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Application of temperature-controlled metabolic chamber in mice
Su In Jang,Seul Gi Yoon,Hye Sun Go,Yong Jae Kim,Hak Su Kim,Ji Hyeon Baek,Tae Ho Kim,Ji Min Choi,Soo Kyung Kang,Da In On,Hyun A Noh,Il Yong Kim,Je Kyung Seong 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Recently, research on various metabolic diseases such as obesity and diabetes has been in the spotlight. A representative example of this is the study of metabolic function analysis using Metabolic cage. It is believed that these studies will greatly contribute to the prevention and treatment of various metabolic diseases in humans. This study focuses on the study of obesity in mice. Mouse metabolic phenotyping has been widely used for detecting metabolic disorder in genetically engineered mouse. Korea Mouse Phenotyping Center (KMPC), nation-wide program for mouse production and phenotyping in Korea has been establishing several pipelines for disease-specific mouse phenotyping to support the mouse research. KMPC has been providing mouse metabolic phenotyping including high fat diet, exercise and cold challenges. Multiple parameter including energy expenditure (EE), O2/CO2 consumption (RER), heat generation and activity has been provided with histology service and body composition. Also temperature can be measured during metabolic chamber with telemetric system. Brown adipogenesis is one of key mechanism for developing new candidate drug target for curing obesity and type 2 diabetes. Several factors including cold, adrenergic b3 agonist and exercise are well known factor leading to brown adipogenesis. Here we introduce mouse metabolic phenotyping services with environmental control chamber at KMPC. Temperature-controlled metabolic cage, the climate chambers can control temperatures from 4 °C to 35 °C, while measuring energy consumption using oxygen consumption, carbon dioxide production, and respiratory exchange ratio and food intake. Using this, exposing the mouse to a low temperature environment can activate BAT by browning WAT, which causes various diseases such as heart disease, diabetes, and obesity. The changes of metabolic parameter was finely measured during cold exposure with temperature-controlled metabolic cage.
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A STUDY ON THE DETERMINANTS OF FRANCHISING IN KOREAN FOOD SERVICE INDUSTRY
Ho-Jeong Noh,Duk-Hwa Yun,Jee-In Jang,Da-Ae Jung,Min-Ho Cho 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.10
Purpose This study, for the first time attempts to investigate the determinants of the Korean foodservice franchising employing various theories. In addition this study attempts to consider distinguishable foodservice characteristics such as the segment of foodservice and the market demand. This study expects to contribute to the theoretical underpinnings of the foodservice franchising by incorporating distinguishable foodservice characteristics to franchising theories. Method The sample for this study came from uniform franchise offering circular based on Korea Fair Trade Commission. There were 1,598 food service franchisors in uniform franchise offering circular 2009-2011 listing. However, 596 were excluded because of data irregularities remaining 1,002 available for sample. Based on the literature review, we choose seven determinants. The seven determinants were measured as follows. Firm age was measured as two proxy variables. One was measured as the years of franchising business. The other was measured as the years of business. Firm size was measured as total sales. Capital scarcity was measured as the ratio of total debt to total asset. Start-up costs were measured as initial investment. Monitoring costs were measured as the number of major cities franchised units operates. Royalty was measured as sales of a franchised unit. Finally, brand name was measured as advertising expenditures. Results The first proposition (firm age is related to the use of franchising) was supported by the signaling theory and the transaction costs theory instead of the resource scarcity theory. The age (measured as the years of franchising business) had a statistically significant positive relationship with the use of franchising. The second proposition (firm age is related to the use of franchising) was supported by the logic of the resource scarcity. The age (measured as the years of business) had a statistically significant negative relationship with the use of franchising. The third proposition (firm size is related to the use of franchising) was supported by the signaling theory instead of the resource scarcity theory. The firm size had a statistically significant positive relationship with the use of franchising. The fourth proposition (capital scarcity is related to the use of franchising) was not supported by the resource scarcity theory. The capital scarcity had not a statistically significant positive relationship with the use of franchising. The fifth proposition (start-up costs is related to the use of franchising) was not supported. The start-up costs had not a statistically significant either positive or negative relationship with the use of franchising. The sixth proposition (monitoring costs is related to the use of franchising) was supported by the agency theory. The monitoring costs had a statistically significant positive relationship with the use of franchising.. The seventh proposition (royalty is related to the use of franchising) was not supported by the agency