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Fam83h is Associated with Intracellular Vesicles and ADHCAI
Ding, Y.,Estrella, M.R.P.,Hu, Y.Y.,Chan, H.L.,Zhang, H.D.,Kim, J.-W.,Simmer, J.P.,Hu, J.C.-C. SAGE Publications 2009 Journal of dental research Vol.88 No.11
<P>Defects in <I>FAM83H</I> on human chromosome 8q24.3 cause autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI). <I>FAM83H</I> does not encode a recognizable signal peptide, so we predicted that the Fam83h protein functions within the cell. We tested this hypothesis by constitutively expressing mouse Fam83h with green fluorescent protein (GFP) fused to its C-terminus in HEK293 and HeLa cell lines. Green fluorescent signal from the Fam83h-GFP fusion protein was associated with perinuclear vesicles, usually in the vicinity of the Golgi apparatus. No signal was observed within the nucleus. In addition, we identified <I> FAM83H</I> nonsense mutations in Hispanic (C1330C>T; p.Q444X) and Caucasian (c.1192C>T; p.Q398X) families with ADHCAI. We conclude that Fam83h localizes in the intracellular environment, is associated with vesicles, and plays an important role in dental enamel formation. <I>FAM83H</I> is the first gene involved in the etiology of amelogenesis imperfecta (AI) that does not encode a secreted protein.</P>
Origin of the ferromagnetism in ZnCoO from chemical reaction of Co<sub>3</sub>O<sub>4</sub>
Lee, S.,Kim, B.S.,Chan Cho, Y.,Shin, J.M.,Seo, S.W.,Cho, C.R.,Takeuchi, I.,Jeong, S.Y. Elsevier 2013 Current Applied Physics Vol.13 No.9
We investigated conversion of Co<SUB>3</SUB>O<SUB>4</SUB> to Co nanoclusters through hydrogen reduction. Quantitative analysis is performed on the conversion of Co<SUB>3</SUB>O<SUB>4</SUB> to Co metal as a function of hydrogen-injection conditions. Our results reveal that Co<SUB>3</SUB>O<SUB>4</SUB> must be completely eliminated to avoid formation of the metal phase in ZnCoO. We also propose a new M-T curve based method for detecting nano-sized Co clusters which are below the detection limit of diffraction techniques. It is also found that the Co phase can be transformed back to the Co<SUB>3</SUB>O<SUB>4</SUB> phase through oxygen annealing and that, as a result, the ferromagnetism can be eliminated. These findings are discussed in the context of the origin of ferromagnetism in ZnCoO.
Kim, S.J.,Kim, W.K.,Chan Cho, Y.,Park, S.,Jeong, I.K.,Yang, Y.S.,Kuroiwa, Y.,Moriyoshi, C.,Tanaka, H.,Takata, M.,Jeong, S.Y. Elsevier 2011 CURRENT APPLIED PHYSICS Vol.11 No.3
This study investigated the bonding nature and electrostatic potential of asymmetric Li ionic mobility in Li<SUB>2</SUB>B<SUB>4</SUB>O<SUB>7</SUB> crystals using the maximum entropy method (MEM) combined with Rietveld refinement and Ewald's technique. Compared with the interaction between oxygen and boron, Li<SUP>+</SUP> ions exhibited weak interactions with both oxygen and boron. Furthermore, electrostatic-potential-distribution analysis showed that Li<SUP>+</SUP> ions had a much weaker interaction with the matrix along the c-axis channel, suggesting that higher ionic conductivity occurred along the c-axis than along the a- and b-axes.
Kang, Y.-K.,Yau, T.,Park, J.-W.,Lim, H. Y.,Lee, T.-Y.,Obi, S.,Chan, S. L.,Qin, SK.,Kim, R. D.,Casey, M.,Chen, C.,Bhattacharyya, H.,Williams, J. A.,Valota, O.,Chakrabarti, D.,Kudo, M. Oxford University Press 2015 Annals of oncology Vol.26 No.12
<P>Axitinib plus best supportive care failed to meet the primary end point of overall survival in second-line treatment of advanced hepatocellular carcinoma in a randomized phase II study. However, the axitinib arm showed substantially improved progression-free survival, time to tumour progression, and clinical benefit rate compared with the placebo arm, with acceptable safety profile. Background: The efficacy and safety of axitinib, a potent and selective vascular endothelial growth factor receptors 1-3 inhibitor, combined with best supportive care (BSC) was evaluated in a global, randomized, placebo-controlled phase II trial in patients with locally advanced or metastatic hepatocellular carcinoma (HCC). Patients and methods: Patients with HCC and Child-Pugh Class A who progressed on or were intolerant to one prior antiangiogenic therapy were stratified by tumour invasion (presence/absence of extrahepatic spread and/or vascular invasion) and region (Asian/non-Asian) and randomized (2:1) to axitinib/BSC (starting dose 5 mg twice-daily) or placebo/BSC. The primary end point was overall survival (OS). Results: The estimated hazard ratio for OS was 0.907 [95% confidence interval (CI) 0.646-1.274; one-sided stratified P = 0.287] for axitinib/BSC (n = 134) versus placebo/BSC (n = 68), with the median (95% CI) of 12.7 (10.2-14.9) versus 9.7 (5.9-11.8) months, respectively. Results of prespecified subgroup analyses in Asian versus non-Asian patients or presence versus absence of tumour invasion were consistent with the overall population. Improvements favouring axitinib/BSC (P < 0.01) were observed in secondary efficacy end point analyses [progression-free survival (PFS), time to tumour progression (TTP), and clinical benefit rate (CBR)], and were retained among Asian patients in the prespecified subgroup analyses. Overall response rate did not differ significantly between treatments and patient-reported outcomes favoured placebo/BSC. Most common all-causality adverse events with axitinib/BSC were diarrhoea (54%), hypertension (54%), and decreased appetite (47%). Baseline serum analyses identified potential new prognostic (interleukin-6, E-selectin, interleukin-8, angiopoietin-2, migration inhibitory factor, and c-MET) or predictive (E-selectin and stromal-derived factor-1) factors for survival. Conclusions: Axitinib/BSC did not improve OS over placebo/BSC in the overall population or in stratification subgroups. However, axitinib/BSC resulted in significantly longer PFS and TTP and higher CBR, with acceptable toxicity in patients with advanced HCC. Trial Registration: ClinicalTrials.gov, NCT01210495.</P>
