Specific Mutations in APC, with Prognostic Implications in Metastatic Colorectal Cancer

Huan Peng,Jun Ying,Jia Zang,Hao Lu,Xiaokai Zhao,Pengmin Yang,Xintao Wang,Jieyi Li,Ziying Gong,Daoyun Zhang,Zhiguo Wang 대한암학회 2023 Cancer Research and Treatment Vol.55 No.4

Purpose Loss-of-function mutations in the adenomatous polyposis coli (APC) gene are common in metastatic colorectal cancer (mCRC). However, the characteristic of APC specific mutations in mCRC is poorly understood. Here, we explored the clinical and molecular characteristics of N-terminal and C-terminal side APC mutations in Chinese patients with mCRC. Materials and Methods Hybrid capture-based next-generation sequencing was performed on tumor tissues from 275 mCRC pati-ents to detect mutations in 639 tumor-associated genes. The prognostic value and gene-pathway difference between APC specific mutations in mCRC patients were analyzed. Results APC mutations were highly clustered, accounting for 73% of all mCRC patients, and most of them were truncating mutations. The tumor mutation burden of the N-terminal side APC mutations group (n=76) was significantly lower than that of the C-terminal side group (n=123) (p < 0.001), further confirmed by the public database. Survival analysis showed that mCRC patients with N-terminus side APC mutations had longer overall survival than C-terminus side. Tumor gene pathway analysis showed that gene mutations in the RTK/RAS, Wnt and transforming growth factor β signaling pathways of the C-terminal group were significantly higher than those of the N-terminal group (p < 0.05). Additionally, KRAS, AMER1, TGFBR2, and ARID1A driver mutations were more common in patients with C-terminal side APC mutations. Conclusion APC specific mutations have potential function as mCRC prognostic biomarkers. There are obvious differences in the gene mutation patterns between the C-terminus and N-terminus APC mutations group, which may have certain guiding significance for the subsequent precise treatment of mCRC.

CMOS Startup Charge Pump With Body Bias and Backward Control for Energy Harvesting Step-Up Converters

Peng, Huan,Tang, Nghia,Yang, Youngoo,Heo, Deukhyoun IEEE 2014 IEEE Transactions on Circuits and Systems I: Regul Vol.61 No.6

<P>A new low voltage charge pump is developed to help start up a step-up converter in energy harvesting applications. The proposed charge pump is the first to utilize both backward control scheme and two branches of charge transfer switches (CTSs) to direct charge flow. The backward control scheme uses the internal boosted voltage to dynamically control the CTSs' gate, and the two branches utilize both NMOS and PMOS to implement their switching structure. The combination of backward control scheme and two-branch operation allows the CTSs to be completely turned on and off. Thus, the reverse charge sharing phenomenon and switching loss are significantly reduced, which effectively improves pumping efficiency. The last stage is specially designed to improve the charge pump's charge and capacitance drivability. Using subthreshold operation and body-bias technique, the charge pump and its clock generator can operate under a low voltage supply. The proposed charge pump circuit is designed in a standard 0.18 mu m CMOS process. It consists of 6 stages, each with a 24 pF pumping capacitor (total 288 pF pumping capacitance area). Under a 320 mV supply, the measured output voltage of the proposed charge pump can rise from 0 to 2.04 V within 0.1 milliseconds.</P>

How Does Leadership Influence Follower Creativity? - The Role of Follower Identifications and Perceived Organizational Support -

Wang Huan Huan,Zhang Hong Peng,Kim Jong Kwan,Lee Yun Kyeong 한국인적자원관리학회 2018 인적자원관리연구 Vol.25 No.5

