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김두화,박정환,한도수,허선아,김성현,조성동 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1
The reaction of Asymmetrical organotins with acid chlorides in the presence of Benzylbis (triphenylphosphine) palladium(Ⅱ) chloride gave good yields of ketones in chloroform.
문학치료 연구 패러다임 -국내학위논문을 중심으로(2004-2014)
허선아(Heo, Seon-Ah) 대한문학치료학회 2020 대한문학치료연구 Vol.10 No.1
본 연구는 국내 문학치료 관련 학위 논문을 분석하여 문학치료 연구 동향(動向)을 살펴보는데 그 목적이 있다. 이를 위해 2004년 1월부터 2014년 12월까지 국내에서 발표된 문학치료 관련 학위 논문 164편을 대상으로 연도별 연구방법, 연구 내용, 주요 키워드 등을 분석하였다. 결과에 의하면 연구 방법은 문헌연구가 44.5%로 가장 많았으며 그 다음으로 혼합연구(20.1%), 양적연구(17.7%), 질적연구(15.2%)순이었다. 연구 대상으로는 청소년이 62.7%로 가장 많았으며, 성인(25.3%), 유아(3%), 노인(2.&%)을 대상으로 연구되었다. 문학치료 프로그램 분석에서는 자존감과 표현력 향상, 스트레스감소와 우울 감소를 위한 목적이 주를 이루었다. 또한 문학치료가 학제간 융복합 학문임을 알 수 있는 교육학, 국문학, 상담학, 예술치료학, 신학 등 다양한 영역에서 연구가 진행되고 있었다. 특히 교육학(국어교육전공) 전공의 연구자들이 문학치료의 교육적 활용 가능성을 모색한 수업모형 탐색에 관한 연구가 많았다. 이러한 연구를 바탕으로 몇 가지 제언을 하고자 한다. The purpose of this research is to analyze research status and trends in literature therapy and establish one of the foundations for upcoming research based on domestic dissertation. For this research, 164 dissertations, which are published from January 2004 to December 2014, in literature therapy are used as sample. The coverage of research includes year-by-year trends analysis in terms of research methodology, main contents of research, keyword, etc. According to the analysis, 44.5% of research uses ‘literature research’ as a research methodology followed by ‘mixed research’ (20.1%), ‘quantitative research’ (17.7%) and ‘qualitative research’ (15.2%). Majority of the researches are done with the teenager (62.7%), and also done with the adult (25.3%), infant (3%) and old people (2.7%). The purpose of analysis on the literature therapy program is found mainly for the improvement of self-esteem and self-expression and the relief of stress and depression. Also, the research on literature therapy is appearing in various academic domains such as the pedagogy, Korean literature, counseling, art therapeutics and theology. Particularly, in pedagogy (Korean language education) many studies try to explore a class model by seeking educational use of the literature therapy. Based on the findings, some implications and suggestions are summarized.
