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( Hyo Sun Kim ),( Chang Seok Bang ),( Yeon Soo Kim ),( Oh Kyung Kwon ),( Min Sun Park ),( Jeong Ho Eom ),( Gwang Ho Baik ),( Dong Joon Kim ) 대한장연구학회 2014 Intestinal Research Vol.12 No.3
Gastrocolocutaneous fistula is a rare complication of the percutaneous endoscopic gastrostomy (PEG) procedure. Typical symptoms usually occur in the first few months. We recently encountered 2 patients with 8- and 33-month asymptomatic periods. A 74-year-old man presented with watery diarrhea for 1 month. He had undergone PEG 9 months earlier. During workup, an upper endoscopy and abdominal CT scan revealed the migration of the feeding tube into the transverse colon. He was discharged with a nasogastric tube after treatment. A 77-year-old man presented with sudden loosening of his PEG tube with a duration over 3 days. He had undergone PEG procedure three times until that time. During workup, a gastrocolocutaneous fistula was diagnosed. However, when previous studies were reviewed, an abdominal CT scan, which was done 6 months ago before the third PEG, showed the fistula already existed at that time, suggesting that it was created about 33 months earlier when he underwent the second PEG procedure. The patient died of pneumonia aggravation despite conservative treatment. Both a high index of suspicion and the careful inspection of the upper endoscopy are very important for early diagnosis regardless of symptoms. (Intest Res 2014;12:251-255)
( Hyo Sun Kim ),( Gwang Ho Baik ),( Sang Hyun Park ),( Eun Jin Kim ),( Chang Seok Bang ),( Jin Bong Kim ),( Ki Tae Suk ),( Jai Hoon Yoon ),( Yeon Soo Kim ),( Dong Joon Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) was observed in 61~80% of all neuroendocrine tumors (NETs). Furthermore, GEP-NETs in ileum were reported in 2.38~15% of all NETs. GEP-NETs can be asymptomatic. The gold standard in diagnosis is detailed histology and this should be obtained whenever possible. Here we report a rare case of GEP-NETs in the terminal ileum with a long asymptomatic period. Case: A 43-year-old woman who visited our hospital with periumbilical pain, 18 months ago. Colonoscopy revealed ulcer and obstruction of terminal ileum. Abdominal computed tomography (CT) showed focal irregular wall thickening with enhancement at terminal ileum. Lymph node enlargement was observed at ileocecal region. The result of interferon-gamma for tuberculosis was negative. We try to evaluate about the possibility of malignancy. However, the patient was refused further evaluation. Fortunately, the symptoms were improved during conservative management with oral antibiotics and laxatives. Thereafter, the patient didn`t visit our hospital until periumbilical pain was recurred. Colonoscopy (Fig. 1A, 1B) and Abdominal CT (Fig. 1C, 1D) showed similar fi ndings to previous examinations. The patient was admitted to our hospital since periumbilical pain was not improved in spite of medical treatment. Laparoscopic ileocecal resection was performed on hospital stay day 3. Pathologic fi ndings was neuroendocrine carcinoma inside ileocecal valve (Fig. 2). TNM staging was T3N1M0. Discussion: In this case, the diagnosis of GEP-NETs in terminal ileum was delayed until surgical resection since colonoscopic evaluation of terminal ileum was diffi cult since obstruction of terminal ileum. Careful colonoscopic evaluation of terminal ileum and suspicion of hidden malignancy was required to the patient with ulceration and bowel wall edema of terminal ileum.
Identification of Hybrids using SSR markers from Polyembryonic Citrus Breeding Lines
Sun-Yung Yoon,Hyo-Min Ahn,Hyun-Jeong Oh,Kyung-Hwan Boo,Ho-Bang Kim,Gyoeng-Lyong Jeon 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Polyembryony in many citrus varieties is an impediment in breeding because it makes hard to identify hybrids after crossbreeding. So, it has become imperative for developing efficient methods to distinguish zygotic seedling generated from polyembryonic seed depending on citrus variety. Simple sequence repeat(SSR) marker is one of useful systems for such purpose. However, SSR markers to separate zygotic seedlings derived from the crossbreeding between ‘Marita unshiu’ (Citrus unshiu) ‘Seongjeon’ and ‘Shiranuhi mandarin’ [(C. unshiu x C. sinensis) x C. reticulata] ‘Hallabong’ have not been developed yet. In this study we tried to identify an effective SSR marker to screen zygotic seedling after crossbreeding between ‘Seongjeon’ and ‘Hallabong’. For this investigation, 387 seedlings were generated from 114 seeds produced from crossing those two varieties. A total of 116 SSR markers were tested to identify a special marker for distinguishing origin, zygotic or nucellar seedling. As a result, two markers, SSR012 and SSR093, were found to be more effective than other markers. These two SSR markers might be useful to select zygotic individuals in crossbreeing between ‘Seongjeon’ and ‘Hallabong’.
