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      • Immediate Breast Reconstruction vs. Mastectomy Alone in Locally Advanced Breast Cancer; Local Recurrence and Distant Recurrence

        Youngjin Kim,Eun-Shin Lee,Jong Ho Cheun,Jigwang Jung,Han-Byoel Lee,Hyeong-Gon Moon,Dong-Young Noh,Wonshik Han 한국유방암학회 2019 Journal of Breast Disease Vol.7 No.2

        Purpose: The oncologic safety of immediate breast reconstruction (IBR) has been demonstrated. However, the outcome of IBR for locally advanced breast cancer (LABC) is still under debate. We compared the survival outcome of LABC patients who underwent IBR vs. mastectomy alone. Methods: We retrospectively analyzed a total of 248 patients with stage III breast cancer who were treated with mastectomy between 2004 and 2015. The study subjects were divided into 2 groups: patients who received IBR (n=77) or mastectomy alone (MA) (n=171). We compared disease-free survival (DFS) of both groups. Results: Median follow-up duration was 49 months and the mean age of patients was 49 years. Patients in the IBR group were significantly younger and had lower body mass index (BMI) than those in the MA group. In a univariate analysis, IBR group showed better DFS than the MA group (DFS 81.3 months vs. 49.8 months, p<0.001). There was no delay in adjuvant treatment in the IBR group. In a multivariate analysis, IBR was associated with better DFS (hazard ratio (HR) for recurrence: 0.37, 95% CI 0.20–0.69, p=0.002) when adjusted for potential prognostic factors. In a subgroup analysis performed according to disease stage (IIIA and IIIB/IIIC), DFS was significantly better in IBR than MA group in both stage subgroups (p<0.001). Conclusion: We demonstrated that patients who underwent IBR showed better DFS outcome compared with patients who underwent mastectomy alone. Our results can help surgeons to determine if IBR is an option in patients with LABC.

      • KCI등재

        Clinical outcome of early relaparotomy after elective open repair of abdominal aortic aneurysms

        Youngjin Han,Tae-Won Kwon,Gi-Young Ko,Hojong Park,Ji Yoon Choi,Yong-Pil Cho 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.3

        Purpose: The aim of this study was to retrospectively evaluate the association of need for early relaparotomy with clinical outcomes after elective open repair of abdominal aortic aneurysms (AAAs). Methods: A total of 292 consecutive patients who underwent elective open AAA repair at Asan Medical Center from January 2001 to December 2010 were included in this study, and we compared the demographics, clinical characteristics, related risk factors, and clinical outcomes of early relaparotomy versus nonrelaparotomy patients. Results: The incidence of early relaparotomy during a single hospital stay was 4.1% (n = 12), and the most common causes were bowel ischemia (n = 5, 41.7%) and postoperative bleeding (n = 3, 25.0%). Among the demographics and clinical characteristics significantly associated with relaparotomy were: age (P = 0.025), chronic obstructive pulmonary disease (COPD) (P = 0.010), number of RBC units transfused during the AAA repair (P = 0.022) and in the following week (P = 0.005), and length of intensive care (P < 0.001) and overall hospital stay (P < 0.001). On multivariate analysis, presence of COPD (P = 0.009) and number of RBC units transfused during the AAA repair (P = 0.006) were statistically significantly associated with relaparotomy. Furthermore, early relaparotomy was associated with perioperative (within 30 days) (P = 0.048) and overall in-hospital mortality (P = 0.001). Conclusion: Early relaparotomy has an adverse effect on clinical outcomes: increased mortality and hospital length of stay. Presence of COPD and need for RBC transfusion are associated with early relaparotomy.

      • KCI등재

        공간구문론을 의한 전시공간 가시성에 관한 연구 -오문 전시장 특전을 중심으로-

        한한 ( Han Han ),김영진 ( Kim Youngjin ),김주연 ( Kim Jooyun ) 한국공간디자인학회 2023 한국공간디자인학회논문집 Vol.18 No.8

