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( Hyeonji Kim ),( Jeong Seong Yang ),( Minji Kang ),( Ahn Nam Joung ),( Cha So Jeong ),( Nakwon Kwak ),( Jae-joon Yim ),( Young Ae Kang ),( Jong-seok Kim ),( Hwa-jung Kim ),( Gyeong In Lee ),( Seung H 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Nontuberculous mycobacterial pulmonary disease (NTM PD) is increasing not only in South Korea but also worldwide. The seriousness of NTM PD is further raised because of the high relapse rate and low cure rate in its treatment. For the optimization of treatments for NTM PD patients, the first multicenter prospective cohort study named ‘NTM-KOREA’ involving eight hospitals and two institutes in South Korea and East Asia was initiated. One of these institutions, the Korean Tuberculosis Research Institute (KIT), plays the role of a strain bank through the Korea Mycobacterium Resource Center (KMRC) collecting and preserving clinical isolates from NTM-KOREA. Methods In South Korea, all NTM drug susceptibility tests have been performed at KIT except one tertiary hospital. When the patient's treatment is initiated, when the negative conversion fails after treatment, or when relapse/reinfection is observed, a drug susceptibility test is requested, and the clinical isolates are then stored in KMRC. Some strains are specifically registered in a mycobacterial extract library consisting of cell wall lipidomes and secreted proteomes. These strains are cultured on solid medium, and by observing the colonies, it is possible to confirm the presence of mixed infection and the rough or smooth colony surface morphology concerning NTM disease progression. Results From October 2018 to the present, a total of 10,510 NTM isolates of NTM-KOREA have been collected, of which 1,387 strains have been registered in the extract library additionally. Conclusion Despite various studies on NTM PD, the existence of biomarkers and bacterial factors applicable to diagnosis and treatment is still not satisfactory. In the future, genetic mutations will be searched through whole genome sequencing (WGS) analysis of treatment-failing/relapse strains, and related SNP will be searched and selected by comparing them with the control group. We will continue to investigate the characteristics of Korean NTM isolates extensively.
Haloferula chungangensis sp. nov., isolated from marine sediment.
Kang, Hyeonji,Traiwan, Jitsopin,Weerawongwiwat, Veeraya,Jung, Min Young,Jeong, Ji Hoon,Myung, Soon Chul,Lee, Keun Chul,Lee, Jung-Sook,Kim, Wonyong Society for General Microbiology 2013 International journal of systematic and evolutiona Vol.63 No.1
<P>A Gram-stain-negative, non-spore-forming, non-motile, strictly aerobic, rod-shaped bacterial strain, designated CAU 1074(T), was isolated from marine sediment and its taxonomic position was investigated using a polyphasic approach. Strain CAU 1074(T) grew optimally at 30 C and pH 6.5. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CAU 1074(T) formed a distinct lineage within the genus Haloferula and was most closely related to Haloferula harenae KCTC 22198(T) (96.0% similarity). Strain CAU 1074(T) contained MK-9 as the major isoprenoid quinone, and iso-C(14:0,) C(16:1)ω9c and C(16:0) as the major fatty acids. The cell wall peptidoglycan contained meso-diaminopimelic acid. The major whole-cell sugars were glucose, xylose, mannose and ribose. The polar lipids were composed of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, aminoglycolipid and two unidentified phospholipids. The DNA G+C content of the strain was 64.0 mol%. On the basis of phenotypic and chemotaxonomic data, and phylogenetic inference, strain CAU 1074(T) should be classified as a member of a novel species in the genus Haloferula, for which the name Haloferula chungangensis sp. nov. is proposed; the type strain is CAU 1074(T) (= KCTC 23578(T) = CCUG 61920(T)). An emended description of the genus Haloferula is also provided.</P>
Algoriphagus chungangensis sp. nov., isolated from a tidal flat sediment.
