간찰 부위에서 발생한 전신형 고리 육아종 1예

허규 ( Gyoo Huh ),이현주 ( Heun-joo Lee ),최영준 ( Young-jun Choi ),김원석 ( Won-serk Kim ),이가영 ( Ga-young Lee ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.10

Granuloma annulare (GA) is a common non-infectious granulomatous disease. Generalized GA is the second most common variant of GA. It is often associated with recalcitrant disease progression despite treatment. The lesion of generalized GA typically presents widespread papules that coalesce to form annular plaques over the whole body. We report a case of a patient with disseminated papules and coalescing annular plaques, primarily involving the intertriginous area and mimicking tinea corporis or cruris. Histopathological findings confirmed the lesion as GA. This case underscored the unusual clinical presentation of generalized GA. A case of GA localized to the intertriginous area has rarely been reported. Given the recalcitrant nature of the disease, dermatologists should consider generalized GA as a differential diagnosis in patients with an annular lesion involving the intertriginous area. Thus, we report this as an atypical case of generalized GA localized to the intertriginous area. (Korean J Dermatol 2021;59(10):797∼800)

A case of Pfeiffer syndrome with c833_834GC>TG (Cys278Leu) mutation in the $FGFR2$ gene

Lee, Min-Young,Jeon, Ga-Won,Jung, Ji-Mi,Sin, Jong-Beom The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.7

Pfeiffer syndrome is a rare autosomal dominant disorder characterized by coronal craniosynostosis, brachycephaly, mid-facial hypoplasia, and broad and deviated thumbs and great toes. Pfeiffer syndrome occurs in approximately 1:100,000 live births. Clinical manifestations and molecular genetic testing are important to confirm the diagnosis. Mutations of the fibroblast growth factor receptor 1 ($FGFR1$) gene or $FGFR2$ gene can cause Pfeiffer syndrome. Here, we describe a case of Pfeiffer syndrome with a novel c833_834GC>TG mutation (encoding Cys278Leu) in the $FGFR2$ gene associated with a coccygeal anomaly, which is rare in Pfeiffer syndrome.

Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture

Lee, Kyung Hee,Won, Ran,Kim, Un Jeng,Kim, Ga Min,Chung, Myung-Ae,Sohn, Jin-Hun,Lee, Bae Hwan Elsevier 2010 Neuroscience Letters Vol.474 No.3

<P><B>Abstract</B></P> <P>FK506 has been originally classified as an immunosuppressant and is known to exhibit neurotrophic actions <I>in vitro</I> and protective effects on some neurological conditions. We investigated the neuroprotective effects of FK506 on kainic acid (KA)-induced neuronal death in organotypic hippocampal slice cultures (OHSCs). After an 18h KA (5μM) treatment, significantly neuronal death was detected in the CA3 region using propidium iodide staining. However, neuronal death was significantly prevented at 24 and 48h after treatment with 0.1μM FK506. Using cresyl violet staining, we also observed that an increased number of CA3 neurons survived in the 0.1μM FK506 group compared to the KA only group. Based on the results of the Western blot analysis, the expressions of 5-lipoxygenase and caspase-3 were reduced 24h after 0.1μM FK506 treatment. The levels of superoxide dismutase (SOD) and phospho-Akt expression were increased by treatment with 0.1μM FK506. These results suggest that FK506 may have a positive role in protecting neurons against cell death in the KA injury model of OHSCs.</P>

Effects of elevated CO2 on mineralizaion of organic C , N and P in two forest soils , Mt. Jumbong , Korea

Lee, Do Won,Koo, Hee Seung,Yoo, Ga Young 경북대학교 환경과학연구소 1995 環境科學硏究所論文集 Vol.9 No.1