Optimal wind-induced load combinations for structural design of tall buildings
C.M. Chan,F. Ding,K.T. Tse,M.F. Huang,K.M. Shum,K.C.S. Kwok 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.5
Wind tunnel testing technique has been established as a powerful experimental method for predicting wind-induced loads on high-rise buildings. Accurate assessment of the design wind load combinations for tall buildings on the basis of wind tunnel tests is an extremely important and complicated issue. The traditional design practice for determining wind load combinations relies partly on subjective judgments and lacks a systematic and reliable method of evaluating critical load cases. This paper presents a novel optimization-based framework for determining wind tunnel derived load cases for the structural design of wind sensitive tall buildings. The peak factor is used to predict the expected maximum resultant responses from the correlated three-dimensional wind loads measured at each wind angle. An optimized convex hull is further developed to serve as the design envelope in which the peak values of the resultant responses at any azimuth angle are enclosed to represent the critical wind load cases. Furthermore, the appropriate number of load cases used for design purposes can be predicted based on a set of Pareto solutions. One 30-story building example is used to illustrate the effectiveness and practical application of the proposed optimization-based technique for the evaluation of peak resultant wind-induced load cases.
Indium oxide, tin oxide and indium tin oxide nanostructure growth by vapor deposition
M.K. Fung,K.K. Wong,X.Y. Chen,Y.F. Chan,A.M.C. Ng,A.B. Djurišić,W.K. Chan 한국물리학회 2012 Current Applied Physics Vol.12 No.3
Indium oxide, tin oxide and indium tin oxide nanowires have been grown by vapor deposition on Si and quartz substrates. Under the growth conditions used, pure SiOx nanowires, a mixture of SiOx and indium oxide, tin oxide or indium tin oxide nanostructures, or pure indium oxide, tin oxide or indium tin oxide nanostructures could be obtained at different substrate temperatures. The growth mechanism of the obtained nanostructures at different substrate temperatures is discussed. Optical and electrical properties of the deposited pure indium oxide, tin oxide or indium tin oxide nanostructures have been measured, and low sheet resistances on quartz substrates have been obtained for indium oxide and indium tin oxide nanostructures.
Occupant comfort evaluation and wind-induced serviceability design optimization of tall buildings
M.F. Huang,Kenny. C.S. Kwok,C.M. Chan 한국풍공학회 2011 Wind and Structures, An International Journal (WAS Vol.14 No.6
This paper presents an integrated wind-induced dynamic analysis and computer-based design optimization technique for minimizing the structural cost of general tall buildings subject to static and dynamic serviceability design criteria. Once the wind-induced dynamic response of a tall building structure is accurately determined and the optimal serviceability design problem is explicitly formulated, a rigorously derived Optimality Criteria (OC) method is to be developed to achieve the optimal distribution of element stiffness of the structural system satisfying the wind-induced drift and acceleration design constraints. The effectiveness and practicality of the optimal design technique are illustrated by a full-scale 60-story building with complex 3D mode shapes. Both peak resultant acceleration criteria and frequency dependent modal acceleration criteria are considered and their influences on the optimization results are highlighted. Results have shown that the use of various acceleration criteria has different implications in the habitability evaluations and subsequently different optimal design solutions. The computer based optimization technique provides a powerful tool for the lateral drift and occupant comfort design of tall building structures.
Indium tin oxide nanorods by dc sputtering
M.K. Fung,Y.C. Sun,A.M.C. Ng,A.B. Djurišić,W.K. Chan 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Growth of indium tin oxide (ITO) nanorods by sputtering without any use of templates or oblique angle deposition has been achieved. The morphology, optical and electrical properties of ITO nanorods obtained under different deposition conditions have been characterized. The deposition conditions resulting in high transmission and low sheet resistance have been determined. Dense ITO nanorod array has potential for application as a contact in light-emitting diodes