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- 저자 : Gatti, Manasa G. (검색결과 13 건)
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Gattis, Samuel G.,Chung, Hak Suk,Trent, M. Stephen,Raetz, Christian R. H. American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.13
<P>Lipopolysaccharide (LPS; endotoxin) is an essential component of the outer monolayer of nearly all Gram-negative bacteria. LPS is composed of a hydrophobic anchor, known as lipid A, an inner core oligosaccharide, and a repeating O-antigen polysaccharide. In nearly all species, the first sugar bridging the hydrophobic lipid A and the polysaccharide domain is 3-deoxy-<SMALL>d</SMALL>-manno-octulosonic acid (Kdo), and thus it is critically important for LPS biosynthesis. Modifications to lipid A have been shown to be important for resistance to antimicrobial peptides as well as modulating recognition by the mammalian innate immune system. Therefore, lipid A derivatives have been used for development of vaccine strains and vaccine adjuvants. One derivative that has yet to be studied is 8-amino-3,8-dideoxy-<SMALL>d</SMALL>-manno-octulosonic acid (Kdo8N), which is found exclusively in marine bacteria of the genus <I>Shewanella</I>. Using bioinformatics, a candidate gene cluster for Kdo8N biosynthesis was identified in <I>Shewanella oneidensis</I>. Expression of these genes recombinantly in <I>Escherichia coli</I> resulted in lipid A containing Kdo8N, and <I>in vitro</I> assays confirmed their proposed enzymatic function. Both the <I>in vivo</I> and <I>in vitro</I> data were consistent with direct conversion of Kdo to Kdo8N prior to its incorporation into the Kdo8N-lipid A domain of LPS by a metal-dependent oxidase followed by a glutamate-dependent aminotransferase. To our knowledge, this oxidase is the first enzyme shown to oxidize an alcohol using a metal and molecular oxygen, not NAD(P)<SUP>+</SUP>. Creation of an <I>S. oneidensis</I> in-frame deletion strain showed increased sensitivity to the cationic antimicrobial peptide polymyxin as well as bile salts, suggesting a role in outer membrane integrity.</P>
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ON CERTAIN SUBCLASSES OF STARLIKE AND CONVEX FUNCTIONS ASSOCIATED WITH WRIGHT FUNCTION
NIRANJAN BASAVANTHAPPA GATTI,Saurabh Porwal,NANJUNDAN MAGESH 장전수학회 2022 Advanced Studies in Contemporary Mathematics Vol.32 No.3
In the present investigation to obtain certain sufficient conditions for normalized Wright function to be in certain classes of starlike and convex functions defined in unit disc △ :={z∈C : |z|<}. Further, we obtain some inclusion relations and integral operator associated with Wright function.
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Structural analysis of cracked R.C. members subjected to sustained loads and imposed deformations
Mola, F.,Gatti, M.C.,Meda, G. Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.11 No.6
A structural analysis of cracked R.C. members under instantaneous or sustained loads and imposed displacements is presented. In the first part of the paper the problem of deriving feasible moment-curvature diagrams for a long term analysis of R.C. sections is approached in an exact way by using the Reduced Relaxation Function Method in state I uncracked and the method suggested by CEB in state II cracked. In both states the analysis of the main parameters governing the problem has shown that it is possible to describe the concrete creep behaviour in an approximate way by using the algebraic formulation connected to the Effective Modulus Method. In this way the calculations become quite simple and can be applied in design practice without introducing significant errors. Referring to continuous beams, the structural analysis is then approached in a general way, applying the Force Method and the Principle of Virtual Works. Finally, considering single members, the structural analysis is performed by means of a graphical procedure based on the application of feasible moment-rotation diagrams which allow to easily solve various structural problems and to point out the most interesting aspects of the long term behaviour of cracked R.C. members with rigid or elastically deformable redundant restraints.
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Load response of the natural tooth and dental implant: A comparative biomechanics study
Robinson, Dale,Aguilar, Luis,Gatti, Andrea,Abduo, Jaafar,Lee, Peter Vee Sin,Ackland, David The Korean Academy of Prosthodonitics 2019 The Journal of Advanced Prosthodontics Vol.11 No.3
PURPOSE. While dental implants have displayed high success rates, poor mechanical fixation is a common complication, and their biomechanical response to occlusal loading remains poorly understood. This study aimed to develop and validate a computational model of a natural first premolar and a dental implant with matching crown morphology, and quantify their mechanical response to loading at the occlusal surface. MATERIALS AND METHODS. A finite-element model of the stomatognathic system comprising the mandible, first premolar and periodontal ligament (PDL) was developed based on a natural human tooth, and a model of a dental implant of identical occlusal geometry was also created. Occlusal loading was simulated using point forces applied at seven landmarks on each crown. Model predictions were validated using strain gauge measurements acquired during loading of matched physical models of the tooth and implant assemblies. RESULTS. For the natural tooth, the maximum vonMises stress (6.4 MPa) and maximal principal strains at the mandible ($1.8m{\varepsilon}$, $-1.7m{\varepsilon}$) were lower than those observed at the prosthetic tooth (12.5 MPa, $3.2m{\varepsilon}$, and $-4.4m{\varepsilon}$, respectively). As occlusal load was applied more bucally relative to the tooth central axis, stress and strain magnitudes increased. CONCLUSION. Occlusal loading of the natural tooth results in lower stress-strain magnitudes in the underlying alveolar bone than those associated with a dental implant of matched occlusal anatomy. The PDL may function to mitigate axial and bending stress intensities resulting from off-centered occlusal loads. The findings may be useful in dental implant design, restoration material selection, and surgical planning.
