Development of Next Generation Lipid Nanoparticle for mRNA Delivery

Hyunjung YOO,Junghyun KIM,Eunyoung PARK,Jeewon KIM,Joonyoung PARK,Jinahn CHOI,Minkyu KIM,Sunhee KANG,Jaeyoung BAN,Jiyeon SON 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

소비자의 식품안전에 대한 우려와 표시정보신뢰가 표시확인행동 및 비용지불의사에 미치는 영향

HyunJung Yoo 위기관리 이론과 실천 2016 Crisisonomy Vol.12 No.2

본 연구는 식품 안전과 표시에 대한 소비자들의 전반적 인식수준을 알아보고, 표시신뢰와 불안감이표시확인행동과 비용지불의사에 미치는 영향을 알아보기 위해 한국농촌경제연구원(이하 농경연)의2015년 식품소비행태 조사자료 중 성인편 자료(n=5,121)를 분석대상으로 하였다. 주요 연구결과는다음과 같다. 첫째, 연구결과 표시에 대한 인식은 전반적으로 보통수준이었고, 비용지불의사가 높은집단과 낮은 집단을 비교했을 때에는 비용지불의사가 높은 집단이 표시정보 활용도가 더욱 높은것으로 나타났다. 둘째, 표시신뢰도와 식품불안감이 소비자의 식품표시확인행동과 가격지불의사에미치는 영향과 효과를 분석한 결과를 통해 표시신뢰도가 소비자의 안전행동을 발현시키는 중요한요인임이 밝혀졌다. 셋째, 식품정책만족도는 소비자의 표시확인행동과 비용지불의사에 부적인 영향을 미치는 것으로 나타났다. 식품정책에 대한 만족도가 높다는 것은 식품시장에 대한 정부관리가잘 이루어진다고 생각하는 것이 전제되기 때문에, 이 경우 소비자들은 표시확인행동이나 비용지불과 같은 추가적인 노력을 기울이지 않아도 안심하고 식품을 구매할 수 있다고 판단한다는 것을 추론할 수 있다. This study analyzed the adult section of the 2015 survey data on food consumption patterns collected bythe Korea Rural Economic Institute (n=5,121). The major findings are as follows: First, although there wasan average level of knowledge on food label overall in the sample, it is found that the group with a higherwillingness to pay were more likely to use label information than the group with a lower willingness to pay.Secondly, trust in label information was found to be the most important factor for affecting consumers’ useof label information and willingness to pay. Finally, the level of satisfaction on food policies was negativelyassociated with their actions to check labels and willingness to pay, which indicates that those who arehappy with the government’s food-related policies tend to make no extra efforts for their food purchasedecision such as checking label and paying for additional charge.

각진 형태의 구조물 주위 유동장 모사를 위한 전산 난류 모형 적정성 연구

유현정(Yoo, Hyunjung),이승수(Lee, Sungsu),엄정아(Um, Jeong Ah),이슬기(Lee, Seul Gi),함희정(Ham, Hee Jung) 대한토목학회 2020 대한토목학회 학술대회 Vol.2020 No.10

지역별 소비생활문제와 소비격차

유현정(Yoo Hyunjung) 한국소비자원 2018 消費者問題硏究 Vol.49 No.2

한국의 소비생활지표를 활용한 1인 가구의 소비생활 특성 분석

유현정(Yoo Hyunjung),이아름(Lee Arum),송유진(Song Eugene),안혜리(Ahn Heari) 한국소비자원 2017 消費者問題硏究 Vol.48 No.2

간호대학생의 문화적 역량과 문화 간 의사소통 관계

유현정(Yoo, Hyunjung),김관희(Kim, Kwanhee),이하정(Lee, Hajeong),박보미(Park, Bomi),박수빈(Park, Subin),박주희(Park, Juhui),박진희(Park, Jinhui),반민주(Ban, Minjoo),임지현(Lim, Jihyun),박준후(Park, Junhoo),이예은(Lee, Yee Eun) 한국농촌간호학회 2019 한국농촌간호학회지 Vol.14 No.2

Purpose: This study was done to identify the cultural capacity of college nursing students and the relationship of intercultural communication. Methods: The participants were 200 students in colleges of nursing from 6 universities in C city, who understood the purpose of the study and agreed to participate. Collected data were analyzed with t-test, ANOVA, correlation analysis, and stepwise regression analysis using SPSS/WIN 22.0. Results: Cultural sensitivities in this study (r=.372, p<.001), cultural knowledge (r=.399, p=.001), cultural awareness (r=.547, p<.001), and cultural technology (r=.550, p<.001) each showed a statistically significant correlation with intercultural communication skills. Conclusion: The results of this study show that reinforcement of the cultural and intercultural communication ability of college nursing students, in-depth exploration of the cultural area and religious inspection, cultural and professional backgrounds, assessment and consideration of cultural characteristics, nursing diagnosis, and health appropriate to the cultural background. It is suggested that education such as service provision should be conducted systematically.

