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Cong Minh Tran(뜨랑민꽁),Sojeong Yoon(윤소정),Jongjin Park(박종진),Ki-Tae Kim(김기태) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
Parabens are a family of parahydroxybenzoates that have been widely used as additional preservatives in cosmetics and household care products. Due to non-covalent characteristics, parabens are easily released into the environment during the scouring process. To understand the neuroendocrine toxicity of common parabens (i.e., ethyl, methyl, and propylparaben), we assessed the behavior locomotor and conducted transcriptome sequencing (RNA-seq) analysis using zebrafish embryos after exposure to various sublethal concentrations at 0, BMD<sub>5</sub>/50, BMD<sub>5</sub>/10, and BMD<sub>5</sub> of each paraben from 2 to 120 hours post-fertilization (hpf). Zebrafish larvae showed hyperactivity and ambiguous behavioral disorders after exposure to ethyl- and methylparaben, respectively. In contrast, exposure to propylparaben did not induce any significant difference in zebrafish behavioral locomotion. Transcriptome results showed that the expression of 265, 69, and 142 transcription factors were significant affected in zebrafish larvae after exposure to ethyl, methyl, and propylparaben, respectively. Using Kyoto encyclopedia of genes and genomes (KEGG) pathways we found that endocrine-related pathways of pyrimidine, purine metabolism, and ECM-receptor interaction were significantly affected by ethyl- and methylparaben exposure at BMD<sub>5</sub>. Our study provides the considerable insight into the neuroendocrine toxicity induced by paraben on the living organism at sublethal concentration.
Cong Minh Tran(뜨랑민꽁),Sojeong Yoon(윤소정),Jongjin Park(박종진),Ki-Tae Kim(김기태) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
Biocidal products are widely utilized as multi-component mixtures of active substances to prevent harmful organisms (i.e., algae, bacteria, molds, and parasites). However, the adverse effects of biocides mixtures are not well-known compared with effects of individual biocides. In this study, seventy individual ingredients and thirty mixtures (a combination of 2 – 4 individual biocides) were exposed to dechorionated zebrafish embryos at various concentrations of individual ingredients to evaluate the developmental mortality and malformations. In addition, the calculated lethal concentration representing 10% mortality (LC<sub>10</sub>) was employed to analyze behavioral locomotion disorders of zebrafish embryos exposed to individual and mixture ingredients. The LC<sub>50</sub> ranges from 0.73 nM to 0.058 M and zebrafish larvae exhibited malformations (i.e., yolk sac edema, pericardial edema, axis, notochord, and tail defects) after exposure to 27 single ingredients. Behavior assessment revealed that hyperactivity (23 %), hypoactivity (20 %), abnormal sensitivity (16 %), complex effect (10 %), constant movement (4 %), and no-movement (3 %) were observed after exposure to 53 individual ingredients (75 %). For mixtures, zebrafish locomotion depends on the proportion of its single components:25 mixtures (83.3 %) induced behavioral abnormality in zebrafish embryos including constant movement (23.3 %), hyperactivity (20 %), hypoactivity (16.67 %), abnormal sensitively (10 %), complex effect (10 %), and no-movement (3 %). Our established developmental-neurotoxicity database provides effective in determining the list of biocidal products requiring more consideration.
The Role of Zn Doping on the Catalytic Activity of the Nanoparticle Perovskite La0.7Sr0.3MnO3
Tran Thi Minh Nguyet,Nguyen Quang Huan,Tran Que Chi,Do The Chan,Nguyen Doan Thai,Nguyen Cong Trang,Luu Tien Hung,Le Van Tiep,Nguyen Van Qui 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
The nanometer complex oxide La0:7Sr0.3Mn0.6Zn0.₄O₃ was prepared by using a Sol-Gel method with citric acid as a ligand. The in uence of Zn doping of La0.7Sr0.₃MnO₃ on the structure, the morphology, the surface properties and on the catalytic activity of material was studied by using X-ray diraction (XRD), transmission electron microscopy (TEM), a high-resolution images and selected area electron diraction (SAED), physical adsorption and temperature programmed surface reaction (TPSR) methods. The results showed that perovskite La0:7Sr0:3Mn0:6. Zn0.₄O₃ could well catalyse propene oxidation in the temperature range 190 { 280 ℃, which was reduced to 100 { 120 ℃ for catalyst La1-χSrχMnO₃ The nanometer complex oxide La0:7Sr0.3Mn0.6Zn0.₄O₃ was prepared by using a Sol-Gel method with citric acid as a ligand. The in uence of Zn doping of La0.7Sr0.₃MnO₃ on the structure, the morphology, the surface properties and on the catalytic activity of material was studied by using X-ray diraction (XRD), transmission electron microscopy (TEM), a high-resolution images and selected area electron diraction (SAED), physical adsorption and temperature programmed surface reaction (TPSR) methods. The results showed that perovskite La0:7Sr0:3Mn0:6. Zn0.₄O₃ could well catalyse propene oxidation in the temperature range 190 { 280 ℃, which was reduced to 100 { 120 ℃ for catalyst La1-χSrχMnO₃
Dinh Tien Minh,Tran Ngoc Thuy,Ngo Nguyen Gia Nghi,Nguyen Yen Vy,Nguyen Thi Thanh Lam,Pham Cong Minh KINFORMS 2021 Management Review Vol.16 No.2
In Vietnam, young people are gradually becoming the most accessible objects to social networks. With the development of technology, they usually use online social networks (ONS) as a tool to update information through multimedia content, which may contain other people s information. In different cases, other people s information will be shared and received for different purposes. Therefore, the risk is inevitable and may affect the privacy of individuals whose information is shared, causing turbulence in the community. This study aims to measure impact and find out the factors that influence the willingness of others to share information on social networks in Ho Chi Minh City by examining young people s perceptions that their activities on Facebook may be risky for other people s information. Besides that, the study proposes solutions to avoid possible risks when sharing information with others.
Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Vernonia gratiosa Hance
Cong Pham Van,Anh Hoang Le Tuan,Vinh Le Ba,Han Yoo Kyong,Trung Nguyen Quang,Minh Bui Quang,Duc Ngo Viet,Ngoc Tran Minh,Hien Nguyen Thi Thu,Manh Hoang Duc,Lien Le Thi,Lee Ki Yong 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.6
Species belonging to the Vernonia (Asteraceae), the largest genus in the tribe Vernonieae (consisting of about 1,000 species), are widely used in food and medicine. These plants are rich sources of bioactive sesquiterpene lactones and steroid saponins, likely including many as yet undiscovered chemical components. A phytochemical investigation resulted in the separation of three new stigmastane-type steroidal saponins (1 – 3), designated as vernogratiosides A–C, from whole plants of V. gratiosa. Their structures were elucidated based on infrared spectroscopy (IR), one-dimensional (1D) and two-dimensional nuclear magnetic resonance (2D NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and electronic circular dichroism analyses (ECD), as well as chemical reactivity. Molecular docking analysis of representative saponins with αglucosidase inhibitory activity was performed. Additionally, the intended substances were tested for their ability to inhibit α-glucosidase activity in a laboratory setting. The results suggested that stigmastane-type steroidal saponins from V. gratiosa are promising candidate antidiabetic agents.