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Accumulation and Toxicity of Germanium in Cucumber under Different Types of Germaniums
Choi, Ik Won,Seo, Dong Cheol,Han, Myung Ja,DeLaune, R. D.,Ok, Yong Sik,Jeon, Weon Tai,Lim, Byung Jin,Cheong, Yong Hwa,Kang, Hang Won,Cho, Ju Sik Taylor Francis 2013 Communications in soil science and plant analysis Vol.44 No.20
Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
Choi, Bo-Gil,Kim, Ok-Young,Chung, Byung-Ho,Cho, Won-Jea,Cheon, Seung-Hoon,Choi, Sang-Un,Lee, Chong-Ock The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2
Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.
Calcific Amyloidoma of Tibialis Anterior Muscle
Byung-Ki Cho(조병기),Yong-Min Kim(김용민),Dong-Soo Kim(김동수),Eui-Sung Choi(최의성),Hyun-Chul Shon(손현철),Kyung-Jin Park(박경진),Hu-Shan Cui(최호산),Seok-Won Kim(김석원),Ok-Jun Lee(이옥준) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.3
연부조직에 발생하는 단발성 아밀로이드종은 매우 드물다. 저자들은 경골 근위부 골절 후 20여년 뒤에 전경골근에서 발생한 염증을 동반한 석회화성 아밀로이드종 1예를 경험하였으며, 종양 제거술 후 재발없이 만족스런 결과를 얻을 수 있었다. 아밀로이드종은 매우 드물기도 하고 골수염이나 골종양과 구분이 어려웠던 경우이므로 문헌고찰과 함께 증례보고를 하는 바이다. Calcific amyloidoma of the soft tissue is quite rare and it is difficult to make a differential diagnosis from other lesions such as osteomyelitis or bone tumor. We encountered a case of a calcified amyloidoma found in the anterior tibial muscle that occurred more than 20 years after a proximal tibial fracture adjacent to the origin of the muscle. The features of the lesion resembled osteomyelitis. Satisfactory result was obtained by a thorough mass excision. We report this case with review of the relevant literature.
Byung Rim Park,Jin Ok Kim,Min Sun Kim,Moon Young Lee,Jae Hyo Kim,Yuan-Zhe Jin,Myung Ae Choi 대한생리학회-대한약리학회 2001 The Korean Journal of Physiology & Pharmacology Vol.5 No.2
<P> To investigate the effects of electrical stimulation on vestibular compensation, which is the recovery of vestibular symptoms following unilateral labyrinthectomy (UL), intermittent electrical stimulation was applied to the injured vestibular portion in Sprague-Dawley rats. Vestibuloocular and vestibulospinal reflexes, electrical activity and expression of c-Fos protein in medial vestibular nuclei (MVN) were measured with time following UL. Spontaneous nystagmus occurred with frequency of 2.9⁑0.2 beats/sec at 2 hours after UL and disappeared after 72 hours. Electrical stimulation decreased the frequency of nystagmus significantly till 24 hours after UL. Roll head deviation was 107⁑9.7<SUP>o </SUP>at 2 hours after UL and the deviation was maintained till 72 hours, but electrical stimulation decreased the deviation significantly 6 hours after UL. Resting activity of type I neurons in ipsilateral MVN to the injured vestibular side decreased significantly compared with control at 6 and 24 hours after UL, but the activity of type I neurons was recovered to control level by electrical stimulation at 24 hours after UL. Gain of type I neurons induced by sinusoidal rotation of 0.1 Hz decreased significantly till 24 hours after UL, but electrical stimulation restored the activity at 24 hours. The gain of type II neurons decreased significantly at 6 hours after UL, but electrical stimulation restored the activity. Expression of c-Fos protein was asymmetric between bilateral MVN till 24 hours after UL, but the asymmetry disappeared by electrical stimulation 6 hours after UL. These results suggest that electrical stimulation to the injured vestibular portion facilitates vestibular compensation following UL by restoration of symmetry of neuronal activity between bilateral vestibular nuclei resulting from increased activity in ipsilateral vestibular nuclei to the injured side.
The Development of a Korean Drug Dosing Database
Byung Koo, Lee,Sun Ah, Kim,Jung Hoon, Kim,Yoo Jin, Jang,Young Mi Jeong,Joong Un, Hwang,Kyung Suk, Choi,Iyn Hyang, Lee,Jin Ok, Jeon,Hong Bin, Kim,Ho Jun, Chin,Ji Hye, Ha 이화여자대학교 약학연구소 2012 藥學硏究論文集 Vol.- No.22
OBJECTIVES: This report describes the development process of a drug dosing database for ethical drugs approved by the Korea Food & Drug Administration (KFDA). The goal of this study was to develop a computerized system that supports physicians' prescribing decisions, particularly in regards to medication dosing. METHODS: The advisory committee, comprised of doctors, pharmacists, and nurses from the Seoul National University Bundang Hospital, pharmacists familiar with drug databases, KFDA officials, and software developers from the BIT Computer Co. Ltd. analyzed approved KFDA drug dosing information, defined the fields and properties of the information structure, and designed a management program used to enter dosing information. The management program was developed using a web based system that allows multiple researchers to input drug dosing information in an organized manner. The whole process was improved by adding additional input fields and eliminating the unnecessary existing fields used when the dosing information was entered, resulting in an improved field structure. RESULTS: A total of 16,994 drugs sold in the Korean market in July 2009, excluding the exclusion criteria (e.g., radioactivity drugs, X-ray contrast medium), usage and dosing information were made into a database. CONCLUSIONS: The drug dosing database was successfully developed and the dosing information for new drugs can be continually maintained through the management mode. This database will be used to develop the drug utilization review standards and to provide appropriate dosing information.