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金亮均,李準熙,崔正鎬,申鉉穆 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.2
Computer programs called "PCBRG" and "PCPST' were developed to analyze and design the prestressed concrete bridge. PCBRG is a structural analysis program which can determine the member forces, displacements and adaptable area of tendon by iteration method. PCPST is a post-processor for design. It enables design variables verified and the results of analysis (stress, member force and displacement, etc) are presented in the screen. Also the shear force and bending strength by the deformation compatibility method were checked.
李龍均,朴유미,鄭大一,金寅植,朴鍾勳,盧信愛,鄭逸守,朴敏洙 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.1
Tropinone 화합물들은 색다른 고리계의 존재로 아주 오래전부터 약리학적으로 매우 흥미로운 연구과제로 주목되어 최근에 그들의 합성법,?? 입체적 구조분석?? 그리고 약리학적인 연구??가 활발히 진행되고 있다. Tropinone 1은 흔히 마약으로 알려져 있는 cocaine 2, 소염작용과 항경련성 작용 및 심장박동수를 조절 등 다양한 약리작용을 하는 tropane spirohy-dantoin ?? 그리고 안과질환을 검사 할 때 눈의 동공을 확장시키는 데 사용하는 atropine ??등을 합성하는 데 중요한 중간체이다. ??????????? Trigo, G, G등 ??은 aliphatic amine과 succinic aldehyde를 acetonedicarboxylic acid와 반응하여 nortropane 유도체를 합성하였으며, 그 후 [3+2] nitrone cycloaddition? 과 [3+4] cyclocoupling? 을 거치는 tropane alkaloid의 새로운 합성법이 개발되었다. 최근 lzquier M. L. 등¹은 acetonedicarboxylic acid를 사용하여 1차 지방족 amine과 succinic aldehyde대신 2,5-dimethoxytetrahydrofuran을 반응시켜 N-alkyl nortropinone 유도체를 합성하였다. 그러나 일반적으로 빙초산 속에서 amine과 2,5-dimethoxytetrahydrofuran을 반응시키면 pyrrole 유도체가 합성되어진다.?? 이러한 사실은 분명히 반응조건(예, 산, 온도)에 따른 다양한 화학이 존재한다고 볼 수 있다. 따라서 우리는 반응조건, 즉 산의 변화 및 온도 변화에 의한 amine과 2,5-dimethoxytetrahydrofuran의 반응을 자세하게 검토하면서 새로운 N-arylnortropinone 유도체를 합성하고자 한다.
이수정,신정혜,김정균,성낙주 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.4
염건조기(굴비)는 참조기를 염장·건조하여 만든 염건품으로 예부터 우리나라 사라들이 즐겨 먹어 왔으며 오늘날까지 그 수요가 증가하고 있는 우리나라 특유의 수산가공품이다. 본 실험은 굴비를 가공하는 데 있어서 염의 종류, 염장방법을 달리하여 가공할 때 발암성 NA의 전구물질인 DMA, TMA, nitrate 및 nitrite를 분석함으로써 굴비의 안전성을 위한 기초자료를 확보코져 하였다. DMA 및 TMA 함량은 굴비 가공 및 저장중 증가하는 경향을 보였다. DMA는 생시료에서 0.3㎎/㎏였던 것이 염장 3일 후에는 17.4∼25.2배 증가하였고, TMA는 염건 15일후에 9.6∼15.4㎎/㎏의 범위였는데, 대체로 마른간법으로 제조한 시료에서 DMA 및 TMA의 증가폭이 더 큰 것으로 나타났다 질산염 및 아질산염함량은 생시료에서 각각 3.6, 0.4㎎/㎏으로 검출되었는데, 가공 및 저장중 점차적으로 감소하는 경향이었으나 질산염함량은 저장 40일 후에 5.2∼6.5㎎/㎏의 범위로 다소 증가되었다. DMA, TMA, 질산염 및 아질산염과 같은 NA전구물질의 생성을 억제시키는 측면에서 볼 때 정제염을 이용하여 물간법으로 염장하는 것이 비교적 효과적이라는 결과를 얻었다. The changes of amine, nitrate and nitrite nitrogen in yellow corvenia were studied during its processing and storage in order to clarify the precursors of N-nitrosamine(NA) formation in the salted and dried yellow corvenia(Gulbi), prpared by using the different salting method like dry and brine salting by pure and crude salt. As a result, during the processing and storage of Gulbi, DMA and TMA contents were significantly increased in the yellow corvenia. And after 40 days storage the increase rate showed 25.7∼45.7, 3.3∼5.6 times higher than those of 0.3, 2.4㎎/㎏, respectively, in raw sample. Regardless of the processing condition, contents of nitrate were also increased irregularlly, while nitrite contents, during its processing and storage, were scarcely changed in the salted and dried yellow corvenia. During the processing and storage of Gulbi, DMA and TMA contents were less produced in brine salted and dried yellow corvenia using crude salt than in sample prepared using pure salt, while the former were more effective than the latter in inhibiting the production of nitrate and nitrite. Therefore, it was revealed that reductions of NA precursors such as DMA, TA, nitrate and nitrite were more effective in preparing with the brine salting method than with the dry salting method.
