Nonlinearity of shear response of unidirectional laminates under combined loading

Hongli Jia,Hyun-Ik Yang 한국생산제조학회 2017 한국생산제조시스템학회 학술발표대회 논문집 Vol.2017 No.12

The influence of material shear nonlinearity on multidirectional laminates in terms of failure envelopes

Hongli Jia,양현익,강태원 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.12

Influence of material shear nonlinearity on multidirectional laminates in terms of failure envelopes was investigated. In applying classic laminate theory, elastic constants were employed in transverse and longitudinal directions, while initial shear modulus was substituted by the secant shear modulus, which was achieved by means of Ramberg-Osgood model. The fracture curves were generated from maximum stress, Tsai-Wu and Puck criteria. The similarities and differences between nonlinear and linear shear models can be expressed in terms of symmetric balanced laminates [±θ°] 2 s and asymmetric laminates [0° 2 /±θ°], which are both arranged by material E-glass/MY750 oriented at different directions. All σ 1 - σ 2 failure envelopes due to material nonlinearity extend outward in tensile and compressive directions, but the phenomenon is not obvious with increasing ply angles. Similarly, the differences of all σ 1 - τ 12 failure envelopes between nonlinear shear analysis and linear shear analysis are decreasing with increased ply angles. Ply orientations and loading directions are involved in the effect of nonlinear shear properties on failure envelopes. According to the failure modes obtained from maximum stress criterion, it is reasonably derived that the influence of material shear nonlinearity will lead whether the failure envelopes from the other two failure criteria are more conservative or not.

The influence of material shear nonlinearity on predictive failure envelopes of multidirectional laminates

Hongli Jia,양현익,김창완,Hun Bong Lim 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.4

In present study, laminates with the type of [±θ°] S and [0° 2 /±θ°] S are investigated in order to clearly show the effect of material shear nonlinearity, and then theoretical predictions are compared with experimental data. In the whole process of generating failure envelopes, secant shear modulus instead of initial shear modulus is used for accurate shear stress-strain relation. The modulus values are recalculated every time when the combining load is changed. Final failure envelopes are then compared between numerical models. It is found that the variation in the size of safe regions from nonlinear analysis is closely related to the way of combing load and fiber directions. So in the process of improving failure theories or in the applications of failure theories, the effect of material nonlinearity can be considered appropriately.

Association between FGFRs and the susceptibility of digestive and reproductive system cancers in Chinese population

Jia-Kang Wang,Shu-jun Guo,Bao-qing Tian,Chnag-jun Nie,Hai-long Wang,Jia-lang Wang,An Hong,Xiao-jia Chen 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4

Fibroblast growth factors(FGFs) and their receptors (FGFRs) modulate a wide range of biological functions, especially tumor genesis. The aim of this study was to investigate the possible association of FGFR expression with the susceptibility of digestive system and reproductive system cancers in Chinese population. In total, 343 patients with digestive or reproductive system cancers were enrolled in this study. The expression levels of four highly-conserved FGFRs including FGFR1, FGFR2, FGFR3 and FGFR4 were measured by immunohistochemistry (IHC). The expression levels of FGFRs were compared between carcinoma and para-carcinoma tissues. FGFR1 expression significantly differed between carcinoma and para-carcinoma tissues in colon and gastric cancers. FGFR2 expression significantly differed between carcinoma and para-carcinoma tissues in esophageal cancer. FGFR3 expression was significantly different between carcinoma and para-carcinoma tissues in liver and gastric cancers. FGFR2 showed the highest expression probability in all the selected cancers and FGFR4 showed the lowest expression probability. FGFR1 and FGFR3 showed comparable moderate expression probabilities. Our findings have demonstrated significant differences regarding FGFR expression levels between carcinoma and para-carcinoma cells in digestive or reproductive system cancer patients. The data also implicated that FGFR2 and FGFR4 could serve as two prominent factors closely related to the susceptibility of digestive and reproductive system cancers.

Nonlinearity of Shear Response of Unidirectional Laminates under Combined Loading

