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( Gi Hyun Kim ),( Jung Wha Chung ),( Jong Ho Lee ),( Kyeong Sam Ok ),( Eun Sun Jang ),( Jaihwan Kim ),( Cheol Min Shin ),( Young Soo Park ),( Jin Hyeok Hwang ),( Sook Hyang Jeong ),( Nayoung Kim ),( D 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.4
Background/Aims: Vitamin E improves the biochemical profiles and liver histology in nonalcoholic steatohepatitis, but the role of vitamin E is not clearly defined in the management of nonalcoholic fatty liver disease (NAFLD) which includes both simple steatosis and steatohepatitis. Co-morbid metabolic syndrome increases the probability of steatohepatitis in NAFLD. In this study, we aimed to determine the short-term effects of vitamin E and off-treatment durability of response in a propensity-score matched cohort of NAFLD patients with metabolic syndrome. Methods: A retrospective cohort was constructed by retrieving 526 consecutive NAFLD patients from the electronic medical record data warehouse of a tertiary referral hospital in South Korea. Among them, 335 patients (63.7%) had metabolic syndrome and were eligible for vitamin E therapy. In order to assess the effect of vitamin E, propensity score matching was used by matching covariates between control patients (n=250) and patients who received vitamin E (n=85). Results: The PS-matched vitamin E group (n=58) and control group (n=58) exhibited similar baseline metabolic profiles. After 6 months of vitamin E therapy, the mean ALT levels decreased significantly compared to PS-matched control (P<0.01). The changes in metabolic profiles (body weight, lipid and glucose levels) did not differ between control and vitamin E groups during the study period. Conclusions: Short-term vitamin E treatment significantly reduces ALT levels in NAFLD patients with metabolic syndrome, but metabolic profiles are not affected by vitamin E. (Clin Mol Hepatol 2015;21:379-386)
Son, Jin Ho,Kim, Da In,Park, Ju Hyang,Seo, Hojun,Hong, Sang Gi,Choi, Ji Hyun,Kim, Jongbok,Moon, Geon Dae,Hyun, Dong Choon Elsevier 2019 Polymer Vol.167 No.-
<P><B>Abstract</B></P> <P>We study thermal annealing-driven surface sealing of polymer hollow particles with a different surface property. Use of phase separation between polystyrene (PS) solid particles incorporated with sulfonate (SO<SUB>3</SUB> <SUP>-</SUP>) group and decane allows their transformation into hollow particles with an opening on the surface. Control of the phase separation enables us to tune the structure (outer and inner diameters, and size of the opening) of the hollow particles. While thermally annealed at a temperature above <I>T</I> <SUB> <I>g</I> </SUB> of the polymer, structural change of the hollow particles is experimentally observed and theoretically analyzed. The results demonstrate that the change in the surface property of the hollow particles due to the incorporation of the SO<SUB>3</SUB> <SUP>-</SUP> group can have a direct impact on their sealing behavior and surface-sealed structure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sealing behavior of polymer hollow particles with a surface opening was studied. </LI> <LI> The sealing behavior was strongly dependent on the surface property of the particle. </LI> <LI> The surface property affected the structure of the surface-sealed particles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
IgA 신병증을 동반한 쇼그렌증후군과 피부근염의 중복증후군
신진향 ( Jin Hyang Shin ),박근우 ( Keun Woo Park ),조자경 ( Ja Kyoung Cho ),한석재 ( Seok Jae Han ),정승혜 ( Seung Hie Chung ),김채기 ( Chae Gi Kim ),최정윤 ( Jung Yoon Choe ),김상경 ( Sang Gyung Kim ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.4
An overlap syndrome is used to describe patients who have two or more well-defined connective tissue diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis. Their coexistence is defined clinically and often by specific serologic tests. We report a case of dermatomyositis associated with IgA nephropathy that had overlapping features of Sjogren`s syndrome. This dermatomyositis and Sjogren`s overlap is a rarely reported overlap syndrome worldwide.
