DYNAMICS CHARACTERISTICS ANALYSIS AND CONTROL OF FWID EV

Dongmei Wu,Haitao Ding,Changqing Du 한국자동차공학회 2018 International journal of automotive technology Vol.19 No.1

Compared with internal combustion engine (ICE) vehicles, four-wheel-independently-drive electric vehicles (FWID EV) have significant advantages, such as more controlled degree of freedom (DOF), higher energy efficiency and faster torque response of an electric motor. The influence of these advantages and other characteristics on vehicle dynamics control need to be evaluated in detail. This paper firstly analyzed the dynamics characteristics of FWID EV, including the feasible region of vehicle global force, the improvement of powertrain energy efficiency and the time-delays of electric motor torque in the direct yaw moment feedback control system. In this way, the influence of electric motor output power limit, road friction coefficient and the wheel torque response on the stability control, as well as the impact of motor idle loss on the torque distribution method were illustrated clearly. Then a vehicle dynamics control method based on the vehicle stability state was proposed. In normal driving condition, the powertrain energy efficiency can be improved by torque distribution between front and rear wheels. In extreme driving condition, the electric motors combined with the electro-hydraulic braking system were employed as actuators for direct yaw moment control. Simulation results show that dynamics control which take full advantages of the more controlled freedom and the motor torque response characteristics improve the vehicle stability better than the control based on the hydraulic braking system of conventional vehicle. Furthermore, some road tests in a real vehicle were conducted to evaluate the performance of proposed control method.

Drain Pipe Inspection Robot using Wireless Communication System

Dongmei Wu,Harutoshi Ogai,Yichun Yeh,Katsumi Hirai,Takahiko Abe,Gunkichi Sato 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

Pipe lines of various materials need to be inspected after certain years. Therefore, it is necessary to develop a flexible pipe inspection robot using wireless communication system. In this research, wireless communication system istested, it is verified that the wireless communication system can steadily transmit image information at high speed. On the basis of wireless communication system, a new pipe inspection robot for drain pipe is developed. With this new system, movement of the robot can be controlled, defects or troubles inside pipe would be inspected and image inside pipe also can be transmitted in real time.

Automobile Optimal Driving Control Using Information of Traffic Jam and Signal based on Model Prediction Control

Dongmei Wu,Yang Xia,Masatoshi Ogawa,Yi-Chun Yeh,Harutoshi Ogai,Taketoshi Kawabe 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

As a basis of an intelligent driving assist system, an on-line calculation method calculating a desirable driving path based on information and prediction of surrounding traffic environment is developed. The problem is how to use information of traffic jam and signal. This paperreports an automobile optimal driving control system using information of traffic jam and signal based onthe model prediction control to support drivers. Moreover, physical models for information of traffic jam and signal are constructed.

Role of NHE1 in the Cellular Dysfunction of Acute Metabolic Acidosis

Wu, Dongmei,Kraut, Jeffrey A. S. Karger AG 2014 American journal of nephrology Vol.40 No.1

<P>Abstract</P><P><B><I>Background:</I></B> Metabolic acidosis is associated with impaired cellular function. This has been attributed to the accompanying reduction in intracellular and interstitial pH of the myocardium. Recent studies suggest that activation of the cellular Na<SUP>+</SUP>-H<SUP>+</SUP> exchanger NHE1 might contribute to myocardial dysfunction. This review examines the experimental evidence which supports the role of NHE1 in the genesis of acidosis-induced cellular dysfunction, the benefits of its inhibition, and the type of acidosis that might benefit from therapy. <B><I>Summary:</I></B> Information was obtained by searching MEDLINE for articles published between 1969 and 2013 using the terms: NHE1, metabolic acidosis, lactic acidosis, ischemia-reperfusion, shock, resuscitation, high anion gap acidosis, and non-gap acidosis. Each article was also reviewed for additional suitable references. Nineteen manuscripts published between 2002 and 2013 assessed the impact of inhibition of NHE1 on cellular function. They revealed that NHE1 is activated with metabolic acidosis associated with hypoxia, hypoperfusion, hemorrhagic shock, and sepsis. This was associated with a rise in cellular sodium and calcium and cardiac dysfunction including reduced contractility and a predisposition to cardiac arrhythmias. Inhibition of NHE1 with specific inhibitors improved cardiac function, reduced blood and tissue levels of proinflammatory cytokines, and decreased mortality. <B><I>Key Message:</I></B> These results suggest that use of inhibitors of NHE1 might be worthwhile in the treatment of some types of acute metabolic acidosis, specifically the lactic acidosis associated with hypoxia, hemorrhagic shock, and cardiac arrest. Its potential role in the treatment of other forms of acute metabolic acidosis remains to be determined.</P><P>© 2014 S. Karger AG, Basel</P>

Experimental investigation of vortex-induced aeroelastic effects on a square cylinder in uniform flow

Dongmei Huang,Teng Wu,Shiqing He 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.1

To investigate the motion-induced aeroelastic effects (or aerodynamic feedback effects) on a square cylinder in uniform flow, a series of wind tunnel tests involving the pressure measurement of a rigid model (RM) and simultaneous measurement of the pressure and vibration of an aeroelastic model (AM) have been systematically carried out. More specifically, the aerodynamic feedback effects on the structural responses, on the mean and root-mean-square wind pressures, on the power spectra and coherence functions of wind pressures at selected locations, and on the aerodynamic forces were investigated. The results indicated the vibration in the lock-in range made the shedding vortex more coherent and better organized, and hence presented unfavorable wind-induced effects on the structure. Whereas the vibration in the non-lock-in range generally showed insignificant effects on the flow structures surrounding the square cylinder.

Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents

Wanhe Luo,Dongmei Chen,Mengru Wu,Zhenxia Li,Yanfei Tao,Qianying Liu,Yuanhu Pan,Wei Qu,Zonghui Yuan,Shuyu Xie 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.5

Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in bacterial resistance, clinical treatment failure, and drug residues. To address these problems, consistent and appropriate dosage regimens for veterinary antimicrobial agents are needed. Pharmacokinetics/Pharmacodynamics (PK/PD) models have been widely used to establish rational dosage regimens for veterinary antimicrobial agents that can achieve effective prevention and treatment of bacterial diseases and avoid the development of bacterial resistance. This review introduces building methods for PK/PD models and describes current PK/PD research progress toward rational dosage regimens for veterinary antimicrobial agents. Finally, the challenges and prospects of PK/PD models in the design of dosage regimens for veterinary antimicrobial agents are reviewed. This review will help to increase awareness of PK/PD modeling among veterinarians and hopefully promote its development and future use.

Evaluation of Renal Oxygenation Level Changes after Water Loading Using Susceptibility-Weighted Imaging and T2* Mapping

Jiule Ding,Wei Xing,Dongmei Wu,Jie Chen,Liang Pan,Jun Sun,Shijun Xing,Yongming Dai 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.4

To assess the feasibility of susceptibility-weighted imaging (SWI) while monitoring changes in renal oxygenation level after water loading. Thirty-two volunteers (age, 28.0 ± 2.2 years) were enrolled in this study. SWI and multi-echo gradient echo sequence-based T2* mapping were used to cover the kidney before and after water loading. Cortical and medullary parameters were measured using small regions of interest, and their relative changes due to water loading were calculated based on baseline and post-water loading data. An intraclass correlation coefficient analysis was used to assess inter-observer reliability of each parameter. A receiver operating characteristic curve analysis was conducted to compare the performance of the two methods for detecting renal oxygenation changes due to water loading. Both medullary phase and medullary T2* values increased after water loading (p < 0.001), although poor correlations were found between the phase changes and the T2* changes (p > 0.05). Interobserver reliability was excellent for the T2* values, good for SWI cortical phase values, and moderate for the SWI medullary phase values. The area under receiver operating characteristic curve of the SWI medullary phase values was 0.85 and was not different from the medullary T2* value (0.84). Susceptibility-weighted imaging enabled monitoring changes in the oxygenation level in the medulla after water loading, and may allow comparable feasibility to detect renal oxygenation level changes due to water loading compared with that of T2* mapping.

Potential implications of hydrogen peroxide in the pathogenesis and therapeutic strategies of gliomas

Ying Zhou,Long Wang,Chaojia Wang,Yilin Wu,Dongmei Chen,Tae Ho Lee 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2

Glioma is the most common type of primarybrain tumor, and it has a high mortality rate. Currently,there are only a few therapeutic approaches for gliomas, andtheir effects are unsatisfactory. Therefore, uncovering thepathogenesis and exploring more therapeutic strategies forthe treatment of gliomas are urgently needed to overcomethe ongoing challenges. Cellular redox imbalance has beenshown to be associated with the initiation and progression ofgliomas. Among reactive oxygen species (ROS), hydrogenperoxide (H2O2) is considered the most suitable for redoxsignaling and is a potential candidate as a key moleculethat determines the fate of cancer cells. In this review, wediscuss the potential cellular and molecular roles of H2O2in gliomagenesis and explore the potential implications ofH2O2in radiotherapy and chemotherapy and in the ongoingchallenges of current glioma treatment. Moreover, we evaluateH2O2as a potential redox sensor and potential driver molecule of nanocatalytic therapeutic strategies for gliomatreatment.

Coadministration of a Na+-H+ exchange inhibitor and sodium bicarbonate for the treatment of asphyxia-induced cardiac arrest in piglets.

Lin, Xinchun,Kraut, Jeffrey A,Wu, Dongmei Williams & Wilkins Co.[etc.] 2014 Pediatric research Vol.76 No.2

<P>The present study tested the hypothesis that addition of an inhibitor of Na(+)/H(+) exchanger (NHE1) to sodium bicarbonate might improve the response to base therapy from prolonged asphyxial cardiac arrest in piglets.</P>

Application of Three-phase Hollow Fiber LPME using an Ionic Liquid as Supported Phase for Preconcentration of Malachite Green from Water Samples with HPLC Detection

Yanmin Zou,Zhen Zhang,Xiaoling Shao,Yao Chen,Xiangyang Wu,Liuqing Yang,Jingjing Zhu,Dongmei Zhang 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2

A novel three-phase hollow fiber liquid phase microextraction was developed for the determination of malachite green (MG) in environmental waters, which selected [BMIM][PF6] mixed with 1% trioctylphosphine oxide (TOPO) as supported phase. Several parameters (accepter phase pH, sample pH, supported phase membrane, volume of accepter phase, salinity, extraction time) that could affect extraction performance were investigated. Under the optimal extraction conditions, the established approach showed excellent characters as: high enrichment factor (212), wide linear range (0.20-100 μg L-1), low detection limit (0.01 μg L-1), good reproducibility (RSD, 8.9%, n=5) and satisfactory recovery (84.0-106.2%). The method was applied to detect MG at Yangtze River and pond waters in Zhenjiang, Jiangsu province, and 4 sites among 15 sampling sites were found MG with the concentration of 1.73-11.06 μg L-1, which confirmed that the proposed environmentally friendly method was simple and effective for monitoring MG in aquatic system.