중·한 교육 현황 및 개혁 동향의 비교

황현옥,정홍섭 新羅大學校 2003 論文集 Vol.52 No.-

There are a lot of similarities between China and Korea in their cultural and historical background. Both countries have adopted the 6:3:3:4 pattern for their elementary school, junior high school, senior high school and college education. Their difference lies in the fact that most schools in China are public schools but the schools in Korea are both private and public ones. Korea is superior to China in teachers' quality, teaching facilities and ratio of high school students who can enter colleges and universities. But Korea is not as good as China in the quality of higher education owing to its over-reliance on private school education and students' tuition fees. In recent years both China and Korea have made great efforts in reformation of education. For example, they have given more financial support to education, changed their college entrance examination from purely written examination to comprehensive evaluation, and decentralized their control over education. But China falls behind Korea in financial support, reform of teaching methodology and introduction of market economy into education. At present, China is trying to put the idea of market economy into the development of private schools and the decision on the amount of tuition fees. Korean government, on the other hand, is giving more support to its private schools. This paper holds that China should learn from Korea in private school management, teachers' training and occupational education whereas Korea should learn from China in improving the quality of tertiary education.

Metastasis associated genomic aberrations in stage II rectal cancer

Hong Zhao,Zhi-Zhou Shi,Rui Jiang,Dong-Bing Zhao,Hai-Tao Zhou,Jian-Wei Liang,Xin-Yu Bi,Jian-Jun Zhao,Zhi-Yu Li,Jian-Guo Zhou,Zhen Huang,Ye-Fan Zhang,Jian Wang,Xin Xu,Yan Cai,Ming-Rong Wang,Yu Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11

Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.

Using the Juice of Water Lettuce (Pistia stratiotes) as Culture Medium to Increase the Cell Density and the Production of Microbial Lipid

Yu-Hsien Lien,Fu-Yao Liu,Jyy-Ning Chen,Yu-Shan Huang,Yu-Hong Wei,Chiyang Yu,Che-Chi Shu 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.2

Water lettuce (Pistia stratiotes) is one of the most well-known aquatic weeds as it causes problems in watercourses all over the world. This invasive species is fast-growing and thus has the potential for its use in preparing growth medium of microorganisms. Toward it, the pretreatment and enzymatic saccharification are positively the decisive processes. But there are other crucial processes, which are usually ignored by researchers. To the best of my knowledge, this presented work is the first time discovering that the juice obtained from water lettuce is valuable. Except for sterilization, no treatment is needed for the water lettuce’s juice and it can be directly served for cell growth. For Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Bacillus subtilis, Lactococcus Lactis, Lactobacillus rhamnosus, and Lactobacillus plantarum, the cell density in the broth of water lettuce’s juice as the only carbon source is 10-60% higher than that in LB, YPD, BHI, M17, MRS. We then examined the production of microbial lipid by YM prepared in the juice of water lettuce. In comparison to commercial medium YM broth, the YM with juice caused 84% increase in the production of microbial lipid. A simple process of collecting juice notably increased productivity.

Decreased Expression of LKB1 Correlates with Poor Prognosis in Hepatocellular Carcinoma Patients Undergoing Hepatectomy

Huang, Yue-Han,Chen, Zhen-Kun,Huang, Ka-Te,Li, Peng,He, Bin,Guo, Xu,Zhong, Jun-Qiao,Zhang, Qi-Yu,Shi, Hong-Qi,Song, Qi-Tong,Yu, Zheng-Ping,Shan, Yun-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Aim: To study any correlation of LKB1 expression with prognosis in hepatocellular carcinoma (HCC) cases. Methods: A total of 70 HCC patients and 20 primary intrahepatic stone patients in the first affiliated hospital of Wenzhou Medical College were enrolled in this study. LKB1 expression was detected by immunohistochemistry. Patients were followed-up and prognostic factors were evaluated. Result: LKB1 expression was decreased in the HCC samples. Loss of LKB1 expression in HCC was significantly related to histologic grade (P=0.010), vascular invasion (P=0.025) and TMN stage (P=0.011). Patients showing negative LKB1 expression had a significantly shorter disease-free and overall survival than those with positive expression (P = 0.001, P=0.000, respectively). Multivariate Cox regression analysis indicated that LKB1 expression level was an independent factor of survival (P = 0.033). Conclusion: HCC patients with decreased expression LKB1 have a poor prognosis. The loss of LKB1 expression is correlated with a lower survival rate.

Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts antiinflammatory effect by direct inhibiting toll like receptor 4 signaling pathway

Hong-Lin Xu,Guang-Hong Chen,Yu-Ting Wu,Ling-Peng Xie,Zhang-Bin Tan,Bin Liu,Hui-Jie Fan,Hong-Mei Chen,Gui-Qiong Huang,Min Liu,Ying-Chun Zhou 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1

Background: Panax ginseng Meyer (P. ginseng), a herb distributed in Korea, China and Japan, exerts benefits on diverse inflammatory conditions. However, the underlying mechanism and active ingredients remains largely unclear. Herein, we aimed to explore the active ingredients of P. ginseng against inflammation and elucidate underlying mechanisms. Methods: Inflammation model was constructed by lipopolysaccharide (LPS) in C57BL/6 mice and RAW264.7 macrophages. Molecular docking, molecular dynamics, surface plasmon resonance imaging (SPRi) and immunofluorescence were utilized to predict active component. Results: P. ginseng significantly inhibited LPS-induced lung injury and the expression of proinflammatory factors, including TNF-a, IL-6 and IL-1b. Additionally, P. ginseng blocked fluorescence-labeled LPS (LPS488) binding to the membranes of RAW264.7 macrophages, the phosphorylation of nuclear factor-kB (NF-kB) and mitogen-activated protein kinases (MAPKs). Furthermore, molecular docking demonstrated that ginsenoside Ro (GRo) docked into the LPS binding site of toll like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) complex. Molecular dynamic simulations showed that the MD2-GRo binding conformation was stable. SPRi demonstrated an excellent interaction between TLR4/MD2 complex and GRo (KD value of 1.16 × 10<SUP>-9</SUP> M). GRo significantly inhibited LPS488 binding to cell membranes. Further studies showed that GRo markedly suppressed LPS-triggered lung injury, the transcription and secretion levels of TNF-α, IL-6 and IL-1β. Moreover, the phosphorylation of NF-kB and MAPKs as well as the p65 subunit nuclear translocation were inhibited by GRo dose-dependently. Conclusion: Our results suggest that GRo exerts anti-inflammation actions by direct inhibition of TLR4 signaling pathway.

Corrigendum to "Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway" [J Ginseng Res 46 (2022) 156-166]

Xu, Hong-Lin,Chen, Guang-Hong,Wu, Yu-Ting,Xie, Ling-Peng,Tan, Zhang-Bin,Liu, Bin,Fan, Hui-Jie,Chen, Hong-Mei,Huang, Gui-Qiong,Liu, Min,Zhou, Ying-Chun The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.2

Serum Insulin-Like Growth Factor Binding Protein 7 as a Potential Biomarker in the Diagnosis and Prognosis of Esophagogastric Junction Adenocarcinoma

Can-Tong Liu,Yi-Wei Xu,Hong Guo,Chao-Qun Hong,Xin-Yi Huang,Yu-Hao Luo,Shi-Han Yang,Ling-Yu Chu,En- Min Li,Yu-Hui Peng 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.6