Heo, Kyung-Sun,Ryoo, Sung-Woo,Kim, Lila,Nam, Miyoung,Baek, Seung-Tae,Lee, Hyemi,Lee, Ah-Reum,Park, Song-Kyu,Park, Youngwoo,Myung, Chang-Seon,Kim, Dong-Uk,Hoe, Kwang-Lae Korean Society for Molecular Biology 2008 Molecules and cells Vol.26 No.5
<P>Low-density lipoprotein (LDL) induces cell proliferation in human aortic smooth muscle cells (hAoSMCs), which may be involved in atherogenesis and intimal hyperplasia. Recent studies have demonstrated that Cl- channels are related to vessel cell proliferation induced by a variety of stimuli. In this study, we investigated a potential role of Cl- channels in the signaling pathway of LDL effects on hAoSMC proliferation with a focus on the activation of Erk1/2-PI3K/Akt and the subsequent upregulation of Egr-1. Cl- channel blockers, DIDS, but neither NPPB nor Furosemide, completely abolished the LDL-induced DNA synthesis and cell proliferation. Moreover, DIDS, but not NPPB, significantly decreased LDL-stimulated Cl- concentration, as judged by flow cytometry analysis using MQAE as a Cl--detection dye. DIDS pretreatment completely abolished the activation of Erk1/2 and PI3K/Akt in a dose-dependent manner that is the hallmark of LDL activation, as judged by Western blot and proliferation assays. Moreover, pretreatment with DIDS (Cl- channel blockers) but not LY294002 (PI3K inhibitors) completely abolished the LDL-induced upregulation of Egr-1 to the same extent as PD98059 (MEK inhibitors to inhibit Erk), as judged by Western blot and luciferase reporter assays. This is the first report, to our knowledge, that DIDS-sensitive Cl--channels play a key role in the LDL-induced cell proliferation of hAoSMCs via the activation of Erk1/2 and PI3K/Akt and the upregulation of Egr-1.</P>
( Seon Mi Jeon ),( Ji Hyung Kim ),( Tae Ho Kim ),( Areumi Park ),( Ah Ra Ko ),( Se Jong Ju ),( Soo Jin Heo ),( Chul Hong Oh ),( Md. Abu Affan ),( Won Bo Shim ),( Do Hyung Kang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5
Microalgae hold promise as producers of sustainable biomass for the production of biofuels and other biomaterials. However, the selection of strains with efficient and robust production of desirable resources remains challenging. In this study, we isolated a green microalga from Korea and analyzed its morphological, molecular, and biochemical characteristics. Microscopic and phylogenetic analyses demonstrated that the isolate could be classified into the genus Chlamydomonas, and we designated the isolate Chlamydomonas s p. K IOST -1. Compositions of protein, lipid, and carbohydrate in the microalgal cells were estimated to be 58.8 ± 0.2%, 22.7 ± 1.2%, and 18.5 ± 1.0%, respectively. Similar to other microalgae belonging to Chlorophyceae, the dominant amino acid and monosaccharide in Chlamydomonas sp. KIOST-1 were glutamic acid and glucose. On the other hand, the proportions of saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids clearly differed from other species in the genus Chlamydomonas, and monounsaturated fatty acids accounted for a large portion (41.3%) of the total fatty acids in the isolate. Based on these results, Chlamydomonas sp. KIOST-1 has advantageous characteristics for biomass production.
Heo, Dae-Hyuk,Hwang, Joo-Hee,Choi, Seung Hee,Jeon, Mir,Lee, Ju-Hyung,Lee, Jae-Hoon,Hwang, Seon-Do,Lee, Kyeong-Ah,Lee, Seung-Hun,Lee, Chang-Seop The Korean Academy of Medical Sciences 2019 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.34 No.11
<P>We report 17 patients with human granulocytic anaplasmosis between January 2015 and September 2018 at two tertiary university hospitals in Korea. Monthly incidence peaked in May and June. Among these patients, we identified three who were co-infected with scrub typhus, and one patient with hemorrhagic fever with renal syndrome.</P>
Jeong-Ah Song,Hyo-Seon Yang,Jinsoo Lee,Soonjin Kwon,Kyung Jin Jung,Jeong-Doo Heo,Kyu-Hyuk Cho,Chang Woo Song,Kyuhong Lee 한국독성학회 2010 Toxicological Research Vol.26 No.3
Bronchoalveolar lavage (BAL) is a useful tool in researches and in clinical medicine of lung diseases because the BAL fluid contains biochemical and cytological indicators of the cellular response to infection, drugs, or toxicants. However, the variability among laboratories regarding the technique and the processing of the BAL material limits clinical research. The aim of this study was to determine the suction frequency and lavage fraction number necessary to reduce the variability in lavage using male Sprague-Dawley rats. We compared the total cell number and protein level of each lavage fraction and concluded that more cells and protein can be obtained by repetitive lavage with a suction frequency of 2 or 3 than by lavage with a single suction. On the basis of total cell recovery, approximately 70% of cells were obtained from fractions 1~3. The first lavage fraction should be used for evaluation of protein concentration because fractions 2~5 of lavage fluid were diluted in manifolds. These observations were confirmed in bleomycin-induced inflamed lungs of rats. We further compared the BAL data from the whole lobes with data from the right lobes and concluded that BAL data of the right lobes represented data of the whole lobes. However, this conclusion can only be applied to general lung diseases. At the end, this study provides an insight into the technical or analytical problems of lavage study in vivo.
