved photoluminescence methods. The observed differences in the energy transfer efficiency are not fully explained by the Förster radius, deduced from the spectral overlap calculation. The order of energy transfer efficiencies for different donor/acceptor pairs does not follow the sequence of Förster radius, particularly for the acceptors having relatively long PL lifetimes. Hence, an alternative simple model is proposed to account for the order of energy transfer efficiency, which is to include the effect of the acceptor PL lifetime, specifically in the presence of excess donor. Such is the case with usual polymer LED devices.</P>
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Jae-Woong Yu,Jai Kyeong Kim,Dong Young Kim,Chulhee Kim,Nam Woong Song,Dongho Kim 한국물리학회 2006 Current Applied Physics Vol.6 No.1
The energy transfer process upon photoexcitation in binary polymer blends with dierent donor/acceptor pairs were investigatedwith the aid of the steady-state and time-resolved photoluminescence methods. The observed dierences in the energy transfer e-ciency are not fully explained by the Fo¨rster radius, deduced from the spectral overlap calculation. The order of energy transfer¨rster radius, particularly for the acceptors havingrelatively long PL lifetimes. Hence, an alternative simple model is proposed to account for the order of energy transfer eciency,which is to include the eect of the acceptor PL lifetime, specically in the presence of excess donor. Such is the case with usualpolymer LED devices.
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( Jae-jun Shim ),( Tae-woong Choi ),( Chi Hyuck Oh ),( Soyung Park ),( Yu Jin Um ),( Byung-ho Kim ),( Ju-seog Lee ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Hepatocelluar carcinoma (HCC), the most common primary liver cancer, shows very heterogeneous gene expression patterns compared with intrahepatic cholangiocarcinoma (CC). Recent studies revealed a subset of HCCs showing CC - like features in histopathologic and genomic levels. We tried to identify these overlapping tumors and to characterize this unique phenotype of HCC in clinical perspective. Methods: Genomic data were downloaded from The Cancer Genome Atlas (TCGA) on human HCC (n=374) and intrahepatic CC (n=30). Using uniquely expressed genes between HCC and intrahepatic CC, total 52 tumors (13.9%) were predicted as “CC-like” phenotype among HCCs (BRB array tool, BCCP model, P<0.001, cut off probability = 0.1). We found uniquely expressed 1,122 genes (CC signature set) between CC-like HCCs and the other HCCs ((P<0.0001, four fold changes). Using the CC signature set, we identified CC-like subgroup in other independent HCC cohorts. Results: Gene expression patterns of CC-like HCCs were significantly correlated with poor prognosis. They shared gene expressions with hepatic progenitor-origin tumors suggesting their origin might be shared with intrahepatic CC. The CC-like HCC also showed more aggressive gene expression patterns. Finally, CC-like HCCs showed significantly shorter overall survival than non-CC type in validation cohorts. Conclusions: Unique phenotype of HCC exists sharing similar gene expressions with CC and its genetic features are correlated with aggressive tumor biology.
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Risk Factors of Invasion in Early Gastric Cancer Resected by Endoscopic Submucosal Dissection
( Jae Gyu Shin ),( Cheol Woong Choi ),( Yu Yi Choi ),( Hyung Wook Kim ),( Dae Hwan Kang ),( Su Bum Park ),( Su Jin Kim ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Backgroud: Knowing the exact depth of the lesion before submucosal dissection (ESD) remains a question and can only be confirmed by final pathologic report following ESD. And patients with submucosal or lymphovascular (SM/LV) invasion may need additional surgery including lymph node dissection because SM/LV invasion have relevant to higher risk for lymph node metastasis. The purpose of the study is to investigate the risk factors for SM/LV invasion in EGC. Methods: We retrospectively reviewed clinical and pathological datas in patients underwent ESD from Jan 2010 to May 2014 and presenting EGC of 2.0 cm or smaller in size, a differentiated-type adenocarcinoma, and without ulceration. Results: Among 425 lesions consecutively resected by ESD, 323 lesions in 302 patients were included in this study. Submucosal and lymphovascular invasions were detected in 42 lesions. Multivariate analysis revealed that histology of moderate-differentiated (odds ratio (OR) 4.231; 95% CI 1.925-9.013; p=0.000), location of upper and middle third (U/M) of stomach (OR 3.200, 95% CI 1.511-7.001; p=0.007) were significant risk factors for SM/LV invasions. Conclusions: Histology of moderate-differentiated adenocarcinoma, and location of U/M were identified as independent risk factors of SM/LV invasion in EGC meeting absolute criteria for ESD.
