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Hyein Jung,Hyein Shim,Jiwon Jeong,Jungeun Lee,Sangah Shin 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Alcohol abuse is one of the health risk factors worldwide. It is known that the presence of alcoholic liver disease (ALD) has the greatest correlation with alcohol consumption. A cross-sectional analysis was conducted to investigate the alcohol consumption and nutritional status of ALD patients among Korean adults. A total of 156,790 subjects, 2,226 (1,921 males, 305 females) in the ALD group, and 154,564 (50,593 males, 103,971 females) in the normal group were included in the final analysis. Alcohol and nutrient intakes were assessed using a validated food frequency questionnaire. The ALD was defined as heavy alcohol consumption (male >40 g/day, female >20g/day) and elevated level in the liver function test. It was confirmed that ALD patients exhibited a higher total alcohol intake, the proportion of heavy drinkers, and increased total energy intake compared to the normal group, and tended to lack micronutrient intake through dairy and plant-based foods. Based on the results of the study, it is recommended to reduce the amount and frequency of alcohol consumption and to consume sufficient vitamins and minerals through dairy and plant-based foods for patients with ALD.
NF‑κB p65 represses microRNA‑124 transcription in diffuse large B‑cell lymphoma
Hyein Shim,Jehyun Nam,Sang‑Woo Kim 한국유전학회 2020 Genes & Genomics Vol.42 No.5
Background Previous studies have shown that the copy number of microRNA (miR)-124 is decreased in diffuse large B cell lymphoma (DLBCL), and that miR-124 is a tumor suppressor by targeting NF-κB p65 in B-cell lymphoma. In turn, miR124 expression is regulated by transcription factors such as HNF4α, ETS2, and p53. However, whether and how miR-124 transcription is modulated by NF-κB transcription factors remain unknown in DLBCL. Objective To investigate whether the activation of NF-κB signaling could inhibit the expression of miR-124, possibly contributing to the pathogenesis of DLBCL. Methods Potential transcription factors regulating miR-124 transcription were predicted using the Transfac software. The cellular effects of NF-κB p65 on miR-124 were examined by MTS assay, Western blot assay, qPCR, and chromatin immunoprecipitation (ChIP) assays using DLBCL cell lines. Results Inhibition of NF-κB signals using Bay11-7085 increased miR-124 expression whereas exposure to TNF-α decreased it. Ectopic expression of p65 suppressed miR-124 expression, suggesting that p65 may be a transcriptional repressor of miRNA-124. Pharmacological analyses showed that phosphorylated/activated p65 downregulates miR-124 via two signaling pathways: (1) TAK1/IKKα-IKKβ/IκBα and (2) MAPK/p65. Moreover, ChIP assay demonstrated that p65 directly regulates miR-124 by binding to the NF-κB consensus sequence in its promoter region. Finally, we also confirmed that stable ectopic expression of miR-124 suppresses cell proliferation and survival. Conclusion Taken together, our study uncovered a mechanism by which active NF-κB signaling disrupts the function of miR-124 as a tumor suppressor in DLBCL.
심혜인(Hyein Shim),류두진(Doojin Ryu) 한국증권학회 2017 한국증권학회지 Vol.46 No.1
본 논문은 우리나라의 가계부채와 민간소비의 현황을 파악하고, 국내 가계대출의 증가가 소비에 미치는 영향을 살펴본다. 본 연구에서는, 우리나라 16개 시도의 월별 패널자료를 이용하였으며, 생애주기-항상소득 가설에 근거하여 고정효과 분석 및 자기회귀시차(ARDL) 모형을 사용한 장·단기효과 분석을 수행하여 심도 있는 계량분석접근을 시도하였다. 실증분석 결과, 가계부채는 소비와 통계적으로 유의한 음(-)의 상관관계가 있는 것으로 나타나, 분석기간인 2008년 1월부터 2014년 12월까지의 기간에 대하여 가계부채의 증가는 민간소비를 감소시킨 것으로 나타났다. 실증분석 결과를 토대로, 본 연구는 다음과 같은 정책적 시사점을 제안한다. 향후 가계부채 문제를 해결하기 위해서는 통화정책과의 공조 등 포괄적인 금융정책의 수립이 필요하며, 특히 거시건전성 감독을 위한 정책수단이나 운용방식 등에 대해서는 보다 신중한 접근이 요구된다. 금융기관 간 또는 대출상품 간 풍선효과에 대한 고려를 포함한 부채총량 규제에 힘써야 할 것으로 보이며, 동시에 채무상환능력에 대한 감독을 강화 및 세분화하고 건전한 금융경제상황을 유지하기 위한 정책적인 노력이 필요할 것이다. This study examines the effects of household debt on consumption based on the life cycle-permanent income hypothesis. We conduct the autoregressive distributed-lag (ARDL) bounds test and panel analysis on the Korean regional panel data. We find that household debt has a statistically significant negative effect on consumption. The empirical results suggest that in order to solve household debt problems, the financial authorities should regulate the total debt amount, devise and implement macroprudential regulation, and strengthen monitoring on borrowers` ability to repay their debts.
Hwang, Hyein,Lim, Dongwook,Kim, Taewoo,Lee, Duwon,Shim, Sang Eun,Baeck, Sung-Hyeon American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.5
<P>Oxygen evolution reaction for alkaline water electrolysis was studied using various mixed metal oxide catalysts. Mixed metal oxide electrodes consisting of RuO2, IrO2, and Ta2O5 with various ratios on a titanium substrate were prepared by spray thermal decomposition. The crystallinity of the synthesized catalyst was investigated via X-ray diffraction, and the oxidation state of each component was determined using X-ray photoelectron spectroscopy (XPS). Surface morphology was investigated by scanning electron microscopy, and the roughness factor was determined by cyclic voltammetry (CV) in 1 M H2SO4. Electo-catalytic activity for oxygen evolution reaction was measured by cyclic voltammetry (CV) in 1 M KOH at room temperature, and it was found to be strongly dependent on composition of catalyst. Among all electrodes tested, catalyst with a composition of Ru:Ir:Ta= 1:2:2.5 exhibited the highest current density of 100 mA cm(-2) at 1.67 V, corresponding to an overpotential of 0.44 V.</P>