양파(Allium cepa L.) 음료의 콜린성 활성 증가 및 뇌신경세포 보호로 인한 Amyloid β Peptide 유도에 대한 인지장애 개선 효과
박선경(Seon Kyeong Park),김종민(Jong Min Kim),강진용(Jin Yong Kang),하정수(Jeong Su Ha),이두상(Du Sang Lee),김아나(Ah-Na Kim),최성길(Sung-Gil Choi),이욱(Uk Lee),허호진(Ho Jin Heo) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.11
본 연구는 양파의 불쾌치를 저감화시킨 무취음료와 양파 과피 추출물을 첨가한 생리활성 성분 강화음료의 H₂O₂로 유도된 산화적 스트레스에 대한 뇌신경세포 보호 효과와 Aβ로 유도된 인지기능 장애 동물모델에서의 개선 효과를 검증하고자 수행되었다. 뇌신경세포 보호 효과에서는 상대적으로 강화음료에서 무취음료 대비 우수한 산화적 스트레스 억제효과 및 생존율을 나타내었다. Aβ로 유도된 인지기능 장애동물모델에 있어 Y-maze, passive avoidance 및 Morris water maze test에서 강화음료가 상대적으로 우수한 학습 및 기억력 개선 효과를 나타내는 것을 확인할 수 있었다. 마우스의 뇌 조직에서 강화음료 그룹은 AChE 활성을 저해하고, 신경전달물질인 ACh의 함량을 증가시킴으로써 Aβ로 유도된 cholinergic system 장애에 있어 개선 효과를 나타내었다. 또한, 마우스 뇌에서 SOD 함량의 증가, oxidized GSH/total GSH와 MDA 함량을 감소시킴으로써 Aβ와 같은 산화적 스트레스 인자에 대한 뛰어난 항산화 효과를 나타내었다. 최종적으로 무취음료와 강화음료의 주요성분들을 QTOF UPLC/MS system을 통하여 분석한 결과, 강화음료의 경우 무취음료보다 생리활성을 가진 2개의 steroidal saponin과 6개의 phenolic 화합물 등이 추가 검출되었다. 이러한 결과들을 종합해볼 때 강화음료는 상대적으로 protocatechuic acid와 quercetin 같은 강력한 항산화 효과를 나타내는 phenolic 화합물과 steroidal saponin 계열에 의한 우수한 인지기능 개선 효과를 기반으로 한 고부가가치 식품으로 활용될 수 있는 산업적 가능성이 있다고 판단된다. To examine the cognitive function of onion (Allium cepa L.) beverages (odourless and fortified), we analyzed in vitro neuronal cell protection against H₂O₂-induced cytotoxicity and performed in vivo tests on amyloid beta (Aβ)-induced cognitive dysfunction. Cellular oxidative stress and cell viability were evaluated by DCF-DA assay and MTT assay. These results show that fortified beverage resulted in better neuronal cell protection than odourless beverage at lower concentration (0∼100 μg/mL). Fortified beverage also showed more excellent acetylcholinesterase (AChE) inhibitory activity (IC50: 4.20 mg/mL) than odourless beverage. The cognitive functions of odourless beverage and fortified beverage in Aβ-induced neurotoxicity were assessed by Y-maze, passive avoidance, and Morris water maze tests. The results show improved cognitive function in both groups treated with beverages. After in vivo tests, cholinergic activities were determined based on AChE inhibition and acetylcholine levels, and antioxidant activities were measured as SOD, oxidized glutathione (GSH)/total GSH ratio, and MDA levels in mouse brain tissue. In a Q-TOF UPLC/MS system, main compounds were analyzed as follows: odourless beverage (five types of sugars and three types of phenolics) and fortified beverages (six types of phenolics and two types of steroidal saponins).