http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effects of Tetracyclines on Primary Root Length and Chlorophyll Contents of Vegetable Crops
Hyeonji Choe,Hadjer Chohra,Vimalraj Kantharaj,Mi Sun Cheong,Yong Bok Lee 한국토양비료학회 2021 한국토양비료학회지 Vol.54 No.1
By increasing the use of antibiotics, it is concerned that unexpectedly contaminated the effect of antibiotics occurs in agricultural soil. In this study, we investigated the impact of antibiotics on the early stages of crop growth using lettuce (Lactuca sativa), cabbage (Brassica campestris), and radish (Raphanus raphanistrum). These crops were grown on agar plates vertically without antibiotics (0 ㎎/L) and with tetracycline 5 (TC5), 10 (TC10), and 20 (TC20) ㎎/L, chlortetracycline 5 (CTC5), 10 (CTC10), and 20 (CTC20) ㎎/L, and oxytetracycline 5 (OTC5), 10 (OTC10), and 20 (OTC20) ㎎/L at 20℃ for five days. Root length of all crops inhibited in a concentration-dependent manner except for cabbage of OTC treatment. For lettuce, root length (㎝) showed an average 6.06 and 1.39 upon control (0 ㎎/L) and TC20, respectively. Similarly, cabbage and radish exhibited an average 7.20 and 5.47, respectively, without TCs whereas TC20 inhibits the root length down to 2.26 and 1.59, respectively. The chlorophyll contents of cabbage and radish reduced as increased antibiotic concentration. Interestingly, chlorophyll contents of lettuce did not show significantly different. Therefore, we suggest future research directions by showing the effect of antibiotics on crops.
( Hyeonji Kim ),( Jeong Seong Yang ),( Minji Kang ),( Seung Heon Lee ),( Nakwon Kwak ),( Jae-joon Yim ),( Young Ae Kang ),( Hong Jo Choi ),( Jong-seok Kim ),( Hwa-jung Kim ),( Jake Whang ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0
Background Nontuberculous mycobacteria pulmonary disease (NTM PD) is rapidly increasing worldwide, including in south Korea. As part of the trend to find biomarkers for NTM PD, a multicenter prospective observational cohort study named ‘NTM-KOREA’ involving seven hospitals and two institutes in south Korea was initiated. In order to discover meaningful bacterial factors from preserved strains, the central role of Korean Mycobacterium Resource Center (KMRC) in KIT has been extended from strain preservation to research since 2018. Methods In South Korea, all NTM drug susceptibility tests have been performed at KIT except one tertiary hospital. When the patient's treatment is initiated, when the negative conversion fails after treatment, or when relapse/reinfection is observed, a drug susceptibility test is requested, and the clinical isolates are then stored in KMRC. Some strains are specifically registered in a mycobacterial extract library consisting of cell wall lipidomes and secreted proteomes. These strains are cultured on solid medium, and by observing the colonies, it is possible to confirm the presence of mixed infection and the rough or smooth colony surface morphology concerning NTM disease progression. Results From October 2018 to the present, a total of 7,000 NTM isolates of NTM-KOREA have been collected, of which 350 strains have been registered in the extract library additionally. Through a recent joint study with Seoul National University Hospital, we found that the treatment rate of clofazimine as an NTM treatment is related to minimum inhibitory concentration of each clinical isolate. Conclusions Despite various studies on NTM PD, the existence of biomarkers and bacterial factors applicable to diagnosis and treatment is still not satisfactory. When considering as an infectious disease, the causative agent is also very important as well as biomarkers. Accordingly, we will continue to investigate the characteristics of Korean NTM isolates extensively and to select prominent bacterial factors.
A study on the determination of a Health based Guidance Value of Formaldehyde
Hyeonji Oh,Heeju Choi,Yongmu Kim,Seo Yun Kim,Jae-Hong Park,Haejung Yoon,Yun-Sook Kang 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Formaldehyde can be exposed through various routes, including the environment such as air and water, food and cosmetics. Therefore, a risk assessment is necessary to identifiy and manage human health effect. This study aims to identify the relationship between formaldehyde exposure and adverse effects as a hazard characterization step in the risk assessment process and to establish and propose a Health based Guidance Value. In order to carry out ther research, we used some online databases to find scientific papers, reports and opinions published by other institutions. Data for dose-response assessment were selected and classified, as properties of toxicity, and then the most appropriate study for establishing Health based Guidance Value was finally decided. Til et al (1989), 2-years carcinogenicity study with rats, was the optimal toxicity data. As the toxicity endpoint, the Health based Guidance Value TDI 0.15 mg/kg bw/day was proposed by applying an uncertainty factor of 100(interspecies difference 10, intraspeices difference 10) to NOAEL 15 mg/kg bw/day for chronic atrophic gastritis, focal ulceration and glandular hyperplasia in the landular forestomach.
