전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.

직장암에 대한 수술 전 방사선-화학요법 적용시 통상적인 영상진단 검사로 충분한가?

안병권 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

Background : Recently, preoperative chemoradiation has been accepted to control locally advanced rectal cancer according to increasing the anal sphincter preservation, improving the resectability and survival. However, patient selection of preoperative chemoradiation should be done carefully, because distant metastasis or peritoneal seeding of cancer was found in some patients during interval between preoperative chemoradiation and surgery, or in surgery or at immediate postoperative period. Methods : We reviewed a total of 139 patients who were treated by preoperative chemoradiation between January, 1995 and December, 2004, all of them had locally advanced rectal cancer. In work-up study for preoperative chemoradiation, no distant metastasis was proven by chest x-ray, abdominal and pelvic CT. All patients received the full scheduled dose of radiation (range, 4500- 5500 cGy). The radiation was administered in divided tractions over a five-week period. 5flurouracil (450 mg/㎡/day) and leucovorin (20 mg/㎡/day) were administered continuously on day 1-5 and 19-33. Interval between preoperative chemoradiation and surgery was within 48 weeks. Before surgery, all patients underwent chest x-ray, liver ultrasonography and pelvic CT to do restaging. Results : One lung metastasis, 1 inguinal lymph node metastasis, and 1 bone metastasis were identified by restaging period. Three hepatic metastasis, 1 peritoneal seeding, 5 paraaortic lymph node metastasis were identified in operation field. Two bone metastases were identified at immediate postoperative period within 3 months. The 3 patients with bone metastasis complained of shoulder pain or back pain and all of bone metastases were identified by bone scan. As a result, 14 patients(10.1%) were inadequately included to preoperative chemoradiation with conventional imaging study. All of them died within one and a half year. Conclusions : In conclusion, in order to select preoperative chemoradiation adequately in locally advanced rectal cancer, it seems that specific imaging study is necessary to confirm liver metastasis or peritoneal seeding of cancer precisely. In addition, bone scan is mandatory to work-up of preoperative chemoradiation, if patient complained of shoulder or back pain.

미소 진폭 파형벽을 가진 유로내에서 凝縮을 수반하는 定常 2次元 超音速 流動

權純範,金丙知,安亨濬 慶北大學校 1992 論文集 Vol.52 No.-

The characteristic of the steady two-dimensional supersonic flow with condensation along a wavy wall of small amplitude in channel is investigated through the direct marching method of characteristics. The very complex problem that may appear where the overlapping of the same family charateristics occurs, can be satisfactorily solved by means of the modified method suggested by Zucrow. In the present study for the case of supersonic moist air flow, the dependency of location of formation and reflection of oblique shock wave generated by the wavy wall, and distributions of flow properties, on the relative humidity and temperature at the entrance of wavy wall is clarified by plots of frozen Mach number and iso-flow properties. Also, it is confirmed that the wavy wall plays an important key role in the formation of oblique shock wave, and that the effect of condensation on the flow field appears apparently.

미소 진폭 파형벽을 가진 유로내에서 응축이 수반되는 초음속유동의 Prandtl-Meyer 팽창에 관한 실험적 연구

권순범,안형준,김병지,선우은 경북대학교 산업기술연구소 1993 産業技術硏究誌 Vol.21 No.-

The characteristics of the Prandtl-Meyer expansion of supersonic flow with condensation through a channel with a small amplitude wavy wall are investigated experimentally. In the present study, for the case of moist air flow in the type of indraft supersonic wind tunnel, the dependency of formation and reflection locations of the oblique shock wave and the distribution of flow properties are clarified by flow visualization and pressure measurement with the variation of the specific humidity and temperature at the entrance of the wavy wall and the attack angle of the wavy wall to the main stream. Also, we confirm that the wavy wall plays an important key role in the formatio of oblique shock wave, and that the effect of condensation on the flow field appears apparently.