대사증후군 대상자의 영양소 섭취 특성에 관한 연구

유현정(Yoo HyunJung),김양하(Kim Yangha) 韓國營養學會 2008 Journal of Nutrition and Health Vol.41 No.6

본 연구는 대사증후군 유병률을 조사하고, 대사증후군 대상자들의 영양소 섭취의 특성과 성별과 연령별에 따른 영양소 섭취의 차이를 분석하기 위하여 수행되었다. 1) 대사증후군 유병률은 남자 17%, 여자 4.5%로 전체 평균 10.3%를 나타냈다. 2) 조사대상자의 평균 연령은 정상군 39.0세, 대사증후군 42.8세였으며, BMI는 정상군 22.5 kg/㎡보다 대사증후군 대상자등이 27.5 kg/㎡로 대사증후군이 유의적으로 높았다(p < 0.01). 혈당, 중성지방, 이완기 혈압에서 정상군보다 대사증후군 대상자들이 유의적으로 높았다 (p < 0.001). 3) 영양소 섭취에서 열량은 정상군 1699.5 kcal보다 대사증후군 대상자들이 2047.1 kcal로 유의적으로 높았으며(p < 0.001), 동물성지방 (p < 0.01), 콜레스테롤 (p < 0.001), 나트륨 (p < 0.05)의 섭취도 유의적으로 높은 섭취량을 나타냈다. 4) 성별에 따라서 대사증후군 대상자들의 영양소 섭취의 특성은 남녀 모두 정상군보다 대사증후군대상자들의 열량섭취가 높았다. 남자는 지방 (p < 0.05), 콜레스테롤 (p < 0.01)에서, 여자는 탄수화물 (p < 0.05), 단백질 (p < 0.05)에서 정상군보다 대사증후군 대상자들이 높은 섭취량을 나타냈다. 5) 연령별에 따라서 대사증후군 대상자들의 영양소 섭취의 특성을 살펴보면 30대는 열량, 동물성지방, 콜레스테롤에서, 40대는 지방과 콜레스테롤에서, 50대는 열량, 탄수화물, 식물성지방에서 정상군보다 대사증후군 대상자들이 유의적으로 높은 섭취량을 나타냈다. 본 연구 결과 전체대상자의 영양소 섭취 특성은 총열량, 동물성지방, 콜레스테롤, 나트륨에서 정상군보다 대사증후군 대상자들이 유의적으로 높은 섭취량을 나타냈다. This study was conducted to investigate the prevalence of metabolic syndrome (MS) and characteristics of nutrient intake in MS subjects by gender and age. The subjects were 957 (447 men and 510 women) who visited medical center for regular medical check-up. The diagnosis of MS subjects was adapted from NCEP-ATPⅢ with blood glucose, cholesterol, triglycerides, and blood pressure and Aisa-Pacific definition with waist-circumference. Anthropometric and biochemical measurements were practiced, then the nutrient intake analysis was assessed through the 24-hour recall method. The MS prevalence of all subjects was 10.3% in average -17% in men and 4.5% in women, respectively. The energy intake in MS group was 2047.1 kcal and 1699.5 kcal for normal group, showing significantly higher in MS compared to normal subjects. For intakes of animal fat, cholesterol, and sodium, MS group were significantly higher than normal group. In respect of gender, men subjects of MS group showed significantly higher nutrient intakes than normal group for energy, fat, and cholesterol. Women subjects of MS group showed higher intakes for energy, carbohydrate, and protein. For 30s, MS group showed higher intakes of energy, animal fat, and cholesterol than normal group. Fat and cholesterol for 40s and energy, carbohydrate, vegetable fat for 50s, MS group showed significantly higher intakes than normal group. In summary, MS group showed higher intakes of energy, animal fat, cholesterol, and sodium than normal group. (Korean J Nutr 2008; 41(6): 510 ~ 517)

대학생의 돈에 대한 태도 및 물질주의 성향

유현정(Yoo, Hyunjung),박초롱(Park, Chorong),이종대(Lee, Jongdae),조보미(Cho, Bomi) 충북대학교 생활과학연구소 2004 생활과학연구논총 Vol.8 No.2

The purpose of this study was to identify money attitudes and materialism among Korean university students. For this study, questionnaire survey method was conducted and 300 university students were selected. Factor analysis, cluster analysis, and descriptive analysis were utilized. The results were as follows: First, the money attitudes were composed of six factors and they were categorized by six clusters. Most university students believed money is a tool for emotional satisfaction, while the least number of students were niggardly of money. Second, materialism were composed of two factors and they were categorized by two clusters. Generally the level of materialism among Korean university students found not to be high for the precedent outputs.

