The Utility of Intraoperative Handheld Gamma Camera for Detection of Sentinel Lymph Nodes in Melanoma

Elgin Ozkan,Aydan Eroglu 대한핵의학회 2015 핵의학 분자영상 Vol.49 No.4

Accurate identification of the sentinel lymph node (SLN) is an important prognostic factor for melanoma. In a minority of cases drainage to interval nodal basins, such as the epitrochlear region, are possible. Intraoperative handheld gamma cameras have been used to detect SLNs which are located in different anatomical localizations. In this case we report the utility of an intraoperative handheld gamma camera in the localization of epitrochlear drainage of distal upper extremity melanoma and its impact on surgical procedure.

Calcium and Magnesium Contents in Three Hypericum L. Species from Turkey

Gozde Elgin Cebe,Ozlem Sogut 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.8

Hypericum L. (Hypericaceae), which has 400 species in the world and 96 species in Turkey, has grown in Europe, Asia, North Africa, and America. Hypericum species have antidepressant, analgesic, spazmolytic, anti-inflammatory, antiviral, and wound healing effects. The purpose of this study was to analyze the magnesium (Mg) and calcium (Ca) contents of three Hypericum species (Hypericum perforatum L., Hypericum triquetrifolium Turra, and Hypericum empetrifolium Willd.) collected from the western part of Turkey. Analyses were done by atomic absorption spectrometer using convenient conditions. Mg and Ca concentrations were determined in three Hypericum species. Mg levels were determined as 1.053 ± 0.09, 0.792 ± 0.06, and 0.798 ± 0.17 mg.g−1 and Ca levels were determined as 0.573 ± 0.19, 0.433 ± 0.06, and 0.329 ± 0.005 mg.g−1 in H. perforatum L., H. triquetrifolium Turra, and H. empetrifolium Willd., respectively. The sedative effect of the drug is compensated with the metal concentration observed from the analysis, which shows that high Mg levels overlap with the sedative effect of the drug.

ZEROS OF PARTIAL SUMS OF THE LAURENT SERIES OF ANALYTIC FUNCTIONS

Abian, Alexander,Johnston, Elgin H. Department of Mathematics 1981 Kyungpook mathematical journal Vol.21 No.1

Original Articles : Comparison of the Outcome of Repeat Trabeculectomy with Adjunctive Mitomycin C and Initial Trabeculectomy

( Ali Bulent Cankaya ),( Ufuk Elgin ) 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.6

Purpose: To compare the efficacy and safety of repeat and initial trabeculectomy with mitomycine C (MMC). Methods: Eighty seven patients, who had underwent repeat (repeat group) or initial (initial group) trabeculectomy with MMC, were enrolled in this prospective trial. Postoperative outcome measures included the amount of decrease in intraocular pressure (IOP), the number of anti-glaucoma medications, and the complications. The success of trabeculectomy was defined on the basis of three definitions which were: IOP ≤18 mmHg (definition 1), IOP ≤21 mmHg (definition 2), and the amount of decrease in IOP from baseline ≥30% (definition 3). Success was further defined as "complete" when these criteria were obtained without any anti-glaucoma medications and "qualified" with or without medical therapy and no further surgical procedures. Results: Fifty nine eyes underwent initial and 28 eyes underwent repeat trabeculectomy. The mean follow-up period was 19.1 ± 5.9 months. Complete success rates were significantly greater in the initial trabeculectomy group (p = 0.02 for definition 1, p = 0.038 for definition 2, p = 0.003 for definition 3). A higher proportion of eyes in the initial group achieved qualified success relative to the group A eyes, but the differences were not statistically significant (p = 0.33 for definition 1, p = 0.99 for definition 2, p = 0.24 for definition 3). The mean number of antiglaucomatous medications at the last examination was 1.2 ± 1.2 in repeat group and 0.7 ± 1.1 in initial group (p = 0.01). The number of complications during the follow up period did not differ significantly between the two groups (p = 0.65). Conclusions: Repeat trabeculectomy with MMC has high success and low complication rates in patients with previously failed trabeculectomy in spite of the need of higher number of anti-glaucoma medications.

Adjuvant Radiotherapy for Gastric Carcinoma: 10 years Follow-up of 244 cases from a Single Institution

Misirlioglu, Hasan Cem,Coskun-Breuneval, Mehtap,Kucukpilakci, Bulent,Ugur, Vahide Isil,Elgin, Yesim,Demirkasimoglu, Taciser,Kara, Sakire Pinar,Ozgen, Aytul,Sanri, Ergun,Guney, Yildiz Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Background: Postoperative chemoradiotherapy (CRT) of gastric carcinoma improves survival among high-risk patients. This study was undertaken to analyse long-term survival probability and the impact of certain covariates on the survival outcome in affected individuals. Materials and Methods: Between January 2000 and December 2005, 244 patients with gastric cancer underwent adjuvant radiotherapy (RT) in our institution. Data were retrieved retrospectively from patient files and analysed with SPSS version 21.0. Results: A total of 244 cases, with a male to female ratio of 2.2:1, were enrolled in the study. The median age of the patients was 52 years (range, 20-78 years). Surgical margin status was positive or close in 72 (33%) out of 220 patients. Postoperative adjuvant RT dose was 46 Gy. Median follow-up was 99 months (range, 79-132 months) and 23 months (range, 2-155 months) for surviving patients and all patients, respectively. Actuarial overall survival (OS) probability for 1-, 3-, 5- and 10-year was 79%, 37%, 24% and 16%, respectively. Actuarial progression free survival (PFS) probability was 69%, 34%, 23% and 16% in the same consecutive order. AJCC Stage I-II disease, subtotal gastrectomy and adjuvant CRT were significantly associated with improved OS and PFS in multivariate analyses. Surgical margin status or lymph node dissection type were not prognostic for survival. Conclusions: Postoperative CRT should be considered for all patients with high risk of recurrence after gastrectomy. Beside well-known prognostic factors such as stage, lymph node status and concurrent chemotherapy, the type of gastrectomy was an important prognostic factor in our series. With our findings we add to the discussion on the definition of required surgical margin for subtotal gastrectomy. We consider that our observations in gastric cancer patients in our clinic can be useful in the future randomised trials to point the way to improved outcomes.