단일전력단으로 구성된 AC/DC 풀 브리지 컨버터에 관한 연구

안병무,권순도,김용,백수현 동국대학교 산업기술연구원 2000 산업기술논문집 Vol.11 No.1

본 논문에서는 단일단 AC/DC 폴브리지 토포로지에 적합한 고주파 소프트 스위칭 컨버터응용에 근거를 두고 제안한다. 제안된 컨버터는 입력전류를 불연속 모드로 동작시켜 역률을 개선하며 입력전류의 zero-crossing-point에서의 왜곡을 개선함으로써 고조파를 감소시켜 고역률, 영전압 스위칭, 저잡음과 고효율을 구현한다. 펄스폭 변조 제어방식은 각각의 스위칭과 정류손실을 저감하기 위해 사용되었다. 제안한 컨버터는 IGBT를 전력스위치로서 주로 사용되지는 고전압, 고전력 컨버터응용에 적용할 수 있으며, 실험을 통하여 1.5kW, 30kHz로 동작하는 컨버터를 구현하였다. A single stage AC/DC converter based on a full bridge topology suitable for high frequency soft switching converter applications is proposed. The power factor correction can be achieved by the discontinuous conduction mode(DCM) operation of the input current. The proposed converter gives the good power factor, low line current harmonics. The proposed converter has high power factor, zero voltage switching low noise and high efficency. A pulse width modulation control is employed to reduce the switching and rectification losses respectively. The proposed converter is attractive for high-voltage, high-power applications where IGBT's are predominantly used as the power switches. The principle of operation, features, and design are verified on a 1.5kW, 30kHz, IGBT based experimental circuit.

산처리에 의한 정수슬러지 감량화

이병문,권재현,안규홍,이석헌,권대영 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

The acidic treatment of waterworks sludge released organic materials as well as inorganics such as Al, Fe and Mn. Through solubilization as mentioned above, the content of suspended solids reduced by 18% at final pH 3.5. It also increased thickening efficiency and dewaterability of sludge. However overdosing of H_2SO_4 made dewaterability deteriorated. It showed that the optimal condition of acidic treatment be as follows; 5.5㎖ dose of H_2SO_4(97%)/1 sludge, final pH 3.5 and 15minutes of reaction time. Under these conditions, reduction efficiencies of sludge through thickening and dewatering were 57% and 92.2% respectively and then 7.8% of raw sludge released as cake compared to 10.5% without acidic pre-treatment. Therefore, mass of dewatered cake decreased by 26% through acidic treatment. Water content of dewatered cake was reduced from 71% to 62% due to this treatment. The changes of sludge properties including particle size, zeta-potential and bound water by acidic treatment appear to be important keys in assesment of the improvement of sludge dewaterability.

직장암 절제 수술 후에 발생하는 문합부 누출의 위험 인자

이승현,안병권,배승언 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: Anastomotic leakages are one of the most serious complications after rectal cancer resection. The aim of this study was to identify the relevant risk factors of anastomotic leakage after low anterior resection for rectal cancer. Methods: We reviewed retrospectively the medical records of 251 patients, who underwent low anterior resection for rectal cancers between January, 2001 and December, 2004. All patients underwent a tumor-specific mesorectal excision. We excluded the patients underwent emergent surgery, protective stoma formation and used pelvic drainage. Results: The mean distance of the tumor from the anal verge was 8.0 cm (3-16 cm). Lower anterior resection was performed in 214 patients and ultra-low anterior resection in 37 patients. Fifteen patients had preoperativechemoradiation for rectal cancer. The anastomotic leakage was identified in 10 patients (4.0%). Seven patients with anastomotic leakage underwent corrective surgery.Other postoperative complications included 5 rectovaginal fistula (2.0%) and 4 intra-abdominal abscess (1.6%). The incidences of anastomotic leakage were significantly different according to preoperative chemoradiation (13.3% vs. 3.4%, p=0.05) and rectal obstruction (33.3% vs. 3.3%, p=0.00). Conclusions: In patients with history of preoperative chemoradiation and rectal obstruction, the careful management for anastomotic leakage is necessary

상행 결장의 게실염을 동반한 S상 결장암 1예

이승현,안병권,백승언 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

The coexistence of colon cancer and colonic diverticulum has been reported. It is suggested to share similar epidemiologic features and risk factors between diverticular disease and colorectal neoplasia. An 51-year-old man patient was admitted for evaluation. He had no subjective symptoms. He had a mass-like lesion of ascending colon on CT. Multiple outpouching diverticuli with pus-like discharge of ascending colon were identified on colonofiberscope. A sigmoid polyp was also noted incidentally. Biopsy confirmed the diagnosis of adenocarcinoma. Thereafter, the patient underwent right hemicolectomy with sigmoidectomy.

