Two New Phenolic Glycosides from Hypoxis aurea Lour

Cheng, Zhong-Quan,Yang, Dan,Liu, Yu-Qing,Hu, Jiang-Miao,Jiang, He-Zhong,Wang, Peng-Cheng,Li, Ning,Zhou, Jun,Zhao, You-Xing Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10

Bicluster and Pathway Enrichment Analysis of HCV-induced Cirrhosis and Hepatocellular Carcinoma

Cheng, Peng,Cheng, You,Su, Mei X.,Li, Dong,Zhao, Guo Z.,Gao, Hui,Li, Yan,Zhu, Jie Y.,Li, Hua,Zhang, Tao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the most common form of liver cancer. However, while it is associated frequently with hepatitis C virus (HCV) there is only an elementary understanding of its molecular pathogenesis. Methods: To gain insight into the molecular mechanisms of HCV-induced hepatocarcinogenesis, we performed microarray analysis on 75 surgical liver samples from 48 HCV-infected patients. Results: There were 395 differentially expressed geness between cirrhotic samples and HCC samples. Of these, 125 genes were up-regulated and 270 genes were down-regulated. We performed pathway enrichment analysis and screened as described previously. Conclusions: The differentially expressed genes might be involved in hepatocarcinogenesis through upregulating the pathways of ECM-receptor interaction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulating the pathways of "complement and coagulation cascades". We hope our results could aid in seeking of therapeutic targets for HCV-induced hepatocellular carcinoma.

Comparison of the Gene Expression Profiles Between Smokers With and Without Lung Cancer Using RNA-Seq

Cheng, Peng,Cheng, You,Li, Yan,Zhao, Zhenguo,Gao, Hui,Li, Dong,Li, Hua,Zhang, Tao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Lung cancer seriously threatens human health, so it is important to investigate gene expression changes in affected individuals in comparison with healthy people. Here we compared the gene expression profiles between smokers with and without lung cancer. We found that the majority of the expressed genes (threshold was set as 0.1 RPKM) were the same in the two samples, with a small portion of the remainder being unique to smokers with and without lung cancer. Expression distribution patterns showed that most of the genes in smokers with and without lung cancer are expressed at low or moderate levels. We also found that the expression levels of the genes in smokers with lung cancer were lower than in smokers without lung cancer in general. Then we detected 27 differentially expressed genes in smokers with versus without lung cancer, and these differentially expressed genes were foudn to be involved in diverse processes. Our study provided detail expression profiles and expression changes between smokers with and without lung cancer.

Synthesis of intermediate for lamellarin H

Ye-cheng You,Guang Yang,Ai-ling Wang,De-peng Li 한국물리학회 2005 Current Applied Physics Vol.5 No.5

Fabrication processing of a intermediate, 2,4,5-trimethoxy-a-chlor-acetophenone, was reported in details in this paper. The inter-mediate is the key substance for synthesis of lamellarin H and its derivatives by a simple synthesis route proposed recently. Lam-ellarin H has been shown to have antitumour activity (in particular, against human lung cancer) and anti-HIV properties. Theformed intermediate was identied by means of IR spectrum, HPLC, UV spectrum, H NMR and melting point measurement..

從《漂海錄》看崔溥的中國觀

宋成有(Cheng-You Song),崔昌源(Chang-Yuan Cui) 중국어문논역학회 2012 中國語文論譯叢刊 Vol.0 No.30

Pyohaerok written by Choi Bu, has cleaned text with its vivid andcopious content; China and Korea both historical records is not the least of lacking new historical records; so that is comparable with The Travels of Marco Polo written by Marco Polo and Seungsarok written by Choi Du-chan; that is rank with these records. In recent years, the international academic community has starts to study of Pyohaerok, the result is many. This paper studied from the domestic and foreign scholars, it is procured a few topics about early dynasty in Joseon View of China from Korean Nobles; it further explores the Pyohaerok. This paper is divided into three parts. First, it focuses on Pyohaerok, so exhibited by the context elements and their formation process by early dynasty in Joseon View of China from Korean Nobles; that is the theory of justification and cultural sociability; these is the political and emotional elements in context elements by View of China from Korean Nobles of those time. Analysis of both elements, that is help to grasp Pyohaerok written by Choi Bu’s view of China historical background. Second, it focuses a description on political view of China by Theory of Justification; it based by Choi Bu, and real view of China which is according to the trip to China at their face value based on the fact that the formation of a large number of variegated. Of course, its including the law of the land is very strict, a eunuch in power, officials of official ethics, good and bad, north-south differences are significant, such as human well-being of uncertain perceptions and impressions of China. Third, it focuses on the analysis of the causes of the Korean Nobles in early dynasty of Joseonview of China’s political reasons and cultural reasons. That the coexistence with the Chinese for thousands of years in ancient Korea; it has been able to continue. With different times in the country of Haedong is attached great importance to properly deal with diplomatic issues with China are not unrelated. In other words, in political, that is interactive relationship between of two countries have formed a framework for stable and lasting, is a basic reason. At the same time, it derived from the consistency of the cultural system is a cause cannot be ignored.

Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan

Ying-Cheng Chiang,Chi-An Chen,Chun-Ju Chiang,Tsui-Hsia Hsu,Ming-Chieh Lin,San-Lin You,Wen-Fang Cheng,Mei-Shu Lai 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4

Objective: To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. Methods: The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed. Results: Totally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995. Conclusion: An increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.

High Char-Yield in AN-AM Copolymer by Acidic Hydrolysis of Homopolyacrylonitrile

Run Cheng,You Zhou,Jing Wang,Yumin Cheng,Seungkon Ryu,Riguang Jin 한국탄소학회 2013 Carbon Letters Vol.14 No.1

Acrylonitrile (AN)-acrylamide (AM) copolymers were prepared by nitric acidic hydrolysis of homopolyacrylonitrile. The acrylamino group increased as a function of hydrolysis time, while crystallinity decreased. Differential scanning calorimetry and a thermal gravimetric analysis indicated that the acylamino introduced by acidic hydrolysis effectively enhanced the cyclization reaction at low temperature due to the change of the cyclization reaction mechanism. Char-yield of AN-AM copolymers also gradually increased with increasing hydrolysis time. The maximum char-yield was 49.48% when hydrolized at 23°C in 65% nitric acid solution for 18 h, which was 30% higher than that of non-acidic hydrolysis of homopolyacrylonitrile. Simulation of the practical process also showed an increase of char yields, where the char yields were 55.43% and 62.60% for homopolyacrylonitrile and copolyacrylonitrile, respectively, with a hydrolysis time of 13 h.

Two New Phenolic Glycosides from Hypoxis aurea Lour

Zhong-Quan Cheng,Dan Yang,Yu-Qing Liu,Jiang-Miao Hu,He-Zhong Jiang,Peng-Cheng Wang,Jun Zhou,You-Xing Zhao,Ning Li 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.10

Expression of C4.4A is a Potential Independent Prognostic Factor for Patients with Gastric Cancer

Cheng, Da-Qing,Gu, Xiao-Dong,Li, Zhen-Yang,Xiang, Jian-Bin,Chen, Zong-You Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

C4.4A, a metastasis-associated gene, encodes a glycolipid-anchored membrane protein which is overexpressed in several human malignancies. However, there are few data available on C4.4A expression and its relationship with progression in gastric cancer. Our study was designed to explore the expression of C4.4A in gastric cancer and to correlate it with clinical outcome. C4.4A expression was studied by quantitative real-time RT-PCR and immunohistochemistry for assessment of correlations with clinicopathological factors. C4.4A mRNA expression was significantly up-regulated in gastric cancer as compared with noncancerous tissue (p<0.05)., being observed in 107 (88.4%) of the 121 gastric cancer cases by immunohistochemistry. We found that the expression of C4.4A mRNA was correlated with size of the tumor, depth of invasion, lymph node metastasis, distant metastasis and TNM stage. Moreover, patients with overexpression of C4.4A has a significantly worse survival (p<0.05). Further multivariable analysis indicated that the expression of C4.4A was an independent prognostic indicator for gastric cancer (p<0.05). In conclusion, overexpression of C4.4A correlates with metastatic potential of gastric cancer and C4.4A could be a novel independent prognostic marker for predicting outcome.

ON STRONG M_α-INTEGRAL OF BANACH-VALUED FUNCTIONS

You, Xuexiao,Cheng, Jian,Zhao, Dafang Chungcheong Mathematical Society 2013 충청수학회지 Vol.26 No.2

In this paper, we define the Banach-valued strong $M_{\alpha}$-integral and study the primitive of the strong $M_{\alpha}$-integral in terms of the $M_{\alpha}$-variational measures. We also prove that every function of bounded variation is a multiplier for the strong $M_{\alpha}$-integral.