Background/Aims: Esophagogastric junction adenocarcinoma (EJA) is a malignant tumor associated with high morbidity and has attracted increasing attention due to a rising incidence and low survival rate. Pathological biopsy is the gold standard for diagnosis, but noninvasive and effective tests are lacking, resulting in diagnoses at advanced stages. This study explored the diagnostic value of insulin-like growth factor binding protein 7 (IGFBP7) in EJA. Methods: A total of 120 EJA patients and 88 normal controls were recruited, and their serum levels of IGFBP7 were measured by enzymelinked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic value, and Pearson chi-square analysis was used to evaluate the correlation between IGFBP7 and clinical parameters. Kaplan- Meier survival analysis was carried out to assess the effect of IGFBP7 on overall survival (OS). Results: The levels of IGFBP7 were higher in both early- and late-stage EJA patients than in normal controls (p<0.001). The area under the ROC curve for EJA patients was 0.794 (95% confidence interval [CI], 0.733 to 0.854), with a cutoff value of 2.716 ng/mL, a sensitivity of 63.3% (95% CI, 54.0% to 71.8%) and a specificity of 90.9% (95% CI, 82.4% to 95.7%). For the diagnosis of early-stage EJA, the same cutoff value and specificity were obtained, but the sensitivity of IGFBP7 was 54.3% (95% CI, 36.9% to 70.8%). Patients with low IGFBP7 protein expression had lower OS than those with high expression (p=0.034). The multivariate analysis showed that IGFBP7 is an independent prognostic factor for EJA (p=0.011). Conclusions: Serum IGFBP7 acts as a potential diagnostic and prognostic marker for EJA.

A real-time demand response algorithm for heterogeneous devices in buildings and homes

Hong, Seung Ho,Yu, Mengmeng,Huang, Xuefei Elsevier 2015 ENERGY Vol.80 No.-

<P><B>Abstract</B></P> <P>The growing demand for electricity, coupled with increased efficiency requirements, creates new opportunities for the development of demand-side management systems. Here we describe an approach for load allocation among different classes of device. We adopt the concept of strategic choice to determine the optimal strategy for a given situation. Electricity resources are allocated based on demand, priority, fairness, the available electrical resources, and the budget, so that even when the unit price is high (i.e., the available resources are restricted), higher-priority devices continue to operate without interruption. When the price falls, resources are distributed to satisfy the requirements of a larger number of devices. We include ESSs (energy storage systems) in the algorithm to reserve energy during low-price times for use during high-price times. The algorithm described here can be used to allocate resources among heterogeneous devices, and has potential not only to reduce peak demand but also to increase the overall efficiency of the system.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Propose a real-time demand-response (DR) approach for buildings and homes. </LI> <LI> Introduce “strategic choice” for performing the energy allocation among devices. </LI> <LI> Design a utility function to evaluate different strategies for a given situation. </LI> <LI> The optimal strategy is automatically selected by the proposed algorithm. </LI> <LI> Simulation results verify DR performances of peak demand and daily cost reduction. </LI> </UL> </P>

Model Parameters Online Identifi cation and SOC Joint Estimation for Lithium-Ion Battery Based on a Composite Algorithm

Hong-Yu Long,Cheng-Yong Zhu,Bi-Bin Huang,Chang-hao Piao,Ya-Qing Sun 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.4

The purpose of this paper is to discuss how to solve the problem of on-line identifi cation of model parameters of Li-ion battery and on-line estimation of SOC. Based on the matlab/simulink platform, a fi rst-order RC equivalent circuit model of the battery is built, and a joint estimation algorithm of the model parameters and SOC of the lithium ion battery is designed based on the dynamic model, which is compared with the single adaptive Kalman fi lter algorithm (AEKF). The simulation results show that the proposed joint estimation algorithm can make eff ective online estimation and update of the battery model parameters and SOC. The average estimation error of SOC is less than 2.8%, the estimation accuracy is higher than that of adaptive Kalman fi lter, and its robustness level is relatively high.

An efficient approach to reliability-based design optimization within the enhanced sequential optimization and reliability assessment framework

Hong-Zhong Huang,Xudong Zhang,Debiao Meng,Zhonglai Wang,Yu Liu 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.6

Reliability based design optimization (RBDO) has been widely implemented in engineering practices for high safety and reliability. It is an important challenge to improve computational efficiency. Sequential optimization and reliability assessment (SORA) has made great efforts to improve computational efficiency by decoupling a RBDO problem into sequential deterministic optimization and reliability analysis as a single-loop method. In this paper, in order to further improve computational efficiency and extend the application of the current SORA method, an enhanced SORA (ESORA) is proposed by considering constant and varying variances of random design variables while keeping the sequential framework. Some mathematical examples and an engineering case are given to illustrate the proposed method and validate the efficiency.