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- 검색키워드
- 저자 : Hangyeol Kim (검색결과 49 건)
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Lee, Donghee,Seo, Yelim,Kim, Young-Won,Kim, Seongtae,Choi, Jeongyoon,Moon, Sung-Hee,Bae, Hyemi,Kim, Hui-sok,Kim, Hangyeol,Kim, Jae-Hyun,Kim, Tae-Young,Kim, Eunho,Yim, Suemin,Lim, Inja,Bang, Hyoweon,Ki The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5
Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in the immune regulation, but the roles of muscle cells in AD are poorly understood. We aimed to identify the relationship between mitochondria and atopy by genome-wide analysis of skeletal muscles in mice. We induced AD-like symptoms using house dust mite (HDM) extract in NC/Nga mice. The transcriptional profiles of the untreated group and HDM-induced AD-like group were analyzed and compared using microarray, differentially expressed gene and functional pathway analyses, and protein interaction network construction. Our microarray analysis demonstrated that immune response-, calcium handling-, and mitochondrial metabolism-related genes were differentially expressed. In the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology pathway analyses, immune response pathways involved in cytokine interaction, nuclear factor-kappa B, and T-cell receptor signaling, calcium handling pathways, and mitochondria metabolism pathways involved in the citrate cycle were significantly upregulated. In protein interaction network analysis, chemokine family-, muscle contraction process-, and immune response-related genes were identified as hub genes with many interactions. In addition, mitochondrial pathways involved in calcium signaling, cardiac muscle contraction, tricarboxylic acid cycle, oxidation-reduction process, and calcium-mediated signaling were significantly stimulated in KEGG and Gene Ontology analyses. Our results provide a comprehensive understanding of the genome-wide transcriptional changes of HDM-induced AD-like symptoms and the indicated genes that could be used as AD clinical biomarkers.
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Donghee Lee,Yelim Seo,Young-Won Kim,Seongtae Kim,Jeongyoon Choi,Sung-Hee Moon,Hyemi Bae,Hui-sok Kim,Hangyeol Kim,Jae-Hyun Kim,Tae-Young Kim,Eunho Kim,Suemin Yim,Inja Lim,Hyoweon Bang,Jung-Ha Kim,Jae-H 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5
Although atopic dermatitis (AD) is known to be a representative skin disorder, it also affects the systemic immune response. In a recent study, myoblasts were shown to be involved in the immune regulation, but the roles of muscle cells in AD are poorly understood. We aimed to identify the relationship between mitochondria and atopy by genome-wide analysis of skeletal muscles in mice. We induced AD-like symptoms using house dust mite (HDM) extract in NC/Nga mice. The transcriptional profiles of the untreated group and HDM-induced AD-like group were analyzed and compared using microarray, differentially expressed gene and functional pathway analyses, and protein interaction network construction. Our microarray analysis demonstrated that immune response-, calcium handling-, and mitochondrial metabolism-related genes were differentially expressed. In the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology pathway analyses, immune response pathways involved in cytokine interaction, nuclear factor-kappa B, and T-cell receptor signaling, calcium handling pathways, and mitochondria metabolism pathways involved in the citrate cycle were significantly upregulated. In protein interaction network analysis, chemokine family-, muscle contraction process-, and immune response-related genes were identified as hub genes with many interactions. In addition, mitochondrial pathways involved in calcium signaling, cardiac muscle contraction, tricarboxylic acid cycle, oxidation-reduction process, and calcium-mediated signaling were significantly stimulated in KEGG and Gene Ontology analyses. Our results provide a comprehensive understanding of the genome-wide transcriptional changes of HDM-induced AD-like symptoms and the indicated genes that could be used as AD clinical biomarkers.
