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The Tuning of the KEK-PS K2 Beam Line for the Hybrid-Emulsion Experiment
Ieiri, M.,Kim, J.Y.,Kim, T.I.,Song, J.S.,Park, I.G.,Chung, K.H.,Kim, C.O.,Park, J.N.,Bahk, S.Y.,Kim, S.K. 慶尙大學校 기초과학연구소 1988 基礎科學硏究所報 Vol.4 No.-
We have shortened the downstream part of the K2 beam line from the original design to raise the kaon yields for the requirement. A layout of the modified K2 beam line is shown in fig. I and the total beam length is 25.7m. Since the high beam flux is not required. Q5 which made the beam flux is not required. Q5 which made the beam achromatic at FF, is omitted. The drift length between Q5 and Q7 is adjusted, so that the total length becomes short and that the beam ellipse at FF satisfies the above condition.
Reliable multi-hop communication for structural health monitoring
Tomonori Nagayama,Parya Moinzadeh,Kirill Mechitov,Mitsushi Ushita,Noritoshi Makihata,Masataka Ieiri,Gul Agha,Billie F. Spencer, Jr.,Yozo Fujino,Ju-Won Seo 국제구조공학회 2010 Smart Structures and Systems, An International Jou Vol.6 No.5
Wireless smart sensor networks (WSSNs) have been proposed by a number of researchers to evaluate the current condition of civil infrastructure, offering improved understanding of dynamic response through dense instrumentation. As focus moves from laboratory testing to full-scale implementation, the need for multi-hop communication to address issues associated with the large size of civil infrastructure and their limited radio power has become apparent. Multi-hop communication protocols allow sensors to cooperate to reliably deliver data between nodes outside of direct communication range. However, application specific requirements, such as high sampling rates, vast amounts of data to be collected, precise internodal synchronization, and reliable communication, are quite challenging to achieve with generic multi-hop communication protocols. This paper proposes two complementary reliable multi-hop communication solutions for monitoring of civil infrastructure. In the first approach, termed herein General Purpose Multi-hop (GPMH), the wide variety of communication patterns involved in structural health monitoring, particularly in decentralized implementations, are acknowledged to develop a flexible and adaptable any-to-any communication protocol. In the second approach, termed herein Single-Sink Multi-hop (SSMH), an efficient many-to-one protocol utilizing all available RF channels is designed to minimize the time required to collect the large amounts of data generated by dense arrays of sensor nodes. Both protocols adopt the Ad-hoc On-demand Distance Vector (AODV) routing protocol, which provides any-to-any routing and multi-cast capability, and supports a broad range of communication patterns. The proposed implementations refine the routing metric by considering the stability of links, exclude functionality unnecessary in mostly-static WSSNs, and integrate a reliable communication layer with the AODV protocol. These customizations have resulted in robust realizations of multi-hop reliable communication that meet the demands of structural health monitoring.
Reliable multi-hop communication for structural health monitoring
Nagayama, Tomonori,Moinzadeh, Parya,Mechitov, Kirill,Ushita, Mitsushi,Makihata, Noritoshi,Ieiri, Masataka,Agha, Gul,Spencer, Billie F. Jr.,Fujino, Yozo,Seo, Ju-Won Techno-Press 2010 Smart Structures and Systems, An International Jou Vol.6 No.5
Wireless smart sensor networks (WSSNs) have been proposed by a number of researchers to evaluate the current condition of civil infrastructure, offering improved understanding of dynamic response through dense instrumentation. As focus moves from laboratory testing to full-scale implementation, the need for multi-hop communication to address issues associated with the large size of civil infrastructure and their limited radio power has become apparent. Multi-hop communication protocols allow sensors to cooperate to reliably deliver data between nodes outside of direct communication range. However, application specific requirements, such as high sampling rates, vast amounts of data to be collected, precise internodal synchronization, and reliable communication, are quite challenging to achieve with generic multi-hop communication protocols. This paper proposes two complementary reliable multi-hop communication solutions for monitoring of civil infrastructure. In the first approach, termed herein General Purpose Multi-hop (GPMH), the wide variety of communication patterns involved in structural health monitoring, particularly in decentralized implementations, are acknowledged to develop a flexible and adaptable any-to-any communication protocol. In the second approach, termed herein Single-Sink Multi-hop (SSMH), an efficient many-to-one protocol utilizing all available RF channels is designed to minimize the time required to collect the large amounts of data generated by dense arrays of sensor nodes. Both protocols adopt the Ad-hoc On-demand Distance Vector (AODV) routing protocol, which provides any-to-any routing and multi-cast capability, and supports a broad range of communication patterns. The proposed implementations refine the routing metric by considering the stability of links, exclude functionality unnecessary in mostly-static WSSNs, and integrate a reliable communication layer with the AODV protocol. These customizations have resulted in robust realizations of multi-hop reliable communication that meet the demands of structural health monitoring.