Kim, Hyo Song,Hong, Min Hee,Kim, Kiyeol,Shin, Sang-Joon,Ahn, Joong-Bae,Jeung, Hei Chul,Chung, Hyun Cheol,Koh, Youngil,Lee, Se-Hoon,Bang, Yung-Jue,Rha, Sun Young S. Karger AG 2011 Oncology Vol.80 No.5
<P>Abstract</P><P><I>Objective:</I> We aimed to describe the efficacy and safety of sunitinib in unselected Korean advanced renal cell carcinoma (RCC) patients. <I>Patients and Methods:</I> From November 2005 to August 2008, 132 histologically confirmed advanced RCC patients (100 in the global expanded access program) were enrolled. Response and toxicity were assessed regularly according to the protocol. <I>Results:</I> Within this population, 82.6% had clear cell RCC, and 28.8% were treatment naïve. Patients received a median of 5 cycles of sunitinib (range 1–30), and the mean relative dose intensity was 82.0 ± 14.20 (SD). The progression-free survival (PFS) and overall survival rates were 8.2 and 23.1 months, respectively. For the 130 evaluable patients, the objective response rate was 34.1% (n = 45); 44.7% (n = 59) exhibited stable disease. Reasons for discontinuation were disease progression (75.0%) and toxicity (7.6%). The most frequent adverse events were thrombocytopenia (75.0%), neutropenia (70.5%), and anemia (69.7%). Low body surface area (OR = 4.2, 95% CI 1.2–13.8, p = 0.02) and previously treated status (OR = 3.1, 95% CI 1.3–7.4, p = 0.01) were highly predictive of grade 3–4 toxicities. Based on these findings, a nomogram predicting the probability of 12-month PFS was constructed, giving a concordance index of 0.675. <I>Conclusions:</I> Despite the different toxicity profiles, maintaining adequate dose modifications and a careful follow-up enables comparable treatment outcomes for unselected Korean advanced RCC patients.</P><P>Copyright © 2011 S. Karger AG, Basel</P>
SMART-ITL 안전주입배관 파단시 노심보충수탱크 주입성능에 관한 실험적 연구
변선준(Sun-Joon Byun),배황(Hwang-Bae),류성욱(Sung-Uk Ryu),전병국(Byong-Guk Jeon),유효봉(Hyo-Bong Ryu),민경호(Kyoung-Ho Min),방윤곤(Yun-Kon Bang),전우진(Woo-Jin Jeon),이성재(Sung-Jae Yi),박현식(Hyun-Sik Park) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
System-integrated modular advanced reactor (SMART) is an integral-type nuclear reactor which received its design certificate in 2012 for the first time in the world. Currently, to improve its safety level, passive safety systems are designed and their performance has been evaluated. In this study, to examine the injection characteristics of a core makeup tank, a small-break loss of coolant accident is simulated using the SMART integral test loop (SMART-ITL). The experimental results provide more understanding on the behaviors of core makeup tanks (CMTs) as well as supporting future licensing process.
자아존중감 집단중재 프로그램이 품행장애 위험 고등학생의 학교생활 적응과 자아존중감에 미치는 영향
이효선 ( Hyo Sun Lee ),방명애 ( Myong Ye Bang ) 한국정서·행동장애아교육학회(구 한국정서학습장애아교육학회) 2012 정서ㆍ행동장애연구 Vol.28 No.2
본 연구의 목적은 자아존중감 집단중재 프로그램이 품행장애 위험 고등학생의 학교생활적응과 자아존중감에 미치는 영향을 밝히는데 있다. 연구설계는 사전-사후검사 통제집단 설계이며, 연구대상은 학력인증제 고등학교에 재학 중이며 K-YSR의 외현화 척도 점수에 근거한 임상범위에 해당하여 품행장애 위험군에 속하는 학생들로서 실험집단과 통제집단을 각각 24명씩 선정하였다. 사전검사 대비 사후검사의 증가분에 대한 두 독립표본 t 검증을 사용하여 자료를 분석하였다. 연구결과는 다음과 같다. 첫째, 자아존중감 집단중재 프로그램이 품행장애 위험 고등학생의 학교생활 적응에 긍정적인 영향을 미치었으며, 학교규칙 준수 하위영역에서 통계적으로 유의미한 향상이 있었다. 둘째, 자아존중감 집단중재 프로그램이 품행장애 위험 고등학생의 자아존중감에 긍정적인 영향을 미치었다. 후속연구를 위한 제언과 교육현장을 위한 시사점에 대해 논의하였다. The purpose of the study was to investigate the impact of a self-esteem group intervention program on the adaptation to school life and the self-esteem of at-risk high school students with conduct disorders. The subjects were 48 at-risk high school students with conduct disorders. The 24 students in school A were assigned into the experimental group and the 24 students in school B were assigned into the control group. The research design was pre and post control group design and independent two sample t-tests were implemented to answer the research questions. The group intervention program was composed of 20 sessions. Instructional materials such as books, multi-media materials, games, and songs were used. The results of the study were as follows: (a) The self-esteem group intervention program had positive impact on the adaptation to school life of at-risk high school students with conduct disorders; (b) The self-esteem group intervention program had positive impact on the self-esteem of at-risk high school students with conduct disorders. Limitations of the study and implications for future research were discussed.
최효경,구동억,방선우,이문규,조경식,오용호 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2
It may be difficult to differentiate renal cell carcinoma involving collecting system from renal pelvis urothelial tumor invading into renal parenchyma. The purpose of this study was to find out CT differential points of two diseases. 15 cases suggested invasion into other compartment in CT images were selected and evaluated about the presence or absence of hydronephrosis, CT renal function, renal contour changes due to mass and tentative diagnosis. Renal cell carcinoma was characterized by no hydronephrosis(80%), normal CT renal function (100%) and outward bulging mass(100%). However, renal pelvis urothelial tumor showed hydronephrosis(70%), abnormal CT renal function(60%) and preserved reniform shape(100%). In conclusion, renal contour changes and CT renal function are reliable criteria in differentiating two diseases.