내린천 유역의 HEC-HMS 모형 적용에 관한 연구

최한규,백효선,정병하 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A

HEC-HMS model should be calibrated to be applied to these basins in Gangwon-do unlike the general basins. In the study, it is investigated whether the HEC-HMS model may be applied or not to Naerinchon basin where is the typical basin of Gangwon-do Additionally, the straightforword module of HEC-HMS for simulating the hydrologic characteristic of Gangwon-do basins well will be suggested by comparison of the numerical results with the observed data. The hydrologic results estimated by several modules such as Clark, SCS and Snyder methods in HEC-HMS model have been compared with the observed data for 1999~2000 storm events. It is concluded that Clark method are relatively applicable to the basins in Gangwon-do rather than the others methods. The parametric studies for HEC-HMS model should be studied further in order to apply to Gangwon-do basins more accurately.

파랑에 의한 항내진동의 제어에 관한 실험적 연구

최한규,이선용 江原大學校 産業技術硏究所 1994 産業技術硏究 Vol.14 No.-

This study is to investigate harbor oscillation phenomenon according to combination of the wall structures by model experiment in a three dimensional wave basin. Six different types of wall combination were chosen through combination of erect wall, erect dissipation block, and san beach, wave height at selected points in the harbor were measured by electronic wave gage. Test results show that the wall structure composed solely of erect walls showed generally highest harbor oscillation. Since natural beach shows lower reflection than erect dissipation block do, we thought it would be more efficient to use natural beach for improved harbor oscillation. The result showed, however, that the erect dissipation block are more efficient than natural beach to attain less harbor oscillation. The reason seens that the erect dissipation blocks have better capability to control breaking wave on the surface of the structure.

불규칙파랑 효과를 고려한 평형단면의 특성

최한규,이철웅,한춘호 江原大學校 産業技術硏究所 1996 産業技術硏究 Vol.16 No.-

The equilibrium beach profiles with the effects of random waves and nonuniform grain size in the surt zone are drived from the Thornton and Guza91983)'s energy dissipation model. The derived beach profiles are the functions of the breaking wave strength, the frequency of the incident wave, and the wave induced-energy dissipation at breaking point. It is not confirmed that the equilibrium beach profiles are better agreement with the measured profiles than the classical profiles. However, the characteristic of the changes of the beach profiles with respect to the breaking wave stgrngth and the frequency of the incident wave can be analyzed which has not been studied by the classical model.

일련연속교각, 다중연속교각, 말뚝군의 세굴특성에 관한 실험적 연구

최한규,김인호,최용묵 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

As materials on the river bed have been changing through erosion, transportation and accumulation, so does the waterway's section. So many bridges have nowadays been constructed to the same direction as water flows. However further researches are still needed on the scours of succession row piers and multiple row piers. Analyzing them through hydraulic stimulation experiments, this study deals with the scour character with the change of diameters in row piers which have been built in the identical direction of water flow and also the part-scour change in multiple row piers.

다변량 분석법을 이용한 소양강댐 상류 유역의 하천 수질 평가

최한규,백효선,허준영 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A

The object of this study is to evaluate the factors affecting the water quality and to propose the influence of dominant factor quantitatively. The correlation analysis was performed to know the correlationship among the water quality items. As a result of partial correlation analysis, it was shown that the water quality items are affected by the rainfall item directly. The factor analysis was performed to grasp some number of factors on each point for deducing the items of similar variable characteristics. The four points were divided into different factor groups. It was grasped that NH_3-N and NO_3-N items have different variable characteristics after comparing the items. The Multiple regression analysis can decrease the number of observation. In the deduced multiple regression formula, it was shown that the rate of T-N, NH_3-N and NO_3-N in the independent variable took about 60% among all the regression formulas.

春川댐 放流時 橋梁의 安定性 檢討를 위한 水理模型實驗 硏究

최한규,백효선,최상순 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

In The case of the bridge which is located in the downstream of the dam, effect of the running water and stability of the bridge is studing by using the Hydraulic model test. 1. The water level change of `Seosang1 bridge' along Chunchon dam spill occurred through this experiment more greatly than a numerical conspiracy. 2. Bight is the spot where a difference occurs in located bridge piers(p18-p28) greatly, and an influence of Chunchon dam occurs in greatly.