Hongli Jia(지아홍리),Hyun-Ik Yang(양현익) 한국고분자학회 2018 폴리머 Vol.42 No.6

본 논문에서는 보완된 변형 에너지 밀도 함수를 기반으로 하여 평면내 비선형 응력-변형률 곡선 모델을 제시한다. 다방향의 적측판에 전단방향과 축방향의 응력이 조합되어 작용할 때의 전단방향의 응답을 예측하였으며, 실험값과 비교하여 제시 모델의 정확성을 검증하였다. 이 과정에서 compliance 상수는 기존 축방향의 응력에 대한 측정값과 일치하도록 결정되었다. 마지막으로 제시된 모델을 이용한 E-glass/vinylester의 전단 응력-변형률 거동은 모든 축외 각도에 대하여 실험 곡선과 일치하며, boron/epoxy와 T800H/3633 적층판의 전단 거동은 15도를 제외한 30도, 45도, 60도의 축외 각도(off-axis angle)에 대하여 실험값과 일치한다. 이는 작은 적층 각도의 변화에도 종방향의 탄성계수는 다른 탄성계수에 비하여 매우 높기 때문이다. We present the prediction of nonlinear in-plane shear stress strain curves based on complementary strain energy density function. When the [θ˚] unidirectional laminates are subjected to a combination of shear stresses and axial stresses, the predicted shear responses of laminates are compared with measured experimental data for verifying this accuracy of this model. In this process, the compliance constants are determined to match the measured test results in terms of the influence of on-axis axial stress. Finally, it is shown that the predicted shear stress strain behavior of E-glass/vinylester concurs with experimental curves for all off-axis angles, while shear behavior predictions of boron/epoxy and T800H/3633 laminates agree with experimental results for 30˚ 45˚ 60˚ off-axis angles laminates except 15˚ off-axis angle laminates. This is because the elastic longitudinal modulus is still significantly higher than the other modulus even for a small off axis angle.

Intracellular Polysaccharide and its Antioxidant Activity by Pleurotus citrinopileatus SM-01

Su-Qian Wu,Shang-Long Gao,Hong-Hong Liu,Xin-Yi Sun,Long Hao,Le Jia,Li-Fei Pang,Shou-Hua Jia,Meng-Shi Jia 한국고분자학회 2013 Macromolecular Research Vol.21 No.6

The extraction parameters of intracellular polysaccharide (IPS) from Pleurotus citrinopileatus SM-01mycelia were optimized, and the in vitro and in vivo antioxidant activities of IPS were investigated. The optimum conditions of IPS extraction were predicted to be an ultrasonic treatment time of 664.09 s, precipitation time of 23.03h and pH 7.36, and IPS yield was estimated at 16.13%. The in vitro inhibition effects of IPS at a dosage of 5 g/L on the superoxide anion, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals were 73.96±4.62%, 69.2±4.37%,and 50.75±4.39%, respectively, which were 72.56±5.08%, 22.83±1.94%, and 43.93±3.26% higher than that of butylated hydroxytoluene (BHT), respectively. The reducing power of IPS was 0.9±0.07, 69.81±5.24% higher than that of BHT. The activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and alanine aminotransferase (ALT) in mice blood were 241.38±23.19, 454.95±42.39, 60.32±5.16, and 32.39±2.54 U/mL,respectively, and the malonaldehyde (MDA) level was 9.54±0.72 nmol/mL. The results provided a reference for the large-scale extraction of IPS by P. citrinopileatus SM-01 in industrial fermentation, suggesting that the IPS can be used as a potential antioxidant, which enhances adaptive immune responses.

Antimycobacterial Activity of Fusaric Acid from a Mangrove Endophyte and its Metal Complexes

Jia-Hui Pan,Yi Chen,Yu-Hong Huang,Yi-Wen Tao,Jun Wang,Yan Li,Yi Peng,Tao Dong,Xiao-Min Lai,Yong-Cheng Lin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

Due to the increasing prevalence of multidrug-resistant Mycobacterium tuberculosis, there is an urgent need for new antituberculosis drugs that have novel mechanisms of action. As part of our ongoing search for antimycobacterial metabolites from mangrove endophytes, chemical analysis of the active extract of a strain of Fusarium sp. was performed, which led to the isolation of fusaric acid as the predominant constituent. A variety of metal complexes of fusaric acid were prepared. Antimycobacterial assays showed that Cadmium (II) and Copper (II) complexes exhibited potent inhibitory activity against the M. bovis BCG strain [minimum inhibitory concentration (MIC) = 4 μg/mL] and the M. tuberculosis H37Rv strain (MIC = 10 μg/mL), respectively. This is the first report of the antimycobacterial activity of the mangrove Fusarium metabolite and its coordinating metal complexes.

