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Dinesh Babu,박수영,김영휘,양홍철,김정애,Dinesh Thapa,이종숙,김아라 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1
An aqueous extract of Cornus kousa Burg. leaves (ACK) that contained high amount of polyphenols showed significant antioxidant activity against diphenylpicrylhydrazyl (DPPH) radicals and TNF-α-generated reactive oxygen species. ACK at concentrations of 10 and 50 μg/mL significantly inhibited TNF- α-induced adhesion of U937 pre-monocytic cells to HT-29 colon epithelial cells in a concentrationdependent manner. The reduced adhesion by ACK correlated with the suppressed expressions of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8, the major inflammatory bowel disease (IBD)-associated chemokines. Moreover, ACK significantly suppressed TNF-α-induced translocation of redox-sensitive nuclear factor (NF)-κB as well as degradation of cytosolic I-κBα. The effective concentrations of ACK were much lower than that of 5-aminosalicylic acid (3.06 mg/mL), which is an active metabolite of sulfasalazine, a well-known drug used in the treatment of IBD. The results indicate that ACK may provide a potential benefit for the prevention and treatment of inflammatory diseases such as IBD.
Babu, Dinesh,Lee, Jong-Suk,Park, Su-Young,Thapa, Dinesh,Choi, Mi-Kyoung,Kim, Ah-Ra,Park, Young-Joon,Kim, Jung-Ae 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
Oxidative stress and the activation of nuclear factor (NF)-${\kappa}B$ play crucial roles in the pathogenesis of inflammatory bowel disease (IBD). In the present study, we examined the effects of the ethanol extract of Platycarya strobilacea Sieb. stem (EPS) on TNF-$\alpha$-induced monocyte adhesion to HT29 human colon epithelial cells, an initial step of colon inflammation. EPS contained high amount of polyphenols ($0.241{\pm}0.017\;mg$ of catechin equivalent/g of extract) and showed substantial DPPH radical scavenging activity. In addition, EPS significantly suppressed TNF-$\alpha$-induced reactive oxygen species (ROS) increase. Moreover, TNF-$\alpha$-induced monocyte adhesion to HT29 colon epithelial cells was significantly suppressed by EPS in a concentrationdependent manner. The reduced adhesion by EPS was correlated with suppressed expression of MCP-1 and IL-8, the major chemokines in IBD. EPS also prevented the TNF-$\alpha$-induced nuclear translocation of NF-${\kappa}B$, one of the redox-sensitive transcription factors, in a concentration-dependent manner. Taken together, our results suggest that the anti-oxidant components of EPS prevent TNF-$\alpha$-induced NF-${\kappa}B$ activation, chemokine induction, and monocyte adhesion at the site of intestinal inflammation.
A Study on CRM Practices for Public sector Insurance Companies
Dinesh, Reetha KNU The Institute of Management Economy Research 2012 Asia-Pacific Journal of Business Vol.3 No.1
Organizations pursue a CRM strategy for the purpose of increasing business performance and value. However, firms face a multitude of organizational challenges associated with this endeavor. To reduce their risk of failure, it is suggested that firms undertake a deep analysis of organizational readiness prior to committing to a CRM initiative. Insurance sector is no exception to this fact. There is an increased need to concentrate on the various challenges thrown open by the public insurance firms in implementing CRM. Many insurance firms have invested into customer driven CRM but research indicates varying outcomes (Schmith 2004). While it is clear that there are significant issues involved in the CRM implementation and success and environment faced by the public sector. It is clear that business should have an easier time in applying CRM systems is the strategic value for public sector. With customers demanding more service and accessibility from administrators, public sector CRM software technologies have to offer best solutions for achieving process and cost objectives (Souder 2001). With results which go far beyond improved service delivery and include sustained cost reductions, increased customer knowledge and better employee morale, CRM software implementation and post product environments offer great upside value. Although there are material differences in public sector use of CRM strategy, they share at least one glaring similarity - they have much to gain from proven CRM software technology. As business methods cross over in the public sector, many government bodies are investigating how they can adopt and adapt various CRM models (Bleyer 2003). There is a need to understand the similarities and differences in public sector CRM to foster shared knowledge, business processes and planning functions to integrate disparate technologies and software platforms and then, of course, the organizational culture to support knowledge sharing (Peters 1997). For the public sector, there are clearly identified CRM processes which have resulted in increased profits and improved efficiency. These have focused on sales, marketing and customer service activities, which often operate along fundamentally different lines in various public sector insurance companies. Thus the present research paper makes an attempt to explore how public sector CRM methods can be adopted and subsequently adapted.
Deadline Constrained Adaptive Multilevel Scheduling System in Cloud Environment
( Dinesh Komarasamy ),( Vijayalakshmi Muthuswamy ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.4
In cloud, everything can be provided as a service wherein a large number of users submit their jobs and wait for their services. Thus, scheduling plays major role for providing the resources efficiently to the submitted jobs. The brainwave of the proposed work is to improve user satisfaction, to balance the load efficiently and to bolster the resource utilization. Hence, this paper proposes an Adaptive Multilevel Scheduling System (AMSS) which will process the jobs in a multileveled fashion. The first level contains Preprocessing Jobs with Multi-Criteria (PJMC) which will preprocess the jobs to elevate the user satisfaction and to mitigate the jobs violation. In the second level, a Deadline Based Dynamic Priority Scheduler (DBDPS) is proposed which will dynamically prioritize the jobs for evading starvation. At the third level, Contest Mapping Jobs with Virtual Machine (CMJVM) is proposed that will map the job to suitable Virtual Machine (VM). In the last level, VM Scheduler is introduced in the two-tier VM architecture that will efficiently schedule the jobs and increase the resource utilization. These contributions will mitigate job violations, avoid starvation, increase throughput and maximize resource utilization. Experimental results show that the performance of AMSS is better than other algorithms.
Metabolic engineering of E. coli for the production of glycosylated flavonoids
Dinesh Simkhada,EuiMin Kim,Nagendra Prasad Kurumbang,Tae-Jin Oh,Hei Chan Lee,Jae Kyung Sohng 한국당과학회 2008 한국당과학회 학술대회 Vol.2008 No.1
Glycosylation of flavonoid play crucial roles in stabilization of antocyanins and cyanidins; storage of flavonoid and terpenoids; and regulation of hormones. In addition, glycosylation has been recognized as one of the important mechanisms for detoxification of exogenous compounds. Here in this research, we have metabolically engineered the E. coli BL21DE3 (Δ pgi mutant) host to generate four different engineered host to produce glycosylated flavonoid. E. coli BL21DE3 (Δ pgi mutant) was engineered by integration of GalU, expression of CalS8 (dehydrogenase) and CalS9 (decarboxylase) together by cloning in pDuet/ampr vector and expression of four different 3-O-glycosyltransferase and 7-O- glycosyltransferase gene from Arabidopsis thaliana. Engineered hosts are expected to produce glucosyl as well as xylosyl glycosylated flavonoids which are characterized by HPLC as well as LC-MS analysis.