theory. The royalty had not a statistically significant positive relationship with the use of franchising. The eighth proposition (brand name is related to the use of franchising) was not supported by the agency theory. Brand name had not a statistically significant negative relationship with the use of franchising. Conclusions Five propositions were found to be statistically significant from eight propositions. The four determinants such as firm age, firm size, monitoring costs, and brand name can affect the use of franchising for the foodservice industry in South Korea. Relating the significant propositions to the diverse theories, there was no one theory that dominated all propositions. The signaling theory was more appropriate for both firm age (the years of franchising business) and firm size while the transaction costs theory was more appropriate for age (the years of franchising business) as well. In addition, the resource scarcity theory was more appropriate for firm age (the years of business). Finally, the agency theory was appropriate for monitoring costs although this theory needed to be ameliorated for brand name.
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A STUDY ON THE DETERMINANTS OF FRANCHISING IN KOREAN FOOD SERVICE INDUSTRY
Ho-Jeong Noh,Duk-Hwa Yun,Jee-In Jang,Da-Ae Jung,Min-Ho Cho 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7
Purpose This study, for the first time attempts to investigate the determinants of the Korean foodservice franchising employing various theories. In addition this study attempts to consider distinguishable foodservice characteristics such as the segment of foodservice and the market demand. This study expects to contribute to the theoretical underpinnings of the foodservice franchising by incorporating distinguishable foodservice characteristics to franchising theories. Method The sample for this study came from uniform franchise offering circular based on Korea Fair Trade Commission. There were 1,598 food service franchisors in uniform franchise offering circular 2009-2011 listing. However, 596 were excluded because of data irregularities remaining 1,002 available for sample. Based on the literature review, we choose seven determinants. The seven determinants were measured as follows. Firm age was measured as two proxy variables. One was measured as the years of franchising business. The other was measured as the years of business. Firm size was measured as total sales. Capital scarcity was measured as the ratio of total debt to total asset. Start-up costs were measured as initial investment. Monitoring costs were measured as the number of major cities franchised units operates. Royalty was measured as sales of a franchised unit. Finally, brand name was measured as advertising expenditures. Results The first proposition (firm age is related to the use of franchising) was supported by the signaling theory and the transaction costs theory instead of the resource scarcity theory. The age (measured as the years of franchising business) had a statistically significant positive relationship with the use of franchising. The second proposition (firm age is related to the use of franchising) was supported by the logic of the resource scarcity. The age (measured as the years of business) had a statistically significant negative relationship with the use of franchising. The third proposition (firm size is related to the use of franchising) was supported by the signaling theory instead of the resource scarcity theory. The firm size had a statistically significant positive relationship with the use of franchising. The fourth proposition (capital scarcity is related to the use of franchising) was not supported by the resource scarcity theory. The capital scarcity had not a statistically significant positive relationship with the use of franchising. The fifth proposition (start-up costs is related to the use of franchising) was not supported. The start-up costs had not a statistically significant either positive or negative relationship with the use of franchising. The sixth proposition (monitoring costs is related to the use of franchising) was supported by the agency theory. The monitoring costs had a statistically significant positive relationship with the use of franchising.. The seventh proposition (royalty is related to the use of franchising) was not supported by the agency theory. The royalty had not a statistically significant positive relationship with the use of franchising. The eighth proposition (brand name is related to the use of franchising) was not supported by the agency theory. Brand name had not a statistically significant negative relationship with the use of franchising. Conclusions Five propositions were found to be statistically significant from eight propositions. The four determinants such as firm age, firm size, monitoring costs, and brand name can affect the use of franchising for the foodservice industry in South Korea. Relating the significant propositions to the diverse theories, there was no one theory that dominated all propositions. The signaling theory was more appropriate for both firm age (the years of franchising business) and firm size while the transaction costs theory was more appropriate for age (the years of franchising business) as well. In addition, the resource scarcity theory was more appropriate for firm age (the years of business). Finally, the agency theory was appropriate for monitoring costs although this theory needed to be ameliorated for brand name.
