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Efficacy and safety of cold forceps polypectomy utilizing the jumbo cup: a prospective study
( Hiroshi Hasegawa ),( Shigeki Bamba ),( Kenichiro Takahashi ),( Masaki Murata ),( Taketo Otsuka ),( Hiroshi Matsumoto ),( Takehide Fujimoto ),( Rie Osaki ),( Hirotsugu Imaeda ),( Atsushi Nishida ),( 대한장연구학회 2019 Intestinal Research Vol.17 No.2
Background/Aims: There are few prospective studies on cold forceps polypectomy (CFP) using jumbo cup forceps. Therefore, we examined patients with diminutive polyps (5 mm or smaller) treated with CFP using jumbo cup forceps to achieve an ade-noma-free colon and also assessed the safety of the procedure and the recurrence rate of missed or residual polyp after CFP by performing follow-up colo-noscopy 1 year later. Methods: We included patients with up to 5 adenomas removed at initial colonoscopy and analyzed data from a total of 361 patients with 573 adenomas. One-year follow-up colonoscopy was performed in 165 patients, at which 251 lesions were confirmed. Results: The one-bite resection rate with CFP was highest for lesions 3 mm or smaller and decreased significantly with increasing lesion size. Post-procedural hemorrhage was observed in 1 of 573 lesions (0.17%). No perforation was noted. The definite recurrence rate was 0.8% (2/251 lesions). The probable recurrence rate, which was defined as recurrence in the same colorectal segment, was 17%. Adenoma-free colon was achieved in 55% of patients at initial resection. Multivariate analysis revealed that achievement of an adenoma-free colon was significantly associated with number of adenomas and years of endoscopic experience. Conclusions: CFP using jumbo biopsy forceps was safe and showed a high one-bite resection rate for diminutive lesions of 3 mm or smaller. The low definite recurrence rate confirms the reliability of CFP using jumbo biopsy forceps. Number of adenomas and years of endoscopic experience were key factors in achieving an adenoma-free colon. (Intest Res 2019;17:265-272.)
Development of a Multi-Channel Processing Matched Filter Using FPGA for CDMA-QAM Method
Hiroshi Mochizuki,Sei Takahashi,Hideo Nakamura,Satoshi Nishida,Ryo Ishikawa 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
At present, we attempt to apply our proposed CDMA-QAM method to railway signaling, and evaluate basic characteristics using computer simulation. In this paper, we describe development of a multichannel processing matched lter as a CDMA receiver. We noted that Walsh code is 1 or -1, and proposed the design that has no multipliers. In addition, we applied some techniques such as time-sharing processing, and optimized the design to reduce number of logic elements that an FPGA has. As a result, we show that we could implement the multi-channel processing matched lter in an FPGA.
Hiroshi Mochizuki,Sei Takahashi,Hideo Nakamura,Satoshi Nishida,Ryo Ishikawa 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
In this paper, we propose a new modulation method combining code-division multiple access (CDMA) and quadrature amplitude modulation (QAM), called CDMAQAM. It transmits QAM symbols allocated based on a CDMA signal, and it has the benefit that QAM errors can be recovered if they are in a range where they can be absorbed by CDMA demodulation. We applied the method to railway signaling and developed a CDMA-QAM rail transmission system having a transmission speed of 1500 bps using digital signal processors. We also conducted a field experiment using an actual rail and verified that the system can achieve favorable constellation characteristics.
Shigeto Nishida,Takenao Sugi,Akio Ikeda,Takashi Nagamine,Hiroshi Shibasaki,Masatoshi Nakamura 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
A method for detecting spikes and slow burst in photic evoked electroencephalogram (EEG) was proposed. The spikes were detected by combining methods of the morphological filter and the similarity coefficient in the time domain. The slow burst was detected by using pole of AR model in the frequency domain. The proposed method was applied for the photic evoked EEG data containing spikes and slow burst, and brought satisfactory coincidence with the results interpreted by a qualified electroencephalographer.
Yuki Nakajima,Hiroshi Nishida,Seiichi Matsugo,Tetsuya Konishi 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
Previously, we studied the antioxidant potential of Chaga mushroom [Inonotus obliquus (persoon) Pilat] extracts and isolated several small (poly)phenolic compounds as the major antioxidant components in the 80% methanol (MeOH) extract. In the present study, these isolated phenolic ingredients together with several other types of Chaga extracts were examined for cytotoxic effects against normal (IMR90) and cancer (A549, PA-1, U937, and HL-60) cell lines. Results revealed decoctions from both the fruiting body (FB) and sclerotium (ST) parts of Chaga, especially the ST part, showed considerable cytotoxicity toward tumor cells, but the cytotoxicity appeared to be stronger against normal cells than cancer cells. The 80% MeOH ST extract also showed the same trend. On the other hand, the 80% MeOH extract of FB showed significant cytotoxicity towards tumor cell lines without affecting normal cells, for example, the 50% lethal dose was 49.4±2.9μg/mL for PA-1 cells versus 123.6±13.8μg/mL for normal cells. The phenolic components isolated from the 80% MeOH extracts had markedly greater cancer cell toxicity than the extracts themselves. In particular, two out of seven compounds showed strong cytotoxicity towards several tumor cell lines without giving rise to significant cell toxicity toward normal cells. For example, the 50% lethal dose for 3,4-dihydroxybenzalacetone was 12.2μmol/L in PA-1 cells but was 272.8μmol/L in IMR90 cells. Fluorescence-activated cell sorting analysis further revealed these phenolic ingredients have high potentiality for apoptosis induction in PA-1 cells.
Nakajima, Yuki,Nishida, Hiroshi,Matsugo, Seiichi,Konishi, Tetsuya The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
Previously, we studied the antioxidant potential of Chaga mushroom [Inonotus obliquus (persoon) Pilat] extracts and isolated several small (poly)phenolic compounds as the major antioxidant components in the 80% methanol (MeOH) extract. In the present study, these isolated phenolic ingredients together with several other types of Chaga extracts were examined for cytotoxic effects against normal (IMR90) and cancer (A549, PA-1, U937, and HL-60) cell lines. Results revealed decoctions from both the fruiting body (FB) and sclerotium (ST) parts of Chaga, especially the ST part, showed considerable cytotoxicity toward tumor cells, but the cytotoxicity appeared to be stronger against normal cells than cancer cells. The 80% MeOH ST extract also showed the same trend. On the other hand, the 80% MeOH extract of FB showed significant cytotoxicity towards tumor cell lines without affecting normal cells, for example, the 50% lethal dose was $49.4\;{\pm}\;2.9\;{\mu}g/mL$ for PA-1 cells versus $123.6\;{\pm}\;13.8\;{\mu}g/mL$ for normal cells. The phenolic components isolated from the 80% MeOH extracts had markedly greater cancer cell toxicity than the extracts themselves. In particular, two out of seven compounds showed strong cytotoxicity towards several tumor cell lines without giving rise to significant cell toxicity toward normal cells. For example, the 50% lethal dose for 3,4-dihydroxybenzalacetone was $12.2\;{\mu}mmol/L$ in PA-1 cells but was $272.8\;{\mu}mmol/L$ in IMR90 cells. Fluorescence-activated cell sorting analysis further revealed these phenolic ingredients have high potentiality for apoptosis induction in PA-1 cells.