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Liu Furu,Gao Menghui,Wu Qiongqiong,Yan Meiqi,Wu Renrong,Shao Ping,Huang Jing 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.5
Objective This study aimed to evaluate the consistency or stability of mental disorders diagnosed in the psychiatry ward setting, investigate factors associated with consistency, and observe the disease distribution over the decade.Methods A total of 20,359 psychiatric inpatients were included in this retrospective study from June 2011 to December 2020. Diagnoses from the first admission to discharge were evaluated to determine the diagnostic consistency during hospitalization. Readmissions were selected as the subgroup, whose first and last discharge diagnoses were compared to analyze the relatively long-term diagnostic stability. Demographic and clinical characteristics were collected to identify predictors of diagnostic discrepancy.Results From 2011–2020, the hospitalization rate decreased from 42.7% to 20.7% for schizophrenia and grew from 13.3% to 23.8% for depression. Diagnoses were retained by 92.6% of patients at their first discharge diagnosis, ranging from 100% for disorders of psychological development to 16.3% for unspecified mental disorders. About 33.9% of diagnostic conversions were to bipolar disorder in patients having inconsistent diagnoses. However, among rehospitalizations, the diagnostic stability notably dropped to 71.3%. For rehospitalizations, mood disorders and schizophrenia spectrum disorders were relatively stable diagnoses categories, with 72.6% to 76.7% of patients receiving the same diagnosis, although results of specified diagnoses within these categories ranged from 5.9% to 91.0%. Except for mood disorders and schizophrenia spectrum disorders, the diagnoses of all other categories were below 70%. Long lengths of hospitalization and old age were associated with short-term diagnosis alterations.Conclusion Longitudinal follow-up and integration of multiple aspects of information are essential for accurate diagnosis.
Huabin Zhou,Gaoqiang Liu,Furu Huang,Xiangting Wu,Hailong Yang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.12
Polysaccharides from Ganoderma lucidumshowed multiple biological activities, such as immunomodulating,antitumor, antioxidant, and hepatoprotectiveactivity, etc. Adlay oil was added into the media to enhancepolysaccharide production by submerged culture of G. lucidumin this work. The results revealed the optimal concentrationof adlay oil was 1.5 % for polysaccharideproduction of G. lucidum. Analysis of the polysaccharidecomponents confirmed that no novel components werebiosynthesized by the addition of adlay oil. The mainfraction of extracellular polysaccharide, GLEP-2, wasisolated from the submerged culture broth of G. lucidum byethanol precipitation, filtration, DEAE cellulose-52 andSepharose CL-6B chromatography. GLEP-2, which wascomposed of glucose, galactose, mannose, arabinose, andrhamnose in a ratio of 332:55:32:13:3 respectively, had anaverage molecular weight of *2.08 9 104 Da. The bioactivitytests demonstrated that GLEP-2 enhanced the Tlymphocyte proliferation significantly at a concentration of200 lg/mL and B lymphocyte proliferation at lower concentrationsof 50 lg/mL. The results suggest polysaccharidesfrom the submerged culture of G. lucidum arepotential candidates for further development and possiblecommercial applications, especially in the pharmaceuticaland functional foods industries.