Yi, SoJeong,An, Hyungmi,Lee, Howard,Lee, Sangin,Ieiri, Ichiro,Lee, Youngjo,Cho, Joo-Youn,Hirota, Takeshi,Fukae, Masato,Yoshida, Kenji,Nagatsuka, Shinichiro,Kimura, Miyuki,Irie, Shin,Sugiyama, Yuichi,S Wolters Kluwer Health | Lippincott Williams Wilkin 2014 PHARMACOGENETICS AND GENOMICS Vol.24 No.10
BACKGROUND: Interethnic differences in genetic polymorphism in genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic differences in drug response. This study aimed to investigate genetic polymorphisms in genes involved in drug metabolism, transport, and excretion among Korean, Japanese, and Chinese populations, the three major East Asian ethnic groups. METHODS: The frequencies of 1936 variants representing 225 genes encoding drug-metabolizing enzymes and transporters were determined from 786 healthy participants (448 Korean, 208 Japanese, and 130 Chinese) using the Affymetrix Drug-Metabolizing Enzymes and Transporters Plus microarray. To compare allele or genotype frequencies in the high-dimensional data among the three East Asian ethnic groups, multiple testing, principal component analysis (PCA), and regularized multinomial logit model through least absolute shrinkage and selection operator were used. RESULTS: On microarray analysis, 1071 of 1936 variants (>50% of markers) were found to be monomorphic. In a large number of genetic variants, the fixation index and Pearson’s correlation coefficient of minor allele frequencies were less than 0.034 and greater than 0.95, respectively, among the three ethnic groups. PCA identified 47 genetic variants with multiple testing, but was unable to discriminate ethnic groups by the first three components. Multinomial least absolute shrinkage and selection operator analysis identified 269 genetic variants that showed different frequencies among the three ethnic groups. However, none of those variants distinguished between the three ethnic groups during subsequent PCA. CONCLUSION: Korean, Japanese, and Chinese populations are not pharmacogenetically distant from one another, at least with regard to drug disposition, metabolism, and elimination.
Apple juice greatly reduces systemic exposure to atenolol
Jeon, Hyewon,Jang, In‐,Jin,Lee, SeungHwan,Ohashi, Kyoichi,Kotegawa, Tsutomu,Ieiri, Ichiro,Cho, Joo‐,Youn,Yoon, Seo Hyun,Shin, Sang‐,Goo,Yu, Kyung‐,Sang,Lim, Kyoung Soo Blackwell Publishing Ltd 2013 British journal of clinical pharmacology Vol.75 No.1
<P><B>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT</B></P><P>• Atenolol is an antihypertensive drug, of which negligible amounts are metabolized.</P><P>• Fruit juices may decrease the oral absorption of drugs by inhibiting intestinal drug transporters, as demonstrated <I>in vitro</I> and <I>in vivo</I>.</P><P><B>WHAT THIS STUDY ADDS</B></P><P>• The pharmacokinetic characteristics of atenolol were determined according to the <I>SLCO2B1</I> genotype after apple juice administration in healthy Korean volunteers.</P><P>• Apple juice ingestion markedly reduced the systemic exposure to atenolol, but genetic variations in <I>SLCO2B1</I> were unlikely to contribute substantial variability to the pharmacokinetics of atenolol.</P><P><B>AIM</B> Fruit juice reduces the plasma concentrations of several β‐adrenoceptor blockers, likely by inhibiting OATP2B1‐mediated intestinal absorption. The aim of this study was to investigate the effects of apple juice on the pharmacokinetics of atenolol.</P><P><B>METHODS</B> Twelve healthy Korean volunteers with genotypes of <I>SLCO2B1</I> c.1457C> T (*<I>1/</I>*<I>1</I> (<I>n</I>= 6) and *<I>3/</I>*<I>3</I> (<I>n</I>= 6)) were enrolled in this study. In a three‐phase, one‐sequence crossover study, the pharmacokinetics (PK) of atenolol was evaluated after administration of 50 mg atenolol. Subjects received atenolol with either 300 ml water, 1200 ml apple juice or 600 ml apple juice.</P><P><B>RESULTS</B> Apple juice markedly reduced the systemic exposure to atenolol. The geometric mean ratios (95% confidence intervals) of apple juice : water were 0.18 (0.13, 0.25, 1200 ml) and 0.42 (0.30, 0.59, 600 ml) for the AUC(0,<I>t</I><SUB>last</SUB>). In this study, the PK parameters of atenolol responded in a dose‐dependent manner to apple juice.</P><P><B>CONCLUSIONS</B> Apple juice markedly reduced systemic exposure to atenolol. The genetic variation of <I>SLCO2B1</I> c.1457C>T had a minimal effect on the pharmacokinetics of atenolol when the drug was administered with water or apple juice.</P>
Evidence of Weak Decay of Heavy Double Hypernuclei
Aoki, S.,Bahk, S. Y.,Chung, K. S.,Chung, S. H.,Funahashi, H.,Hahn, C. H.,Hara, T.,Hirata, S.,Hoshino, K.,Ieiri, M.,Iijima, T.,Imai, K.,Ishigami, T.,Itow, Y.,Kazuno, M.,Kikuchi, K.,Kim, C. O.,Kim, D. C 國立昌原大學校 基礎科學硏究所 1992 基礎科學硏究所論文集 Vol.3 No.-
We have studied 80 events of candidates for ??? capture star at rest in nuclear emulsion, where ??? hyperons are produced in (??????) reactions identified by a ?? spectrometer. The weak decay of heavy double hypernuclei is confirmed, studying the distribution of visible energy-release and the probability of emission of two fast protons, in comparison with those for single hypernuclei.
Search for the H Dibaryon in (K-, K+) Reactions
Bahk,S. Y.,Chung,K. S,Chung,S. H.,Funahashi,H.,Hahn,C. H.,Hara,T.,Hirata,S.,Hoshino,K.,Ieiri,M.,Iijima,T.,Imai,K.,Ishigami,T.,Itow,Y.,Kazuno,M.,Kikuchi,K.,Kim,C. O.,Kim,D. C.,Kim,J. Y.,Kobayashi,M.,Ko 國立昌原大學校 基礎科學硏究所 1992 基礎科學硏究所論文集 Vol.3 No.-
We have studied(??) reactions from an emulsion target. The S--2H dibaryon has been searched for by the analysis of the ??? momentum spectrum together with emulsion data. No evidence of H production was observed in the mass range of 1.90-2.16 GeV/c². Upper limits for the production cross section of the H are (0.2-0.6)% of that for the quasifree ??? production at the 90% confidence level.