A clinical study on the trocar-guided mesh repair system for pelvic organ prolapse surgery
( Seul Gi Bak ),( Jeong Beom Moon ),( Sang Ki Hong ),( Kyoung Jin Kim ),( Kyoung A Kim ),( Ju Hyang Lee ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.3
Objective To evaluate the complication and recurrence rates in patients undergoing trocar-guided mesh implant for pelvic organ prolapse (POP) treatment. Methods A retrospective study was performed based on the medical records of patients who had undergone mesh implant by one surgeon from May 2006 to August 2013 at the Presbyterian Medical Center in Korea. We evaluated perioperative complications such as bladder injury, mesh exposure, urinary symptoms, infections, and chronic pelvic pain. Recurrence was defined as a POP-quantification system stage ≥II or any symptomatic prolapse. Results Sixty-seven patients were evaluated, and the mean age of patients was 65.4±7.2 years. Stage ≥III POP-quantification Ba was noted in 61 patients (91%). Intraoperative complications included three cases of bladder injury (4.5%). The mean follow-up period was 44.1±7.9 months. Postoperative complications occurred in seven women (10.5%): four cases of urinary symptoms (6%), two cases of infections (3%), and one case of chronic pelvic pain (1.5%). Mesh exposure did not occur (0%). Prolapse recurrence was reported in five patients (7.5%). Conclusion Based on our operational result, the trocar-guided mesh implant seems to provide safe and effective outcomes.
Oh, Gi-Su,Kim, Hyung-Jin,Choi, Jae-Hyuck,Shen, AiHua,Choe, Seong-Kyu,Karna, Anzani,Lee, Seung Hoon,Jo, Hyang-Jeong,Yang, Sei-Hoon,Kwak, Tae Hwan,Lee, Chul-Ho,Park, Raekil,So, Hong-Seob Springer-Verlag 2014 Kidney international Vol.85 No.3
Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells and may induce adverse effects, such as ototoxicity, nephrotoxicity, and neuropathy. Various mechanisms, such as DNA adduct formation, mitochondrial dysfunction, oxidative stress, and inflammatory responses, are critically involved in cisplatin-induced adverse effects. As NAD<SUP>+</SUP> is a cofactor for various enzymes associated with cellular homeostasis, we studied the effects of increased NAD<SUP>+</SUP> levels by means of NAD(P)H:quinone oxidoreductase 1 (NQO1) activation using a known pharmacological activator (β-lapachone) in wild-type and NQO1<SUP>−/−</SUP> mice on cisplatin-induced renal dysfunction in vivo. The intracellular NAD<SUP>+</SUP>/NADH ratio in renal tissues was significantly increased in wild-type mice co-treated with cisplatin and β-lapachone compared with the ratio in mice treated with cisplatin alone. Inflammatory cytokines and biochemical markers for renal damage were significantly attenuated by β-lapachone co-treatment compared with those in the cisplatin alone group. Notably, the protective effects of β-lapachone in wild-type mice were completely abrogated in NQO1<SUP>−/−</SUP> mice. Moreover, β-lapachone enhanced the tumoricidal action of cisplatin in a xenograft tumor model. Thus, intracellular regulation of NAD<SUP>+</SUP> levels through NQO1 activation might be a promising therapeutic target for the protection of cisplatin-induced acute kidney injury.
Cho, Tae Jin,Kim, Nam Hee,Hong, Yoon Ji,Park, ByoungIl,Kim, Hee Sung,Lee, Hyang Gi,Song, Min Kyung,Rhee, Min Suk Elsevier 2017 Food Control Vol.79 No.-
<P>Although the Fukushima nuclear accident (FNA) in 2011 led to strong public anxiety about radioactive contamination of foods, the most appropriate way to communicate this risk has been poorly researched. We sought to design, develop, evaluate, and optimize an effective risk communication (RC) tool for food consumers after the FNA. To design this tool, a classical systematic qualitative research framework that consisted of formative evaluation, development of a pilot RC tool, and outcome evaluation was applied. The formative evaluation consisted of focus group interview (FGI) with food consumers: its aim was to identify the major risk messages. Due to the low knowledge base of the food consumers and the absence of a credible existing information source, a pilot RC tool was developed. An educational book was selected as the most effective RC vehicle. The FGI results were reflected in the content of the book, which was presented in a 'frequently asked questions and answers' format. To ensure ready comprehensibility of the book, the scientific words were paraphrased and visual aids were employed. To ensure credibility of the RC, evidence supporting its statements was provided and it was made clear that the RC was a collaborative message from multiple risk communicators (consumer organizations, government bodies, and academia). Outcome evaluation with a consumer survey showed that the RC tool effectively increased the knowledge base of food consumers and relieved their anxieties. This study suggests that in the event of another nuclear accident, food safety RCs should meet the following key requirements: 1) the RC should send a clear message that reassures food consumers that the fatal risk is well controlled, which will reduce public fear and outrage; 2) the RC should improve the knowledge base of food consumers about food safety by providing appropriate education; and 3) the RC should be produced via multi-institutional cooperation so that the credibility of risk communicators is rebuilt. Our results may help the planning of an effective radiological RC strategy for food consumers, thereby preventing misunderstandings and relieving food consumers of unnecessarily severe anxiety. (C) 2017 Elsevier Ltd. All rights reserved.</P>