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Marta Pizzetti,Lucia Gatti,Peter Seele 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
In the last few years, the attention on false and misleading communications regarding company’s commitment towards the environment – a practice known as greenwashing – has drastically increased. Greenwashing has several consequences for companies: it deteriorates brand reputation and trust (Duan and Jie, 2013), increases consumer skepticism (Delmas and Burbano, 2011), reduces purchase intentions (Murray and Vogel 1997; Swaen and Vanhamme 2004, 2005), and erodes investor’s confidence in environmentally friendly firms (Delmas and Burbano, 2011). Indeed, private investors are interested in CSR and look for information about it (Cellier et al., 2016; Nath, et al., 2013) but little is known about the consequences of greenwashing on private investments. Moreover, greenwashing often happens because of the bad management of the supply chain and various company’s faults are related to the difficulty to manage it (Crane et al., 2014). The aim of this research is to investigate how greenwashing affects intention to invest depending on the involvement of the supply chain. In two experiments we compared three types of greenwashing, which vary according to the supply chain role in the misconduct and the declared CSR commitment of the company. We call indirect greenwashing when a company that declares to be CSR committed is accused of greenwashing because it purchases raw materials or services from a supplier that does not meet sustainability standards (e.g. child labor, environmental damages). Conversely, a company that does not follow its CSR talk because of its own production procedures is an example of direct greenwashing. We also propose a third category of greenwashing, which we called vicarious greenwashing: when the misconduct and the relative accusation regard a company’s supplier, but the company does not claim to be sustainable (so it’s vicariously affected). A scenario-based experimental design (n =107) asked participants to indicate the intention to invest on a company accused of direct greenwashing (vs. indirect vs. vicarious). Results showed that direct greenwashing is particularly detrimental on investment intentions, especially compared to vicarious greenwashing, but not compared to indirect greenwashing (even if the means were lower). This result suggests that greenwashing is detrimental for investments even when the company does not perform the misconduct. A second experiment (n = 202) investigated whether the declared control on the supply chain affects intention to invest when the company is involved in greenwashing. Direct greenwashing was the more detrimental for investments, but, when companies declared high control on the supply chain, greenwashing significantly decreased intention to invest, so that in high control condition direct greenwashing did not differ from vicarious and indirect greenwashing. These results show how the involvement in greenwashing affects investment intentions of private investors and expand our knowledge on the consequences of greenwashing, so far mostly investigated from the consumer side. We show that greenwashing has potential disruptive consequences from a broader perspective, because it reduces stakeholders’ willingness to invest, even when the misconduct is attributable to a supplier.
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Patil, Pravin,Madhuprasad, Pravin,Bhat, Mahesh P.,Gatti, Manasa G.,Kabiri, Shervin,Altalhi, Tariq,Jung, Ho-Young,Losic, Dusan,Kurkuri, Mahaveer Elsevier 2017 Chemical engineering journal Vol.327 No.-
<P><B>Abstract</B></P> <P>The rhodamine based receptor, P2 has been developed for the detection of environmentally hazardous Hg<SUP>2+</SUP> ions with a limit of detection, 1.5×10<SUP>−6</SUP> M. The P2 showed a significant colour change from colourless to pink upon binding with Hg<SUP>2+</SUP> ions. As a result, a new peak at 533nm was observed in UV–vis spectroscopy which was attributed to spirolactum ring opening followed by through bond energy transfer (TBET). In addition, the presence of other competing cations did not interfere the detection of Hg<SUP>2+</SUP> ions. Further, P2 has been successfully immobilized onto the naturally available and highly porous diatomaceous earth particles (P2D) for removal of Hg<SUP>2+</SUP> ions from water. The covalently attached organic molecule in P2D forms complex with Hg<SUP>2+</SUP> ion present in the water and thus traps the Hg<SUP>2+</SUP> ions. Based on this, a proof-of-concept cartridge has been developed for water purification. The cartridge having 450mg of P2D was able to purify 30mL of water containing 1ppm Hg<SUP>2+</SUP> ions. The efficiency of cartridge could be visualized with a colour change from colourless to pink.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Detection and removal of Hg<SUP>2+</SUP> from water using chemodosimeter P2 were realized. </LI> <LI> P2 has been successfully immobilized onto naturally available diatoms (P2D). </LI> <LI> Organic receptor and hazardous Hg<SUP>2+</SUP> ions were physically contained in diatoms. </LI> <LI> Eco-friendly cartridge containing P2D was developed for the removal of Hg<SUP>2+</SUP> ions. </LI> <LI> Device efficiency (time to replace) could be realized through visual colour change. </LI> </UL> </P>
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