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한방병원 중증치료실 입원 환자의 임상적 분석 - 주 질환 및 합병증 위주로 -
노현인,이지숙,윤다래,이서라,류재환,Noh, Hyun-In,Lee, Jee-Sook,Yoon, Da-Rae,Yi, Seo-Ra,Ryu, Jae-Hwan 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.2
Objectives : This study was designed to quantify the characteristics, main diagnosis and complications in the intensive care unit (ICU) at an Oriental Medical Hospital. Methods : The medical records of 44 patients admitted to the ICU at Kyunghee Oriental Medical Hospital between January 1, 2011 and December 31, 2011 were reviewed. Basic characteristics of patients, admission channel, main diagnosis, east-western medical therapy, mortality, and complications were investigated retrospectively based on medical notes. Results : 1. The total number of patients was 44. Males were 63.6%, females 36.3%. Average admission days was 15.9. 2. The most frequent age group is eighties, 38.6%. 3. The most frequent disease is cerebrovascular disease, 61.3%. 4. The medical therapy done after admission to ICU was intubation. Central vein insertion was performed next, followed by Foley's catheter insertion, ventilator, tracheostomy, nasogastric intubation, and thoracentesis in order. The proportion of Oriental medical treatment provided to the patients of ICU was as follows: herbal medication only 6.8%; herbal medication plus acupuncture 31.8%; herbal medication, acupuncture electro-acupuncture, plus subcutaneous acupuncture 2.3%; and none 27.3%. 5. The number of cases of complications occurred since ICU admission was 18. The most frequently observed complication was infection, including 6 cases of pneumonia and 4 cases of urinary tract infection. Conclusions : We suggest that ICUs of Oriental medical hospitals need to be managed effectively to treat diseases including cerebrovascular disease and prevent complications.
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Lei, Bo,Shin, Kwan-Ha,Noh, Da-Young,Jo, In-Hwan,Koh, Young-Hag,Choi, Won-Young,Kim, Hyoun-Ee The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.28
<P>We herein propose a novel way of producing nanofibrous gelatin–silica hybrid scaffolds through thermally induced phase-separation (TIPS) particularly using mixtures of gelatin solution and silica sol, which can mimic the physical structure, chemical composition, and eventually functions of the native bone extracellular matrix (ECM). The gelatin solutions were homogeneously hybridized with various contents of a silica sol using simple magnetic stirring, which enabled the construction of a nanofibrous structure with a uniform distribution of the silica in the gelatin nanofibers. The nanofibrous gelatin–silica hybrid scaffolds showed much better mechanical properties and <I>in vitro</I> biodegradation stability and apatite-forming ability than the nanofibrous pure gelatin scaffold, which were achieved by the presence of a stiff, bioactive silica phase in the nanofibers and the interaction between the silica hydroxyls and the amino group in the gelatin polymer. In addition, the nanofibrous gelatin–silica hybrid scaffold with a silica content of 30 wt% showed reasonably high <I>in vitro</I> biocompatibility. These findings suggest that the highly porous, nanofibrous hybrid structure mimicking the bone ECM can provide an excellent matrix for bone tissue regeneration.</P> <P>Graphic Abstract</P><P>We herein propose a novel way of producing nanofibrous gelatin–silica hybrid scaffolds through thermally induced phase-separation (TIPS) particularly using mixtures of gelatin solution and silica sol, which can mimic the physical structure, chemical composition, and eventually functions of the native bone extracellular matrix (ECM). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm31290e'> </P>
