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Nonlinear programming approach for a class of inverse problems in elastoplasticity
Ferris, M.C.,Tin-Loi, F. Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.8
This paper deals with a special class of inverse problems in discrete structural plasticity involving the identification of elastic limits and hardening moduli on the basis of information on displacements. The governing equations lead naturally to a special and challenging optimization problem known as a Mathematical Program with Equilibrium Constraints (MPEC), a key feature of which is the orthogonality of two sign-constrained vectors or so-called "complementarity" condition. We investigate numerically the application of two simple algorithms, both based on the use of the general purpose nonlinear programming code CONOPT accessed via the GAMS modeling language, for solving the suitably reformulated problem. Application is illustrated by means of two numerical examples.
Gold, Silver, Bronze or Tin? The Short and Long Term Effects of Mega Sporting Events
Stephen P. Ferris,Sulgi Koo,Kwangwoo Park,David T. Yi 한국재무학회 2012 한국재무학회 학술대회 Vol.2012 No.05
This paper examines the short and long term effects of the Summer Olympics, Winter Olympics, and the World Cup on the economy of the hosting country. We find that the immediate effect of such an announcement on equity market returns is statistically insignificant, with the construction industry being the only exception. We further show that mega sports events generally fail to provide significant positive long-term stock market performance to the hosting country. We do however find that the Summer Olympic game hosting nations generate significant positive economic performance up to 3 years prior to hosting the event, while this positive economic performance disappear after 1 year of the hosting the Summer Olympic game. Our results suggest that unlike the common claims of mega sports organizers, it appears that there are no significant long-run economic gains from hosting any of the three mega sporting events.
Thomas, Courtney R.,Ferris, Daniel P.,Lee, Jae-Hyun,Choi, Eunjoo,Cho, Mi Hyeon,Kim, Eun Sook,Stoddart, J. Fraser,Shin, Jeon-Soo,Cheon, Jinwoo,Zink, Jeffrey I. American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.31
<P>Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-31/ja1022267/production/images/medium/ja-2010-022267_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja1022267'>ACS Electronic Supporting Info</A></P>
Simple and Rapid Lateral-Flow Assay for the Detection of Foot-and-Mouth Disease Virus
Oem, Jae Ku,Ferris, Nigel P.,Lee, Kwang-Nyeong,Joo, Yi-Seok,Hyun, Bang-Hun,Park, Jong-Hyeon American Society for Microbiology 2009 CLINICAL AND VACCINE IMMUNOLOGY Vol.16 No.11
<B>ABSTRACT</B><P>A simple lateral-flow assay (LFA) based on a monoclonal antibody (MAb 70-17) was developed for the detection of foot-and-mouth disease virus (FMDV) under nonlaboratory conditions. The LFA was evaluated with epithelial suspensions (<I>n</I> = 704) prepared from current and historical field samples which had been submitted to the Pirbright Laboratory (United Kingdom) and from negative samples (<I>n</I> = 100) collected from naïve animals in Korea. Four FMDV serotypes (type O, A, Asia 1, and C) were detected in the LFA, but not the remaining three FMDV serotypes (SAT 1, SAT 2, and SAT 3). The diagnostic sensitivity of the LFA for FMDV types O, A, C, and Asia 1 was similar, at approximately 87.3%, to that of 87.7% obtained with antigen enzyme-linked immunosorbent assay (Ag-ELISA). The diagnostic specificity of the LFA was 98.8%, compared to 100% for the Ag-ELISA. These results demonstrate that the LFA using the FMDV MAb 70-17 to detect FMDV is a supportive method for taking rapid measurements at the site of a suspected foot-and-mouth disease outbreak in Asia before diagnosing the disease in the laboratory, thereby offering the possibility of implementing control procedures more rapidly.</P>
Clavulanic acid protects neurons in pharmacological models of neurodegenerative diseases
Huh, Youngbuhm,Ju, Mi Sun,Park, Hanbyeol,Han, Shengjun,Bang, Yu-Mi,Ferris, Craig F.,Koppell, Gary A.,King, Jean A.,Kim, Minkyu Leo,Kim, Deog Joong,Ahn, Chang Ho,Oh, Myung-Sook Wiley Subscription Services, Inc., A Wiley Company 2010 Drug development research Vol.71 No.6
<P>Clavulanic acid is a psychoactive compound with excellent blood-brain barrier permeability and safety profiles. Previous studies showed that clavulanic acid suppresses anxiety in rodents and in a primate model. In addition, clavulanic acid is thought to enhance sexual function in animal models via central nervous system (CNS) mechanisms. To further examine its potential as a CNS-modulating agent, we investigated the effects of clavulanic acid in neurotoxin-induced animal models that emulate neurodegenerative disease symptoms. Clavulanic acid was administered to rodents that were exposed to kainic acid or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Using histochemical staining of brain sections, we demonstrated that clavulanic acid protects hippocampal and dopaminergic neurons from toxin-induced acute death. We also observed that clavulanic acid improves motor function in MPTP-treated mice in a behavioral test. These data indicate that clavulanic acid may have neuroprotective effects and warrants further investigation of its therapeutic use in CNS disorders, such as Parkinson's and Alzheimer's disease. Drug Dev Res 71:351–357, 2010. © 2010 Wiley-Liss, Inc.</P>