오늘 날 4 차 산업혁명으로 명명되는 기술적 융합과 디지털 신기술의 태동으로 인간의 노동을 대체할 수 있는 인공지능의 등장은 인간의 가치가 창의적인 사고에 있음을 다시금 깨닫게 하고 있다. 이와 같은 환경의 병화에서 많은 조직과 기업들은 창의적인 사고, 지식 공유 등을 통하여 고유한 가치를 개발하고 발전시키기 위해 노력하고 있다. 조직 내 창의성은 단순히 창의적인 개인으로 인하여 만들어 질 수 있는 것이 아니라, 구성원이 창의적일 수 있는 조직문화가 중요하다. 많은 연구에서는 리더의 역할이 조직문화 조성에 중요한 기반으로 보고 있다. 본 연구에서는 변혁적 리더십과 거래적 리더십의 개념 및 구성요소에 대한 명확한 설명을 토대로 팔로어의 창의성과 리더십의 관계를 검증하고자 한다. 기존에 연구된 리더십과 창의성의 관계에 팔로어의 정체성을 매개변수로, 지각된 조직지원인식을 조절변수로 하여 보다 포괄적인 관계를 알 수 있을 것으로 생각한다. 연구를 위해 중국 북경과 상하이의 기업을 대상으로 설문을 실시하여 242 부의 설문지를 통계에 사용하였다. 가설검증 결과 변혁적 리더십과 거래적 리더십은 오두 팔로어의 창의성에 긍정적인 영향이 있는 것으로 나타났다. 또한 팔로어의 정체성이 리더십과 팔로어의 창의성의 관계를 매개하고 있으며, 리더십과 팔로어의 관계적 정체성은 지각된 조직지원인식에 의해 조절되고 있었다. 이와 같은 연구결과를 바탕으로 연구의 시사점, 한계점 및 향후의 연구 방향이 제시되었다. The importance of creativity to an organization and society is undeniable, simultaneously, leadership is a key factor affecting the creativity of followers within an organization. Based on the clarification of the concepts and dimensions of transformational leadership and transactional leadership, this paper examined follower identifications as a mediator and employees’ perceptions of organizational support as a moderator in the relationship between leadership and follower creativity. Using a sample of 242 employees who engaged in manufacturing working in Beijing and Shanghai, China, we found that most of our hypotheses were supported. Specifically, results showed that follower identifications mediate the positive influence relationship between leadership on follower creativity, and follower’s perceived organizational support moderate both transformational leadership and transactional leadership in the relationship with follower relational identification. Implications of the findings, Limitations of the study and directions for future research are discussed.

Effects of alkali- and alkaline-earth-metals on hydrogen generation during fluidized bed gasification of artificial waste

Tzu-Huan Peng,Chiou-Liang Lin,Hsien Chen 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.2

We evaluated the effects of Na, K, Ca, and the steam-to-biomass (S/B) ratio on gasification efficiency duringsyngas production. The results show that H2 production was positively correlated with the S/B ratio. However, increasesin the S/B ratio were limited because excessive steam decreased the reactor temperature and hampered the gasificationprocess. Regarding the effects of alkali metals on syngas composition, we found that the addition of either Na or Kincreased the molar percentages of H2 and CO, but decreased CH4 and CO2. The results also clearly show that the additionof Na or K improved the yield of syngas, the carbon conversion efficiency, and the cold gas efficiency. Improvementswere especially pronounced with K. Furthermore, Ca had different interactions with Na and K during gasification. WhenNa and Ca existed simultaneously, H2 production was enhanced.

Enhanced Removal of Phenol from Aquatic Solution in a Schorl-catalyzed Fenton-like System by Acid-modified Schorl

Huan-Yan Xu,Murari Prasad,Peng Wang 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.4

Schorl modified by H₂SO4 has been successfully developed to enhance schorl-catalyzed Fenton-like reaction for removal of phenol in an aqueous solution. The phenol removal percentage can be increased from 4% to 100% by the system of modified schorl and H₂O₂. Batch experiments indicate that the percent increases in removal of phenol by increasing the dosage of catalyst, temperature and initial concentration of H₂O₂. The results of XRD, FT-IR and SEM suggest that no new phases are formed after removal of phenol by modified schorl. ICP-AES results reveal that more dissolution of iron results in higher catalytic oxidant activity in the system of modified schorl and H₂O₂. Besides minor adsorption, mineralcatalyzed Fenton-like reaction governs the process.

Type II transmembrane serine proteases 4 (TMPRSS4) promotes proliferation, invasion and epithelial–mesenchymal transition in endometrial carcinoma cells (HEC1A and Ishikawa) via activation of MAPK and AKT

Huan Xiao,Zhian Zhang,Dan Peng,Chunqing Wei,Benling Ma 한국통합생물학회 2021 Animal cells and systems Vol.25 No.4

Endometrial cancer is the most common gynecological cancer in the developed countries. Type II transmembrane serine proteases 4 (TMPRSS4) is a newly discovered transmembrane protein, which may be related to the invasion, metastasis of the tumor and the poor prognosis. This study aims to investigate the role of TMPRSS4 in endometrial cancer and the detailed molecular mechanism. The results showed that TMPRSS4 was highly expressed in human endometrial cancer cells (HEC1A and Ishikawa). TMPRSS4 knockdown inhibited proliferation of endometrial cancer cells. In TMPRSS4 knockdown cells, the invasion of cells was significantly supressed. The expression of E-cadherin was significantly enhanced, while the levels of fibronectin and vimentin decreased in TMPRSS4 knockdown cells, which indicated thatTMPRSS4 knockdown attenuated the EMT of cancer cells. TMPRSS4 positively regulated the activation of MAPK and AKT signaling pathways in endometrial cancer. In conclusion, this study indicated that TMPRSS4 may be associated with the progression of endometrial cancer through promoting proliferation, invasion and EMT via activation of MAPK and AKT in endometrial cancer cells. TMPRSS4 may be a new and more effective target or therapeutic strategy for treating endometrial cancer.