다시마 식이가 흰쥐에서 글리피지드의 체내동태에 미치는 영향

최한곤,장보현,이종달,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Drug interactions with food, on occasion, lead to serious nutritional and functional changes in the body as well as alternations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increase risk of micovascular, macrovascurlar, and neuropathic complications. However, the precise mechanixm of diabetes mellitus remains unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo- or hyperglycemia and preventing complications. The purpose of this study was to investigate the effect of Laminaria japonica diet on the absorption, distribution, metabolism and excretion of glipizide which are frequently used in the treatment of diabetes. Diabetic rats induced by streptozotocin were employed in this study. Blood concentrations of oral hypoglycemic agents were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_a, t_1/2, C_max, t_max, and AUC. Administration of glipzide in normal rats treated with Laminaria japonica diet showed significant increase in AUC, k_a, t_1/2, t_max and decrease in C_max, compared to those without Laminaria japonica diet. This might result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption. Administration of glipizide in diabetic rats treated with Laminaria japonica diet showed significant increase in t_1/2 and t_max, and decrease in C_max, compared to those without Laminaria japonica diet. This might also result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption and flattened blood concentration of glipizide. The oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of glipizide caused by long-term Laminaria japonica diet.

흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

최한곤,장보현,이종달,김정애,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

Drug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.

3차원 분자 모델을 사용한 재료내의 저장 에너지 계산에 관한 연구

최덕기,유한규 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.5

This paper addresses a theoretical approach to calculate the amount of the stored energy during a deformation using atomistic level simulation. During a deformation, only a small percent of the energy input is stored in the material, and most of input energy is converted into heat. The cause of the temperature rise within materials is traditionally credited to dislocations, vacancies and other defects. An atomistic material model for fcc such as copper is used to calculated the stored elastic energy. The potential energy is obtained by a molecular dynamics (MD) simulation. Two different states are considered for comparison: one is a perfect state and the other is a state with dislocations. The calculated potential energies in these two states are compared. The difference in the potential energies is considered the amount of the stored elastic energy of dislocations. The conversion factor, i.e., the fraction of the input energy that is stored as elastic energy within a material is then calculated. (Received December 22, 2003)

자궁경부 종양에서 Nested PCR을 이용한 인유두종 바이러스 16형 및 18형의 검출과 임상적 의의

최규연,이종국,최승도,배동한,김휘준,김민관 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

The aim of this study is to estimate the prevalence of HPV types(16, 18) in cervix of gynecologic patients and to elucidate the relationship of HPV types(16, 18) and clinical characteristics. Human papilloma virus(HPV) has attracted attention as one of the viruses linked to human cancers. Numerous clinical, epidemiological, and molecular studies indicate that certain genital HPV types are associated with cervical carcinoma. Of 100 types of HPV identified today, at least 40 have been found in the anogenital mucosa. A classification of these types into three groups with differing pathogenicity has been proposed: HPV type 6, 11, 42, 43, and 44 are detected more frequently in benign lesions such as condylomata; HPV type 31, 33, 35, 51, 52, and 58 are found more often in low grade squamous intraepithelial lesions than invasive lesions; and HPV 16, 18, 45, and 56 are predominant in high grade squamous intraepithelial lesions and invasive carcinoma. To detect HPV types prevalent in carcinoma of the uterine cervix, a type-specific, sensitive polymerase chain reaction(PCR)-based assay for HPV types 16, 18 was applied to 18 cervical carcinomas(15 squamous cell carcinomas and 3 adenocarcinomas), 21 cases of cervical intraepithelial neoplasia(CIN), and 42 samples of cervicitis and histologically normal. DNA extraction from cervical swab was done using DNAzol™(MBI, USA) and Nested PCR was done using HPV detection kit(Bioneer, Korea). The amplified product was analyzed directly on the basis of the site of ethidium bromide-stained band visible after agarose gel electrophoresis. The results were as follows 1. The positivity rates of HPV type 16 and HPV type 18 were 12.5%(90/718), 2,5%(18/718). so, HPV 16 positive cases(12.5%) was five folds as HPV 18 positive cases(2.5%) 2. Forty eight percents(39/81) of HPV 16 or HPV 18 positive cases were CIN, microinvasive cancer. 3. Age, Gestation number, Clinical stage, Histologic cell type in relation to HPV types were not statistically significant.