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Expressional Regulation of Replication Factor C in Adipocyte Differentiation
Hyun Kook Cho(조현국),Hye Young Kim(김혜영),Hyun Jeong Yu(유현정),JaeHun Cheong(정재훈) 한국생명과학회 2011 생명과학회지 Vol.21 No.2
지방세포 분화 과정 중에 key regulator로서 기능을 하는 여러 전사조절인자(PPARγ, C/EBPα, SREBP, LXR)가 동정되었고, 주로 DNA 복제나 DNA 수선 단계에서 중요한 역할을 한다고 밝혀진 복제 조절인자인 RFC140이 지방세포 분화에도 중요한 인자임이 밝혀졌다. 이 연구에서 우리는 RFC140과 RFC38에 대한 발현조절을 확인하였으며, RFC140이 PPARγ와의 단백질-단백질 결합을 통하여 PPARγ에 의해 조절되는 유전자의 발현을 증가시킴을 확인하였다. 이러한 결과들은 특이적인 지방세포 전사인자에 의해 발현이 조절되는 RFC140과 RFC38이 지방세포의 분화과정에 필수적임을 제시한다. Adipocyte differentiation is an ordered multistep process requiring the sequential activation of several groups of adipogenic transcription factors, including CCAAT/enhancer-binding protein-α and peroxisome proliferator-activated receptor-γ, and coactivators. In previous reports, we identified that replication factor C 140 (RFC140) protein played a critical role in regulating adipocyte differentiation as a coactivator. Here, we show expressional regulation of RFC140 and small RFC subunit, RFC38, following characterization of gene promoter of RFC140 and RFC38. In addition, RFC140 increases PPARγ -mediated gene activation, resulting from direct protein-protein interaction of RFC140 and PPARγ. Taken together, these findings demonstrate that the regulated expression of RFC140 and RFC38 by specific adipocyte transcription factors is required for the adipocyte differentiation process.
황태준 ( Tae Jun Hwang ),김정순 ( Jeong Soon Kim ),권유석 ( Yoo Seok Kwon ),유현정 ( Hyun Jung Yu ),김현수 ( Hyun Soo Kim ),허선 ( Sun Huh ),최창규 ( Chang Kyu Choi ),임연정 ( Yeun Jung Lim ),김도훈 ( Do Hoon Kim ),최정희 ( Jeong 대한천식알레르기학회 2005 천식 및 알레르기 Vol.25 No.4
Eosinophilic mcningitis is defined as the presence of 10 or more eosinophils per microliter in the cerebrospinal fluid (CSF) or eosinophilis of at least 10% of the total CSF leukocyte count. Eosinophilic meningitis is a rare disease and the most common cause is the invasion of the central nervous system by helminthic parasites, particularly Angio-strongylus cantonensis. Toxocara canis, a common intestinal parasite of dog, has been also reported to cause eosinophilic meningitis. We report a case of eosinophilic meningitis which was proven to be a human toxocariasis by the serologic test. (Korean J Asthma Allergy Clin Immunol 2005;25:324-327)