미중패권경쟁에서 아세안을 통한 한국의 경제개발 전략에 관한 연구

유근환(Keun Hwan Yoo),양혜원(Hye Won Yang) 대구과학대학교 국방안보연구소 2023 사회융합연구 Vol.7 No.6

미국과 중국의 무역 경쟁은 관련 동맹국에게도 영향을 미칠 정도로 치열하다. 반도체는 첨단산업의 쌀이라고 불릴 정도로 최첨단 기술에서 중요한 역할을 하며 자동차, 휴대폰, 디스플레이 등에 반드시 들어가기 때문에 산업에서도 반드시 안전한 공급망이 확보될 필요가 있다. 본 연구는 미중패권경쟁 속에서 한국의 국익을 높이기 위하여 아세안을 활용한 경제외교를 강화하는 것이 필요하다는 것에 주목하여 연구를 하였다. 아세안 국가들은 헤징(Hedging)전략을 통하여 실리를 추구한다. 우크라이나 전쟁이 계속되고 이스라엘과 하마스가 이끄는 팔레스타인 급진 무장 단체가 전쟁을 치르면서 국제적으로 안보 위기가 나타나고 아세안 국가들은 전략적으로 협력하는 것이 필요하다는 데 의견을 모으고 있다. 미국은 아시아로의 회귀((Pivot to Asia)를 강조하면서 관계를 개선하려는 노력을 꾸준하게 하였다. 중국은 중국은 동남아시아 지역에서 중국의 영향력을 확보하는 것이 필요하다고 보고 아세안에 적극 참여하고 있다. 한국이 전략적으로 이러한 어려운 상황을 타개하기 위해서는 아세안 국가들과의 협력을 강화하고 경제외교를 추진하여 실리적인 이익을 확보하여야 한다. 한국은 지리적으로 아세안 국가들과 가까운 편에 속하기 때문에 수출 다변화와 수입 다변화의 측면에서도 아세안을 통하여 협력하는 것이 필요하다. 한국은 아세안과의 경제외교를 강화하여 향후 아세안 국가들이 빠르게 경제 성장을 하였을 때 상생하는 관계가 되도록 전략적인 노력을 하여야 한다. 한국은 베트남, 라오스, 태국, 캄보디아, 미얀마, 필리핀, 브루나이, 말레이시아, 싱가포르, 인도네시아와 협력하고 경제외교를 강화하여 한국의 국익을 확보하여야 한다. The trade competition between the United States and China is fierce enough to affect relevant allies. Semiconductors play an important role in cutting-edge technology, so much so that they are called the rice of the high-tech industry. Since they are essential for automobiles, mobile phones, displays, etc., there is a need to ensure a safe supply chain in the industry. This study focused on the need to strengthen economic diplomacy using ASEAN to enhance Korea's national interests amid the US-China hegemony competition. ASEAN countries pursue practical benefits through hedging strategies. As the war in Ukraine continues and Israel and the Palestinian radical armed group led by Hamas are at war, an international security crisis is emerging, and ASEAN countries are converging on the need for strategic cooperation. The United States has consistently made efforts to improve relations, emphasizing a pivot to Asia. China believes that it is necessary to secure Chinese influence in the Southeast Asian region and is actively participating in ASEAN. Korea In order to strategically overcome this difficult situation, we must strengthen cooperation with ASEAN countries and promote economic diplomacy to secure practical benefits. Korea should strengthen economic diplomacy with ASEAN and make strategic efforts to create a win-win relationship when ASEAN countries achieve rapid economic growth in the future. Korea should secure its national interests by cooperating with Vietnam, Laos, Thailand, Cambodia, Myanmar, the Philippines, Brunei, Malaysia, Singapore, and Indonesia and strengthening economic diplomacy.