Selective control of cubic and hexagonal mesophases for titania and silica thin films with spin-coating

Hong Pan, Jia,In Lee, Wan Royal Society of Chemistry 2005 NEW JOURNAL OF CHEMISTRY Vol.29 No.6

<P>Highly organized mesoporous titania and silica thin films were synthesized using a triblock copolymer-templated sol-gel method <I>via</I> an evaporation-induced self-assembly (EISA) process. For the first time, we have found that the mesophase of these metal oxides can be selectively controlled by varying the spin-coating conditions. With spin-coating at a low speed, such as 600 rpm, cubic mesoporous TiO<SUB>2</SUB> or SiO<SUB>2</SUB> thin films are obtained, whereas 2D hexagonal mesoporous thin films are formed at a high spin-coating speed of around 2000 rpm for 20 s. On the other hand, a mixture of hexagonal and cubic phase is formed for films prepared at an intermediate spinning speed of 1000 rpm for 10 s. The fabricated mesoporous thin films, characterized by XRD, TEM, and UV-visible spectroscopy, show that the mesopore structures are highly ordered, without any cracks, and thermally stable (up to 400 °C). The hexagonal and cubic mesoporous TiO<SUB>2</SUB> films of 300–320 nm thickness have about 95% transparency and exhibit a ultra-uniform surfaces. We believe that the evaporation rate of volatile components in the coated film is qualitatively proportional to the speed of spin-coating, and this determines the mesophase of the resultant films.</P> <P>Graphic Abstract</P><P>Highly ordered cubic and hexagonal mesoporous TiO<SUB>2</SUB> and SiO<SUB>2</SUB> thin films can be selectively obtained by varying the spin-coating conditions in the evaporation-induced self-assembly process. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b417310d'> </P>

Genetic Diversity and Structure of Cordyceps sinensis Populations from Extensive Geographical Regions in China as Revealed by Inter-Simple Sequence Repeat Markers

Hong-Hui Liang,Zhou Cheng,Xiao-Ling Yang,Shan Li,Zu-Quan Ding,Tong-Shui Zhou,Wen-Ju Zhang,Jia-Kuan Chen 한국미생물학회 2008 The journal of microbiology Vol.46 No.5

Cordyceps sinensis is one of the most valuable medicinal caterpillar fungi native to China. However, its productivity is extremely limited and the species is becoming endangered. The genetic diversity of eighteen C. sinensis populations across its major distributing regions in China was evaluated by inter-simple sequence repeat (ISSR) markers. A total of 141 markers were produced in 180 individuals from the 18 populations, of which 99.3% were polymorphic. The low average of Shannon (0.104) and Nei index (0.07) of the 18 populations indicates that there are little genetic variations within populations. For all 18 populations, estimates of total gene diversity (HT), gene diversity within populations (HS), coefficient of genetic differentiation (GST), and gene flow (Nm) were 0.170, 0.071, 0.583, and 0.357, respectively. This pattern suggests that the genetic diversity of C. sinensis is low and most of the ISSR variations are found among populations with little gene exchange. The 18 populations are divided into five groups based on the genetic distance and the grouping pattern matches with the geographic distribution along the latitudinal gradient. The five groups show obvious difference in the GST and Nm values. Therefore, the genetic diversification of C. sinensis populations may be determined by geographic isolation and the combined effects of life history characters and the interaction with host insect species. The information illustrated by this study is useful for selecting in situ conservation sites of C. sinensis.

Serum Proteomics Analysis of Feline Mammary Carcinoma Based on Label-free and PRM Techniques

Jia-San Zheng,Ren-Yue Wei,Zheng Wang,Ting-Ting Zhu,Hong-Ri Ruan,Xue Wei,Kai-Wen Hou,Rui Wu 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.3

Background: Feline mammary carcinoma is the third most common cancer that affects female cats. Objectives: The purpose of this study was to screen differential serum proteins in feline and clarify the relationship between them and the occurrence of feline mammary carcinoma. Methods: Chinese pastoral cats were used as experimental animals. Six serum samples from cats with mammary carcinoma (group T) and six serum samples from healthy cats (group C) were selected. Differential protein analysis was performed using a Label-free technique, while parallel reaction monitoring (PRM) was performed to verify the screened differential proteins. Results: A total of 82 differential proteins were detected between group T and group C, of which 55 proteins were down regulated and 27 proteins were up regulated. Apolipoprotein A-I, Apolipoprotein A-II (ApoA-II), Apolipoprotein B (ApoB), Apolipoprotein C-III (ApoC-III), coagulation factor V, coagulation factor X, C1q, albumen (ALB) were all associated with the occurrence of feline mammary carcinoma. Differential proteins were involved in a total of 40 signaling pathways, among which the metabolic pathways associated with feline mammary carcinoma were the complement and coagulation cascade and cholesterol metabolism. According to the Label-free results, ApoB, ApoC-III, ApoA-II, FN1, an uncharacterized protein, and ALB were selected for PRM target verification. The results were consistent with the trend of the label-free. Conclusions: This experimen is the first to confirm ApoA-II and ApoB maybe new feline mammary carcinoma biomarkers and to analyze their mechanisms in the development of such carcinoma in feline.