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Calcium Intake is Negatively Associated with Bone Loss During Lactation: A Pilot Study
Cheawon Lee,Seunghee Kim,Hangyeol Jeon,Suyoung Kim,Seolhui Jeong,A Mi Kim,Yoonha Kim,Jongwoon Kim,Clara Yongjoo Park 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Calcium (Ca) requirements during lactation are unknown. We investigated the association between Ca intake and bone mineral density (BMD) during lactation. Twenty-one pregnant women with singletons (non-breastfeeding [NBF] n=7; breastfeeding [BF] n=14) were enrolled before delivery. Ca intake during the 3rd trimester and 6 months postpartum was assessed by food frequency questionnaire and interview. Maternal BMD was measured by dual energy X-ray absorptiometry at the lumbar spine, femoral neck, trochanter, intertrochanter (IT), and total hip at delivery and weaning (or 6 months postpartum). The association of Ca intake with % change of BMD (%ㅿBMD) and change of Z-score (ㅿZ) were assessed by linear regression and Spearman’s rank correlation coefficient. No association was observed in NBF women. Similarly, %ㅿBMD and 3rd trimester Ca intake were not associated in BF women. However, Ca intake during lactation was positively associated with IT ㅿZ (β: 0.613, p=0.02). Ca:P ratio during lactation was also positively correlated with IT ㅿ%BMD (β: 0.587, p=0.03). Higher intake of Ca during lactation may prevent lactation-related bone loss at the IT.
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Electrical characteristics of heterogeneous polymer layers in PEDOT:PSS films
Kim, Yunryeol,Cho, Wonseok,Kim, Youngno,Cho, Hangyeol,Kim, Jung Hyun The Royal Society of Chemistry 2018 Journal of Materials Chemistry C Vol.6 No.33
<P>(3,4-Ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), a representative conducting polymer, is environment-friendly and offers easy processing and flexibility owing to its hydro-dispersive properties. In this study, we investigated the electrical properties of PEDOT:PSS films with H2SO4/DMSO post-treatment. PEDOT:PSS is an electrolyte complex that has been attracting attention as a next-generation transparent electrode. The PEDOT:PSS films are composed of two heterogeneous phases: a PSS-rich layer and a PEDOT-rich layer. The PSS-rich layer is observed to be a homogeneous phase that does not influence the electrical properties. Thus, the PSS-rich layer, which occupies a large area of the PEDOT:PSS films, was removed to obtain films having high electrical properties. Both the layers exhibit a homogeneous phase regardless of their electrical properties. In particular, the PSS-rich layer without the PEDOT chains does not affect the electrical properties, since it does not contribute to hole transport. The heterogeneity of the PEDOT:PSS films with good electrical properties has been revealed by eliminating the unnecessary PSS-rich layers. The highest electrical conductivity obtained was 2239 S cm<SUP>−1</SUP>, which is about 4.1 times higher than that of the pristine PEDOT:PSS films, for the films involving 15 M H2SO4/DMSO post-treatment.</P>
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김한결(Kim Hangyeol),오세일(Oh Seil) 서강대학교 생명문화연구소 2017 생명연구 Vol.44 No.-
Love, intimacy, and dating are very important themes and tasks for youth, in particular, university students. There were much research on love and dating of university students from the perspectives of psychology, culture or gender studies; however, most research lacked interactional implication of dating couples. While psychological studies mainly focused on individual satisfaction, they could not shed light on the problem of self-growth. Therefore, this research aims at empirical explanation on relations between relational-self-oriented love types and authenticity-reflexivity as internal capacity for building up relations. This research collected surveys