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온열환경과 부자이중탕(附子理中湯)이 Rat의 면역반응 및 지질대사에 미치는 효과
노현인,윤다래,이서라,이인희,홍성인,류재환,Noh, Hyun-In,Yoon, Da-Rae,Yi, Seo-Ra,Lee, In-Hee,Hong, Sung-In,Ryu, Jae-Hwan 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.1
Objectives : This study was designed to test the effect of a warm environment and Bujaijung-tang on immune and lipid metabolism in rats. Methods : The extract from Bujaijung-tang was made by the pharmacy department of Kyung-Hee oriental medical hospital. The animals were divided into four groups, by room or warm environment and Bujaijung-tang administration. Each group had 8 Sprague-Dawley Rats. We measured body temperature twice a week, body weight three times a week. After 3 weeks of experiment, serum lipid level, WBC, differential count, lymphocyte proliferation and immune cytokine concentration were measured. Results : 1. warm environment induced weight loss in rats. 2. warm environment induced a decrease of total cholesterol and low-density lipoprotein (LDL) cholesterol gain. 3. warm environment and Bujaijung-tang induced an increase of tumor necrosis factor (TNF)-${\alpha}$ concentration. Conclusions : The warm environment had a hyperlipidemia modulating effect. The warm environment and Bujaijung-tang had an immune modulating effect.
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대학생의 전공관련 봉사활동이 공동체 의식과 직업가치관에 미치는 효과
강수경(Su-Gyeong Kang),김다혜(Da-Hye Kim),김선혁(Sun-Hyuk Kim),노시홍(Si-Hong Noh),신민규(Min-Gyou Sin),신혜인(Hue-In Shin),윤효정(Huo-Jenog Yun),임동욱(Dong-Wook Lim),오명화(Myung-Hwa Oh) 한국엔터테인먼트산업학회 2019 한국엔터테인먼트산업학회논문지 Vol.13 No.1
본 연구는 대학생의 전공관련 봉사활동이 공동체 의식과 직업가치관형성에 미치는 효과를 알아보기 위해 실시하였다. 전라도에 소재한 D대학교에 재학중인 학생 566명을 대상으로 2017년 09월 06일부터 09월 13일까지 공동체의식과 직업가치관대한 설문지를 배포하여 자가 기입방식으로 응답하도록 하였다. 그 결과 봉사활동참여 유무는 성별, 학년, 계열에 따라 유의한 차이가 있었으나 전공관련 봉사활동은 계열에 따라서만 차이가 있었다. 봉사활동 참여유무에 따른 공동체의식과 직업가치관을 살펴본 결과 유의한 차이를 보였으나, 전공관련 봉사활동 참여유무에 따른 공동체의식과 직업가치관은 직업가치관에서만 유의한 차이가 있었다. 이상의 연구 결과를 바탕으로 향후 대학생들의 전공관련 봉사활동을 포함한 봉사활동 참여의 확대를 위해 다양한 프로그램 개발과 적극적인 노력이 필요할 것으로 생각된다. This study aims to find out that major-related voluntary services of university students have an effect on forming their community spirit and occupational value somehow. This study carried out the survey targeting students in "D" University, which is located at Jeonnam Province of Korea, on September 6 through 13, 2017. The self-administered questionnaire was structured in questions about community spirit and occupational value. 566 copies of the questionnaires handed out were collected. As a result, participation in voluntary services makes a significant difference according to gender, grade, and departments but major related voluntary services was ignificant difference according to departments. There was a significant difference in community spirit and occupational value of participants in voluntary services. However, major-related voluntary services showed significant difference in occupational value only. Based on the results of this study, it is necessary to develop a lot of volunteer programs in order to encourage students to join major-related voluntary activities.
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