In addition to increasing atmospheric COz, ecosystems experience various levels of COz. For example, levels of COz must be heterogeneous in soil matrices as expected from spatial variation of denitrification rates (Parkin 1987). The patchy distribution of particulate organic matter may lead to highly variable levels of COz through microbial consumption of Oz in soil air, when isolation of air pocket due to poor aeration in soil pores impedes diffusive transport of gases. The isolation may occur at micropores inside soil aggregates and at macropores between aggregates. In particular, many confined air pockets may be distributed in poorly drained soils and even in general soils during and just after a period of rainfall. Two sandy loam soils were taken from in the south- and north-facing slopes. respectively, located at a local area of forest floors in Mt. Jumbong. After the soils were incubated for 6 weeks under five different environments of COa (final levels ranged from 0.00 to 1.95), available and microbial pools and mineralization of C. N, and P were determined. Overall. COz enrichment lowered pool of NHa-N and enlarged that of N03 -N in the soils, indicating that it stimulated nitrification, enlarged the ratio of microbial C/N, inhibited mineralization of organic C, and stimulated mineralization of N. Effect of COz enrichment on mineralization of organic C has not been identified

Characterization of Polymetal Gate Transistors With Low-Temperature Atomic-Layer-Deposition-Grown Oxide Spacer

Ga-Won Lee,Hi-Duck Lee,Kwan-Yong Lim,Yong Soo Kim,Hong-Sun Yang,Gyu-Seog Cho,Sung-Kye Park,Sung-Joo Hong IEEE 2009 IEEE electron device letters Vol.30 No.2

<P>In this letter, W/WNx/poly-Si gate DRAM transistors with oxide spacers grown by low-temperature atomic layer deposition (ALD) have been fabricated, and the electrical characteristics are analyzed. The low-temperature ALD oxide effectively prevents the oxidation of exposed tungsten, and the fabricated devices show superior electrical properties to those with nitride/oxide spacer. The data retention time is improved by 30%, and the hot-carrier degradation characteristics are also enhanced. The threshold voltage of the fabricated W/WNx/poly-Si gate n-channel transistors with ALD oxide spacer is increased due to the suppression of boron deactivation by hydrogen. In particular, the transconductance of n-channel transistors in core/peripheral circuits was found to be enhanced by less-compressive stress in ALD oxide spacers.</P>

Synthesis and Electro-Optic Properties of Novel Polyester Containing Dioxybenzylidenecyanoacetate as a NLO-Chromophore

Lee, Ga-Young,Won, Dong-Seon,Lee, Ju-Yeon TaylorFrancis 2009 Molecular Crystals and Liquid Crystals Vol.504 No.1

<P> A novel polyester (4) containing dioxybenzylidenecyanoacetate group as a NLO-chromophore was prepared and characterized. Polyester 4 was soluble in common organic solvents such as acetone and DMSO. Polymer 4 showed thermal stability up to 280°C in TGA thermogram with Tg value measured from DSC thermogram near 108°C. The SHG coefficient (d33) of poled polymer film at the 1064 nm fundamental wavelength was around 3.54 × 10-9 esu. The dipole alignment exhibited a thermal stability up to near Tg and no significant SHG decay was observed below 95°C due to the partial main-chain character of polymer structure, which was acceptable for NLO device applications.</P>

Tradeoff Between Hot Carrier and Negative Bias Temperature Degradations in High-Performance <tex> $\hbox{Si}_{1 - x}\hbox{Ge}_{x}$</tex> pMOSFETs With High-<tex> $k$</tex>/Metal Gate Stacks

Won-Ho Choi,Chang-Young Kang,Jung-Woo Oh,Byoung-Hun Lee,Majhi, Prashant,Hyuk-Min Kwon,Jammy, Raj,Ga-Won Lee,Hi-Deok Lee IEEE 2010 IEEE electron device letters Vol.31 No.11

<P>Analyzed herein is the effect of different germanium (Ge) concentrations on negative bias temperature instability (NBTI) and channel hot carrier (CHC) degradations in high-performance Si1-xGex pMOSFETs. It is shown that higher concentrations result in less NBTI degradation due to the increased barrier height between the SiGe and high-k dielectric interface, but it causes greater CHC degradation due to the decreased channel bandgap with higher Ge concentrations. Therefore, the tradeoff between NBTI and HC degradations for different Ge concentrations should be considered when developing high-performance Si1- xGex pMOSFETs.</P>

S-454 : Does timing of adjuvant chemotherapy for gastric cancer influence outcome?