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( Jae-jun Shim ),( Tae-woong Choi ),( Chi Hyuck Oh ),( Soyung Park ),( Yu Jin Um ),( Byung-ho Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Asians have a higher risk of hepatocellular carcinoma (HCC) development than Caucasians. However, the risk of HCC was not compared among Asian countries. Methods: Population data, prevalence of chronic hepatitis B or C, and annual number of hepatitis B virus (HBV) - or hepatitis C virus (HCV) - related HCC cases (40-79 years of age) were acquired from publicly available data. The incidence of HCC among patients with chronic viral hepatitis were calculated according to age groups Results: The risk of HBV-related HCC in Koreans was more than twice that in Taiwanese. The annual incidence of HCC was 947 per 100,000 HBsAg-positive patients in 2005. This was equivalent to 1 HCC occurrence for every 106 patients with chronic hepatitis B (CHB) per year. From 2005 to 2011, the annual incidence in Korea did not change; the average was 906 per 100,000 persons (0.91%/year). In Taiwan, the incidence was 378 per 100,000 patients per year in 2002. One HCC was diagnosed for every 265 patients with CHB. The incidence among young adults (40-49 years of age) was compared because most HCCs that develop in individuals in this age group are HBV-related. The incidence was 495 and 155 per 100,000 patients with CHB in Korea and Taiwan, respectively. The mortality rate due to HBV-related HCC was 434 and 136 per 100,000 patients in Korea and Taiwan, respectively. However, the incidence of HCV-related HCC was similar in the two countries; 570 and 519 per 100,000 patients with chronic hepatitis C in Korea and Taiwan, respectively. Conclusions: The risk of HCC is much higher in Korean patients with CHB than in Taiwanese, however the risk is similar among chronic hepatitis C.
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( Jae-jun Shim ),( Tae-woong Choi ),( Chi Hyuck Oh ),( Soyung Park ),( Yu Jin Um ),( Byung-ho Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: To optimize efficacy of National Liver Cancer Screening Program (NLCSP) for subjects with hepatitis B surface antigen (HBsAg) positive, it is crucial to know the incidence of hepatocellular carcinoma (HCC) development and its predisposing factors in the program. Methods: From January 2010 to December 2014, all the HBsAg positive participants who received at least two or more abdominal ultrasonography under NLCSP were retrospectively enrolled in a single tertiary hospital. Annual incidence of HBV-related HCC was calculated and related clinical factors were investigated. Results: During 5 years, 541 subjects were enrolled. Mean age was 53 years old and 310 (57.3%) were male. Most subjects (86.5%) were patients of current hospital. Two hundred ninety two subjects (54%) were receiving antiviral agents at the moment. Liver cirrhosis (LC) was diagnosed in 212 (39.2%) by ultrasonography or upper endoscopy. Esophageal varices were found in 63 (14.8%). Total bilirubin, albumin, platelets, and aminotransferases were normal in most subjects. HBV DNA were less than 2,000 IU/mL in 356 subjects (79.6%). Mean follow-up time was 2.4 years and 16 new HCCs were diagnosed. Annual incidence of HBV-related HCCs were 980 per 100,000 patient year (1% per year). Subjects more than 60 years old (2.2% per year) had higher risk of HCC development than those under 60 years (0.6% per year, P<0.005 by Log Rank test). Presence of LC (2.2% per year) also showed higher risk of HCC than LC-free state (0.2% per year, P<0.0001 by Log Rank test). In cirrhotic patients older than 60 years old, the incidence increased up to 3.8% per year. Conclusions: Despite of high rate of antiviral therapy, incidence of HBV-related HCC is not low in participant of NLCSP in Korea. Old age and presence of liver cirrhosis are associated with higher risk of HCC development.
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( Jae-jun Shim ),( Tae-woong Choi ),( Chi Hyuck Oh ),( Soyung Park ),( Yu Jin Um ),( Byung-ho Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: REACH-B is a simple scoring system to predict HCC risk in non-cirrhotic patients with chronic hepatitis B (CHB). However, it is not known whether the model can accurately predict HCC risk in patients under long-term antiviral therapy. This study aimed to validate modified REACH-B model to predict HCC risk in patients receiving entecavir. Methods: From 2007 to 2013, total 136 naive patients (40 to 70 years of age) with CHB who had been treated for more than 6 months were retrospectively collected. None of them had liver cirrhosis. We hypothesized that HCC risk remains unchanged during the first two year and decrease thereafter. Two-year HCC risk was calculated from baseline data before antiviral therapy and the remaining 3-year risk was calculated from improved parameters following 2-year antiviral therapy. Results: Median age of patients was 49 years. HBeAg positive CHB were 77 (56.6%). Median ALT was 102 U/L. Baseline serum HBV DNA level was 7.51 log10 copies/mL. The patients were observed for total 507.5 years. The 5-year HCC risk of non-treated patients was predicted as 7.36%. It was equivalent to annual incidence of 1,472 per 100,000 persons with CHB. If they were treated, the 5-year HCC risk was dramatically decreased to 2.48%. Annual incidence was 496 per 100,000 persons with CHB. During actual follow-up period, two patients developed HCC. The incidence was 394 per 100,000 person year and 5-year cumulative incidence was estimated to 1.97%. There was no difference between predicted and actual incidence of HCC (P = 0.907 by Log Rank test). Actual and predicted incidence following antiviral therapy decreased as compared with that of non-treatment, however, the difference did not meet statistically significance (P = 0.176 by Log Rank test). Conclusions: Modified REACH-B model can predict 5-year risk of HCC in patients with CHB under long-term antiviral therapy.
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