Enhanced charge collection efficiency by thin-TiO₂-film deposition on FTO-coated ITO conductive oxide in dye-sensitized solar cells

Yoo, Beomjin,Kim, Kyungkon,Lee, Doh-Kwon,Ko, Min Jae,Lee, Hyunjung,Kim, Yong Hyun,Kim, Won Mok,Park, Nam-Gyu Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.21

<P>We have investigated effect of thin TiO<SUB>2</SUB> layers deposited on an indium tin oxide (ITO)/fluorine-doped tin oxide (FTO) double-layered transparent conductive oxide on the performance of dye-sensitized solar cell. FTO is deposited on an ITO-coated glass, followed by TiO<SUB>2</SUB> deposition using a radio frequency magnetron sputtering technique. The thicknesses of the sputtered-TiO<SUB>2</SUB> layers are varied from 10 nm to 20 nm, while the ITO and FTO are fixed to be 150 nm and 70 nm, respectively. Atomic force microscopy (AFM) shows that the surface roughness is similar but the surface morphology is altered by thin TiO<SUB>2</SUB> layer deposition. The sheet resistance of the ITO/FTO conductive glass is hardly changed by thin TiO<SUB>2</SUB> layer deposition. Photovoltaic performance is significantly enhanced after introduction of thin TiO<SUB>2</SUB> underlayer. The 15 nm thick TiO<SUB>2</SUB> underlayer leads to the increases of photocurrent density from 9 mA cm<SUP>−2</SUP> to 10.3 mA cm<SUP>−2</SUP> and fill factor from 0.715 to 0.747, as a result, the overall conversion efficiency is improved from 5.28% to 6.37%, corresponding to 20.6% increase. Photovoltage, however, remains almost unchanged. Photocurrent is improved over the entire wavelength. The increased transmittance at wavelength ranging from 300 to 600 nm contributes in part to increase in photocurrent. Improvement of charge collection efficiency from ∼90% to ∼97% is also attributed to the increased photocurrent, where the increased transport rate is responsible for the improved charge collection, indicating that the thin TiO<SUB>2</SUB> underlayer has influence on opto-electronic property in the dye-adsorbed bulk TiO<SUB>2</SUB> film.</P> <P>Graphic Abstract</P><P>A thin TiO<SUB>2</SUB> layer 15 nm thick was deposited on an ITO/FTO bilayered transparent conductive substrate by radio frequency magnetron sputtering, which improved charge collection efficiency from 90% to 97% in dye-sensitized solar cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b926145a'> </P>

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

Yoo, Hae Yong,Sung, Min Kyung,Lee, Seung Ho,Kim, Sangok,Lee, Haeseung,Park, Seongjin,Kim, Sang Cheol,Lee, Byungwook,Rho, Kyoohyoung,Lee, Jong-Eun,Cho, Kwang-Hwi,Kim, Wankyu,Ju, Hyunjung,Kim, Jaesang,K Nature Publishing Group, a division of Macmillan P 2014 Nature genetics Vol.46 No.4

The molecular mechanisms underlying angioimmunoblastic T cell lymphoma (AITL), a common type of mature T cell lymphoma of poor prognosis, are largely unknown. Here we report a frequent somatic mutation in RHOA (encoding p.Gly17Val) using exome and transcriptome sequencing of samples from individuals with AITL. Further examination of the RHOA mutation encoding p.Gly17Val in 239 lymphoma samples showed that the mutation was specific to T cell lymphoma and was absent from B cell lymphoma. We demonstrate that the RHOA mutation encoding p.Gly17Val, which was found in 53.3% (24 of 45) of the AITL cases examined, is oncogenic in nature using multiple molecular assays. Molecular modeling and docking simulations provided a structural basis for the loss of GTPase activity in the RHOA Gly17Val mutant. Our experimental data and modeling results suggest that the RHOA mutation encoding p.Gly17Val is a driver mutation in AITL. On the basis of these data and through integrated pathway analysis, we build a comprehensive signaling network for AITL oncogenesis.