( Ga Won Song ),( Mi Sun Ahn ),( Jin Hyuk Choi ),( Seok Yun Kang ),( Hyun Woo Lee ),( Yong Kwan Cho ),( Sang Uk Han ),( Hoon Hur ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background: According to recent large phase III trials, adjuvant chemotherapy is currently established as standard treatment in patients with stage II, III gastric cancer. However, to the authors` knowledge, the effect of the interval between surgery and the start of chemotherapy on outcome has not been investigated. Methods: A retrospective review was conducted of 716 patients who underwent adjuvant chemotherapy for stage IB-IIIC (AJCC 7th edition) gastric cancer after radical surgery with D2 dissection between 1994 and 2004 at the Ajou University Hospital. Overall survival (OS) was compared among patients grouped by time from surgery to start of adjuvant chemotherapy. Results: In terms of chemotherapy regimens, 5-FU/mitomycin-C-based (61.3%) was the most commonly used regimen, followed by 5-FU/doxorubicin-based one (16.9%), oral fluoropyrimidines (10.3%) and others (11.4%). The median time from surgery to chemotherapy was 20 days (range: 4-105 days), while 114 patients (15.9%) began adjuvant chemotherapy >4 weeks after surgery. The median follow-up duration was 152 months (range: 97-222 months) for the survivors. There was no significant difference in 10 year-OS between patients starting chemotherapy ≤ 20 days after surgery and those initiating later (51.2% vs. 48.5%, p=0.896). Commencing chemotherapy 4 weeks, 6 weeks and 8 weeks after surgery was not associated with inferior OS, compared with earlier initiation at each time interval (p=0.183, 0.739, 0.434, respectively). Even very early initiation of chemotherapy (≤ 2 weeks after surgery) did not correlate with better outcome (p=0.579). Conclusion: This study did not demonstrate any significant survival benefit from early initiation of adjuvant chemotherapy after surgery.

Retrospective Study of Cysts in the Oral and Maxillofacial Regions: Statistical and Clinical Analysis

Lee, Hyun-Kyung,Ryu, Kyung-Sun,Kim, Moo-Gun,Park, Kwang-Won,Kim, Ryun-Ga,Roh, Sang-Hwa,Jung, Tae-Young,Park, Sang-Jun Korean Association of Maxillofacial Plastic and Re 2014 Maxillofacial Plastic Reconstructive Surgery Vol.36 No.1

Purpose: This study was designed for identification of the main clinicopathological features of cysts in the oral and maxillofacial regions. Methods: A retrospective observational study was conducted on 164 patients who had been diagnosed with cyst of the jaw, from the database of 168 histopathological diagnoses at the Department of Oral and Maxillofacial Surgery of Busan Paik Hospital at Inje University, from January 2009 to December 2011. The subjects were treated and the following variables were recorded: gender, age, clinical signs and symptoms, histopathological distribution, treatment methods, and complications. A descriptive analysis of the study variables was performed using a chi-square test. Results: Among the 164 patients, there were more male than female patients (male-female ratio: 1.7:1). The most predominant ages were the 20s and 40s. Among the classes of pathological cysts, radicular cysts and dentigerous cysts were the most common, with incidences of 56.0% and 35.1%. Thirty-six percent of the patients had no symptoms; and of those who had symptoms, the main signs and symptoms were swelling (24.4%) and pain (17.1%). The most frequent management method was the combination operation, such as enucleation with or without extraction and apicoectomy of the causative teeth. Of the 164 patients, 13 had complications; and one patient who had been treated with enucleation with apicoectomy had a recurrent cyst. Conclusion: Using a chi-square test, no significant differences in prevalence were observed in relation to gender according to age. Comparative analysis of radicular and dentigerous cysts showed a significant difference in their prevalence according to their anatomical location, however, no significant differences in were observed in their incidence rates according to age.

Reliable Data Transfer using Overhearing for Implicit ACK

Ga-Won Lee,Eui-Nam Huh 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

Many applications in Wireless Sensor Networks require collecting all data without loss from nodes.End-to-End data retransmission, which is used in the Internet for reliable transport, becomes very inefficient in Wireless Sensor Networks, since wireless communication, and constrained resources pose new challenges. We look at factorsaffecting reliability, and search for efficient combinations of the possible options. This paper proposes an efficient Overhearing based reliable transfer protocol in Wireless Sensor Networks by calculate Reliability and using implicit Acknowledgement. Finally, it is clarified that the proposed scheme is efficient for reliable data transfer in WSN.