from 368 students at C University in Seoul. Statistical findings are quite interesting. Current dating does not mechanically guarantee self-growth. Regarding love-types, only ‘Fog style’ which indicates dissolving or sacrificing oneself for his/her lover, is significantly correlated with love-satisfaction and self-growth; other types did not appear meaningful. In terms of internal capacity, authenticity stemming from one’s emotion and motif is significantly correlated with emotional and problem-solving communication; it does not show significant relation to self-growth. On the contrary, reflexivity as mental feed-back capacity for changing one’s attitudes, values, and behaviors is significantly related not only to emotional communication but also to self-growth. In addition, self-esteem on appearance is related to love-satisfaction while self-esteem on performance is related to self-growth. In sum, this paper examined various relational implications of love and dating for university students. It suggests that self-sacrifice, reflexivity and self-esteem on practices are significant elements for self-growth of lovers. 현대사회에서 연애는 중요한 연구주제로 부각되고 있다. 특히 대학생들에게 연애는 발달과업으로서의 성장과정이자, 동시에 불안한 경쟁사회에서 안정감을 제공하는 친밀한 관계로서 중요한 화두이다. 그런데 심리, 문화 혹은 젠더 차원에서 진행된 기존의 연구들은 연애 중인 행위자들 간의 ‘상호작용’ 영역에 관해서는 깊이 있게 분석하지 못하였다. 특히 심리학적 연구는 연애 만족에 치중하여 분석하는 경향이 강하였기 때문에, 연애가 자아 성장에 미치는 영향을 검토하지 못하였다. 따라서 본 연구는 ‘관계적 자기에 기반한 연애 유형’, ‘진정성’과 ‘성찰성’, ‘자존감’의 개념에 근거하여 행위자 간의 상호작용으로서 연애를 이해하고, 이들이 ‘연애 만족’과 ‘연애를 통한 자아 성장’에 미치는 영향을 살펴보고자 하였다. 본 연구는 서울 소재 C 대학의 대학생 368명으로부터 연애에 대한 설문을 수집하였다. 그 결과, 현재 연애의 여부는 연애 만족과는 정적 관련이 있지만, 연애를 통한 자아 성장과는 유의미한 관련이 없다. 연애 유형에 따른 연애 성향의 경우 연애 만족과 자아 성장 둘 다와 유의미한 관계를 보인다. 특히 (자기희생의) ‘안개성향’은 다양한 차원에서의 연애만족 뿐 아니라 자아 성장과도 유의미한 정적 상관관계를 나타내지만, 껍질성향, 난장이성향, 산만성향은 대개 부적 관계를 보인다. 한편, 감정적 자기표현 차원에서 수행되는 ‘진정성’은 정서적 의사소통 만족 및 문제 해결 의사소통에 긍정적으로 영향을 주지만, 연애를 통한 자아 성장에는 영향을 미치지 못 한다. 다른 한편, 자신의 의식, 감정, 행위 등을 반추하고 재구성함으로써 수행되는 ‘성찰성’은 정서적 의사소통만족과 자아 성장에 정적 영향을 미친다. 끝으로 외모 자존감이 전반적 연애 만족과 정서적 의사소통 만족에 긍정적인 영향을 미치고 수행 자존감이 자아 성장과 정적 관련이 있다. 요컨대, 본 논문은 대학생들의 연애에서의 만족과 자아 성장에는 진정성과 성찰성의 요인이 별개로 작용하고 있으며, 특히 연애에서 자아 성장을 위해서는 자기희생과 수행에 대한 자신감 그리고 성찰성이 중요하다는 점을 제기한다.
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Effect of 42 amino acid long amyloid-β peptides on Arabidopsis plants
Lee, HanGyeol,Kim, Ji Woo,Jeong, Sangyun,An, Jungeun,Kim, Young-Cheon,Ryu, Hojin,Lee, Jeong Hwan The Korean Society of Plant Biotechnology 2020 JOURNAL OF PLANT BIOTECHNOLOGY Vol.47 No.4
Although the evolution of Arabidopsis thaliana and humans diverged approximately 1.6 billion years ago, recent studies have demonstrated that protein function and cellular processes involved in disease response remain remarkably conserved. Particularly, γ-secretase, a multisubunit protein complex that participates in intramembrane proteolysis (RIP) regulation, is also known to mediate the cleavage of more than 80 substrates including the amyloid precursor protein (APP) and the Notch receptor. Although the genes (PS1/2, APH-1, PEN-2, and NCT) coding for the γ-secretase complex components are present in plant genomes, their function remains largely uncharacterized. Given that the deposition of 42 amino acid long amyloid-β peptides (hAβ<sub>42</sub>) is thought to be one of the main causes of Alzheimer's disease, we aimed to examine the physiological effects of hAβ<sub>42</sub> peptides on plants. Interestingly, we found that Arabidopsis protoplast death increased after 24 h of exposure to 3 or 5 µM hAβ<sub>42</sub> peptides. Furthermore, transgenic Arabidopsis plants overexpressing the hAβ<sub>42</sub> gene exhibited changes in primary root length and silique phyllotaxy. Taken together, our results demonstrate that hAβ<sub>42</sub> peptides, a metazoan protein, significantly affect Arabidopsis protoplast viability and plant morphology.
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