Enhanced Removal of Phenol from Aquatic Solution in a Schorl-catalyzed Fenton-like System by Acid-modified Schorl

Xu, Huan-Yan,Prasad, Murari,Wang, Peng Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.4

Schorl modified by $H_2SO_4$ has been successfully developed to enhance schorl-catalyzed Fenton-like reaction for removal of phenol in an aqueous solution. The phenol removal percentage can be increased from 4% to 100% by the system of modified schorl and $H_2O_2$. Batch experiments indicate that the percent increases in removal of phenol by increasing the dosage of catalyst, temperature and initial concentration of $H_2O_2$. The results of XRD, FT-IR and SEM suggest that no new phases are formed after removal of phenol by modified schorl. ICP-AES results reveal that more dissolution of iron results in higher catalytic oxidant activity in the system of modified schorl and $H_2O_2$. Besides minor adsorption, mineral-catalyzed Fenton-like reaction governs the process.

Unactuated Force Control of 5-DOF Parallel Robot Based on Fuzzy PI

Shu-Huan Wen,Wei Zheng,Shi-Dong Jia,Zhi-Xin Ji,Peng-Cheng Hao,Hak-Keung Lam 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.6

This paper investigates the fuzzy position/force hybrid control for a class of 5-degree-of-freedom (DOF) redundantly actuated parallel robots. The position control law is designed based on the proportional-integraldifferential (PID) for the 5-DOF redundantly actuated parallel robot. The fuzzy proportional-integral (PI) redundant actuation force control law is designed based on the position/force hybrid control structure for the 5-DOF redundantly actuated parallel robot. The optimum driving force is obtained in the presence of interference, and the force tracking performance of the fuzzy PI controller is better than the conventional PI controller under the interference condition. Based on the fuzzy position/force hybrid controller, the tracking performance of the closed-loop system for the 5-DOF redundantly actuated parallel robot is improved by using the fuzzy position/force hybrid controller and the interference is eliminated effectively in the control system design. Finally, the co-simulation results of ADAMS and MATLAB/SIMULINK are given to show the effectiveness and advantages of the proposed methodscompared with the conventional PI controller.

Enhanced mechanical properties of epoxy composites embedded with MF/TiO2 hybrid shell microcapsules containing n-octadecane

Guangjian Peng,Yahao Hua,Guijing Dou,Yiheng Sun,Yong Huan,Sung Hoon Kang,Zhongyu Piao 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-

Microencapsulated phase change materials (MPCMs) are often mixed with matrix materials to formphase change composites for energy storage. Typically, MPCMs are easily debonded from the matrix orruptured, thereby weakening the mechanical properties of composites. This paper aims to simultaneouslyimprove the rupture strength of microcapsules and the bonding strength between microcapsulesand matrix to enhance the mechanical properties of composites. The titanium dioxide (TiO2) nanoparticlesmodified by a silane coupling agent (KH560) were doped into the melamine formaldehyde (MF) shell,forming n-octadecane@MF/TiO2 hybrid shell MPCMs (HS-MPCMs). The doping of modified TiO2 nanoparticlesreduced supercooling and improved the thermal stability of microcapsules. Compared with MFmicrocapsules, the rupture strength of HS-MPCMs was increased by an average of 30.4%. The modifiedTiO2 nanoparticles also built covalent bonds between microcapsule shell and matrix, which led to bettermicrocapsule/epoxy interface bonding. Thus, the HS-MPCMs/epoxy composites performed higher tensilestrength than the unmodified composites. Specifically, the tensile strength of composites was improvedby an average of 17.2% at the microcapsule content of 10 wt.% with the aid of the MF/TiO2 hybrid shell. The reinforced MPCMs/epoxy composites are expected to be used as anti-icing coatings in the aerospacefield.

Development of Cemented Carbide Industry of China

Shao Peng,Fangling Zou,Yonggui Zhou,Huan Wang 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

Through the review of developing course of China cemented carbide industry, the writer of this paper at the first time generalizes it into five stages. The writer analyses China cemented carbide industry present status in aspects of produce technology, product structure, operation and management etc. Mean while by analysis of existed shortages in cemented carbide industry, the write considers that it also has three advantages in resource and scale, industry foundation and categories, market and price, and brought out some suggestion and imagination for the future develpment of China cemented carbide industry.