Electrochemical Properties of PPy/CNT Electrodes Prepared by Chemical Process for Ultracapacitor
Shin, Jeong-Gyun,Park, Soo-Gil The Korean Electrochemical Society 2007 한국전기화학회지 Vol.10 No.2
Polypyrrole(PPy) was composite with MWNT to attain cycle stable by chemical method. We have been considered PPy is the ideal material for high energy density electrochemical capacitor due to pseudo capacitor reaction. In this study we found that increase in cycle life due to composite MWNT. Also PPy/MWNT composite material have resulted larger capacitance and exhibits better electrochemical behavior. The structural feature was investigated by using SEM and TEM. The PPy/CNT composite is not only a promising ultracapacitor material for energy storages but also has a good possibility because of its great capacitive properties, simple preparation and low cost.
( Shin Ok Jeong ),( Eui Bae Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Sang Gyune Kim ),( Sang Woo Cha ),( Young Seok Kim ),( Young Deok Cho ),( Hong Soo Kim ),( Boo Sung Kim ),( 대한간학회 2017 Gut and Liver Vol.11 No.3
Background/Aims: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Methods: Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS). Results: Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43.2%). In multivariate analyses, tumor size (≤5 cm) and single nodularity were predictive factors for CR, with hazard ratios (HRs) of 0.35 (p=0.002) and 0.41 (p< 0.001), respectively. Elevated serum α-fetoprotein (AFP) (>20 ng/mL) level and multinodularity exhibited significant relationships with recurrence after CR, with HRs of 2.220 (p=0.026) and 3.887 (p< 0.001), respectively. Tumor size (>5 cm), multinodularity, elevated serum AFP (>20 ng/mL) level, Child-Turcotte-Pugh score (B and C), and portal vein thrombosis were significant factors for OS. Conclusions: In patients treated with TACE as a first therapy, tumor size (≤5 cm) and single nodularity were predictive factors for CR, and multinodularity and elevated serum AFP (>20 ng/mL) levels were predictive factors for recurrence after CR. These factors were also significant for OS. (Gut Liver 2017;11:409-416)
Review : The effect of gut microbiota on drug metabolism
( Mi Jeong Kang ),( Hyung Gyun Kim ),( Jin Sung Kim ),( Do Gyeong Oh ),( Yeon Ji Um ),( Chae Shin Seo ),( Ji Won Han ),( Hyun Ji Cho ),( Ghee Hwan Kim ),( Tae Cheon Jeong ),( Hye Gwang Jeong ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Introduction: Numerous drugs and toxicants must be metabolized to an active form. Metabolic activation by host tissues, such as the liver, has been well studied. However, drug and toxicant metabolism by the intestinal microbiota is an unexplored, but essential, field of study in pharmacology and toxicology. The taxonomic diversity and sheer numbers of the intestinal microbiota, and their capacity to metabolize xenobiotics, underscore the importance of this mode of metabolism. Areas covered: Metabolism by the intestinal microbiota has focused on the natural products of glycosides hydrolyzed by intestinal microbiota enzymes, but not by host tissues. Metabolism of synthetic drugs by the intestinal microbiota has been less-intensively investigated. This review provides an overview of xenobiotic metabolism by the intestinal microbiota of both natural products and synthetic drugs. Expert opinion: Metabolism by the intestinal microbiota might result in a different metabolite profile than that produced by host tissues. This could potentially result in either activation or inactivation of the pharmacological and/or toxicological actions of the compound in question. The contribution of the intestinal microbiota to drug metabolism remains relatively unexplored. Therefore, studies of xenobiotic metabolism by the intestinal microbiota need to be included in new drug development as well as classical studies of host tissue metabolism.
Role of Metabolism by Intestinal Bacteria in Arbutin-induced Toxicity In Vitro
( Mi Jeong Kang ),( Hyun Woo Ha ),( Hyung Gyun Kim ),( Dae Hun Lee ),( Min Jeong Kong ),( Young Tae Ahn ),( Dong Hyun Kim ),( Beom Soo Shin ),( Won Ku Kang ),( Hye Gwang Jeong ),( Tae Cheon Jeong ) 영남대학교 약품개발연구소 2011 영남대학교 약품개발연구소 연구업적집 Vol.21 No.-