소아 알레르기비염의 경제적 부담 평가를 위한 다기관 조사

공도연 ( Do Youn Kong ),김경원 ( Kyung Won Kim ),김우경 ( Woo Kyung Kim ),민택기 ( Taek Ki Min ),박용민 ( Yong Mean Park ),안재억 ( Jae Ouk Ahn ),양현종 ( Hyeon Jong Yang ),염혜영 ( Hye Yung Yum ),윤혜선 ( Hae Sun Yoon ),전유훈 ( 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.2

목적: 알레르기비염의 유병률은 전 세계적으로 급격히 증가하고 있으며, 그에 따른 경제적 부담도 증가하고 있다. 그러나, 소아 알레르기 질환이 미치는 경제적 부담에 관한 국내 연구는 제한적이어서 소아 알레르기비염이 환자와 그 가족에게 미치는 경제적 부담을 산출하고자 본 연구를 진행하였다. 방법: 2008년 7월 1일부터 9월 31일까지 서울시 6개 2-3차 의료기관을 방문한 18세 이하 소아 알레르기비염 환자 및 보호자를 대상으로 설문 조사를 진행하였다. 설문을 통해 직접 의료비 (병·의원 진료비, 및 약제비 한방 진료비 및 약제비, 보완/대체요법비), 직접비의료비 (교통비, 환경개선비), 그리고 간접비용 (월 평균 노동 손실)을 조사하였고 그 결과를 질환의 중증도 및 유병 기간에 따라 분석하여 그 차이를 비교하였다. 결과: 모집된 262명의 대상 중 174명(66.4%)이 남자였고, 평균 연령은 6.54세였다. 대상군의 연간 평균 직접 의료비는 177만 원이었고 직접비 의료비는 57만 원이었다. 비록 통계학적 유의성은 없었지만, 알레르기비염의 중증도가 증가할수록 직접 의료비가 증가하는 경향을 보였고, (P=0.053) 유병 기간 또한 직접 의료비의 증가와 유의한 양의 상관 관계를 보였다. (R=0.195, P=0.002) 대상 환자 보호자의 약 17%가 아이의 알레르기비염으로 인해 직장에 결근 또는 조퇴를 경험한 것으로 조사되어 사회적 간접비용을 미루어 생각할 수 있었다. 결론: 알레르기비염이 미치는 경제적 부담은 질환의 중증도가 심할수록, 그리고 유병 기간이 길수록 증가하며, 이는 특히 한방 진료 및 치료비와 보완/대체요법비의 증가에 기인한 것으로 조사되었다. 따라서 알레르기비염으로 인한 경제적 부담을 줄이기 위해서는 환자와 보호자를 대상으로 근거 중심의 치료를 할 수 있도록 지속적이고 체계적인 교육이 필요할 것으로 사료된다. Purpose: The prevalence of allergic rhinitis is rapidly increasing and results in relatively high socio-economic burden on their family and community. However, studies on the economic burden of pediatric allergic rhinitis in Korea are limited. Therefore, we conducted this study to investigate the impact of pediatric allergic rhinitis on economic burden. Methods: Two hundred sixty two children with allergic rhinitis were enrolled in 6 secondary or tertiary medical centers in Seoul from July to September, 2008. We collected data of the economic burden of allergic rhinitis (direct medical costs, direct nonmedical costs, and indirect costs) by face to face questionnaire survey. We compared the economic burden according to the severity and the duration of allergic rhinitis. Results: The mean age of subjects was 6.54 years, and male were 174 (66.4%). Direct medical costs (10,000 Korean Won/yr) were 177.75, and direct nonmedical costs were 57.92. Although, there was no statistical significance, direct medical costs showed increasing trends in severe allergic rhinitis. (P=0.053) In addition, direct medical costs were positively correlated with duration of allergic rhinitis.( R=0.195, P=0.002). About 17% of the parents who care the allergic rhinitis children experienced the work absence due to their child s illness. Conclusion: The economic burdens of allergic rhinitis were positively correlated with the severity and duration of illness. Particularly costs for alternative medicine including oriental medicine` were related with severity and duration allergic rhinitis. Therefore, special efforts for education with evidence based treatment strategy are necessary to decrease the economic burden of allergic rhinitis.

우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계

강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.

