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Xu, Li-Yun,Chen, Dong-Dong,He, Jian-Ying,Lu, Chang-Chang,Liu, Xiao-Guang,Le, Han-Bo,Wang, Chao-Ye,Zhang, Yong-Kui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: The purpose of this study was to investigate Tim-3 expression on peripheral CD3-CD56+ natural killer (NK) cells and CD3+CD56+ natural killer T (NKT) cells in lung cancer patients. Materials and Methods: We analyzed Tim-3+CD3-CD56+ cells, Tim-3+CD3-$CD56^{dim}$ cells, Tim-3+CD3-$CD56^{bright}$ cells, and Tim-3+CD3+CD56+ cells in fresh peripheral blood from 79 lung cancer cases preoperatively and 53 healthy controls by flow cytometry. Postoperative blood samples were also analyzed from 21 members of the lung cancer patient cohort. Results: It was showed that expression of Tim-3 was significantly increased on CD3-CD56+ cells, CD3-$CD56^{dim}$ cells and CD3+CD56+ cells in lung cancer patients as compared to healthy controls (p=0.03, p=0.03 and p=0.04, respectively). When analyzing Tim-3 expression with cancer progression, results revealed more elevated Tim-3 expression in CD3-CD56+ cells, CD3-$CD56^{dim}$ cells and CD3+CD56+ cells in cases with advanced stages (III/IV) than those with stage I and II (p=0.02, p=0.04 and p=0.01, respectively). In addition, Tim-3 expression was significantly reduced on after surgical resection of the primary tumor (p<0.01). Conclusions: Tim-3 expression in natural killer cells from fresh peripheral blood may provide a useful indicator of disease progression of lung cancer. Furthermore, it was indicated that Tim-3 might be as a therapeutic target.
Zhang Chao-lei,Xie li-yao,Liu Guang-lei,Chen lie,Liu Ya-zheng,Li Jian 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.5
Surface decarburization behavior and its adverse effects of air-cooled forging steel C70S6 for automobile engine fracture splitting connecting rod were investigated comprehensively by mechanical properties, microstructure and fracture morphology analysis. The results show that the surface decarburization in the outer surface of the fracture splitting at the big end bore and the micro-cracks in the decarburized layer are result in the uneven and spalling fracture surfaces of the waster connecting rod product. Besides, partial decarburization is produced between 900 °C and 1250 °C for heating 2 h, and decarburization sensitivity reach maximum at 1150 °C, but no complete decarburization forms for heating 2 h at 650-1250 °C. The decarburized depth follows a parabolic law with the increase of the heating time from 0.5 h to 12 h, and the decarburization sensitivity coefficient is 2.05×10 -5 m·s -1/2 at 1200 °C. For the connecting rod manufacturing, surface decarburization must be under effective control during the hot forging process but not the control cooling process.
A two-stage cascaded foreground seeds generation for parametric min-cuts
( Shao-mei Li ),( Jun-guang Zhu ),( Chao Gao ),( Chun-wei Li ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.11
Parametric min-cuts is an object proposal algorithm, which can be used for accurate image segmentation. In parametric min-cuts, foreground seeds generation plays an important role since the number and quality of foreground seeds have great effect on its efficiency and accuracy. To improve the performance of parametric min-cuts, this paper proposes a new framework for foreground seeds generation. First, to increase the odds of finding objects, saliency detection at multiple scales is used to generate a large set of diverse candidate seeds. Second, to further select good-quality seeds, a two-stage cascaded ranking classifier is used to filter and rank the candidates based on their appearance features. Experimental results show that parametric min-cuts using our seeding strategy can obtain a relative small pool of proposals with high accuracy.
Feixia Zhan,Chao Zhang,Shige Wang,Zeyu Zhu,Guang-Chen Jiao,Mingliang Zhao,Li Cao 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.2
Background and Purpose Hyperekplexia (HPX), a rare neurogenetic disorder, is classically characterized by neonatal hypertonia, exaggerated startle response provoked by the sudden external stimuli and followed by a shortly general stiffness. Glycine receptor alpha 1 (GLRA1) is the major pathogenic gene of the disease. We described the clinical manifestations of genetically confirmed HPX patients and made a literature review of GLRA1-related HPX to improve the early recognition and prompt the management of the disorder. Methods Extensive clinical evaluations were analyzed in 4 Chinese HPX patients from two unrelated families. Next generation sequencing was conducted in the probands. Sanger sequence and segregation analysis were applied to confirm the findings. Results All four patients including 3 males and 1 female presented with excessive startle reflex, a cautious gait and recurrent falls. Moreover, startle episodes were dramatically improved with the treatment of clonazepam in all cases. Exome sequencing revealed 2 homozygous GLRA1 mutations in the patients. The mutation c.1286T>A p.I429N has been previously reported, while c.754delC p.L252* is novel. Conclusions HPX is a treatable disease, and clonazepam is the drug of choice. By studying and reviewing the disorder, we summarized the phenotype, expanded the genotype spectrum, and discussed the possible pathogenic mechanisms to enhance the understanding and recognition of the disease. Early awareness of the disease is crucial to the prompt and proper administration, as well as the genetic counseling.
Gui Di Cai,Guang Hui Gao,Hong Yu Yang,Li Dan Zhu,Hua Liu,Guang Feng Wu,Ming Yao Zhang,Chao Zhou,Hui Xuan Zhang 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.3
Core–shell polybutadiene-graft-polystyrene rubber particles with different ratios of polybutadiene core to polystyrene shell were synthesized by an emulsion polymerization using K2S2O8 as an initiator. Then the core–shell rubber particles were blended with PS to prepare PS/PB-g-PS. The rubber particles with a size of 0.3–0.5 mm could toughen polystyrene significantly. The mechanical properties, morphologies and deformation mechanisms of samples were extensively investigated. The experimental results showed that the dispersion of rubber particles in a ‘‘cluster’’ state leads to better impact resistances. Crazing occurred from rubber particles and extended in a bridge-like manner to neighboring rubber particles parallel to the equatorial direction.