        (연구배경 및 목적) 전통건축이 사라지고 있는 정세 속에서 전통건축의 현대화 활용은 중국이 연구해 온 중요 과제이다. 가치 있는 역사 유산을 보호하는 것뿐만 아니라 그 가치를 충분히 활용하여 현대 사회에 공헌할 필요가 있다. 오문 전시장은 베이징 고궁의 입구인 정문성문루(正門城門樓)를 현대화 형태로 개조하여 현재 고궁박물관에서 전시하고 있다. 이에 공간구문론을 활용하여 전통건축의 현대적 활용 방안을 제안하고자 한다. 또한 공간구문론을 통해 오문 전시의 가시성과 관람객 보행 패턴을 분석하고 전시 공간 계획의 최적화 방안을 제시하는 것이 연구의 목적이다. (연구방법 및 범위) 연구의 방법은 첫째, 이론적 고찰을 통해 시각화 분석의 원리와 분석 방법을 이해하고 오문 전시장의 공간 형태를 살펴보았다. 둘째, 4개의 전시 공간 배치 및 전시 계획 계획을 분석하고 DethpmapⅩ를 사용하여 공간 가시성의 연결도/시각적 통합도 및 에이전트 분석을 계산하였다. 셋째, 분석값의 비율을 분석하여 4개의 전시를 평가하고 최종적으로 오문 전시장의 전시 공간 계획의 최적화 방안을 제시하였다. 연구범위는 2019년 베이징 고궁 오문(午門) 전시장에서 개최되는 특별 전시회에 초점을 맞추어 전시 공간의 배치와 구조를 연구하고 시선 흐름과 관람객의 시각적 경험을 분석하였다. (결과) 본 연구는 2019년 오문 전시장에서 개최된 4개의 특별 전시회에 대한 전시 공간 가시성 분석을 통해 4개의 전시 중 3개의 전시가 우수한 공간 연결도를 달성하고 4개의 전시 중 2개의 전시가 우수한 시각적 통합도를 달성했음을 검증하였다. 전시장에서 관람객의 활동 행동을 지능형 연산으로 시뮬레이션한 결과, 4개의 전시 모두 활동도가 높은 지역을 중심으로 관람객들의 관람 동선이 뚜렷하게 드러났다. 향후 전시 공간에서는 시선 지도, 공간 배치, 다단계 전시 및 상호 참여의 3가지 측면에서 전시 구역의 공간 활성을 개선하고 활용도와 노출률을 향상시키는 전시 공간 구성이 이루어져야 함을 알 수 있었다. (결론) 본 연구는 현대적 공간 분석 이론인 공간 구문을 전통건축 공간 형태에 적용하여 전통 공간의 현대적 활용과 관련된 분야의 연구를 위한 새로운 연구 방식의 가능성을 도출하였다. 이에 공간 구문 데이터 연산을 활용하면 전통건축의 현대적인 활용을 위한 공간 최적화 기반을 제공하여 문화적 가치와 경제적 가치를 충분히 발휘할 수 있을 것으로 사료된다. (Background and Purpose) In today's society, with traditional architecture vanishing, China is actively studying the modernization of these cultural treasures. Preserving valuable historical heritage not only entails protection but also leveraging its value to serve contemporary society better. The Omun exhibition hall, the entrance to the Beijing Palace known as Jeongmunseongmunru, has been modernized and is currently hosting significant exhibitions at the Palace Museum. Using spatial syntax, this study aims to intuitively optimize the modern utilization of traditional architecture, enhancing the planning and design process. The primary objective is to analyze the visibility and visitor movement patterns within the five-door exhibitions through spatial syntax. Based on this analysis, optimization proposals for exhibition space planning will be presented, ultimately elevating the overall exhibition experience. (Method) The abstract aims to study the visualization analysis principles and methods, understand the spatial form of the five-mun exhibition hall, and analyze four exhibition space layouts and planning schemes. Utilizing Depthmap Ⅹ, the connectivity, visual integration, and agent analysis of spatial visibility are calculated. Through the analysis of these values, the four exhibitions are evaluated, and optimization plans for the Omun exhibition hall are proposed. The scope of the study focuses on a special exhibition held at the Omun Exhibition Hall in Beijing in 2019, examining the arrangement and structure of the exhibition space, as well as analyzing the gaze flow and visual experiences of visitors. By comprehensively evaluating these factors, the study is completed. (Results) Through an analysis of exhibition space visibility for four special exhibitions held at Omun Exhibition Hall in 2019, this study found that three out of four exhibitions achieved good spatial connectivity, and two out of four exhibitions achieved good visual integration. Moreover, by simulating visitor activity behavior using intelligent calculations, a clear pattern of visitor flow was revealed for all four exhibitions, with a notable concentration in areas of high activity. In the future exhibition space, it was found that the exhibition space should be constructed to enhance the spatial activity of the exhibition area and improve the utilization and exposure rate of the exhibits in three key aspects: gaze map, spatial layout, multi-level exhibition, and interactive participation. (Conclusions) This study applies spatial syntax, as a modern spatial analysis theory, to traditional architectural space forms, presenting a novel research approach for investigating the modern use of traditional spaces in related fields. Therefore, it is believed that the use of spatial syntax data operations will provide a foundation for space optimization for the modern utilization of traditional architecture to fully manifest cultural and economic value.