Kang, Hyeonji,Weerawongwiwat, Veeraya,Jung, Min Young,Myung, Soon Chul,Kim, Wonyong Society for General Microbiology 2013 International journal of systematic and evolutiona Vol.63 No.2
<P>A Gram-stain-negative, non-spore-forming, non-motile, strictly aerobic, rod-shaped bacterial strain, designated CAU 1002(T), was isolated from a tidal flat sediment and its taxonomic position was investigated using a polyphasic approach. Strain CAU 1002(T) grew optimally at 30 C and pH 7.5. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CAU 1002(T) formed a distinct lineage within the genus Algoriphagus and was most closely related to Algoriphagus lutimaris KCTC 22630(T) and Algoriphagus halophilus KCTC 12051(T) (97.75 and 97.74?% 16S rRNA gene sequence similarity, respectively). The strain contained MK-7 as the major isoprenoid quinone and iso-C(15?:?0) and C(16?:?1)ω7c and/or iso-C(15?:?0) 2-OH (summed feature 3) as the major fatty acids. The cell-wall peptidoglycan of strain CAU 1002(T) contained meso-diaminopimelic acids. The major whole-cell sugars were glucose, arabinose, sucrose, and ribose. The polar lipid profile was composed of phosphatidylethanolamine, five unidentified aminolipids, one unidentified aminophospholipid, one unidentified phospholipid, one unidentified aminoglycolipid, one unidentified glycolipid and twelve unidentified lipids. The DNA G+C content of strain CAU 1002(T) was 38.0 mol%. On the basis of phylogenetic inference, phenotypic, chemotaxonomic and genotypic data, strain CAU 1002(T) should be classified into the genus Algoriphagus as a member of a novel species, for which the name Algoriphagus chungangensis sp. nov. is proposed. The type strain is CAU 1002(T) (?=?KCTC 23759(T)?=?CCUG 61890(T)). The description of the genus Algoriphagus is emended.</P>
( Hyeonji Kim ),( Jeong Seong Yang ),( Minji Kang ),( Seung Heon Lee ),( Nakwon Kwak ),( Jae-joon Yim ),( Young Ae Kang ),( Hong Jo Choi ),( Jong-seok Kim ),( Hwa-jung Kim ),( Jake Whang ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0
Background Nontuberculous mycobacteria pulmonary disease (NTM PD) is rapidly increasing worldwide, including in south Korea. As part of the trend to find biomarkers for NTM PD, a multicenter prospective observational cohort study named ‘NTM-KOREA’ involving seven hospitals and two institutes in south Korea was initiated. In order to discover meaningful bacterial factors from preserved strains, the central role of Korean Mycobacterium Resource Center (KMRC) in KIT has been extended from strain preservation to research since 2018. Methods In South Korea, all NTM drug susceptibility tests have been performed at KIT except one tertiary hospital. When the patient's treatment is initiated, when the negative conversion fails after treatment, or when relapse/reinfection is observed, a drug susceptibility test is requested, and the clinical isolates are then stored in KMRC. Some strains are specifically registered in a mycobacterial extract library consisting of cell wall lipidomes and secreted proteomes. These strains are cultured on solid medium, and by observing the colonies, it is possible to confirm the presence of mixed infection and the rough or smooth colony surface morphology concerning NTM disease progression. Results From October 2018 to the present, a total of 7,000 NTM isolates of NTM-KOREA have been collected, of which 350 strains have been registered in the extract library additionally. Through a recent joint study with Seoul National University Hospital, we found that the treatment rate of clofazimine as an NTM treatment is related to minimum inhibitory concentration of each clinical isolate. Conclusions Despite various studies on NTM PD, the existence of biomarkers and bacterial factors applicable to diagnosis and treatment is still not satisfactory. When considering as an infectious disease, the causative agent is also very important as well as biomarkers. Accordingly, we will continue to investigate the characteristics of Korean NTM isolates extensively and to select prominent bacterial factors.
강현지 ( Hyeonji Kang ),고란희 ( Ranhee Ko ),이소연 ( Soyeon Lee ),강신혜 ( Sinhye Kang ),권상철 ( Sangcheol Kwon ),조정원 ( Jungwon Cho ) 한국컴퓨터교육학회 2017 한국컴퓨터교육학회 학술발표대회논문집 Vol.21 No.2
전 세계적으로 과학, 기술, 공학, 예술, 수학이 융합된 STEAM교육이 강조되고 있는 가운데 우리나라도 STEAM교육의 효율성을 높여줄 수 있는 콘텐츠에 대한 관심과 적용이 늘어가고 있다. 본 논문은 "공업입지론“ 내용을 바탕으로 개발된 에듀테인먼트 콘텐츠의 교육적 효과를 향상시키고자 분석 피드백 기능을 강화 하였다. 강화된 분석 피드백 기능은 첫째, 학습자가 공장 선택 조건과 각 공장의 장점 확인, 둘째, 상품의 운송조건 제시, 셋째, 학습 결과에 대한 분석이다. 이에 학습자가 콘텐츠를 통해 학습하는 과정에서 분석 피드백을 제공 받아 학습에 대한 이해도 등 교육적 효과를 향상 시키고자 한다.
피지컬 컴퓨팅을 적용한 가상현실 기반 학교안전교육 어플리케이션
강현지(HyeonJi Kang),강소희(Sohee Kang),고란희(RanHee Ko),이경희(KyungHee Lee),조정원(JungWon Cho) 한국컴퓨터교육학회 2018 한국컴퓨터교육학회 학술발표대회논문집 Vol.22 No.2
학교에서 자연재난으로 인해 학생들의 인명피해가 발생하는 사례가 빈번하게 발생하고 있다. 이에 학생들에게 발생하는 각 재난상황들에 대하여 학생들 스스로 재난상황에 대응할 수 있는 안전능력배양 중요성이 부각되어지고 학교의 안전교육을 강화해야 한다는 지적이 제기되고 있다. 하지만, 현재 학교에서 학생들에게 실시하는 안전교육은 주로 강의식이고, 안전교육을 위한 시설과 장비, 담당하는 인력의 전문성과 안전교육의 체계가 부족하다는 문제점들이 제기되고 있다. 본 논문은 가상현실과 피지컬컴퓨팅 기반의 안전교육 프로그램을 통해 학생들은 동작인식컨트롤러를 이용하여 가상현실 속 재난상황을 체험하고 행동요령과 사용법 등을 학습하여 위기대응능력을 배양 하고자 한다.