WSN Lifetime Analysis: Intelligent UAV and Arc Selection Algorithm for Energy Conservation in Isolated Wireless Sensor Networks

( P. Shunmuga Perumal ),( V. Rhymend Uthariaraj ),( V. R. Elgin Christo ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.3

Wireless Sensor Networks (WSNs) are widely used in geographically isolated applications like military border area monitoring, battle field surveillance, forest fire detection systems, etc. Uninterrupted power supply is not possible in isolated locations and hence sensor nodes live on their own battery power. Localization of sensor nodes in isolated locations is important to identify the location of event for further actions. Existing localization algorithms consume more energy at sensor nodes for computation and communication thereby reduce the lifetime of entire WSNs. Existing approaches also suffer with less localization coverage and localization accuracy. The objective of the proposed work is to increase the lifetime of WSNs while increasing the localization coverage and localization accuracy. A novel intelligent unmanned aerial vehicle anchor node (IUAN) is proposed to reduce the communication cost at sensor nodes during localization. Further, the localization computation cost is reduced at each sensor node by the proposed intelligent arc selection (IAS) algorithm. IUANs construct the location-distance messages (LDMs) for sensor nodes deployed in isolated locations and reach the Control Station (CS). Further, the CS aggregates the LDMs from different IUANs and computes the position of sensor nodes using IAS algorithm. The life time of WSN is analyzed in this paper to prove the efficiency of the proposed localization approach. The proposed localization approach considerably extends the lifetime of WSNs, localization coverage and localization accuracy in isolated environments.

Whole Brain Radiotherapy Combined with Stereotactic Radiosurgery versus Stereotactic Radiosurgery Alone for Brain Metastases

Adas, Yasemin Guzle,Yazici, Omer,Kekilli, Esra,Akkas, Ebru Atasever,Karakaya, Ebru,Ucer, Ali Riza,Ertas, Gulcin,Calikoglu, Tamer,Elgin, Yesim,Inan, Gonca Altinisik,Kocer, Ali Mert,Guney, Yildiz Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: The aim of this study was to evaluate the effect of whole brain radiotherapy (WBRT) combined with streotactic radiosurgery versus stereotactic radiosurgery (SRS) alone for patients with brain metastases. Materials and Methods: This was a retrospective study that evaluated the results of 46 patients treated for brain metastases at Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Radiation Oncology Department, between January 2012 and January 2015. Twenty-four patients were treated with WBRT+SRS while 22 patients were treated with only SRS. Results: Time to local recurrence was 9.7 months in the WBRT+SRS arm and 8.3 months in SRS arm, the difference not being statistically significant (p=0.7). Local recurrence rate was higher in the SRS alone arm but again without significance (p=0,06). Conclusions: In selected patient group with limited number (one to four) of brain metastases SRS alone can be considered as a treatment option and WBRT may be omitted in the initial treatment.

Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery

Jea Giezl N. Solidum,Jeremy A. Ceriales,Erika P. Ong,Eric David B. Ornos,Ruth Joy L. Relador,Elgin Paul B. Quebral,Jose Florencio F. Lapeña Jr.,Ourlad Alzeus G. Tantengco,Ka Yiu Lee 대한악안면성형재건외과학회 2023 Maxillofacial Plastic Reconstructive Surgery Vol.45 No.-

Background Nanotechnology and nanomedicine are rising novel fields in plastic and reconstructive surgery (PRS). The use of nanomaterials often goes with regenerative medicine. Due to their nanoscale, these materials stimulate repair at the cellular and molecular levels. Nanomaterials may be placed as components of nanocomposite polymers allowing enhancement of overall biochemical and biomechanical properties with improved scaffold properties, cellular attachment, and tissue regeneration. They may also be formulated as nanoparticle-based delivery systems for controlled release of signal factors or antimicrobials, for example. However, more studies on nanoparticle-based delivery systems still need to be done in this field. Nanomaterials are also used as frameworks for nerves, tendons, and other soft tissues. Main body In this mini-review, we focus on nanoparticle-based delivery systems and nanoparticles targeting cells for response and regeneration in PRS. Specifically, we investigate their roles in various tissue regeneration, skin and wound healing, and infection control. Cell surface-targeted, controlled-release, and inorganic nanoparticle formulations with inherent biological properties have enabled enhanced wound healing, tumor visualization/imaging, tissue viability, and decreased infection, and graft/transplantation rejection through immunosuppression. Conclusions Nanomedicine is also now being applied with electronics, theranostics, and advanced bioengineering technologies. Overall, it is a promising field that can improve patient clinical outcomes in PRS.