      • Two-Dimensional Phosphorene-Derived Protective Layers on a Lithium Metal Anode for Lithium-Oxygen Batteries

        Kim, Youngjin,Koo, Dongho,Ha, Seongmin,Jung, Sung Chul,Yim, Taeeun,Kim, Hanseul,Oh, Seung Kyo,Kim, Dong-Min,Choi, Aram,Kang, Yongku,Ryu, Kyoung Han,Jang, Minchul,Han, Young-Kyu,Oh, Seung M.,Lee, Kyu T American Chemical Society 2018 ACS NANO Vol.12 No.5

        <P>Lithium-oxygen (Li-O<SUB>2</SUB>) batteries are desirable for electric vehicles because of their high energy density. Li dendrite growth and severe electrolyte decomposition on Li metal are, however, challenging issues for the practical application of these batteries. In this connection, an electrochemically active two-dimensional phosphorene-derived lithium phosphide is introduced as a Li metal protective layer, where the nanosized protective layer on Li metal suppresses electrolyte decomposition and Li dendrite growth. This suppression is attributed to thermodynamic properties of the electrochemically active lithium phosphide protective layer. The electrolyte decomposition is suppressed on the protective layer because the redox potential of lithium phosphide layer is higher than that of electrolyte decomposition. Li plating is thermodynamically unfavorable on lithium phosphide layers, which hinders Li dendrite growth during cycling. As a result, the nanosized lithium phosphide protective layer improves the cycle performance of Li symmetric cells and Li-O<SUB>2</SUB> batteries with various electrolytes including lithium bis(trifluoromethanesulfonyl)imide in <I>N,N</I>-dimethylacetamide. A variety of <I>ex situ</I> analyses and theoretical calculations support these behaviors of the phosphorene-derived lithium phosphide protective layer.</P> [FIG OMISSION]</BR>

      • SCOPUSKCI등재

        A study of the spatio-temporal distribution changes of the Korean Hawk Moth (Lepidoptera: Sphingidae)

        Han, Yong-Gu,Cho, Youngho,Kwon, Ohseok,Kang, Young-Kook,Park, Young-Jun,Kim, Youngjin,Choi, Min-Joo,Nam, Sang-Ho The Ecological Society of Korea 2015 Journal of Ecology and Environment Vol.38 No.1

        This study was conducted in an effort to identify the fluctuation of species according to space and time by collecting information on samples of Korean Sphingid moths housed in Korea. The number of Sphingidae moth species housed in Korea was found to be 53. As 48 species and 47 species were found in Gyeongsangnam-do and Gangwon-do, respectively, relatively diverse species were considered to be distributed in these areas. Comparatively, in Jeollabuk-do only 36 species were found, whereas in Chungcheongbuk-do and Jeju Island 39 species were found. The number of individual Sphingid moths surveyed in Korea was 21,414. With regard to the number of individuals per species, Ampelophaga rubiginosa was highest, at 2,483, followed by Theretra japonica (1,716), Callambulyx tatarinovii (1,457), Acosmeryx naga (1,340), Rhagastis mongoliana (1,191), Marumba sperchius (1,083), and Dolbina tancrei (1,072). By region, the largest number of individuals was surveyed in Gyeongsangnam-do (4,595), followed in order by Gangwon-do (3,648 individuals), Gyeonggi-do (3,011), Jeollanam-do (2,454), and Jeju Island (2,382). Over time, the highest numbers-in this case 9,498 individuals in 52 species-were identified after 2000. In the 1990s, there were 6,027 of 49 species identified; in 1980s, 4,332 individuals of 49 species were identified; and, in the 1970s, 937 individuals of 45 species were identified. It was confirmed that more species and individuals were identified as time passed. The appearance of Sphingid moths by month was found to be as relatively diverse, as they appeared from February to November. Overall, southern species, including M. saishiuana, Cephonodes hylas, Acosmeryx castanea, T. nessus, and T. clotho, which mainly inhabit Jeju Island and the southern part of Korea, have increased over time from the past to the present. Species inhabiting the middle or northern parts of the Korean Peninsula or the entire country of Korea, including Sphingulus mus, Ambulyx schauffelbergeri, and Mimas christophi, show decreases over time.

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