복강경 대장절제술의 초기 경험

이승현,안병권,백승언 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.1

Background : Laparoscopic colon resection has many benefits, such as decreased incidence of pulmonary complication, faster return of the bowel function, decreased narcotic requirements, shorter hospital stay, and faster recovery time. However it has long learning curve because of complex mesenteric blood supply, multiple quadrant location and bowel anastomosis. The aim of this study was to identify the clinical outcome for laparoscopic colorectal surgery as initial experience. Methods : From Jan. 2002 to Dec. 2006, we reviewed 16 patients who had underwent laparoscopic colon resection at Kosin University Gospel Hospital. We studied the clinical outcome, such as operative time, passage of flatus, retrieved lymph node, complications, hospital stay. Results : Of the 16 patients, 6 cases were male, 10 cases were female. The median age was 50.1 years(26-69). The primary diseases were cancer in 15 cases (93.7%), and benign in 1 case. The operative procedure were right hemicolectomy in 3 cases (18.8%), left hemicolectmy in 1 cases (6.3%), anterior resection in 6 cases (37.5%), low anterior resection in 4 cases (25.0%) and total colectomy in 1 case (6.3%). The mean operative time was 227.8 minutes (150-370). The flatus passage was 2.6 days (1-6). The mean number of retrieved lymph node was 12.2 (3-27). The postoperative complication was wound infection in 2 cases. The mean hospital stay was 11.1 days. Conclusions : The laparoscopic colorectal surgery seems to be safe. To evaluate the benefit compare to open colorectal surgery, we need further study.

Trp P-1 변이원성에 대한 Resveratrol의 항돌연변이 효과

장귀현,안병용,권용주,최동성 한국식품영양학회 2001 韓國食品營養學會誌 Vol.14 No.4

Trp P-1에 의해 유도된 돌연변이원성에 대한 resveratrol의 억제효과를 Salmonella typhimurium TA 98, 100를 이용한 Ames test법으로 검색하였다 먼저 틀변경 돌연변이를 일으키는 S. typhimurium TA98과 염기치환 돌연변이 특성을 지닌 S.typhimurium TA 100에서 Trp P-1의 변이원성을 비교한 결과 S. typhimurium TA98에서 복귀돌연변이의 뚜렷하게 수가 증가되었다. 이러한 결과는 Trp P-1의 돌연변이 유발은 틀변경을 주로 일으킨 돌연변이 유도란 사실을 뒷받침하는 결과로 해석되며,S. typhimurium TA98에서 Trp P-1의 최적농도는 400 ng로 나타났다. S. typhimurium TA98의 생육에 영향을 미치지 않는 농도까지 resveratrol의 농도를 assay당 2, 10, 25, 50 100, 300 ㎍으로 증가시켰을 경우 항돌연변이 효과는 각각 13%, 30%, 52%, 65%, 81% 및 89%로 나타났다. 이러한 결과로부터 Trp P-1의 변이원성에 대하여 resveratrol은 강한 돌연변이 억제효과를 나타내며, 용량 의존적으로 억제함이 확인되었다. The antimutagenic activity of resveratrol on the mutagenicity induced by Trp P-1(3-amino-1,4-dimethyl-5H-pyrido{4,3-b}indole) was studied using the Ames test with Salmonella typhimurium TA98 and 100. Trp P-1 showed strong mutagenecity in S. typhimurium TA98, but was higly decreased mutagenecity in S. typhimurium TA100. This result suggests that the mutagenecity of Trp P-1 can be mainly induced by the DNA lesions causing frame shift. Resveratrol itself did not show antibacterial effect upon 300 rig/assay. Resveratrol showed the strongest inhibitory effect with dose dependent manner on the mutagenicity induced by Trp P-1. The inhibition rates of resveratrol at concentration of 2, 10, 25, 50, 100, 300 ㎍/assay were 13%, 30%, 52%, 65%, 81%, 89%, respectively.