Differential Regulation of ErbB2 Expression by cAMP-Dependent Protein Kinase in Tamoxifen-Resistant Breast Cancer Cells

Yang, Ji-Won,Kim, Mi-Ra,kim, Hyung-Gyoon,Kim, Sang-Kyum,Jeong, Hye-Gwang,Kang, Keon-Wook 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3

Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer patients, and Her-2/ErbB2 expression is associated with decreased sensitivity to TAM. We previously reported that cAMP-dependent protein kinase (PKA)-mediated activator protein-2 (AP-2) activation was responsible for the expression of Her-2/ErbB2 in p53-inactivated mammary epithelial cells (Yang et al., 2006). In the present study, we tested the hypothesis that PKA plays a role in the expression of ErbB2 in tamoxifen-resistant breast cancer cells. Treatment with H-89, a specific PKA inhibitor, suppressed 4-hydroxytamoxifen-induced ErbB2 expression in control MCF-7 cells. In contrast, PKA inhibition by H-89 or cAMP-dependent protein kinase inhibitor $I{\gamma}$ overexpression increased the expression levels of ErbB2 in TAM-resistant MCF-7 (TAMR-MCF-7) cells. Transcriptional regulation of the erbB2 gene depends on two transcription factors, AP-2 and polyomavirus enhancer activator3 (PEA3). H-89 decreased nuclear or total levels of PEA3 in TAMR-MCF-7 cells. Chromatin immunoprecipitation assay results revealed that H-89 treatment reduced PEA3 binding to the proximal Ets binding site of the erbB2 gene promoter. Reporter gene analyses using human erbB2 gene promoter supported the critical role of PEA3 in the overexpression of ErbB2 in TAMR-MCF-7 cells treated with H-89. This deregulated PKA signaling cascades required for the ErbB2 expression may be important for the differential response of TAM-resistant breast cancer cells to EGF/ErbB2 stimuli.

Effect of gonadotropin-releasing hormone agonist treatment on near final height in girls with central precocious puberty and early puberty

Yang Eun Hye,Jo Ha Young,Park Su Jeong,Yoo Hye Won,Choi Soo-Han,Kim Hye-Young,Park Kyung Hee,Kim Young Mi,Kwak Min Jung 대한소아내분비학회 2023 Apem Vol.28 No.1

Purpose: The aim of this study was to examine whether gonadotropin-releasing hormone (GnRH) agonist treatment is effective in preserving final height in patients with central precocious puberty (CPP) or early puberty (EP).Methods: The medical records of 40 patients with CPP and 206 patients with EP who completed GnRH agonist treatment following diagnosis were analyzed retrospectively. Height and height standard deviation (height SDS) scores based on bone age (BA) were measured and calculated at baseline, after treatment completion, and at final follow-up to compare changes within and between groups. Predicted adult height (PAH) was estimated by the height corresponding to height SDS for BA in girls at 18 years 11 months of age based on the growth chart.Results: PAH at baseline did not differ significantly between the CPP group (153.67±4.95) and the EP group (154.77±3.72). In the CPP group, PAH significantly increased at treatment completion (156.01±4.61) and at final follow-up (158.52±6.04) compared to baseline. In the EP group, PAH significantly increased at treatment completion (157.7±3.60) and at final follow-up (159.31±4.26) compared to baseline. The increase in PAH at all timepoints compared to baseline did not significantly differ between the CPP and EP groups.Conclusion: Both CPP and EP groups had significantly greater PAH after treatment, with no difference in the amount of increase between groups. These results show that GnRH agonist treatment can help increase final height even in patients diagnosed with EP after the age of 8 years.

Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (<i>Dioscorea opposita</i>)

Yang, Min Hye,Chin, Young-Won,Yoon, Kee Dong,Kim, Jinwoong Informa UK Ltd. 2014 Journal of enzyme inhibition and medicinal chemist Vol.29 No.1

<P>Twenty-three phenolic compounds were isolated from <I>Dioscorea opposita</I> by bioactivity-guided method and their inhibitory effect against pancreatic lipase was evaluated. A total of 15 isolates reduced lipase activity at IC<SUB>50</SUB> values of less than 50 µM and 3,3′,5-trihydroxy-2′-methoxybibenzyl showed the highest inhibition with an IC<SUB>50</SUB> value of 8.8 µM. This study is a first to reveal the pancreatic lipase inhibitory activity by both <I>D. opposita</I> and its isolated compounds.</P>

Antioxidant Effect of Fucoidan from Miyeokgui, Marine Alga in Zebrafish Model

( Hye Won Yang ),( Jae Young Oh ),( Eun A Kim ),( Seo Young Kim ),( Jae Il Kim ),( You Jin Jeon ) 한국키틴키토산학회 2015 한국키틴키토산학회지 Vol.20 No.2

Fucoidan, extracted from Undaria pinnatifida (U. pinnatifida), has been extensively studied because of its wide biological activities. However, antioxidative activities of fucoidan extracted from Miyeokgui have not been yet examined in the zebrafish model. Therefore the present study was designed to evaluate in vitro and in vivo studies on antioxidative activities of fucoidan extracted from Miyeokgui by using 0.1 M hydrochloric acid (MAF). We found that MAF reduced the production of intracellular reactive oxygen species (ROS) in the 2, 2’-azobis dihydrochloride (AAPH) induced oxidative stress in Vero cells. Furthermore, the protective effect of MAF was examined against AAPH-induced oxidative stress in zebrafish model. MAF possesses a protective effect against AAPH-induced toxicity in zebrafish embryos. In addition, MAF significantly reduced AAPH-induced ROS production and lipid peroxidation in zebrafish embryos. These results proved that MAF has antioxidant activities both in vitro Vero cells and in vivo zebrafish model.

Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches

( Hye Jin Cha ),( Kwang Wook Lee ),( Min Ji Song ),( Yang Jin Hyeon ),( Ji Young Hwang ),( Choon Gon Jang ),( Joon Ik Ahn ),( Seol Hee Jeon ),( Hyun Uk Kim ),( Young Hoon Kim ),( Won Keun Seong ),( Ho 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4

Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally under street names such as “Spice” and “Smoke”. Many countries including Korea have started to schedule some of the JWH series compounds as controlled substances, but there are a number of JWH series chemicals that remain uncontrolled by law. In this study, three synthetic CBs with different binding affinities to the CB1 receptor (JWH-073, 081, and 210) and Δ9-tetrahydrocannabinol (Δ9-THC) were evaluated for their potential for psychological dependence. The conditioned place preference test (unbiased method) and self-administration test (fixed ratio of 1) using rodents were conducted. Kivalues of the three synthetic cannabinoids were calculated as supplementary data using a receptor binding assay and overexpressed CB1 protein membranes to compare dependence potential with CB1 receptor binding affinity. All mice administered JWH-073, 081, or 210 showed significantly increased time spent at unpreferred space in a dose-dependence manner in the conditioned place preference test. In contrast, all tested substances except Δ9-THC showed aversion phenomenon at high doses in the conditioned place preference test. The order of affinity to the CB1 receptor in the receptor binding assay was JWH-210 > JWH-081 >> JWH-073, which was in agreement with the results from the conditioned place preference test. However, no change in self-administration was observed. These fi ndings suggest the possibility to predict dependence potential of synthetic CBs through a receptor binding assay at the screening level.

Bioactive Metabolites from the Fruits of Psoralea corylifolia.

Won, Tae Hyung,Song, Inn-Hye,Kim, Kuk-Hwa,Yang, Woo-Young,Lee, Sang Kook,Oh, Dong-Chan,Oh, Won-Keun,Oh, Ki-Bong,Shin, Jongheon American Society of Pharmacognosy ; American Chemi 2015 Journal of natural products Vol.78 No.4

<P>Twenty-four metabolites, including seven new compounds (1-7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1-6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15).</P>

Estimating cancer risks induced by CT screening for Korean population.

Hye Jeong Yang,Won-Seok Yang 대한방사선방어학회 2016 대한방사선방어학회 학술발표회 논문요약집 Vol.2016 No.04