( Hyeonji Kim ),( Jeong Seong Yang ),( Minji Kang ),( Ahn Nam Joung ),( Cha So Jeong ),( Nakwon Kwak ),( Jae-joon Yim ),( Young Ae Kang ),( Jong-seok Kim ),( Hwa-jung Kim ),( Gyeong In Lee ),( Seung H 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Nontuberculous mycobacterial pulmonary disease (NTM PD) is increasing not only in South Korea but also worldwide. The seriousness of NTM PD is further raised because of the high relapse rate and low cure rate in its treatment. For the optimization of treatments for NTM PD patients, the first multicenter prospective cohort study named ‘NTM-KOREA’ involving eight hospitals and two institutes in South Korea and East Asia was initiated. One of these institutions, the Korean Tuberculosis Research Institute (KIT), plays the role of a strain bank through the Korea Mycobacterium Resource Center (KMRC) collecting and preserving clinical isolates from NTM-KOREA. Methods In South Korea, all NTM drug susceptibility tests have been performed at KIT except one tertiary hospital. When the patient's treatment is initiated, when the negative conversion fails after treatment, or when relapse/reinfection is observed, a drug susceptibility test is requested, and the clinical isolates are then stored in KMRC. Some strains are specifically registered in a mycobacterial extract library consisting of cell wall lipidomes and secreted proteomes. These strains are cultured on solid medium, and by observing the colonies, it is possible to confirm the presence of mixed infection and the rough or smooth colony surface morphology concerning NTM disease progression. Results From October 2018 to the present, a total of 10,510 NTM isolates of NTM-KOREA have been collected, of which 1,387 strains have been registered in the extract library additionally. Conclusion Despite various studies on NTM PD, the existence of biomarkers and bacterial factors applicable to diagnosis and treatment is still not satisfactory. In the future, genetic mutations will be searched through whole genome sequencing (WGS) analysis of treatment-failing/relapse strains, and related SNP will be searched and selected by comparing them with the control group. We will continue to investigate the characteristics of Korean NTM isolates extensively.
P-doping Effects of Tungsten Diselenide Transistors by Fluoropolymer Encapsulation
Hyeonji Lee,Seongin Hong,Hocheon Yoo 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
We show that the ambipolar charge transport of the WSe<sub>2</sub> transistor can be made into a unipolar p- type through Cytop fluoropolymer and thermal annealing. After doping, the charge transport can be controlled by thermal annealing temperature. The C-F bond is rearranged through thermal annealing, and the well-aligned dipole moment causes the Fermi level to be lowered, enabling the channel transport to be p-doped.
( Hyeonji Yang ),( Kwanyong Choi ),( Kyeong Jin Kim ),( Soo-yeon Park ),( Jin-young Jeon ),( Byung-gon Kim ),( Ji Yeon Kim ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.2
In this study, the effects of the immune stimulator Euglena gracilis (Euglena) in cyclophosphamide (CCP)-induced immunocompromised mice were assessed. The key component β-1,3-glucan (paramylon) constitutes 50% of E. gracilis. Mice were orally administered Euglena powder (250 and 500 mg/kg body weight (B.W.)) or β-glucan powder (250 mg/kg B.W.) for 19 days. In a preliminary immunology experiment, ICR mice were intraperitoneally injected with 80 mg of CCP/kg B.W. during the final 3 consecutive days. In the main experiment, BALB/c mice were treated with CCP for the final 5 days. To evaluate the enhancing effects of Euglena on the immune system, mouse B.W., the spleen index, natural killer (NK) cell activity and mRNA expression in splenocytes lungs and livers were determined. To detect cytokine and receptor expression, splenocytes were treated with 5 μg/ml concanavalin A or 1 μg/ml lipopolysaccharide. The B.W. and spleen index were significantly increased and NK cell activity was slightly enhanced in all the experimental groups compared to the CCP group. In splenocytes, the gene expression levels of tumor necrosis factor-α, interferon-γ, interleukin (IL)-10, IL-6, and IL-12 receptor were increased in the E. gracilis and β-glucan groups compared to the CCP group, but there was no significant difference. Treatment with 500mg of Euglena/ kg B.W. significantly upregulated dectin-1 mRNA expression in the lung and liver compared to the CCP group. These results suggest that Euglena may enhance the immune system by strengthening innate immunity through immunosuppression.